Abstract:
PURPOSE:Meta-analysis is a quantitative approach to summarize the findings from several studies and has been applied with increasing frequency to clinical trials. Because of their sample size and duration limitations, experimental studies (ESs) could not be able to detect late or rare adverse events (AEs), which may be identified in well-designed observational studies (OSs). This study aims to identify and analyze meta-analyses from both ES and OS where safety was found to be an outcome measure. METHODS:The meta-analyses inclusion criteria was established as at least one AE as primary outcome. Safety outcomes were considered as the increase in the risk for an AE after a pharmacological intervention. A MEDLINE search for meta-analyses published in the New England Journal of Medicine, The Lancet, Journal of American Medical Association, British Medical Journal, Annals of Internal Medicine, PLoS Medicine, Annual Review of Medicine, and Archives of Internal Medicine, between October 2005 and September 2010, was carried out. RESULTS:Sixty meta-analyses met the inclusion criteria. Of these, 53 included only ES, 4 included both ES and OS, and 2 included only OS. Of the 6 meta-analyses that included OS, 4 included cohort and case-control studies, and 2 included cohort, case-control, and cross-sectional studies. One meta-analysis did not report the type of studies included. CONCLUSIONS:Experimental studies were found to be the main source of meta-analyses on drug safety. The role of meta-analyses in pharmacovigilance is a matter of ongoing debate, and efforts are being made to develop guidelines on the use of meta-analysis in drug safety assessments, to better combine evidence about harms.
journal_name
Pharmacoepidemiol Drug Safjournal_title
Pharmacoepidemiology and drug safetyauthors
Alves C,Batel-Marques F,Macedo AFdoi
10.1002/pds.2260subject
Has Abstractpub_date
2012-01-01 00:00:00pages
21-33issue
1eissn
1053-8569issn
1099-1557journal_volume
21pub_type
杂志文章,评审abstract:PURPOSE:vigiRank is a data-driven predictive model for emerging safety signals. In addition to disproportionate reporting patterns, it also accounts for the completeness, recency, and geographic spread of individual case reporting, as well as the availability of case narratives. Previous retrospective analysis suggeste...
journal_title:Pharmacoepidemiology and drug safety
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journal_title:Pharmacoepidemiology and drug safety
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journal_title:Pharmacoepidemiology and drug safety
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更新日期:2009-12-01 00:00:00
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doi:10.1002/pds.1991
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Hydroxyzine is indicated for the management of anxiety, skin and sleep disorders. In 2015, the European Medicines Agency (EMA) concluded that hydroxyzine was pro-arrhythmogenic and changes to the product information were implemented in Europe. This study aimed to evaluate their impact in Denmark, Scotland, E...
journal_title:Pharmacoepidemiology and drug safety
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doi:10.1002/pds.5191
更新日期:2021-01-01 00:00:00
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doi:10.1002/pds.2164
更新日期:2012-02-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
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更新日期:1997-11-01 00:00:00
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doi:10.1002/pds.4634
更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/pds.4140
更新日期:2017-02-01 00:00:00
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更新日期:2012-11-01 00:00:00
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doi:10.1002/pds.646
更新日期:2001-12-01 00:00:00
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更新日期:2011-03-01 00:00:00
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doi:10.1002/pds.3906
更新日期:2016-05-01 00:00:00
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更新日期:2001-05-01 00:00:00
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更新日期:2017-02-01 00:00:00
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更新日期:2003-12-01 00:00:00
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更新日期:2018-03-01 00:00:00
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更新日期:2009-04-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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doi:10.1002/pds.1764
更新日期:2009-08-01 00:00:00