Abstract:
OBJECTIVE:This study evaluated the effectiveness of a single fixed-dose tablet of sumatriptan 85 mg/naproxen sodium 500 mg (sumatriptan-naproxen) using a very early treatment paradigm in migraine patients whose attacks were historically accompanied by cutaneous allodynia. BACKGROUND:Evidence suggests that allodynic migraineurs may demonstrate a better response when treated prior to developing central sensitization, and that these patients are treated more effectively with a compound of sumatriptan and naproxen sodium than either drug alone. This study targeted patients who have accompanying allodynia using a very early treatment paradigm where treatment was initiated while symptoms were still mild. METHODS:This was an open-label prospective, outpatient study of adult migraineurs who had screened positive for cutaneous allodynia and typically experienced moderate to severe pain preceded by an identifiable mild pain phase. Patients were treated with sumatriptan-naproxen using a very early intervention paradigm in 4 test migraines over 12 weeks where dosage occurred within 30 minutes of symptom onset. Data from diaries and questionnaires were used to evaluate the primary endpoints of sustained pain-free response at 24 hours post dose (using no second dose of study drug and no other rescue drugs), and overall satisfaction with sumatriptan-naproxen. RESULTS:Forty allodynic migraineurs enrolled in this study and reported a total of 160 migraines. Of these migraines, 78 (49%) achieved sustained pain-free at 24 hours and 94 (59%) were reported as pain-free at 2 hours. The number of patients who rated their Overall Satisfaction following treatment with sumatriptan-naproxen as "Satisfied" (satisfied or very satisfied) was 32 (80%) after the first migraine and 25 (63%) after 3 or more migraines. CONCLUSIONS:In this open-label study, allodynic patients reported that their migraine attacks responded well and they achieved a high degree of satisfaction following treatment with a fixed-dose tablet of sumatriptan 85 mg/naproxen sodium 500 mg administered in a very early treatment paradigm.
journal_name
Headachejournal_title
Headacheauthors
Landy S,Hoagland R,Hoagland NAdoi
10.1111/j.1526-4610.2011.01992.xsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
133-9issue
1eissn
0017-8748issn
1526-4610journal_volume
52pub_type
临床试验,杂志文章相关文献
HEADACHE文献大全abstract:OBJECTIVE:To investigate the associations between interictal pattern glare, visual stress, and visual triggers of migraine. BACKGROUND:There has been relatively little research on the visual stimuli that can trigger migraine episodes. This is surprising, since if practitioners can obviate such triggers, then some atta...
journal_title:Headache
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1526-4610.2006.00585.x
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Fast relief of migraine pain, associated symptoms, and migraine-related disability are priorities in the acute treatment of migraine. Efforts to improve the pharmacokinetic profiles of acute migraine treatments with the aim of providing faster relief include the development of non-oral routes of administrati...
journal_title:Headache
pub_type: 杂志文章,随机对照试验
doi:10.1111/head.13165
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) and trigeminal neuralgia (TN) are unilateral painful conditions that can share the same triggering factors, autonomic features and the main location, as well as the cyclically recurrent crises. Both these syndromes...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.12007
更新日期:2013-10-01 00:00:00
abstract::Seventy-six patients with vascular (migraine or mixed migraine and tension) headache (HA) participated in a controlled evaluation of a minimal-therapist-contact, largely home-based, treatment program which combined relaxation (R) training with thermal biofeedback (TBF). One group received TBF + R administered in 3 off...
