Optimized amniotic fluid analysis in patients suspected of intrauterine infection/inflammation.

Abstract:

OBJECTIVE:To determine the combination of amniotic fluid (AF) tests with the best diagnostic accuracy for predicting intrauterine infection/inflammation (IUI) in patients with clinical suspicion of chorioamnionitis. STUDY DESIGN:This is a retrospective study of 34 pregnant women who presented with uterine tenderness, maternal fever, maternal tachycardia, and/or fetal tachycardia and underwent AF analysis. IUI diagnosis was based on placental histology, positive AF bacterial cultures, and/or Gram stain. RESULT:Logistic regression analysis revealed a significant relationship between IUI and AF glucose. Glucose is more sensitive than culture or Gram stain (64% vs. 40% and 20%, respectively). Culture and glucose combined achieved the best diagnostic accuracy (sensitivity, 71%; specificity, 100%; positive and negative predictive values, 100-83%, respectively). CONCLUSION:Positive AF Gram stain or glucose <15 mg/dL strongly suggests IUI in symptomatic patients. If both tests are negative, the result of culture should aid the management.

journal_name

J Perinat Med

authors

Ford C,Genç MR

doi

10.1515/JPM.2011.110

subject

Has Abstract

pub_date

2011-09-21 00:00:00

pages

33-7

issue

1

eissn

0300-5577

issn

1619-3997

pii

/j/jpme.2012.40.issue-1/jpm.2011.110/jpm.2011.110.

journal_volume

40

pub_type

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