Abstract：
:Non-alcoholic fatty liver disease (NAFLD) encompasses a range of liver histology severity and outcomes in the absence of chronic alcohol use. The mildest form is simple steatosis in which triglycerides accumulate within hepatocytes. A more advanced form of NAFLD, non-alcoholic steatohepatitis (NASH), includes inflammation and liver cell injury, progressive to cryptogenic cirrhosis. Although prevalence in children is very difficult to establish, NAFLD is probably the most common cause of liver disease in preadolescent and adolescent groups. Over the last two decades the rise in the prevalence rates of overweight and obesity likely explains the NAFLD epidemic worldwide. NAFLD is strongly associated with abdominal obesity, type 2 diabetes, and dyslipidemia, and most patients have evidence of insulin resistance. Thus, NAFLD shares many features of the metabolic syndrome, a highly atherogenic condition, and its presence could signify a substantial cardiovascular risk. Accurate diagnosis and staging of NAFLD requires liver biopsy. The development of non-invasive surrogate markers and the advancement in imaging technology will aid in the screening of large populations at risk for NAFLD. While the optimal treatment has yet to be determined, lifestyle modification through diet and exercise should be attempted in children diagnosed with NAFLD. This review outlines current understanding, recent advances and challenges on pediatric NAFLD for both clinicians and researchers. Key words: Fatty liver.
journal_name
Minerva Pediatrjournal_title
Minerva pediatricaauthors
Poggiogalle E,Olivero G,Anania C,Ferraro F,Pacifico Lsubject
Has Abstractpub_date
2010-12-01 00:00:00pages
569-84issue
6eissn
0026-4946issn
1827-1715pii
R15103499journal_volume
62pub_type
杂志文章,评审abstract：BACKGROUND:Hirschsprung's disease is an important cause of pediatric constipation with high risk of bacterial enterocolitis. Its diagnosis is histological and the suction biopsy is the gold standard. In resource-limited countries, the main diagnostic exam is the contrast enema and mini-invasive surgery lacks. We presen...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.19.05487-2
更新日期：2019-03-21 00:00:00
abstract：:The development and evaluation of early preventative interventions for individuals exposed to a potentially traumatic event (PTE) have been increasing in number and sophistication over the last decade. Evaluation of early interventions for individuals who are symptomatic several weeks after exposure to a PTE have been...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:The aim of this study was to analyze multidrug resistance-associated protein 1 (MRP1) expression of peripheral blood of children intractable epilepsy. METHODS:Sixty children with epilepsy admitted to outpatient and inpatient services of Xuzhou Children's Hospital between November 2010 and October 2011 were ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.16.04358-9
更新日期：2018-04-01 00:00:00
abstract：:West syndrome is a generalized epilepsy syndrome composed of infantile spasms and onset is usually within the first year of life. Although West syndrome is well known clinical epileptic syndrome, there is no agreement about the first- and second-line treatments. In the last years a great progress in the development of...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2007-06-01 00:00:00
abstract：:Counselling is a professional intervention based on skills to communicate and to build relationships. The project "Not alone", related to counselling at our Neonatal Intensive Care Unit, is aimed to let counselling become a "shared culture" for all the care givers. The first essential aspect is to form the ability of ...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2010-06-01 00:00:00
abstract：:Post-traumatic stress disorder (PTSD) is a common psychiatric disorder which is frequently comorbid with major depressive disorder (MDD). It has been suggested that some or all individuals diagnosed with comorbid PTSD and MDD have a separate psychobiological condition that can be termed ''post-traumatic mood disorder'...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2008-12-01 00:00:00
abstract：:Cystic fibrosis (CF) is an inherited, prematurely lethal rare disease affecting more than 85,000 people worldwide. CF is caused by more than 2000 loss-of-function mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR). This review summarizes recent advances in the etiological t...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：10.23736/S0026-4946.19.05506-3
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:The aim of the present trial is to determine the efficacy and safety profile of oxatomide, a potent antiallergic drug, in children aged under 2 years, suffering from atopic dermatitis. A comparison between 2 different dosage schemes was scheduled. METHODS:An oral suspension of oxatomide, in a neonatological...
