Indeterminate lesions on planar bone scintigraphy in lung cancer patients: SPECT, CT or SPECT-CT?


OBJECTIVE:The objective of the present study was to compare the role of single photon emission computed tomography (SPECT), computed tomography (CT) and SPECT-CT of selected volume in lung cancer patients with indeterminate lesions on planar bone scintigraphy (BS). METHODS:The data of 50 lung cancer patients (53 ± 10.3 years; range 30-75; male/female 38/12) with 65 indeterminate lesions on planar BS (January 2010 to November 2010) were retrospectively evaluated. All of them underwent SPECT-CT of a selected volume. SPECT, CT and SPECT-CT images were independently evaluated by two experienced readers (experience in musculoskeletal imaging, including CT: 5 and 7 years) in separate sessions. A scoring scale of 1 to 5 was used, in which 1 is definitely metastatic, 2 is probably metastatic, 3 is indeterminate, 4 is probably benign and 5 is definitely benign. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for each modality, taking a score ≤2 as metastatic. With receiver operating characteristic (ROC) curve analysis, areas under the curve (AUC) were calculated for each modality and compared. Clinical and imaging follow-up and/or histopathology were taken as reference standard. RESULTS:For both readers SPECT was inferior to CT (P = 0.004, P = 0.022) and SPECT-CT (P = 0.003, P = 0.037). However, no significant difference was found between CT and SPECT-CT for reader 1 (P = 0.847) and reader 2 (P = 0.592). The findings were similar for lytic as well as sclerotic lesions. Moderate inter-observer agreement was seen for SPECT images (к = 0.426), while almost perfect agreement was seen for CT (к = 0.834) and SPECT-CT (к = 0.971). CONCLUSION:CT alone and SPECT-CT are better than SPECT for accurate characterisation of indeterminate lesions on planar BS in lung cancer patients. CT alone is not inferior to SPECT-CT for this purpose and might be preferred because of shorter acquisition time and wider availability.


Skeletal Radiol


Skeletal radiology


Sharma P,Kumar R,Singh H,Bal C,Julka PK,Thulkar S,Malhotra A




Has Abstract


2012-07-01 00:00:00












  • Morel-Lavallee lesion in an adolescent with ultrasound and MRI correlation.

    abstract::The Morel-Lavallee lesion is a serous collection in the region of the greater trochanter, resulting from a closed degloving injury at the deep fascial interface. Imaging demonstrates characteristic appearance in relation to this lesion, differentiating it from other mass lesions. We report a case of Morel-Lavallee les...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Mukherjee K,Perrin SM,Hughes PM

    更新日期:2007-06-01 00:00:00

  • Capsular constriction of the hip: arthrographic and clinical considerations.

    abstract::Orthodox radiological examination of patients presenting with disorders of the hip, usually on account of pain and limitation of movement, may vary in diagnostic value. As a supplementary study we have employed arthrography. During this procedure we have, since 1970, routinely assessed the capacity of the joint capsul...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Lequesne M,Becker J,Bard M,Witvoet J,Postel M

    更新日期:1981-01-01 00:00:00

  • Flexor carpi radialis brevis: case report of a symptomatic tear.

    abstract::Anatomical variants of muscle are commonly encountered by surgeons and radiologists. The flexor carpi radialis brevis (FCRB) is an anomalous muscle in the distal forearm with an estimated prevalence of 2-8%. In the literature, there are a few case reports of symptomatic FCRB tenosynovitis without a concomitant tear, a...

    journal_title:Skeletal radiology

    pub_type: 杂志文章,评审


    authors: Kordahi AM,Sarrel KL,Shah SB,Chang EY

    更新日期:2018-12-01 00:00:00

  • Progressive bilateral thinning of the parietal bones.

    abstract::Observation of a case of progressive bilateral parietal thinning within a period of 14 years induced us to study skull films of 3,636 consecutive patients. Parietal thinning was found in 86 patients (2.37%). It was more common in women, with a sex ratio of 1:1.9. The mean age of the females was 72 years, and that of t...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Cederlund CG,Andrén L,Olivecrona H

    更新日期:1982-01-01 00:00:00

  • Determination of digitised radiograph magnification factors for pre-operative templating in hip prosthesis surgery.

    abstract:OBJECTIVE:With digital radiography development, information technology (IT) companies have developed specific software for templating procedures, requiring individual magnification assessments for each patient. The aim of this study was to determine the mean magnification factor of digital radiographs and to evaluate t...

