Abstract:
BACKGROUND:In this study all patients observed between January 1993 and October 1997 with malignant pleural mesothelioma (MPM) have been analyzed in order to describe the impact of treatment modality on survival. METHODS:Medical records of 56 patients with MPM (44 male, 12 female, median age = 59 yrs) were reviewed. In 34 cases the histotype was epithelial, in 4 sarcomatoid, in 4 mixed, in 3 desmoplastic, and in 11 not specified. Four treatment modalities were identified: 1) Surgery (subtotal pleurectomy) = 20 patients; 2) Chemotherapy = 19 patients; 3) Surgery+Chemo-therapy = 8 patients; 4) Supportive care = 9 patients. RESULTS:The median survival was: 1) Surgery = 12.4 months; 2) Chemotherapy = 7.5 months; 3) Surgery+Chemotherapy = 12 months; 4) Supportive care = 11.4 months. Using univariate analysis, 8 prognostic factors were studied (age, sex, asbestos exposure, side, histotype, performance status, stage, treatment). Among these, only the stage and the performance status had shown a prognostic value on survival (p<0.05), while the treatment modality had not significantly influenced the prognosis. Using multivariate analysis only performance status showed to be significatively associated with survival (p=0.01 and odds ratio = 1.9, I.C. 1.2-3.2). CONCLUSIONS:Despite the limits of a retrospective study, personal experience confirms the ineffectiveness of current therapeutical approaches to MPM. A better understanding of MPM is required to develop new therapeutical approaches and alter the dismal prognosis of this disease.
journal_name
Minerva Chirjournal_title
Minerva chirurgicaauthors
Melloni G,Puglisi A,Ferraroli GM,Carretta A,Ceresoli G,Calori G,Zannini Pkeywords:
subject
Has Abstractpub_date
2001-06-01 00:00:00pages
243-50issue
3eissn
0026-4733issn
1827-1626journal_volume
56pub_type
杂志文章,评审abstract:BACKGROUND:Personal preliminary experience with Minimally Invasive Repair of Pectus Excavatum (MIRPE), "Nuss" procedure, using VATS is reported. METHODS:From January 2001 to February 2002, MIRPE has been performed on 5 patients (age range 13-18 y; mean 14.8 y). Under general anesthesia, a curved steel bar is inserted ...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:2004-02-01 00:00:00
abstract::In Italy 250,000 subjects every year are affected by malignant tumors, causing 150,000 deaths/year. The global index (statistic prevalence) of oncological patients, either at first diagnosis, or restored to health or under treatment, aggregates 1 million and 500 thousand individuals. During his whole lifetime, every m...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Gastroduodenal obstruction is a preterminal event in patients with advanced and recurrent malignancies of the stomach, pancreas, and duodenum. It severely limits the quality of life in affected patients due to constant vomiting and associated malnutrition. Gastroduodenal stent placement is a very safe and ef...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:10.23736/S0026-4733.16.06457-9
更新日期:2017-06-01 00:00:00
abstract::Surgical correction of pectus excavatum et carinatum in a series of adult patients is described. The relationship between deformity of the anterior chest wall and cardiac, respiratory and digestive disturbances is assessed. The indications for surgical management are explained. Reference is also made to the satisfacto...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1975-02-15 00:00:00
abstract::The symptomatology and diagnostic procedure adopted in 11 cases of acute mesenteric infarction are examined. Stress is laid on the importance of early, aetiologically accurate diagnosis for the purpose of instituting profitable treatment. In order to comply with such needs it is essential to perform urgent selective a...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1989-07-31 00:00:00
abstract::Resection and thermal ablation procedures are frequently used for the treatment of primary and secondary liver tumors. Various tools for the virtual planning of liver resections and ablation are available and some of them are already used clinically. Resection planes and ablation volumes can be optimized for sufficien...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the efficacy and safety of biliary-intestinal bypass in severely obese subjects (Body Mass Index > 35). METHODS:From January to December 1999, 23 patients (8 men and 15 women, mean age 36.6 years: range 20-51) affected with primary morbid obesity (BMI >40: range 40.1-6...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract::A case of a young male operated on for acute appendicitis due to a carcinoid of the base is reported. Since the tumor was infiltrating the resection margin of the appendix, the patient was later treated with a right hemicolectomy. Carcinoid tumor is unusual, but can be encountered several times during the career of a ...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::The authors report in a retrospective study their experience in the treatment of anal fistulas suggesting the total exercises of the fistula with primary closure of external and internal anal sphincters and rectal mucosa. In our department of surgery between 1987 and 1993, 36 patients (22 males and 14 females) with an...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract::Infected vascular grafts are associated with very high rates of limb loss and mortality. "Classic" treatment has invariably included graft excision. Recent reports have suggested that a more conservative approach may be indicated in selected cases, leaving the graft in place and using an aggressive local treatment ass...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:
更新日期:1994-05-01 00:00:00
abstract:AIM:This study was designed to investigate the risk factors of pelvic lymph node metastasis in early stage cervical cancer in order to establish a prediction model for this metastasis and to explore the feasibility of conservative surgery. METHODS:The records of 207 stage IB-IIA cervical cancer patients were retrospec...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:2011-12-01 00:00:00
abstract::Late thrombosis of inserted prosthetic grafts for arterial reconstructive surgery is one of the most frequent late complication. Its incidence is influenced by many factors: hemodynamic conditions, quality of run-in and run-off, technical aspects of the primary repair. Progressive arteriosclerosis in femoral vessels w...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1989-03-31 00:00:00
