The effect of rectal ozone on the portal vein oxygenation and pharmacokinetics of propranolol in liver cirrhosis (a preliminary human study).

abstract：:1 Six previously untreated emergency admissions to hospital with severe hypertension were given oral treatment with labetalol. 2 Pre-treatment diastolic BP exceeded 130 mmHg, and clinical evidence of either accelerated hypertension or encephalopathy was present. 3 Hypotensive response after treatment followed two patt...

journal_title：British journal of clinical pharmacology

authors： Ghose RR

更新日期：1979-01-01 00:00:00

abstract：:The hypertensive disorders of pregnancy (HDP) are a leading cause of maternal mortality and morbidity in both well and under-resourced settings. Maternal, fetal, and neonatal complications of the HDP are concentrated among, but not limited to, women with pre-eclampsia. Pre-eclampsia is a systemic disorder of endotheli...

journal_title：British journal of clinical pharmacology

authors： Magee LA,Abalos E,von Dadelszen P,Sibai B,Easterling T,Walkinshaw S,CHIPS Study Group.

更新日期：2011-09-01 00:00:00

abstract：:Nine healthy male subjects received oral fluconazole 400 mg daily, ketoconazole 200 mg twice daily or no treatment for 6 days according to a randomized, cross-over design. A single 250 mg oral dose of phenytoin suspension was administered on day 5 and serum phenytoin concentrations were measured over the following 48 ...

journal_title：British journal of clinical pharmacology

authors： Touchette MA,Chandrasekar PH,Milad MA,Edwards DJ

更新日期：1992-07-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:* Exposure to bosentan was lower in paediatric pulmonary arterial hypertension (PAH) patients treated with the marketed adult formulation at a dose of about 2 mg kg(-1) when compared with adult PAH patients. * In healthy adult subjects, bosentan pharmacokinetics are less than do...

journal_title：British journal of clinical pharmacology

authors： Beghetti M,Haworth SG,Bonnet D,Barst RJ,Acar P,Fraisse A,Ivy DD,Jais X,Schulze-Neick I,Galiè N,Morganti A,Dingemanse J,Kusic-Pajic A,Berger RM

更新日期：2009-12-01 00:00:00

abstract：:1. The effects of selective beta-adrenoceptor partial agonist activity on plasma creatine kinase (CK) and skeletal muscle symptoms were studied in normal volunteers. 2. A drug with beta 1-selective partial agonist activity (xamoterol) and one with partial agonist activity acting mainly through beta 2-adrenoceptors (pi...

journal_title：British journal of clinical pharmacology

authors： Tomlinson B,Cruickshank JM,Hayes Y,Renondin JC,Lui JB,Graham BR,Jones A,Lewis AD,Prichard BN

更新日期：1990-11-01 00:00:00

abstract：:1. The pharmacokinetics of butorphanol were evaluated in 18 female volunteers with varying degrees of renal function following a single, 1 mg transnasal dose of butorphanol tartrate. The creatinine clearance (CLCR) values for subjects in the normal (NOR), moderately impaired (MI), and severely impaired (SI) groups wer...

journal_title：British journal of clinical pharmacology

authors： Shyu WC,Morgenthien EA,Barbhaiya RH

更新日期：1996-05-01 00:00:00

abstract：:1. In a double-blind, placebo-controlled, cross-over study, acute pharmacokinetic, neurophysiological and psychotropic effects of suriclone, a new cyclopyrrolone derivative, were investigated and compared with alprazolam. 2. Fifteen normal young volunteers received randomized oral single doses of placebo, 0.1, 0.2 and...

journal_title：British journal of clinical pharmacology

authors： Saletu B,Grünberger J,Linzmayer L,Semlitsch HV,Anderer P,Chwatal K

更新日期：1994-02-01 00:00:00

abstract：:1. Dose response relationships for salbutamol and a new bronchodilator drug NAB 365 have been obtained in patients with reversible airways obstruction. These show that the latter is about one hundred times more potent than the former. 2. NAB 365 has a very long half-life. The implications of this are discussed. ...

journal_title：British journal of clinical pharmacology

authors： Kamburoff PL,Prime FJ,Schmidt OP

更新日期：1977-02-01 00:00:00

abstract：AIMS:The CYP3A metric 4β-hydroxycholesterol (4βOHC) has been shown to correlate with tacrolimus steady-state apparent oral clearance (CL/F). Recently, pretransplant 4βOHC was shown not to predict tacrolimus CL/F after transplantation in a cohort of renal recipients (n = 79). The goal of the current study was determine ...

journal_title：British journal of clinical pharmacology

authors： Vanhove T,Hasan M,Annaert P,Oswald S,Kuypers DRJ

更新日期：2017-11-01 00:00:00

abstract：AIMS:To investigate impacts of withdrawal and regulatory advice regarding cyclooxygenase-2 (COX-2) inhibitors on UK population rates of gastrointestinal haemorrhage and acute myocardial infarction (MI). METHODS:Ecological time series study of prescribing, mortality and hospital admission trends in people aged > or = 5...

