Abstract：
:Over the last years, several new systemic cancer therapy strategies have been introduced to turn the growing insights of molecular aberrations involved in the development and progression of lung cancer into better treatment options fort the patients. This review presents some of the most important biological targets and biomarkers relevant in the treatment of non-small cell lung cancer. Especially EGFR mutations, anti-angiogenesis, multi kinase inhibition, vascular disrupting agents, vaccines, m-TOR inhibitors, TRAIL inhibition and several biomarkers are highlighted including current study results.
journal_name
Minerva Chirjournal_title
Minerva chirurgicaauthors
Zaba O,Grohe C,Merk Jsubject
Has Abstractpub_date
2011-06-01 00:00:00pages
235-44issue
3eissn
0026-4733issn
1827-1626pii
R06115502journal_volume
66pub_type
杂志文章,评审abstract：BACKGROUND:To investigate the efficacy of percutaneous catheter drainage (PCD) and peritoneal dialysis (PD) in the treatment of severe acute pancreatitis (SAP) and its underlying mechanism. METHODS:Totally 64 SAP patients were included in our study and randomly assigned into PCD+PD group (the combination group, N.=32)...
journal_title：Minerva chirurgica
pub_type： 杂志文章,随机对照试验
doi：10.23736/S0026-4733.18.07813-6
更新日期：2019-06-01 00:00:00
abstract：:Sorbsan is a new dressing composed of alginate fibers extracted from seaweed. It is claimed to have important hydrophilic, haemostatic and biocompatible qualities. Sorbsan was used in the treatment of the donor site of split skin grafts in 52 patients operated in this department from 1988 to 1990. The patients of this...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1992-06-15 00:00:00
abstract：BACKGROUND:The incidence of perforative diverticulitis of the left colon is steadily increasing. Today the decision is generally taken to perform two-stage surgery: segmentary resection without (Hartmann's operation) or with anastomosis, but protected by a colostomy ("limited intervention"). This study aimed to examine...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：:Esophago-jejunal reconstruction, after total gastrectomy, is best performed by one of the following three operations: interposed jejunal loop, Roux-en-Y loop and "omega" loop with Braun anastomosis. To assess the effects of the three mentioned techniques three groups of 15 patients each were examined after total gastr...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1989-09-15 00:00:00
abstract：:Self-transfusion represents a clinical method used for the restoration of haematic losses that, in recent years has been employed more and more widely in the surgical ambit. The utilisation of this method has become increasingly frequent because of the high diffusion of haemotransmitted diseases, and of the incidences...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:Among the other complications of enterostomy, prolapse deserves particular mention on account of the therapeutic problems involved in its correction. Based on a report of the authors' personal experience, the paper focuses on the mechanisms of onset and, above all, on the most appropriate forms of treatment, before co...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：1990-05-15 00:00:00
abstract：:Lung cancer is globally the second most common form of cancer in both men and women and the single largest cause of cancer-related mortality in the world. It is a disease with poor prognosis and the survival statistics have scarcely improved since historical times. The advent of targeted therapies has caused an increm...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：2009-12-01 00:00:00
abstract：:The aim of this work is to assess the list of fine needle aspiration in the diagnosis of lesions of the parotid. Thirty-nine patients suffering from parotid pathology were subjected to cytology examination through fine needle aspiration. Thirty seven patients subjected to surgical operation have a histological compari...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：1993-10-31 00:00:00
abstract：AIM:Patients undergoing excision for breast lumps prefer general anesthesia or local anesthesia plus sedation, because of the fear of pain for local anesthesia alone. The aim of this study is to show the efficacy of an eutectic mixture of local anesthetic lignocaine and prilocaine (EMLA®) in these patients. METHODS:Th...
