Indeterminate lesions on planar bone scintigraphy in lung cancer patients: SPECT, CT or SPECT-CT?

Abstract:

OBJECTIVE:The objective of the present study was to compare the role of single photon emission computed tomography (SPECT), computed tomography (CT) and SPECT-CT of selected volume in lung cancer patients with indeterminate lesions on planar bone scintigraphy (BS). METHODS:The data of 50 lung cancer patients (53 ± 10.3 years; range 30-75; male/female 38/12) with 65 indeterminate lesions on planar BS (January 2010 to November 2010) were retrospectively evaluated. All of them underwent SPECT-CT of a selected volume. SPECT, CT and SPECT-CT images were independently evaluated by two experienced readers (experience in musculoskeletal imaging, including CT: 5 and 7 years) in separate sessions. A scoring scale of 1 to 5 was used, in which 1 is definitely metastatic, 2 is probably metastatic, 3 is indeterminate, 4 is probably benign and 5 is definitely benign. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for each modality, taking a score ≤2 as metastatic. With receiver operating characteristic (ROC) curve analysis, areas under the curve (AUC) were calculated for each modality and compared. Clinical and imaging follow-up and/or histopathology were taken as reference standard. RESULTS:For both readers SPECT was inferior to CT (P = 0.004, P = 0.022) and SPECT-CT (P = 0.003, P = 0.037). However, no significant difference was found between CT and SPECT-CT for reader 1 (P = 0.847) and reader 2 (P = 0.592). The findings were similar for lytic as well as sclerotic lesions. Moderate inter-observer agreement was seen for SPECT images (к = 0.426), while almost perfect agreement was seen for CT (к = 0.834) and SPECT-CT (к = 0.971). CONCLUSION:CT alone and SPECT-CT are better than SPECT for accurate characterisation of indeterminate lesions on planar BS in lung cancer patients. CT alone is not inferior to SPECT-CT for this purpose and might be preferred because of shorter acquisition time and wider availability.

journal_name

Skeletal Radiol

journal_title

Skeletal radiology

authors

Sharma P,Kumar R,Singh H,Bal C,Julka PK,Thulkar S,Malhotra A

doi

10.1007/s00256-011-1304-2

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

843-50

issue

7

eissn

0364-2348

issn

1432-2161

journal_volume

41

pub_type

杂志文章
  • Subcutaneous panniculitis-like T-cell lymphoma: MRI features and literature review.

    abstract::Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) represents a rare subclassification of peripheral T-cell lymphoma (PTCL). We present a case of a 21-year-old female who presented with a 1-month history of pain in the left buttock and hip, tender left inguinal lymph nodes, fevers, and night sweats. Percutaneous c...

    journal_title:Skeletal radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00256-014-1879-5

    authors: Levine BD,Seeger LL,James AW,Motamedi K

    更新日期:2014-09-01 00:00:00

  • Reactive endplate marrow changes: a systematic morphologic and epidemiologic evaluation.

    abstract:PURPOSE:To evaluate the morphology and location of vertebral endplate changes, and to analyze their association with age, gender, and body mass index (BMI). DESIGN AND PATIENTS:At 1.5 T (T1-weighted, T2-weighted/STIR) 100 lumbar spines were evaluated separately by three observers. The readers classified the endplate b...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/s00256-004-0886-3

    authors: Karchevsky M,Schweitzer ME,Carrino JA,Zoga A,Montgomery D,Parker L

    更新日期:2005-03-01 00:00:00

  • Spinal osteoid osteoma: efficacy and safety of radiofrequency ablation.

    abstract:OBJECTIVE:The aim of this study was to evaluate the efficacy and complications of CT-guided radiofrequency ablation (RFA) of spinal osteoid osteoma (OO). MATERIALS AND METHODS:Between 2002 and 2012, a total of 61 patients (46 male and 15 female, mean age 26.4 ± 12.7 years) were subjected to RFA for spinal OO. The diag...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/s00256-017-2662-1

    authors: Albisinni U,Facchini G,Spinnato P,Gasbarrini A,Bazzocchi A

    更新日期:2017-08-01 00:00:00

  • MRI and clinical features of Langerhans cell histiocytosis (LCH) in the pelvis and extremities: can LCH really look like anything?

    abstract:OBJECTIVE:To assess clinical and MRI features of Langerhans cell histiocytosis in the pelvis and extremities. MATERIALS AND METHODS:The MRI and clinical features of 21 pathologically proven cases of LCH involving the pelvis and extremities were studied. Multiple characteristics of the lesions were evaluated (location,...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/s00256-016-2330-x

    authors: Samet J,Weinstein J,Fayad LM

    更新日期:2016-05-01 00:00:00

  • Primary perivascular epithelioid cell neoplasm (PEComa) of bone: report of two cases and review of the literature.