journal_title:Headache
pub_type: 临床试验,杂志文章
doi:10.1111/j.1526-4610.1990.hed3006371.x
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:We conducted the present study to determine whether there are headache precipitating and aggravating factors that differentiate migraine from tension-type headache and headache precipitating and aggravating factors that differentiate tension-type headache from migraine. METHODS:We interviewed 38 patients wit...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.2001.041006554.x
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVES:To examine the relationship between migraine and nonmigrainous headache and asthma, hay fever, and chronic bronchitis in a large cross-sectional population-based study. BACKGROUND:Associations between prevalence of migraine and asthma or allergy have been demonstrated in clinic-based and epidemiologic studi...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2006.00597.x
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Migraine is a highly prevalent disorder that imposes an important burden of disability to patients and has social and economic impact in developed countries. A good screening tool for migraine diagnosis is useful to improve disease identification and therapeutic approaches, hopefully reducing the burden of m...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2009.01449.x
更新日期:2010-03-01 00:00:00
abstract::The discussion about neuropsychological sequalae from migraine occurring in adults is controversial. The purpose of our study was to examine whether children with migraine may be at risk for impaired intellectual development compared with their siblings free of migraine. ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.2002.02179.x
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To examine the direct medical costs associated with migraine, when diagnosed alone and in conjunction with anxiety and/or depression in adults and children. BACKGROUND:Migraine is a common disorder that can often be accompanied by comorbid anxiety and/or depression. Given the prevalence of migraine and the l...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2004.446004.x
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of migraine and episodic tension-type headache (ETTH) among university students as well as its impact on academic performance and quality of life. BACKGROUND:Headache is a very common symptom in clinical practice. The reduced capacities due to migraine can be profound, and more st...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.2001.041007710.x
更新日期:2001-07-01 00:00:00
abstract::Pharmacological preparations of cannabinoid compounds have a variety of therapeutic uses in medicine, including different pain syndromes, but have not been previously reported as beneficial for cluster headache. We present a patient with cluster headache who was refractory to multiple acute and preventive medications ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2009.01344.x
更新日期:2009-06-01 00:00:00
abstract::Neurotologic symptoms are common with migraine, yet relatively little is known about the pathophysiology of such symptoms. Motion sensitivity with bouts of motion sickness occurs in about two thirds of patients with migraine. Episodes of vertigo occur in about one fourth of patients and, in some, vertigo is the only s...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1046/j.1526-4610.1997.3710615.x
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the role of the chemokine receptor CX3CR1 in headaches and migraine. METHODS:Distribution of 2 polymorphisms of the chemokine receptor CX3CR1 (V249I and T280M) was determined in a population-based sample of 1179 elderly individuals. RESULTS:Heterozygotes for both CX...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2007.01011.x
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:In Ontario, approximately $3.8 billion is spent annually on publicly funded drug programs. The annual growth in Ontario Public Drug Program (OPDP) expenditure has been limited to 1.2% over the course of 3 years. Concurrently, the Ontario Drug Policy Research Network (ODPRN) was appointed to conduct drug clas...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12585
更新日期:2015-07-01 00:00:00
abstract::The ideal migraine medication would provide rapid “one and done” treatment of migraine for all sufferers. Unfortunately, no such intervention is available. While most people respond to triptans or DHE, some will need to combine these with an NSAID, or will choose to use an NSAID alone because of personal preference or...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.12474
更新日期:2014-11-01 00:00:00
abstract::Minor trauma to the head or neck is occasionally followed by severe chronic headaches. We have evaluated 35 adults (27 women, 8 men) with no prior history of headaches, who developed recurrent episodic attacks typical of common or classic migraine following minor head or neck injuries ("post-traumatic migraine"-PTM). ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.1991.hed3107451.x
更新日期:1991-07-01 00:00:00
abstract:OBJECTIVE:To examine circadian and menstrual patterns of migraine frequency in order to identify properties of the putative migraine generator. METHODS:Analysis of circadian and menstrual migraine attack frequency distributions, using between-interval differences as estimates, at each time point, of the derivative of ...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2005.05134.x
更新日期:2005-07-01 00:00:00
abstract::This systematic review examined the effectiveness of parenteral ketorolac (KET) in acute migraine. Acute migraine headaches are common emergency department presentations, and despite evidence for various treatments, there is conflicting evidence regarding the use of KET. Searches of MEDLINE, EMBASE, Cochrane, CINAHL, ...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12009
更新日期:2013-02-01 00:00:00
abstract::Headache is a common disorder in the general population. It is often highly debilitating for the people affected and highly costly to society. Although we know much about primary headaches, little is known about secondary headaches which, however,are a frequent occurrence in the general population. A study conducted o...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/j.1526-4610.2009.01390.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of rizatriptan for acute migraine treatment and patient satisfaction with the drug in usual clinical practice settings. BACKGROUND:Although rizatriptan has been shown to effectively relieve migraine symptoms in clinical trials, we wished to assess its utility in typical patient ...
