Abstract：
:Many Traditional Chinese Medicines (TCMs) are effective to relieve complicated diseases such as type II diabetes mellitus (T2DM). In this work, molecular docking and network analysis were employed to elucidate the action mechanism of a medical composition which had clinical efficacy for T2DM. We found that multiple active compounds contained in this medical composition would target multiple proteins related to T2DM and the biological network would be shifted. We predicted the key players in the medical composition and some of them have been reported in literature. Meanwhile, several compounds such as Rheidin A, Rheidin C, Sennoside C, procyanidin C1 and Dihydrobaicalin were notable although no one have reported their pharmacological activity against T2DM. The association between active compounds, target proteins and other diseases was also discussed.
journal_name
Comput Biol Chemjournal_title
Computational biology and chemistryauthors
Gu J,Zhang H,Chen L,Xu S,Yuan G,Xu Xdoi
10.1016/j.compbiolchem.2011.07.003subject
Has Abstractpub_date
2011-10-12 00:00:00pages
293-7issue
5eissn
1476-9271issn
1476-928Xpii
S1476-9271(11)00079-Xjournal_volume
35pub_type
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abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
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