Abstract：
BACKGROUND:Exercise tolerance is an important clinical aspect of chronic obstructive pulmonary disease that can be easily and reliably measured with the 6-minute walking test (6MWT). To improve the utility of the 6MWT for patient and health care system management, the interpretation of the functional status measure in relation to death and hospitalization should be elucidated. METHODS:Three-year, prospective, multicenter observational study to evaluate the predictive power of 6MWD for death or exacerbation-related hospitalization and to evaluate the factors that help determine 6MWD. RESULTS:We measured 6MWD at baseline and annually in 2110 patients with clinically stable Global Initiative for Obstructive Lung Disease (GOLD) stage II-IV COPD and recorded exacerbation-related hospitalizations and all-cause mortality. During the study, 200 patients died and 650 were hospitalized. Using receiver operating characteristics, the best predictive thresholds of the 6MWD were 334 m for increased risk of death and 357 m for exacerbation-related hospitalization (area under the curve 0.67 and 0.60 respectively); however, the discriminatory thresholds, especially for mortality, were influenced by age. The mean (SE) 6MWD declined by 1.6 (1.2) m per year in GOLD II, 9.8 (1.3) m per year in GOLD III, and 8.5 (2.4) m per year in GOLD IV. CONCLUSION:The 6MWD provides prognostic information that may be useful for identifying high-risk patients with COPD.
journal_name
J Am Med Dir Assocjournal_title
Journal of the American Medical Directors Associationauthors
Spruit MA,Polkey MI,Celli B,Edwards LD,Watkins ML,Pinto-Plata V,Vestbo J,Calverley PM,Tal-Singer R,Agusti A,Coxson HO,Lomas DA,MacNee W,Rennard S,Silverman EK,Crim CC,Yates J,Wouters EF,Evaluation of COPD Longitudinaldoi
10.1016/j.jamda.2011.06.009subject
Has Abstractpub_date
2012-03-01 00:00:00pages
291-7issue
3eissn
1525-8610issn
1538-9375pii
S1525-8610(11)00236-2journal_volume
13pub_type
杂志文章,多中心研究abstract：OBJECTIVES:The purpose of this review was to describe the characteristics of late-life obesity, including prevalence, pathophysiology, and influences on morbidity and mortality. A second objective was to systematically review the empiric evidence on the effects of intentional weight loss interventions in older individu...
journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章,评审
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abstract：OBJECTIVES:To assess the 30-day mortality predictive markers in the oldest patients with Clostridioides difficile infection (CDI) and to analyze the accuracy of the European severity risk markers in this population. DESIGN:Observational prospective multicenter cohort study conducted by the French Infectious Diseases S...
journal_title：Journal of the American Medical Directors Association
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journal_title：Journal of the American Medical Directors Association
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journal_title：Journal of the American Medical Directors Association
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journal_title：Journal of the American Medical Directors Association
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章,随机对照试验
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更新日期：2012-02-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to evaluate the impact of a well-developed theory-based function-focused care for cognitively impaired (FFC-CI) intervention on eating performance among long-term care (LTC) residents with moderate-to-severe cognitive impairment. DESIGN:A secondary analysis of longitudinal da...
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pub_type： 杂志文章,随机对照试验
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更新日期：2016-03-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章
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journal_title：Journal of the American Medical Directors Association
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
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journal_title：Journal of the American Medical Directors Association
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更新日期：2021-01-29 00:00:00
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journal_title：Journal of the American Medical Directors Association
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更新日期：2013-10-01 00:00:00
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章,评审
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abstract：OBJECTIVES:Nursing facilities have lagged behind in the adoption of interoperable health information technology (ie technologies that allow the sharing and use of electronic patient information between different information systems). The objective of this study was to estimate the nationwide prevalence of electronic he...
journal_title：Journal of the American Medical Directors Association
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更新日期：2019-08-01 00:00:00
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journal_title：Journal of the American Medical Directors Association
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章
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更新日期：2020-08-25 00:00:00
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章
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journal_title：Journal of the American Medical Directors Association
pub_type： 杂志文章,评审
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更新日期：2020-03-01 00:00:00