    abstract::Primary perivascular epithelioid cell neoplasms (PEComas) of bone are rare mesenchymal tumors. Histologically, they are composed predominantly of perivascular epithelioid cells and have the capacity to metastasize. PEComas have been reported within intra-abdominal and intra-pelvic organs. To the best of our knowledge,...

    journal_title:Skeletal radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00256-012-1479-1

    authors: Desy NM,Bernstein M,Nahal A,Aziz M,Kenan S,Turcotte RE,Kahn LB

    更新日期:2012-11-01 00:00:00

  • Calcified or ossified benign soft tissue lesions that may simulate malignancy.

    abstract::The purpose of this article is to review calcified or ossified benign soft tissue lesions that may simulate malignancy. We review the clinical presentations, locations, imaging characteristics, and differential diagnostic considerations of myositis ossificans, tophaceous gout, benign vascular lesions, calcific tendino...

    journal_title:Skeletal radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00256-019-03272-3

    authors: Kwee RM,Kwee TC

    更新日期:2019-12-01 00:00:00

  • Relationship of Modic type 1 change with disc degeneration: a prospective MRI study.

    abstract:OBJECTIVE:The objective was to study the natural course of Modic type 1 change (M1) in relation to lumbar disc degeneration. MATERIALS AND METHODS:Twenty-four chronic low back pain (LBP) patients with M1 on lumbar spine were selected from 1,015 patients with magnetic resonance imaging from a follow-up study lasting fo...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/s00256-008-0611-8

    authors: Luoma K,Vehmas T,Grönblad M,Kerttula L,Kääpä E

    更新日期:2009-03-01 00:00:00

  • Melanotic neuroectodermal tumor of infancy in thigh of an infant--a rare case report with diagnostic implications.

    abstract::Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon tumor of neural crest origin, almost invariably identified in the head and neck region. It is a relatively benign tumor but can recur and rarely metastasize. Herein, a rare case of MNTI in the thigh of an infant is documented. Radiographic imaging showed...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/s00256-011-1113-7

    authors: Rekhi B,Suryavanshi P,Desai S,Gulia A,Desai S,Juvekar SL,Puri A,Jambhekar NA

    更新日期:2011-08-01 00:00:00

  • The pattern of spinal and extraspinal hyperostosis in patients with ossification of the posterior longitudinal ligament and the ligamentum flavum causing myelopathy.

    abstract::Thirty one patients suffering from myelopathy associated with ossification of the posterior longitudinal ligament and ligamentum flavum of the spine have been investigated. The pattern of spinal and peripheral hyperostosis was recorded in each case. Flowing anterior vertebral hyperostosis and ligamentous ossification ...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/BF00360789

    authors: Hukuda S,Mochizuki T,Ogata M,Shichikawa K

    更新日期:1983-01-01 00:00:00

  • Posterior dislocation of the long head of biceps tendon: case report and review of the literature.

    abstract::Posterior or lateral dislocation of the long head of biceps is a rare complication of shoulder dislocation that can result in inability to relocate the humerus. The diagnosis should be suspected when certain radiographic features are present at the initial presentation. Other imaging modalities can aid diagnosis when ...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/s00256-007-0285-7

    authors: Mullaney PJ,Bleakney R,Tuchscherer P,Boynton E,White L

    更新日期:2007-08-01 00:00:00

  • Symmetrical ilial pseudofractures: a complication of chronic renal failure. A case report with a review of the literature.

    abstract::A patient with chronic renal failure and progressive symmetrical ilial pseudofractures (Looser zones, Milkman's syndrome) is presented. The literature is reviewed in light of the findings in this patient, and possible mechanisms of pseudofracture formation are discussed. ...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/BF02219626

    authors: Griffin CN Jr

    更新日期:1982-01-01 00:00:00

  • Giant cell tumor complicating Paget disease of long bone.

    abstract::Giant cell tumor (GCT) is a rare complication of Paget disease of bone. It usually occurs in the skull or pelvic bones of patients with long-standing polyostotic disease. This report describes a 62-year-old patient who presented with monostotic Paget disease of the distal femur complicated by GCT. He had a 2-year hist...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/s00256-007-0310-x

    authors: Hoch B,Hermann G,Klein MJ,Abdelwahab IF,Springfield D

    更新日期:2007-10-01 00:00:00

  • Alveolar soft part sarcoma.

