[Treatment of malignant pleural mesothelioma].

Abstract:

BACKGROUND:In this study all patients observed between January 1993 and October 1997 with malignant pleural mesothelioma (MPM) have been analyzed in order to describe the impact of treatment modality on survival. METHODS:Medical records of 56 patients with MPM (44 male, 12 female, median age = 59 yrs) were reviewed. In 34 cases the histotype was epithelial, in 4 sarcomatoid, in 4 mixed, in 3 desmoplastic, and in 11 not specified. Four treatment modalities were identified: 1) Surgery (subtotal pleurectomy) = 20 patients; 2) Chemotherapy = 19 patients; 3) Surgery+Chemo-therapy = 8 patients; 4) Supportive care = 9 patients. RESULTS:The median survival was: 1) Surgery = 12.4 months; 2) Chemotherapy = 7.5 months; 3) Surgery+Chemotherapy = 12 months; 4) Supportive care = 11.4 months. Using univariate analysis, 8 prognostic factors were studied (age, sex, asbestos exposure, side, histotype, performance status, stage, treatment). Among these, only the stage and the performance status had shown a prognostic value on survival (p<0.05), while the treatment modality had not significantly influenced the prognosis. Using multivariate analysis only performance status showed to be significatively associated with survival (p=0.01 and odds ratio = 1.9, I.C. 1.2-3.2). CONCLUSIONS:Despite the limits of a retrospective study, personal experience confirms the ineffectiveness of current therapeutical approaches to MPM. A better understanding of MPM is required to develop new therapeutical approaches and alter the dismal prognosis of this disease.

journal_name

Minerva Chir

journal_title

Minerva chirurgica

authors

Melloni G,Puglisi A,Ferraroli GM,Carretta A,Ceresoli G,Calori G,Zannini P

keywords:

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

243-50

issue

3

eissn

0026-4733

issn

1827-1626

journal_volume

56

pub_type

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  • [Fistulectomy with closure by first intention in the treatment of perianal fistulae].

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  • [The conservative treatment of infected vascular prostheses in surgery to revascularize the lower limbs].

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    authors: Giuffrida GF,Miani S,Bergamaschi E,Mingazzini P,Giordanengo F

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    doi:

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    doi:

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  • [Position of the operative team during laparotomy cholecystectomy. Looking for the optimal perspective].

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