Abstract：
:A pilot chemoprevention study from the Royal Marsden Hospital in the United Kingdom demonstrated that tamoxifen could be administered safely to healthy women. This led to the establishment of multicenter trials, including the National Surgical Adjuvant Breast and Bowel Project (NSABP) P-1 and Italian National Cancer Institute trials. An interim analysis of the Royal Marsden Hospital trial did not detect a preventive effect. The Italian trial concurred with the Royal Marsden Hospital trial. In contrast, the larger NSABP study detected a 49% reduction in the incidence of breast cancer with tamoxifen chemoprevention. Possible reasons for the different results are examined and the implications for tamoxifen chemoprevention are discussed.
journal_name
Clin Breast Cancerjournal_title
Clinical breast cancerauthors
Ross PJ,Powles TJdoi
10.3816/CBC.2001.n.008keywords:
subject
Has Abstractpub_date
2001-04-01 00:00:00pages
33-6; discussion 37-40issue
1eissn
1526-8209issn
1938-0666pii
S1526-8209(11)70317-2journal_volume
2pub_type
杂志文章,评审abstract：BACKGROUND:Recent observational studies are concerning because they document rising mastectomy rates coinciding with more than a dozen reports that lumpectomy has better overall survival (OS) than mastectomy. Our aim was to determine if there were differences in OS of matched breast cancer patients undergoing lumpectom...
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更新日期：2019-06-01 00:00:00
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journal_title：Clinical breast cancer
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doi：10.3816/CBC.2006.n.035
更新日期：2006-08-01 00:00:00
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更新日期：2020-12-05 00:00:00
abstract：:The management of metastatic breast cancer is changing as a consequence of extraordinary discoveries in cancer research and the development of more advanced diagnostic technologies. Although traditional chemotherapeutics such as anthracyclines and taxanes still represent the mainstay of treatment for this disease, new...
journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
doi：10.3816/CBC.2001.n.002
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abstract：BACKGROUND:Letrozole withdrawal for 3 months might permit estrogenic stimulation in residual resistant breast cancer disease susceptible to letrozole reintroduction. We investigated the impact of a 3-month letrozole-free interval on serum estradiol levels in patients with early stage breast cancer. PATIENTS AND METHOD...
journal_title：Clinical breast cancer
pub_type： 杂志文章
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journal_title：Clinical breast cancer
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journal_title：Clinical breast cancer
pub_type： 杂志文章
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更新日期：2020-11-17 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
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更新日期：2008-03-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
doi：10.3816/cbc.2002.n.004
更新日期：2002-01-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
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journal_title：Clinical breast cancer
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pub_type： 杂志文章,评审
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更新日期：2018-08-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
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更新日期：2003-04-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.1016/j.clbc.2011.11.001
更新日期：2012-02-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.1016/j.clbc.2020.03.002
更新日期：2020-08-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.1016/j.clbc.2017.11.018
更新日期：2018-04-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.clbc.2013.04.004
更新日期：2013-10-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
doi：10.3816/cbc.2004.n.029
更新日期：2004-10-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
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更新日期：2014-12-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
doi：10.3816/cbc.2004.s.006
更新日期：2004-01-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.1016/j.clbc.2019.12.001
更新日期：2020-06-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.3816/CBC.2011.n.006
更新日期：2011-03-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
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更新日期：2020-10-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章,随机对照试验
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更新日期：2012-02-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.1016/j.clbc.2016.10.011
更新日期：2017-07-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.3816/cbc.2000.n.004
更新日期：2000-04-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章,评审
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更新日期：2008-08-01 00:00:00
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journal_title：Clinical breast cancer
pub_type： 杂志文章
doi：10.1016/j.clbc.2019.04.014
更新日期：2019-12-01 00:00:00