journal_title：British journal of clinical pharmacology

authors： Wheeler BW,Metcalfe C,Gunnell D,Stephens P,Martin RM

更新日期：2009-11-01 00:00:00

abstract：:Plasma and synovial fluid concentrations of the enantiomers of flurbiprofen were measured in 15 rheumatoid patients receiving 100 mg racemic flurbiprofen twice daily. Pharmacokinetic parameters showed considerable variability within the group of patients, although differences in S(+)/R(-) plasma concentration ratios w...

journal_title：British journal of clinical pharmacology

authors： Young MA,Aarons L,Toon S

更新日期：1991-01-01 00:00:00

abstract：:Pharmacological interactions in both directions between phenprocoumon and atenolol and metoprolol were investigated using a crossover trial. Co-administration of phenprocoumon did not significantly affect Cmax, tmax, t1/2,22, AUC for atenolol or metoprolol. Co-administration of metoprolol, but not atenolol, increased ...

journal_title：British journal of clinical pharmacology

authors： Spahn H,Kirch W,Mutschler E,Ohnhaus EE,Kitteringham NR,Lögering HJ,Paar D

更新日期：1984-01-01 00:00:00

abstract：:1. A 1.25 mg dose of cilazapril, a new angiotensin-converting enzyme (ACE) inhibitor, was administered orally to two groups of hypertensive patients, five with normal renal function (NRF) and seven with impaired renal function (IRF), once daily for 5 or 8 consecutive days. Blood pressure, heart rate and serum ACE acti...

journal_title：British journal of clinical pharmacology

authors： Shionoiri H,Gotoh E,Sugimoto K,Takasaki I,Minamisawa K,Ishii M

更新日期：1989-01-01 00:00:00

abstract：AIMS:To describe age- and gender-related prescription patterns of diuretics in community-dwelling elderly, and to compare diuretics to other cardiovascular (CV) medications. METHODS:Cross-sectional study of patient-specific prescription data derived from a panel of 10 Dutch community pharmacies. Determination of propo...

journal_title：British journal of clinical pharmacology

authors： van Kraaij DJ,Jansen RW,de Gier JJ,Gribnau FW,Hoefnagels WH

更新日期：1998-10-01 00:00:00

abstract：:A new anti-spasticity agent, brolitene, has been assessed in patients with spasticity of spinal or cerebral origin. Twenty-seven patients were entered in a double-blind cross-over trial lasting 6 weeks, using a fixed dose of six tablets (1200 mg brolitene) per day. Clinical assessment failed to show any therapeutic ef...

journal_title：British journal of clinical pharmacology

authors： Perkin GD,Aminoff MJ

更新日期：1976-10-01 00:00:00

abstract：:1. The effects of benzhexol on the absorption and pharmacokinetics of an oral dose of levodopa have been studied in 10 young healthy volunteers. Subjects were given a suspension of levodopa (250 mg) 90 min after either benzhexol (5 mg) or placebo in a randomized cross over design with doses separated by at least 1 wee...

journal_title：British journal of clinical pharmacology

authors： Roberts J,Waller DG,von Renwick AG,O'Shea N,Macklin BS,Bulling M

更新日期：1996-04-01 00:00:00

abstract：AIM:Experimental pain models may help to evaluate the mechanisms of analgesics and target the clinical indications for their use. This review, the second in a series of two, addresses how the efficacy of non-opioid analgesics have been assessed in human volunteers using experimental pain models. METHODS:A literature s...

journal_title：British journal of clinical pharmacology

authors： Staahl C,Olesen AE,Andresen T,Arendt-Nielsen L,Drewes AM

更新日期：2009-09-01 00:00:00

abstract：:1. The beta-adrenergic blocking potencies of practolol, ICI 66082, tolamolol, acebutolol, H 93/26, H 87/07, pindolol and Ro 3-4787 were compared with that of propranolol, on human and rat adipocytes. 2. A good correlation was found between the potencies on adipocytes of the two species but not between our results and ...

journal_title：British journal of clinical pharmacology

authors： Harms HH,Van der Meer J

更新日期：1975-08-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Performance-enhancing dietary supplements have not been clinically tested for safety or efficacy. In clinical trials performed under resting conditions, performance-enhancing supplements raise blood pressure and affect glucose homeostasis. The effect of exercise on the pharmacok...

journal_title：British journal of clinical pharmacology

authors： Haller CA,Duan M,Jacob P 3rd,Benowitz N

更新日期：2008-06-01 00:00:00

abstract：:Although blood pressure measured at the brachial artery plays a central role in our understanding and management of cardiovascular risk, in recent years great emphasis has been placed on the importance of central blood pressure. It seems straightforward that knowledge of the blood pressure directly affecting the major...

journal_title：British journal of clinical pharmacology

authors： Tomlinson LA,Wilkinson IB

更新日期：2012-08-01 00:00:00

abstract：AIM:We encountered a case of fetal toxicity due to ductus arteriosus (DA) constriction in a 36-week pregnant woman who had applied multiple ketoprofen patches. The aim of the present study was to present the case and develop a model to predict quantitatively the fetal toxicity risk of transdermal administration of keto...