journal_title:Headache
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1046/j.1526-4610.2003.03045.x
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:Personality traits (especially neuroticism) and childhood maltreatment have been independently related to many negative health outcomes later in life, including migraine. Studies have also shown the association between childhood maltreatment and maladaptive personality traits. The mediating role of personali...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.13206
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:A vascular component in ergotamine-induced headache has been proposed. No study has been carried out to evaluate cerebral hemodynamic changes by means of transcranial Doppler during withdrawal from migraine medication; in particular, ergotamine-containing drugs. METHOD:We examined 21 patients suffering from...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1998.3809679.x
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVES:To compare the relative tolerability of 5-HT1B/1D agonists and to investigate the relationships (if any) among systemic exposure, lipophilicity, and clinical tolerability for 5-HT1B/1D agonists. METHODS:Post hoc correlations were sought among the following variables: absolute dose (= administered dose x ora...
journal_title:Headache
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::Migraine is a common disorder that starts at an early age and takes a variable pattern from intermittent to chronic headache with several exacerbations throughout a lifetime. Children and adolescents are significantly affected. If an acute headache is not aborted by outpatient migraine therapy, it often causes severe ...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12694
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:The etiology of transient global amnesia (TGA) remains unclear, and flow disturbances in the mesial temporal lobes secondary to venous congestion have been proposed as a potential cause. The occurrence of TGA during a migraine attack is a rare condition. METHODS:This 11-year retrospective study in one French...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/head.12545
更新日期:2015-06-01 00:00:00
abstract::Spontaneous intracranial hypotension typically results from spontaneous cerebrospinal fluid (CSF) leak, often at spine level and only rarely from skull base. Once considered rare, it is now diagnosed far more commonly than before and is recognized as an important cause of headaches. CSF leak leads to loss of CSF volum...
journal_title:Headache
pub_type: 杂志文章,评审
doi:10.1111/head.12149
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To investigate the influence of different pharmacological treatments on the intensity dependence of auditory evoked cortical potentials in migraineurs. BACKGROUND:Between attacks, patients with migraine show abnormalities in cortical information processing and decreased brain mitochondrial energy reserve. Bo...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.2000.00005.x
更新日期:2000-01-01 00:00:00
abstract::Long-lasting severe headaches are reported to occur in up to 83% of patients who have undergone resection of acoustic neuroma, especially through a suboccipital approach. These headaches, however, are not well defined. The objective of this study was to assess the frequency and character of new-onset headaches after r...
journal_title:Headache
pub_type: 杂志文章
doi:10.1046/j.1526-4610.1999.3902089.x
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE:In this study, we attempted to evaluate the response to lithium treatment and its tolerability in the prevention of episodic cluster headache (CH) and to identify clinical predictors of response. BACKGROUND:Verapamil and lithium are the most widely used drugs in the prevention of CH attacks. Lithium is consi...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2012.02183.x
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:This study compared clinical manifestations and audiovestibular function tests among subjects of basilar-type migraine (BtM), definite and probable migrainous vertigo (dMV and pMV), in order to investigate the relationship between them. BACKGROUND:Various diagnostic criteria such as BtM, dMV, and pMV have be...
journal_title:Headache
pub_type: 杂志文章
doi:10.1111/j.1526-4610.2008.01283.x
更新日期:2009-03-01 00:00:00