journal_title：Minerva chirurgica
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2012-04-01 00:00:00
abstract：:Double pylorus is an extremely rare pathology: it can be an acquired or congenital lesion. Two new cases complicating a peptic ulcer are reported and the clinical appearance and evolution of the different etiological type are described. ...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：1998-10-01 00:00:00
abstract：:A dorsal formation in a newborn girl proved to have been caused by an intestinal cyst, thus forming part of the rare classification of split notochord malformations. ...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1975-07-15 00:00:00
abstract：:Peritoneal carcinomatosis has always been regarded to have a poor prognosis. Surgery is usually limited to palliation of bowel obstruction by performing an intestinal bypass or ostomy. This severe disease has been considered as equal to distant metastasis and intravenous (i.v.) chemotherapy is commonly used in order t...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：2005-06-01 00:00:00
abstract：:The incidence of esophageal adenocarcinoma is on the rise. With advances in endoscopic techniques and imaging technology, early neoplastic lesions are being increasingly detected and treated. Managing early esophageal adenocarcinoma with endoscopic techniques is now considered the cornerstone of therapy, offering an a...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：10.23736/S0026-4733.18.07764-7
更新日期：2018-08-01 00:00:00
abstract：:Clinical, radiological and endoscopic results at follow-up about 1-5 yr after surgery in a series of 62 patients subjected to Billroth I resection are compared with those in the literature. Recurrence of ulcers was observed in 8% (as opposed to 5% with the Billroth II). In addition, there was a marked reduction in the...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1980-07-15 00:00:00
abstract：BACKGROUND:In this study all patients observed between January 1993 and October 1997 with malignant pleural mesothelioma (MPM) have been analyzed in order to describe the impact of treatment modality on survival. METHODS:Medical records of 56 patients with MPM (44 male, 12 female, median age = 59 yrs) were reviewed. I...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：2001-06-01 00:00:00
abstract：:Peri-inguinal and Para-inguinal hernias are included in the group of lateral ventral hernias and must be distinguished from Spigelian and intraparietal ascending inguinal hernias. Peri-inguinal hernia is very unusual in its location and development. Non one similar case has been reported in literature. ...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1991-04-30 00:00:00
abstract：:Solid pseudopapillary pancreatic tumour is an uncommon disease including 2.7% of exocrine malignancies of the pancreas. Its low incidence is associated with an uncertain prognosis and with difficult diagnostic and therapeutic problems, despite routine use of ultrasonography, TC and RMN. A case of solid pseudopapillary...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：2003-12-01 00:00:00
abstract：BACKGROUND:We investigated the application value of nanocarbon lymphatic tracer in thoraco-laparoscopic esophagectomy. METHODS:A total of 80 patients were enrolled and randomly divided into the experimental group (N.=40) and the control group (N.=40). Patients in the experimental group were injected with nanocarbon su...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：10.23736/S0026-4733.17.07298-4
更新日期：2017-12-01 00:00:00
abstract：:The biological and synthetic materials employed over the years for filling breasts after mastectomy or for congenital malformations are reviewed. At the start of the century, breast shape and volume were changed by adipose tissue grafts. In the 50s and 60s dermo-fibro-adipose grafts and later auto-grafts and grafts of...
journal_title：Minerva chirurgica
pub_type： 历史文章,杂志文章
doi：
更新日期：1989-09-30 00:00:00
abstract：:A 54 year-old man, without any remarkable medical history, was examined for recurrent episodes of colicky abdominal pain, over a period of nine months, with positive faecal occult blood test. Three months earlier he had undergone an extensive evaluation for a single episode of melaena, including upper gastrointestinal...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:To evaluate multiple osteochondral autografts for the treatment of traumatic chondral lesions of the knee. METHODS:Twenty-four (19 male and 5 female) patients underwent multiple osteochondral transplantation from 1995 to1999, the age ranging from 19 and 47 years old. Osteochondral lesion was localized on th...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：:The authors discuss the efficacy of the lateral calcaneal artery flap in repairing the calcaneal and malleolar regions. The lateral calcaneal artery flap is a safe flap, with constant vascularization represented by the lateral calcaneal artery and the external saphenous vein; the flap has a sensory nerve (the sural ne...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：:Attention is drawn to the fact that renal transplants are quite commonly complicated by stenosis of the arterial pedicle. The symptomatology (hypertension, oliguria, fever and gradual loss of renal function) points to the need for angiography. In about 70% of cases, surgical management in the light of the nature of th...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1979-08-15 00:00:00
abstract：AIM:Although many studies on laparoscopic surgery of the stomach have been conducted so far, yet they have not provided surgeons with criteria for gradual and safe training with this technique. The results of gastric surgery with 30 patients operated on by laparoscopic approach are hereby described. The aim of this iss...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：2005-02-01 00:00:00
abstract：AIM:The primary objective of the study was to compare the effect of laparoscopic-assisted (LPS) versus open surgery (LPT) for colorectal cancer on postoperative morbidity. The secondary objectives were to evaluate immune response and intestinal wall oxygen perfusion. METHODS:A total of 610 patients with colorectal can...
journal_title：Minerva chirurgica
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2006-08-01 00:00:00
abstract：:Meckel's diverticulum occurs in approximately 2 percent of the population and may present at any age. Although Meckel's diverticulum may produce an intestinal obstruction or perforation, simulating an appendicitis, hemorrhage is its most important clinical presentation. From 1989 to 1994, Meckel's diverticulum was dis...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：:A case of gastric leiomyoblastoma observed in a 76 year old woman, with details of its cytological and histological diagnosis, is reported. Cytologically, the tumour showed spindle-shaped cells, either single or arranged in clusters and bundles and constituted of epithelial-like cells with moderately irregular and hyp...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1989-04-30 00:00:00
abstract：:The symptomatology and diagnostic procedure adopted in 11 cases of acute mesenteric infarction are examined. Stress is laid on the importance of early, aetiologically accurate diagnosis for the purpose of instituting profitable treatment. In order to comply with such needs it is essential to perform urgent selective a...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1989-07-31 00:00:00
abstract：AIM:It is generally impossible to make a distinction between benign and malign with a cytopathological examination using a fine needle aspiration biopsy (FNAB) in follicular lesions of the thyroid gland. This is the reason why lesions are frequently reported as follicular neoplasia (FN). Our study aims to examine the p...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：2012-12-01 00:00:00
abstract：:Open Nissen fundoplication has been established as an effective treatment in the management of gastroesophageal reflux disease (GORD). Progress in minimally invasive surgery has given the chance of performing laparoscopic Nissen fundoplication. The short-term results are encouraging and its outcome promising. The need...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：2001-08-01 00:00:00