journal_title：British journal of clinical pharmacology

authors： Tanaka S,Kanagawa T,Momma K,Hori S,Satoh H,Nagamatsu T,Fujii T,Kimura T,Sawada Y

更新日期：2017-11-01 00:00:00

abstract：AIMS:Aprepitant and fosaprepitant, commonly used for the prevention of chemotherapy-induced nausea and vomiting, alter cytochrome P450 activity. This systematic review evaluates clinically significant pharmacokinetic drug interactions with aprepitant and fosaprepitant and describes adverse events ascribed to drug inter...

journal_title：British journal of clinical pharmacology

authors： Patel P,Leeder JS,Piquette-Miller M,Dupuis LL

更新日期：2017-10-01 00:00:00

abstract：:1. The possibility of a pharmacokinetic interaction between the H2-receptor antagonist cimetidine and the long-acting local anaesthetic agent bupivacaine was studied in seven healthy, non-smoking volunteers. 2. The study consisted of two sessions at a minimum interval of 4 days. In a randomized, crossover fashion, the...

journal_title：British journal of clinical pharmacology

authors： Pihlajamäki KK,Lindberg RL,Jantunen ME

更新日期：1988-10-01 00:00:00

abstract：AIMS:To determine whether enzyme-inducing antiseizure drugs (ASDs) affect the risk of developing chronic obstructive pulmonary disease (COPD) or lung cancer in smokers. METHODS:Cases of COPD and lung cancer and matched controls without these conditions were identified from a population of smokers with ≥1 prescription ...

journal_title：British journal of clinical pharmacology

authors： Leuppi-Taegtmeyer AB,Reinau D,Yilmaz S,Rüegg S,Krähenbühl S,Jick SS,Leuppi JD,Meier CR

更新日期：2020-08-01 00:00:00

abstract：:The effects of locally administered physostigmine and di-isopropylphosphorofluoridate (DFP) were compared on the secretory response of sweat glands to intradermally injected acetylcholine and carbachol in healthy male volunteers (physostigmine: six subjects; DFP: one subject). The response to acetylcholine reached its...

journal_title：British journal of clinical pharmacology

authors： Longmore J,Jani B,Bradshaw CM,Szabadi E

更新日期：1986-02-01 00:00:00

abstract：:1. The oral kinetics of oxazepam after a single 15 mg oral dose was investigated in six healthy volunteers before and during concomitant administration of the beta-adrenoceptor antagonists propranolol (80 mg) and labetalol (200 mg) (racemates). 2. A possible pharmacodynamic interaction between oxazepam and the beta-ad...

journal_title：British journal of clinical pharmacology

authors： Sonne J,Døssing M,Loft S,Olesen KL,Vollmer-Larsen A,Victor MA,Hamberg O,Thyssen H

更新日期：1990-01-01 00:00:00

abstract：:Clinical studies comparing the response and side effects of various opioids have not been able to show robust differences between drugs. Hence, recommendations of the regulatory authorities have been driven by costs with a general tendency in many countries to restrict physician's use of opioids to morphine. Although ...

journal_title：British journal of clinical pharmacology

authors： Drewes AM,Jensen RD,Nielsen LM,Droney J,Christrup LL,Arendt-Nielsen L,Riley J,Dahan A

更新日期：2013-01-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:• The topical second generation anti-histamine azelastine hydrochloride (AZE) and the potent corticosteroid fluticasone propionate (FP) are well established first-line treatments in allergic rhinitis (AR). • MP29-02, a novel intranasal AZE and FP formulation, has been shown to c...

journal_title：British journal of clinical pharmacology

authors： Derendorf H,Munzel U,Petzold U,Maus J,Mascher H,Hermann R,Bousquet J

更新日期：2012-07-01 00:00:00

abstract：:1. Mono(ADP-ribosyl)transferase activity has been identified on the external surface of human polymorphonuclear neutrophil leucocytes (PMNs). The enzyme is released from the plasma membrane by phosphoinositide-specific phospholipase C, suggesting a glycosylphosphatidylinositol (GPI) linkage of the enzyme to the plasma...

journal_title：British journal of clinical pharmacology

authors： Allport JR,Donnelly LE,Kefalas P,Lo G,Nunn A,Yadollahi-Farsani M,Rendell NB,Murray S,Taylor GW,MacDermot J

更新日期：1996-07-01 00:00:00

abstract：AIMS:To estimate the rates of common adverse events in patients treated with the proton pump inhibitors omeprazole, lansoprazole and pantoprazole in general practice in England. METHODS:In prescription-event monitoring cohort studies, data on dispensed prescriptions prescribed by general practitioners in England soon ...

journal_title：British journal of clinical pharmacology

authors： Martin RM,Dunn NR,Freemantle S,Shakir S

更新日期：2000-10-01 00:00:00