    journal_title:Skeletal radiology

    pub_type: 临床试验,杂志文章


    authors: Descamps S,Livesey C,Learmonth ID

    更新日期:2010-03-01 00:00:00

  • Juxta-articular hemangioma of long bone.

    abstract::We report on a rare case of an intraosseous hemangioma involving the proximal tibia in a 70-year-old man. Radiographically, the lesion was a well-defined osteolytic lesion with marginal sclerosis. The CT images demonstrated a well-defined osteolytic lesion with partial cortical breakthrough. T1-weighted MR images show...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Yamamoto T,Kurosaka M,Mizuno K

    更新日期:2000-09-01 00:00:00

  • Bilateral symmetrical metachronous myxofibrosarcoma: a case report and review of the literature.

    abstract::Soft tissue sarcomas (STS) are rare. Affected patients are at increased risk of developing a second primary malignancy, particularly another primary STS. These rarely affect the extremities, tending to occur in the abdomen, head or neck. We describe a patient with myxofibrosarcoma of the buttock who developed a second...

    journal_title:Skeletal radiology

    pub_type: 杂志文章,评审


    authors: Picardo NE,Mann B,Whittingham-Jones P,Shaerf D,Skinner JA,Saifuddin A

    更新日期:2011-08-01 00:00:00

  • Peroneal tendon abnormalities in subjects with an enlarged peroneal tubercle.

    abstract:OBJECTIVE:To examine the association between inframalleolar peroneal tendon abnormalities and an enlarged peroneal tubercle. MATERIALS AND METHODS:Two independent readers evaluated consecutive ankle MR imaging studies to classify inframalleolar peroneal tendon findings as normal, tenosynovitis, partial tear or complet...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Taneja AK,Simeone FJ,Chang CY,Kumar V,Daley S,Bredella MA,Torriani M

    更新日期:2013-12-01 00:00:00

  • Primary thoracic giant cell tumor of bone sensitive to steroids.

    abstract::Spinal giant cell tumor of bone (GCTB) is a rare benign, but locally aggressive, entity. We report the case of a 40-year-old man diagnosed with GCTB of the thoracic spine. The only symptom upon presentation was progressive back pain with pain radiating to the chest. Magnetic resonance imaging showed that the soft tiss...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Yang H,Im GH,Nielsen GP,Kheterpal A,Schwab JH

    更新日期:2018-10-01 00:00:00

  • Rosai-Dorfman disease manifesting as a solitary lesion of the radius in a 41-year-old woman.

    abstract::Rosai-Dorfman disease is a rare entity predominantly affecting children and young adults, characterized in 83-95% of cases by painless bilateral cervical lymphadenopathy. We report the unusual case of a 41-year-old woman with Rosai-Dorfman disease that presented as a solitary lesion of the radius without other clinica...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: George J,Stacy G,Peabody T,Montag A

    更新日期:2003-04-01 00:00:00

  • Society of Skeletal Radiology 2015 annual meeting summary.

    abstract::Peer-reviewed abstracts presented at the 2015 Society of Skeletal Radiology (SSR) 38th Annual Meeting were reviewed following oral presentation. Topics felt to be of potential interest to musculoskeletal (MSK) investigators and practicing clinicians are highlighted in this compilation and analysis of the meeting. New ...

    journal_title:Skeletal radiology



    authors: Fox MG,Bancroft LW

    更新日期:2016-01-01 00:00:00

  • Partial duplication of the scapula.

    abstract::We report an extremely rare case of partial scapular duplication. Mild shoulder area deformity in a newborn prompted further evaluation that included radiography, ultrasonography and spiral CT. These revealed an additional bone in the area of the left shoulder, above the humerus and lateral to the scapula. The accesso...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Simanovsky N,Hiller N,Simanovsky N

    更新日期:2006-09-01 00:00:00

  • Imaging in the diagnosis of symptomatic forearm muscle herniation.

    abstract::Muscle herniation can be defined as protrusion of a portion of muscle through an acquired or congenital defect of enclosing fascia. Although it is usually a cosmetic problem, it can lead to local pain and tenderness after prolonged exertion. In this report, we present a case of flexor digitorum superficialis muscle he...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Kendi TK,Altinok D,Erdal HH,Kara S

    更新日期:2003-06-01 00:00:00

  • Intravascular papillary endothelial hyperplasia (Masson's tumor) presenting as a triceps mass.

