Near real-time vaccine safety surveillance with partially accrued data.

abstract：PURPOSE:In epidemiological studies, non-response may introduce bias and limit generalizability. In genetic pharmacoepidemiological research, collection of DNA might be a major reason for non-response. We determined reasons for non-response and compared characteristics of non-responders and responders in a pharmacogenet...

journal_title：Pharmacoepidemiology and drug safety

authors： van Wieren-de Wijer DB,Maitland-van der Zee AH,de Boer A,Kroon AA,de Leeuw PW,Schiffers P,Janssen RG,Psaty BM,van Duijn CM,Stricker BH,Klungel OH

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To describe a bias that can occur in the analysis of data from certain randomized trials. METHODS AND RESULTS:Although randomized trials are effective at preventing confounding, a potentially strong confounding can arise in certain therapeutic drug trials in which follow-up is extended in an open-label phase t...

journal_title：Pharmacoepidemiology and drug safety

authors： Rothman KJ

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:Epidemiological data on adhesion-related complications following intra-abdominal surgery are limited. We tested the accuracy of recording of these surgeries and complications within The Health Improvement Network (THIN), a primary care database within the UK. METHODS:Individuals within THIN from 1995 to 2011 w...

journal_title：Pharmacoepidemiology and drug safety

authors： Scott FI,Mamtani R,Haynes K,Goldberg DS,Mahmoud NN,Lewis JD

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:The Canadian Network for Observational Drug Effect Studies (CNODES), a network of pharmacoepidemiologists and other researchers from seven provincial sites, provides evidence on the benefits and risks of drugs used by Canadians. The Knowledge Translation Team, one of CNODES' four main teams, evaluates the impac...

journal_title：Pharmacoepidemiology and drug safety

authors： Sketris IS,Carter N,Traynor RL,Watts D,Kelly K,following contributing members of the CNODES Knowledge Translation Team: Pierre Ernst, JM Gamble, Brenda Hemmelgarn, Colleen Metge, Michael Paterson, Robert Platt W. and Gary Teare.

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Hydroxyzine is indicated for the management of anxiety, skin and sleep disorders. In 2015, the European Medicines Agency (EMA) concluded that hydroxyzine was pro-arrhythmogenic and changes to the product information were implemented in Europe. This study aimed to evaluate their impact in Denmark, Scotland, E...

journal_title：Pharmacoepidemiology and drug safety

authors： Morales DR,Macfarlane T,MacDonald TM,Hallas J,Ernst MT,Herings RMC,Smits E,Overbeek JA,Mitchell L,Morant S,Mackenzie I,Doney ASF,Robertson C,Bennie M,Wei L,Nicholson L,Morris C,Flynn RWF

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Stimulants and atomoxetine should generally not be used or used only with caution in adults with pre-existing cardiovascular conditions. The extent to which pre-existing cardiovascular conditions influence initiation of these ADHD medications in adults is not known. METHODS:We performed a retrospective coho...

journal_title：Pharmacoepidemiology and drug safety

authors： Gerhard T,Winterstein AG,Olfson M,Huang C,Saidi A,Crystal S

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:The strong male predominance of gastro-oesophageal cancer suggests that sex hormones play an important role. 5α-Reductase (5AR) inhibitors have antiandrogen effects and have been shown to decrease cancer cell proliferation and metastasis. We conducted the first epidemiologic investigation into the association b...

journal_title：Pharmacoepidemiology and drug safety

authors： Busby J,Karasneh R,Murchie P,McMenamin Ú,Gadalla SM,Camargo MC,Iversen L,Lee AJ,Spence AD,Cardwell CR

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:The General Practice Research Database (GPRD) is a database of longitudinal patient records from general practices in the United Kingdom. It is an important data source for pharmacoepidemiology studies, but until now it has been tedious to calculate the daily dose and duration of exposure to drugs prescribed. T...

journal_title：Pharmacoepidemiology and drug safety

authors： Shah AD,Martinez C

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:The use of prescription opioid analgesics has been increasing over the last few decades in Australia. In particular, oxycodone and fentanyl have increased substantially. We examined the gender and age trends in the prescribing of subsidised opioid analgesics in the Australian population for non-palliative care ...

journal_title：Pharmacoepidemiology and drug safety

authors： Hollingworth SA,Gray PD,Hall WD,Najman JM

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:The aim of this work was to study the use of systemic antibacterials and its possible determinants in Hungarian intensive care units (ICUs). METHODS:Hospital pharmacy. departments provided package level dispensing data for their corresponding ICU (2006). Data were converted into defined daily doses (DDDs) and ...