abstract::Abdomen and pelvic radiation therapy, as a complement to medical and surgery therapy in malignancies, may determine acute and chronic intestinal injuries. The acute intestinal effects of ionizing radiation are the necrosis of crypt epithelial cells and the cessation of the intestinal epithelium; late radiation injury ...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract::The authors report a case of associated injuries (thoracoabdominal trauma with multiple rib and sternum fractures, perforation of the small intestine, abdominal cutaneous ecchymosis) caused by a seat belt, and describe the possible seat-belt mechanisms of lesion in road accidents. Some clinical aspects are discussed; ...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1993-05-15 00:00:00
abstract::Augmented reality (AR) enables the superimposition of virtual reality reconstructions onto clinical images of a real patient, in real time. This allows visualization of internal structures through overlying tissues, thereby providing a virtual transparency vision of surgical anatomy. AR has been applied to neurosurger...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:10.23736/S0026-4733.18.07659-9
更新日期:2018-06-01 00:00:00
abstract::The management of patients with cervical injuries is highly controversial. Some authorities advocate mandatory exploration for all such injuries, while others advocate selective exploration. This paper will objectively review the evidence supporting each approach. The non-operative approach may be pursued through a va...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:
更新日期:2004-12-01 00:00:00
abstract:INTRODUCTION:We provide a comprehensive description of the physio-pathological theories behind oligometastatic prostate cancer (PCa) and analyze modern imaging techniques, presenting a systematic review of the available evidences regarding salvage lymph node dissection (sLND). EVIDENCE ACQUISITION:A systematic review ...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:10.23736/S0026-4733.18.07796-9
更新日期:2019-02-01 00:00:00
abstract::Deep venous thrombosis is a quite frequent pathology with a high degree of morbidity and death-rate. Two are the main problems of this disease: the risk of pulmonary embolism and outcome of a post-thrombotic syndrome, leading patients to infirmity. The patients max exposed to the risk of deep venous thrombosis are the...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::The incidence and prevalence of obesity continues to increase globally. Physicians will therefore provide care for an increasing number of obese patients in their clinical practice. Optimal management of these patients is required to minimize the risk of perioperative complications that increase morbidity and mortalit...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:10.23736/S0026-4733.17.07310-2
更新日期:2017-06-01 00:00:00
abstract::This article addresses emergent endoluminal technologies currently available for the treatment of gastroesophageal reflux disease (GERD) and compares it to the laparoscopic Nissen fundoplication. To date the mainstay of GERD therapy has been achieved with either open or laparoscopic fundoplication or life-long medical...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:
更新日期:2004-10-01 00:00:00
abstract::Operations and follow-up examinations were conducted on 106 patients with ulcerative colitis, 33 with colitis Crohn, and 163 with diverticulitis, at the University Clinics of Cologne and Munich. Overall mortality rates were 24.5% (n = 26), 6.1% (n = 2) and 16% (n = 26), respectively. In the surgical treatment of ulcer...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1978-06-15 00:00:00
abstract:BACKGROUND AND AIM:Over the past decade the use of surgical staplers has resulted in a substantial change in both elective and emergency surgery for gastrointestinal pathologies. A large number of studies have now affirmed the safety, reliability, simplicity, rapidity and usefulness of these instruments. They offer man...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
abstract::The authors report on their initial experience with pylorus-preserving pancreatoduodenectomy. In the last three years 11 patients with neoplastic disease of the pancreatic head and ampullary region underwent the above mentioned procedure. The surgical technique carefully preserved the blood supply and innervation to t...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1989-10-31 00:00:00
abstract::The key concepts regarding nutrition of elderly patients prior to surgery are outlined. The main metabolic changes that occur during surgical stress, paying special attention to the characteristics of elderly patients, are described. Lastly, the caloric-energy intake required by postoperative geriatric patients is eva...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::Following a brief review of the various types of local anesthesia, including a recent method using EMLA cream, the paper focuses on the different complications which arise in relation to the technique used. Treatment protocols are also analysed in relation to the toxic stage. ...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:
更新日期:1992-05-15 00:00:00
abstract::Five hundred and twenty (520) patients with lung resection for cancer and known follow-up were studied. The aim of the study was to analyse long-term results in relation to the age of the patients. Two hundred and forty (240) cases were less than 55 years old, 227 were aged between 55 and 65 years, 53 were aged over 6...
journal_title:Minerva chirurgica
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract::Peritoneal carcinomatosis has always been regarded to have a poor prognosis. Surgery is usually limited to palliation of bowel obstruction by performing an intestinal bypass or ostomy. This severe disease has been considered as equal to distant metastasis and intravenous (i.v.) chemotherapy is commonly used in order t...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:
更新日期:2005-06-01 00:00:00
abstract::A case of gastric leiomyoblastoma observed in a 76 year old woman, with details of its cytological and histological diagnosis, is reported. Cytologically, the tumour showed spindle-shaped cells, either single or arranged in clusters and bundles and constituted of epithelial-like cells with moderately irregular and hyp...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1989-04-30 00:00:00
abstract:AIM:Severe obesity is a major health problem affecting more than 1,000,000 people in Italy, with a 95% failure rate of nonsurgical treatments. We report our over five-years experience with laparoscopic Roux-en-Y gastric bypass (LRYGBP), evaluating the postoperative course of the patients undergoing 3 different gastro-e...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Surgeon's position during open cholecystectomy operation has been standardized since more than 100 years, being traditionally fixed at the right side of the patient. Only a few French authors adopted the "left location" just for the time requested for the common bile duct exploration. METHODS:In this paper ...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00