    abstract::Intravascular papillary endothelial hyperplasia (IPEH) is a nonneoplastic reactive endothelial proliferation most commonly located in the skin or subcutaneous tissues although it has been reported in multiple locations throughout the body. We present a case of intravascular papillary endothelial hyperplasia presenting...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Clifford PD,Temple HT,Jorda M,Marecos E

    更新日期:2004-07-01 00:00:00

  • Prospective and longitudinal evolution of postoperative periprosthetic findings on metal artifact-reduced MR imaging in asymptomatic patients after uncemented total hip arthroplasty.

    abstract:OBJECTIVE:To prospectively assess the evolution of postoperative MRI findings in asymptomatic patients after total hip arthroplasty (THA) over 24 months (mo). METHODS:This prospective cohort study included 9 asymptomatic patients (56.7 ± 15.0 years) after THA. Metal artifact-reduced 1.5-T MRI was performed at 3, 6, 12...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Germann C,Filli L,Jungmann PM,Graf DN,Fritz J,Pfirrmann CWA,Sutter R

    更新日期:2020-11-09 00:00:00

  • Ball-and-socket ankle joint.

    abstract::The ball-and-socket ankle joint is a malformation of the ankle in which the articular surface of the talus is hemispherical in both the anteroposterior and lateral projections and has a congruent, concave tibial articular surface. Fourteen patients with this condition were identified retrospectively. Thirteen patients...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Pistoia F,Ozonoff MB,Wintz P

    更新日期:1987-01-01 00:00:00

  • Multiple congenital cranial hemangiomas.

    abstract::Though cranial hemangiomas are second only to vertebral hemangiomas in frequency, such lesions are rarely congenital and multiple. It is probable that the true incidence of congenital calvarial hemangiomas is higher than that reported in the literature, as they are unlikely to undergo imaging, most being asymptomatic ...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Koulouris G,Rao P

    更新日期:2005-08-01 00:00:00

  • Comparison of CT and MRI in patients with tibial plateau fracture: can CT findings predict ligament tear or meniscal injury?

    abstract:OBJECTIVE:(1) To determine the accuracy of computed tomography (CT) in the evaluation of ligament tear and avulsion in patients with tibial plateau fracture. (2) To evaluate whether the presence or severity of fracture gap and articular depression can predict meniscal injury. DESIGN AND PATIENTS:A fellowship-trained m...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Mui LW,Engelsohn E,Umans H

    更新日期:2007-02-01 00:00:00

  • Intramuscular spindle cell hemangioendothelioma.

    abstract::Spindle cell hemangioendothelioma occurring in skeletal muscle is extremely rare. No reported studies have performed an imaging evaluation of intramuscular spindle cell hemangioendothelioma. We report on such a tumor arising in an unusual site, the right extensor digiti minimi, in a 46-year-old woman. An en bloc resec...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Isayama T,Iwasaki H,Ogata K,Naito M

    更新日期:1999-08-01 00:00:00

  • Clinical and radiological findings in Brazilian patients with mucolipidosis types II/III.

    abstract:OBJECTIVE:The present study aims to provide orientation for clinicians and radiologists to recognize the most prevalent findings leading to diagnosis in mucolipidosis from a description of the natural history of five Brazilian cases. MATERIALS AND METHODS:We conducted an observational and retrospective study of five p...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Ceroni JRM,Spolador GM,Bermeo DS,Honjo RS,de Oliveira LAN,Bertola DR,Kim CA

    更新日期:2019-08-01 00:00:00

  • Osteoid osteomas in common and in technically challenging locations treated with computed tomography-guided percutaneous radiofrequency ablation.

    abstract:OBJECTIVE:To evaluate the efficacy of computed tomography (CT)-guided radiofrequency (RF) ablation for the treatment of osteoid osteomas in common and in technically challenging locations. MATERIALS AND METHODS:Twenty-three patients with osteoid osteomas in common (nine cases) and technically challenging [14 cases: in...

    journal_title:Skeletal radiology

    pub_type: 临床试验,杂志文章


    authors: Mylona S,Patsoura S,Galani P,Karapostolakis G,Pomoni A,Thanos L

    更新日期:2010-05-01 00:00:00

  • Chromomycosis presenting as soft-tissue mass: report of a case with MRI features.