journal_title：Pharmacoepidemiology and drug safety

authors： Benko R,Matuz M,Peto Z,Bogár L,Viola R,Doró P,Soós G,Hajdú E

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:To evaluate the internet way of feedback to prescribing physicians, providing data on antimicrobial use and to assess the applicability of the DU90% (i.e. Drug Utilisation 90%--the number of drugs accounting for 90% of the volume of usage in defined daily doses, (DDDs)) methodology in the hospital setting. MET...

journal_title：Pharmacoepidemiology and drug safety

authors： Bergman U,Risinggård H,Vlahović-Palcevski V,Ericsson O

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:This study was performed to evaluate the change of prescribing patterns after the regulatory action regarding fluoroquinolones in pediatric patients. METHODS:We conducted a time series analysis using the Korea Health Insurance Review and Assessment Service National Patients Sample database. Study subjects cons...

journal_title：Pharmacoepidemiology and drug safety

authors： Shin JY,Kim MH,Shin SM,Lee SH,Park BJ

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Meta-analysis is a quantitative approach to summarize the findings from several studies and has been applied with increasing frequency to clinical trials. Because of their sample size and duration limitations, experimental studies (ESs) could not be able to detect late or rare adverse events (AEs), which may be...

journal_title：Pharmacoepidemiology and drug safety

authors： Alves C,Batel-Marques F,Macedo AF

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:This study quantifies the incidence of liver enzyme abnormalities in the general population of central Massachusetts. METHODS:Computerized data files from a health maintenance organization were used to ascertain potential subjects during the study period of 1 July 1992-30 June 1993. Medical records and labo...

journal_title：Pharmacoepidemiology and drug safety

authors： Duh MS,Walker AM,Kronlund KH Jr

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:Identify if publication of the 2010 drug safety communication (DSC) regarding benzonatate was associated with a decrease in the incidence of severe benzonatate poisonings reported to United States poison centers. METHODS:This retrospective database study utilized the National Poison Data System to compare the ...

journal_title：Pharmacoepidemiology and drug safety

authors： Leonard JB,Seung H,Klein-Schwartz W

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:This paper introduces an improved tool for designing matched-pairs randomized trials. The tool allows the incorporation of clinical and other knowledge regarding the relative importance of variables used in matching and allows for multiple types of missing data. The method is illustrated in the context of a clu...

journal_title：Pharmacoepidemiology and drug safety

authors： Greevy RA Jr,Grijalva CG,Roumie CL,Beck C,Hung AM,Murff HJ,Liu X,Griffin MR

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:During the past two decades, many novel immunosuppressive drugs have been approved for transplant recipients. Trends in the use of maintenance immunosuppressants after liver transplantation in Asia are unclear. Thus, we aimed to analyze the prescription trends in maintenance immunosuppressive drugs among liver ...

journal_title：Pharmacoepidemiology and drug safety

authors： Huang YY,Hsu CC,Chou CL,Loong CC,Wu MS,Chou YC

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Raised blood pressure associated with the sodium excipient content of soluble or effervescent analgesic has been previously reported. However, the influence of other anions associated with sodium on blood pressure is still controversial. METHODS:Observational study of elderly hypertensive patients with unco...

journal_title：Pharmacoepidemiology and drug safety

authors： Ubeda A,Llopico J,Sanchez MT

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:To assess the feasibility of using Clinical Practice Research Datalink (CPRD) data for identifying populations of patients with chronic obstructive pulmonary disease (COPD) eligible for a hypothetical pragmatic trial. METHODS:A retrospective multidatabase cohort study using CPRD primary care and linked seconda...

journal_title：Pharmacoepidemiology and drug safety

authors： Requena G,Wolf A,Williams R,Dedman D,Quint JK,Murray-Thomas T,Pimenta JM

更新日期：2020-12-27 00:00:00

abstract：PURPOSE:We developed a computerized system for signal detection in spontaneous reporting system (SRS) of Shanghai. Data acquisition, data mining could be carried out automatically and the process of data preprocessing and cleaning could be facilitated. This system was expected to detect signals from SRS after drug lice...

journal_title：Pharmacoepidemiology and drug safety

authors： Ye X,Fu Z,Wang H,Du W,Wang R,Sun Y,Gao Q,He J

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:To enhance automated methods for accurately identifying opioid-related overdoses and classifying types of overdose using electronic health record (EHR) databases. METHODS:We developed a natural language processing (NLP) software application to code clinical text documentation of overdose, including identificat...

