Abstract:
OBJECTIVE:To examine whether established diabetes risk factors and diabetes risk algorithms are associated with future frailty. DESIGN:Prospective cohort study. Risk algorithms at baseline (1997-1999) were the Framingham Offspring, Cambridge, and Finnish diabetes risk scores. SETTING:Civil service departments in London, United Kingdom. PARTICIPANTS:There were 2707 participants (72% men) aged 45 to 69 years at baseline assessment and free of diabetes. MEASUREMENTS:Risk factors (age, sex, family history of diabetes, body mass index, waist circumference, systolic and diastolic blood pressure, antihypertensive and corticosteroid treatments, history of high blood glucose, smoking status, physical activity, consumption of fruits and vegetables, fasting glucose, HDL-cholesterol, and triglycerides) were used to construct the risk algorithms. Frailty, assessed during a resurvey in 2007-2009, was denoted by the presence of 3 or more of the following indicators: self-reported exhaustion, low physical activity, slow walking speed, low grip strength, and weight loss; "prefrailty" was defined as having 2 or fewer of these indicators. RESULTS:After a mean follow-up of 10.5 years, 2.8% of the sample was classified as frail and 37.5% as prefrail. Increased age, being female, stopping smoking, low physical activity, and not having a daily consumption of fruits and vegetables were each associated with frailty or prefrailty. The Cambridge and Finnish diabetes risk scores were associated with frailty/prefrailty with odds ratios per 1 SD increase (disadvantage) in score of 1.18 (95% confidence interval: 1.09-1.27) and 1.27 (1.17-1.37), respectively. CONCLUSION:Selected diabetes risk factors and risk scores are associated with subsequent frailty. Risk scores may have utility for frailty prediction in clinical practice.
journal_name
J Am Med Dir Assocjournal_title
Journal of the American Medical Directors Associationauthors
Bouillon K,Kivimäki M,Hamer M,Shipley MJ,Akbaraly TN,Tabak A,Singh-Manoux A,Batty GDdoi
10.1016/j.jamda.2013.08.016subject
Has Abstractpub_date
2013-11-01 00:00:00pages
851.e1-6issue
11eissn
1525-8610issn
1538-9375pii
S1525-8610(13)00505-7journal_volume
14pub_type
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journal_title:Journal of the American Medical Directors Association
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journal_title:Journal of the American Medical Directors Association
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journal_title:Journal of the American Medical Directors Association
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journal_title:Journal of the American Medical Directors Association
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pub_type: 杂志文章
doi:10.1016/j.jamda.2016.06.019
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journal_title:Journal of the American Medical Directors Association
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journal_title:Journal of the American Medical Directors Association
pub_type: 杂志文章
doi:10.1016/j.jamda.2016.02.032
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journal_title:Journal of the American Medical Directors Association
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journal_title:Journal of the American Medical Directors Association
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journal_title:Journal of the American Medical Directors Association
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doi:10.1016/j.jamda.2016.01.006
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journal_title:Journal of the American Medical Directors Association
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journal_title:Journal of the American Medical Directors Association
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doi:10.1097/01.JAM.0000110649.22467.B4
更新日期:2004-03-01 00:00:00
abstract::Currently, the Agency for Healthcare Research and Quality (AHRQ) Common Format for nursing homes (NHs) accommodates voluntary reporting for 4 adverse events: falls with injury, pressure ulcers, medication errors, and infections. In 2015, AHRQ funded a technical brief to describe the state of the science related to saf...
journal_title:Journal of the American Medical Directors Association
pub_type: 杂志文章,评审
doi:10.1016/j.jamda.2016.03.005
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pub_type: 杂志文章,随机对照试验
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journal_title:Journal of the American Medical Directors Association
pub_type: 杂志文章
doi:10.1016/j.jamda.2005.04.006
更新日期:2005-09-01 00:00:00
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journal_title:Journal of the American Medical Directors Association
pub_type: 杂志文章
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更新日期:2021-01-15 00:00:00
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journal_title:Journal of the American Medical Directors Association
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:Journal of the American Medical Directors Association
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Journal of the American Medical Directors Association
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jamda.2017.01.013
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