    abstract::We present a rare case of alveolar soft-tissue sarcoma, with extensive bone invasion. The differential diagnosis with bone metastasis and primary bone tumors is discussed. ...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/s002560050104

    authors: Aluigi P,Sangiorgi L,Picci P

    更新日期:1996-05-01 00:00:00

  • Prevalence of burnout among musculoskeletal radiologists.

    abstract:OBJECTIVE:Burnout is a job-related psychological syndrome with three aspects: emotional exhaustion, depersonalization, and perceived lack of personal accomplishment. Burnout is associated with deleterious effects on both workers and their work. When burnout affects physicians, their well-being, longevity, and care of p...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/s00256-017-2578-9

    authors: Chew FS,Mulcahy MJ,Porrino JA,Mulcahy H,Relyea-Chew A

    更新日期:2017-04-01 00:00:00

  • Fibrous metaphyseal defects--determination of their origin and natural history using a radiomorphological study.

    abstract::The radiomorphological appearance of fibrous metaphyseal defects (FMDs) is demonstrated by long-term follow-up studies. A characteristic radiomorphological course rather than a typical single appearance can be established. These findings correlate well with the duration of these tumor-like lesions; therefore, the radi...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/BF00361448

    authors: Ritschl P,Karnel F,Hajek P

    更新日期:1988-01-01 00:00:00

  • Transient fatty cortical defects following fractures in children.

    abstract::Self-regressing subperiosteal defects appearing during consolidation of fractures were observed in two children aged 6 and 10 years, in the tibia and the radius respectively. These transient defects appeared several weeks after fracture, at a distance from the fracture site. They involved the newly formed subperiostea...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/BF00348864

    authors: Malghem J,Maldague B

    更新日期:1986-01-01 00:00:00

  • Arthrography of painful hips following arthroplasty: digital versus plain film subtraction.

    abstract::Digital and manual subtraction images obtained during the arthrographic evaluation of 78 painful hip prostheses were reviewed retrospectively. Revision arthroplasty was performed in 53 of these cases, and the arthrographic and surgical findings were correlated. The digital and manual subtraction images were evaluated ...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/BF00191080

    authors: Walker CW,FitzRandolph RL,Collins DN,Dalrymple GV

    更新日期:1991-01-01 00:00:00

  • Anatomical and radiological observations concerning ossification of the sacrotuberous ligament: is there a relation to spinal diffuse idiopathic skeletal hyperostosis (DISH)?

    abstract::In a collection of 101 anatomical preparations of the human pelvis, ossification of the sacrotuberous ligament was found in 8 cases. In 7 of these, the ossification showed a characteristic intraligamentous morphology, with a broad-based origin at the ischial tuberosity and tapering off craniomedially. The length varie...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/BF00197139

    authors: Prescher A,Bohndorf K

    更新日期:1993-11-01 00:00:00

  • Ungual tufts in the follow-up of patients on maintenance hemodialysis.

    abstract::A recent publication showed the earliest signs of renal osteodystrophy in patients on maintenance hemodialysis (MHD) to occur in the tufts [1]. We present three patients on MHD, in two of whom the earliest unequivocal radiographic improvement was seen in the tufts. The third patient had been on MHD and, following subt...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/BF00580598

    authors: Sundaram M,Phillipp SR,Wolverson MK,Riaz MA,Rao BJ

    更新日期:1980-01-01 00:00:00

  • Osteoclast abnormalities in fractured bone during bisphosphonate treatment for osteoporosis: a case report.

    abstract::Bisphosphonates have been widely used in the treatment of an array of bone disorders. Recent complications have included unusual femoral fractures in patients who have received long term bisphosphonate treatment for osteoporosis. Although it has been shown that bisphosphonates are effective by blunting osteoclast reso...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/s00256-012-1407-4

    authors: Vigorita VJ,Silver JS,Eisemon EO

    更新日期:2012-07-01 00:00:00

  • High-resolution MR imaging of the proximal zone of the lunotriquetral ligament with a microscopy coil.

    abstract:OBJECTIVE:To evaluate high-resolution MRI of the proximal zone of the lunotriquetral ligament (LTL) using a microscopy surface coil with a 1.5 T scanner. DESIGN AND SUBJECTS:The proximal zone of the LTL was reviewed in 90 subjects (23 asymptomatic normal volunteers and 67 patients with suspicion of triangular fibrocar...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/s00256-005-0070-4

    authors: Yoshioka H,Tanaka T,Ueno T,Shindo M,Carrino JA,Lang P,Winalski CS

    更新日期:2006-05-01 00:00:00

  • Bilateral symmetrical metachronous myxofibrosarcoma: a case report and review of the literature.

    abstract::Soft tissue sarcomas (STS) are rare. Affected patients are at increased risk of developing a second primary malignancy, particularly another primary STS. These rarely affect the extremities, tending to occur in the abdomen, head or neck. We describe a patient with myxofibrosarcoma of the buttock who developed a second...