journal_title：Pharmacoepidemiology and drug safety

authors： Hazlehurst B,Green CA,Perrin NA,Brandes J,Carrell DS,Baer A,DeVeaugh-Geiss A,Coplan PM

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:Drug induced Torsades de Pointes (TdP) is a major concern for new drugs seeking regulatory approval. Prolongation of QT intervals greater than 60 millisecond or to longer than 500 millisecond in an individual patient has been considered to be associated with a higher risk. The purpose of this study is to identi...

journal_title：Pharmacoepidemiology and drug safety

authors： Lin YL,Kung MF

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to generate data regarding the drug utilization pattern in pediatric population of our tertiary care hospital so that we could generate an essential medicine list (EML). BACKGROUND:Drug therapy accounts for a major portion of expenditure toward health care. Reduction in health ...

journal_title：Pharmacoepidemiology and drug safety

authors： Singh I,Mittal R,Shafiq N,Bharati B,Nigah RK,Pandhi P,Chaudhary RR,Malhotra S

更新日期：2010-04-01 00:00:00

abstract：:Adverse drug reaction surveillance conducted by the US Federal Food and Drug Administration (FDA) is important for detecting new safety information about pharmaceuticals. FDA has sought to stimulate reporting of reactions by practitioners and manufacturers. Over the five years from 1989 to 1993, reporting more than do...

journal_title：Pharmacoepidemiology and drug safety

authors： Faich GA

更新日期：1996-11-01 00:00:00

abstract：PURPOSE:We aimed to describe time-trends in the use of NOACs among a group of ambulatory patients with nonvalvular atrial fibrillation (NVAF) in Colombia and to describe treatment patterns and user characteristics. METHODS:Using the Audifarma S.A administrative healthcare database in Colombia, we identified 10 528 pat...

journal_title：Pharmacoepidemiology and drug safety

authors： Machado-Alba JE,Gaviria-Mendoza A,Machado-Duque ME,Tovar-Yepes C,Ruigómez A,García Rodríguez LA

更新日期：2020-10-15 00:00:00

abstract：PURPOSE:To evaluate the outcomes of patients participating in a program of integrated care for osteoporosis in terms of medication supply, fracture incidence and expenses. METHODS:Outcomes were assessed from secondary data provided by the AOK PLUS health insurance for 2455 participants of the program and the same numb...

journal_title：Pharmacoepidemiology and drug safety

authors： Goltz L,Degenhardt G,Maywald U,Kirch W,Schindler C

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:Stimulant medications used for treating attention deficit hyperactivity disorder (ADHD) can be associated with an increased risk of seizures. Atomoxetine is a non-stimulant medication approved for treating ADHD. This retrospective cohort analysis evaluated risk of seizures among pediatric patients naïve to ADHD...

journal_title：Pharmacoepidemiology and drug safety

authors： McAfee AT,Landon J,Jones M,Bangs ME,Acharya N,Hornbuckle K,Wong J

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To learn the evolution of antidepressant and lithium use in Castilla y León (Central Spain) and its relationship with suicide rates. METHODS:A search in the ECOM (Especialidades Consumo de Medicamentos) database of the Spanish Ministry of Health for antidepressants and lithium was carried out for the period ...

journal_title：Pharmacoepidemiology and drug safety

authors： Arias LH,Lobato CT,Ortega S,Velasco A,Carvajal A,del Pozo JG

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:We aimed to quantify the extent of over-the-counter (OTC) low-dose aspirin use among patients in The Health Improvement Network (THIN) in the UK. METHODS:In September 2013, a random sample of low-dose aspirin users (75 past users and 75 never users) was identified based on prescriptions recorded in THIN. Prima...

journal_title：Pharmacoepidemiology and drug safety

authors： Cea Soriano L,Soriano-Gabarró M,García Rodríguez LA

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Discontinuing low-dose acetylsalicylic acid (ASA) therapy after upper gastrointestinal bleeding (UGIB) may increase the risk of cardiovascular-related death. Our aim was to compare mortality in UK primary care patients who discontinue ASA after UGIB with that in patients who continue therapy. METHODS:ASA users...

journal_title：Pharmacoepidemiology and drug safety

authors： González-Pérez A,Sáez ME,Johansson S,Nagy P,García Rodríguez LA

更新日期：2017-02-01 00:00:00