Abstract:
BACKGROUND:Although magnetic resonance imaging (MRI) is a useful imaging modality for invasive cancer, its role in preoperative surgical planning for ductal carcinoma in situ (DCIS) has not been established. We sought to determine whether preoperative MRI affects surgical treatment and outcomes in women with pure DCIS. PATIENTS AND METHODS:We reviewed consecutive records of women diagnosed with pure DCIS on core biopsy between 2000 and 2007. Patient characteristics, surgical planning, and outcomes were compared between patients with and without preoperative MRI. Multivariable regression was performed to determine which covariates were independently associated with mastectomy or sentinel lymph node biopsy (SLNB). RESULTS:Of 149 women diagnosed with DCIS, 38 underwent preoperative MRI. On univariate analysis, patients undergoing MRI were younger (50 years vs. 59 years; P < .001) and had larger DCIS size on final pathology (1.6 cm vs. 1.0 cm; P = .007) than those without MRI. Mastectomy and SLNB rates were significantly higher in the preoperative MRI group (45% vs. 14%, P < .001; and 47% vs. 23%, P = .004, respectively). However, there were no differences in number of re-excisions, margin status, and margin size between the two groups. On multivariate analysis, preoperative MRI and age were independently associated with mastectomy (OR, 3.16, P = .018; OR, 0.95, P = .031, respectively), while multifocality, size, and family history were not significant predictors. CONCLUSION:We found a strong association between preoperative MRI and mastectomy in women undergoing treatment for DCIS. Additional studies are needed to examine the increased rates of mastectomy as a possible consequence of preoperative MRI for DCIS.
journal_name
Clin Breast Cancerjournal_title
Clinical breast cancerauthors
Itakura K,Lessing J,Sakata T,Heinzerling A,Vriens E,Wisner D,Alvarado M,Esserman L,Ewing C,Hylton N,Hwang ESdoi
10.3816/CBC.2011.n.006subject
Has Abstractpub_date
2011-03-01 00:00:00pages
33-8issue
1eissn
1526-8209issn
1938-0666pii
S1526-8209(11)70233-6journal_volume
11pub_type
杂志文章abstract::According to the World Health Organization (WHO) published data in 2015; breast cancer is the most prevalent and the second leading cause of cancer death among females. As approximately 70% of breast cancer tumor cells are estrogen receptor (ER) positive, primary therapeutic agents such as Anti-estrogens were produced...
journal_title:Clinical breast cancer
pub_type: 杂志文章,评审
doi:10.1016/j.clbc.2017.03.013
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:The objective of the study was to compare the accuracy of different magnetic resonance (MR) sequences for measuring tumor size and to evaluate whether the imaging and histopathologic features affect the accuracy of the tumor size estimation on the MR sequence. PATIENTS AND METHODS:Eight hundred women were i...
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abstract:BACKGROUND:Whether sitagliptin may affect breast cancer risk remains to be answered. This study evaluated such an association in Taiwanese female patients with type 2 diabetes. METHODS:A retrospective cohort of female patients with newly diagnosed type 2 diabetes at an age ≥ 25 years between 1999 and 2010 was recruite...
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journal_title:Clinical breast cancer
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doi:10.3816/CBC.2008.n.014
更新日期:2008-04-01 00:00:00
abstract:PURPOSE:The purpose of this study is to determine the response, tolerability, and long-term outcome of a neoadjuvant platinum-containing regimen for locally advanced breast cancer (LABC) and to search for a correlation between pathologic complete response (pCR) and predefined biomarkers in this cohort. PATIENTS AND ME...
journal_title:Clinical breast cancer
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journal_title:Clinical breast cancer
pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
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journal_title:Clinical breast cancer
pub_type: 杂志文章
doi:10.1016/j.clbc.2016.11.006
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journal_title:Clinical breast cancer
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journal_title:Clinical breast cancer
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更新日期:2015-12-01 00:00:00
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更新日期:2016-08-01 00:00:00
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journal_title:Clinical breast cancer
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:Clinical breast cancer
pub_type: 杂志文章
doi:10.1016/j.clbc.2013.10.010
更新日期:2014-04-01 00:00:00
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journal_title:Clinical breast cancer
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2013-12-01 00:00:00
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journal_title:Clinical breast cancer
pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:Clinical breast cancer
pub_type: 杂志文章,评审
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journal_title:Clinical breast cancer
pub_type: 杂志文章,评审
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journal_title:Clinical breast cancer
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journal_title:Clinical breast cancer
pub_type: 杂志文章,评审
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journal_title:Clinical breast cancer
pub_type: 杂志文章,评审
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journal_title:Clinical breast cancer
pub_type: 杂志文章,评审
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更新日期:2016-10-01 00:00:00
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journal_title:Clinical breast cancer
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更新日期:2017-06-01 00:00:00
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journal_title:Clinical breast cancer
pub_type: 杂志文章,随机对照试验
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更新日期:2013-10-01 00:00:00
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journal_title:Clinical breast cancer
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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更新日期:2019-04-01 00:00:00
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journal_title:Clinical breast cancer
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更新日期:2020-08-20 00:00:00
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journal_title:Clinical breast cancer
pub_type: 杂志文章,评审
doi:10.3816/cbc.2003.n.030
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