    journal_title:Skeletal radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00256-011-1123-5

    authors: Picardo NE,Mann B,Whittingham-Jones P,Shaerf D,Skinner JA,Saifuddin A

    更新日期:2011-08-01 00:00:00

  • Bone cortical mass in newborn infants: a comparison between standards in the femur and humerus.

    abstract::The total bone width (T) and medullary width (M) of the humerus and femur of 216 and 138 Nigerian newborn infants, respectively, were measured in order to determine the normal standards for cortical bone mass in the newborn. The cortical width (C), cortical area (CA), and percentage cortical area (PCA) were calculated...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/BF00349862

    authors: Odita JC,Okolo AA,Omene JA

    更新日期:1986-01-01 00:00:00

  • Case report 631: Neo-osseous porosis (metaphyseal osteopenia) in polyglandular autoimmune (Schmidt) syndrome.

    abstract::In summary, a case is reported of a patient with the radiographic findings of diffuse, symmetrical metaphyseal osteopenia of long bones. A constellation termed neo-osseous porosis, associated with polyendocrine failure (Schmidt syndrome) involving the thyroid gland, adrenal glands, and gonads has been described in thi...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/BF00241809

    authors: Vela BS,Dorin RI,Hartshorne MF

    更新日期:1990-01-01 00:00:00

  • The current status of MRI in the pre-operative assessment of intramedullary conventional appendicular osteosarcoma.

    abstract::Osteosarcoma is the commonest primary malignant bone tumour in children and adolescents, the majority of cases being conventional intra-medullary high-grade tumours affecting the appendicular skeleton. Treatment is typically with a combination of neo-adjuvant chemotherapy, tumour resection with limb reconstruction and...

    journal_title:Skeletal radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00256-018-3079-1

    authors: Saifuddin A,Sharif B,Gerrand C,Whelan J

    更新日期:2019-04-01 00:00:00

  • Calcific tendinitis of the vastus lateralis muscle. A report of three cases.

    abstract::Three cases of calcific tendinitis occurring at an unusual site (vastus lateralis tendon) are described. Findings on conventional radiography and computed tomography together with the clinical history are characteristic for this disorder and reflect its natural evolution. The actual role of magnetic resonance imaging ...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/BF00243716

    authors: Ramon FA,Degryse HR,De Schepper AM,Van Marck EA

    更新日期:1991-01-01 00:00:00

  • Ankylosing spondylitis presenting as juxta-articular masses in females.

    abstract::Juxta-articular inflammatory masses, sternomanubrial or sternoclavicular, were noted in two women who were subsequently found to have ankylosing spondylitis. The differential diagnosis of juxta-articular masses should include systemic rheumatic disorders as well as tumor or infection. ...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/BF00367763

    authors: Lindsley HB,De Smet AA,Neff JR

    更新日期:1987-01-01 00:00:00

  • Acetabular retroversion as a rare cause of chronic hip pain: recognition of the "figure-eight" sign.

    abstract::While well-recognized in the orthopedic literature as a cause of chronic hip pain, acetabular retroversion has not been specifically described in the radiologic literature. Acetabular retroversion represents a particular form of hip dysplasia characterized by abnormal posterolateral orientation of the acetabulum. This...

    journal_title:Skeletal radiology

    pub_type: 杂志文章

    doi:10.1007/s00256-006-0150-0

    authors: Banks KP,Grayson DE

    更新日期:2007-06-01 00:00:00

  • MRI in inflammatory myopathies.

    abstract::Inflammatory myopathies encompass a group of acquired muscle disorders caused by infectious agents (bacteria, viruses, fungi and parasitic agents) or autoimmune processes (polymyositis, dermatomyositis and other types). In suspected infection sonography, CT and MRI are all able to show edema and fluid collections in s...

    journal_title:Skeletal radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s002560000238

    authors: Garcia J

    更新日期:2000-08-01 00:00:00

  • Anterior cruciate ligament reconstruction tunnel size: causes of tunnel enlargement and implications for single versus two-stage revision reconstruction.

    abstract::Anterior cruciate ligament (ACL) reconstructions have increased over the past 25 years. The increased incidence of ACL reconstructions has translated into a larger number of graft failures and revision ACL procedures. It is important to understand the causes of graft failure when evaluating for a revision ACL reconstr...

    journal_title:Skeletal radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00256-016-2535-z

    authors: Rizer M,Foremny GB,Rush A 3rd,Singer AD,Baraga M,Kaplan LD,Jose J

    更新日期:2017-02-01 00:00:00