    abstract::Chromomycosis is primarily a skin disease that superficially presents as slowly growing, verrucous lesions, often warty or cauliflower-like in appearance. It may occasionally create a flat, plaque-like lesion in the skin but deep-seated tumorous presentation has not previously been reported. As the lesion is limited t...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Bahk WJ,Chang ED,Chun KA,Lee AH,Park JM,Bahk YW

    更新日期:2009-02-01 00:00:00

  • Preoperative evaluation and monitoring chemotherapy in patients with high-grade osteogenic and Ewing's sarcoma: review of current imaging modalities.

    abstract::Diagnostic imaging is pivotal in the initial detection, characterization, staging and post-treatment follow-up of patients with high-grade osteogenic and Ewing's sarcoma. In the present review article, conventional and new imaging modalities are discussed with regard to the monitoring of the effect of neoadjuvant chem...

    journal_title:Skeletal radiology

    pub_type: 杂志文章,评审


    authors: van der Woude HJ,Bloem JL,Hogendoorn PC

    更新日期:1998-02-01 00:00:00

  • Post-traumatic and stress-induced osteolysis of the distal clavicle: MR imaging findings in 17 patients.

    abstract:OBJECTIVE:To describe the MR imaging findings in patients with osteolysis of the distal clavicle and to compare the MR imaging appearance of clavicular osteolysis following acute injury with that related to chronic stress. DESIGN AND PATIENTS:MR imaging examinations were reviewed in 17 patients (14 men, 3 women; ages ...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: de la Puente R,Boutin RD,Theodorou DJ,Hooper A,Schweitzer M,Resnick D

    更新日期:1999-04-01 00:00:00

  • Magnetic resonance imaging in the evaluation of ligament injuries.

    abstract::Magnetic resonance imaging has had a dramatic effect on the means by which we diagnose ligament injuries. Tears resulting from either acute trauma or overuse can be detected noninvasively, directing appropriate therapy be it conservative or surgical. For the elite athlete, earlier diagnosis leads to earlier interventi...

    journal_title:Skeletal radiology

    pub_type: 杂志文章,评审


    authors: Farooki S,Seeger LL

    更新日期:1999-02-01 00:00:00

  • Trabecular bone structure parameters from 3D image processing of clinical multi-slice and cone-beam computed tomography data.

    abstract:OBJECTIVE:Bone strength depends on both mineral content and bone structure. The aim of this in vitro study was to develop a method of quantitatively assessing trabecular bone structure by applying three-dimensional image processing to data acquired with multi-slice and cone-beam computed tomography using micro-computed...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Klintström E,Smedby O,Moreno R,Brismar TB

    更新日期:2014-02-01 00:00:00

  • Vertebral arch or posterior spinal tuberculosis.

    abstract::Posterior spinal tuberculosis or arch tuberculosis is a form of skeletal tuberculosis that selectively involves the vertebral arch. It may mimic skeletal neoplasm clinically and radiographically. Although posterior spinal tuberculosis has been reported in developing countries it has rarely been found in the United Sta...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Abdelwahab IF,Camins MB,Hermann G,Klein MJ

    更新日期:1997-12-01 00:00:00

  • Painful swelling in the proximal third of the arm.

    abstract:: ...

    journal_title:Skeletal radiology



    authors: Aparisi Gómez MP,Aparisi F,Bazzocchi A

    更新日期:2018-12-01 00:00:00

  • A posterior labral cyst associated with an anterior labral tear of the hip.

    abstract::Paralabral cysts are often associated with labral and other intraarticular hip pathology; MRI as well as diagnostic ultrasound can assist in diagnosis. Although often considered a coincidental finding, paralabral cysts can be a separate pain generator about the hip through compression of surrounding anatomy. They can ...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Scott E,Westermann R,Rosneck J

    更新日期:2018-06-01 00:00:00

  • Distinct focal lesions of the femoral head: imaging features suggesting an atypical and minimal form of bone necrosis.

    abstract:OBJECTIVE:To document the imaging findings observed in patients with an unusual pattern of abnormality of the femoral head, most likely representing osteonecrosis. DESIGN AND PATIENTS:The imaging findings in 11 patients (10 men, 1 woman; age range 32-55 years) with a distinct lesion of the femoral head were reviewed w...

    journal_title:Skeletal radiology

    pub_type: 杂志文章


    authors: Theodorou DJ,Theodorou SJ,Haghighi P,Resnick D

    更新日期:2002-08-01 00:00:00