Abstract：
:We describe the case of a woman who presented to the intensive care unit with acute respiratory failure that required mechanical ventilation. She had severe pulmonary hypertension secondary to interstitial lung disease, and her history included sarcoidosis and tuberculosis. She was dependent on inhaled nitric oxide (INO) to maintain safe arterial oxygen saturation and could not be weaned from mechanical ventilation. Echocardiography revealed a patent foramen ovale with substantial right-to-left shunt, which probably contributed to her hypoxemia. Sildenafil enabled weaning from INO and substantially reduced the flow through the patent foramen ovale. She was successfully extubated and discharged home. To our knowledge, this is the first report of weaning from INO and mechanical ventilation in a patient with both severe secondary pulmonary hypertension and a right-to-left shunt through a patent foramen ovale.
journal_name
Respir Carejournal_title
Respiratory careauthors
Elias S,Sviri S,Orenbuch-Harroch E,Fellig Y,Ben-Yehuda A,Fridlender ZG,Gilon D,Bayya Adoi
10.4187/respcare.01147subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1611-3issue
10eissn
0020-1324issn
1943-3654pii
rc01147r1eliasjournal_volume
56pub_type
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