journal_title：Minerva pediatrica
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：:The clinical importance of the measurement of bone mineral content (BMC) in fullterm infants by photon absorptiometry relies on a comparatively narrow normative range that is necessary requisite to interpret the data from a single child. In the attempt to reduce the artifactual scattering of data, it was undertaken a ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1989-08-01 00:00:00
abstract：AIM:The estimation of peak expiratory flow (PEF) in children is a very easy and practical way to check lung function and helps in the diagnosis, treatment follow-up and evaluation of the development of chronic obstructive pulmonary disease. METHODS:Using a Mini-Wright flowmeter (Clement Clarke International Ltd, Engla...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2005-04-01 00:00:00
abstract：AIM:The increase in life expectancy of cystic fibrosis (CF) patients has brought about a rise in new clinical problems in these patients, such as a decrease in bone mineral density (BMD). The cause of diminished BMD in CF is multi-factorial. METHODS:The aim of this cross-sectional study, conducted on 39 CF patients un...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2008-04-01 00:00:00
abstract：:The past 10 years have seen a return of rickets. Clinical and/or biochemical signs of vitamin D deficiency are still found in some children and adolescents, mainly during the winter. Sunlight exposure is able to prevent vitamin D deficiency and rickets but the dramatic influence of changes in solar ultraviolet-B radia...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：1992-11-01 00:00:00
abstract：AIM:To evaluate the possible effects of recombinant growth hormone (rhGH) therapy on mineral homeostasis and bone turnover, the authors studied calcium-phosphate metabolism parameters, including some bone markers, in 2 prepubertal subjects with Noonan's syndrome (NS). METHODS:Two prepubertal males suffering from NS, s...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：:The diagnosis and treatment of anorexia nervosa (AN) in children and adolescents has some commonality but also differs from that of this condition in adults. A new understanding of AN is emerging: research data from the fields of epidemiology, genetics, and brain biology, suggest that there may be an underlying brain ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2013-02-01 00:00:00
abstract：:Dermatophytosis in newborns and infants has been regarded as very unusual; a case recently observed of a 2-month-old child affected by tinea faciei is described. Twenty days before, localized erythematous infiltrated patches at the upper left eyelid and eyebrows with papules and pustules, were observed. Rarefaction of...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2001-02-01 00:00:00
abstract：:The authors present the developmental outcome of 16 children with congenital hypothyroidism diagnosed by screening in the neonatal period, using the Brazelton and the Dubowitz scales in the newborn and the Griffiths scale subsequently. Results are compared with those of a control group assessed at 6 and 18 months usin...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:A preliminary undiagnosed case of partial carbamyl-phosphate-synthetase deficiency in a 14 year old patient is described. This extremely rare metabolic disorder is unlikely to produce clinical symptoms at such an advanced age. Details are given of the clinical picture, the diagnosis (by liver biopsy and post mortem li...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) is a complex disorder, involving primarily ovarian hyperandrogenism in females and linked with insulin resistance in the majority of cases. Clinical features are widely variable and include a combination of menstrual irregularities, acne, hirsutism, and alopecia. Although it typically ...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2010-10-01 00:00:00
abstract：INTRODUCTION:At present, morphine is the most commonly used first-line therapy to treat Neonatal Abstinence Syndrome (NAS). Unfortunately, there is still lack of evidence and consensus to guide pharmacologic therapy for NAS. In this review, we provide an overview on dosing regimens of morphine currently reported to tre...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：10.23736/S0026-4946.17.04928-3
更新日期：2019-06-01 00:00:00
abstract：:Antibiotics are a cornerstone to treat bacterial infections and children received more frequently these drugs than any other class of medication. However, the improper and excessive use of antibiotics in the past decades has increased the emergence of resistant bacterial strains. Moreover, the lack of specific pediatr...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2014-02-01 00:00:00
abstract：:Syringocele is a cystic dilation of the excretory bulbourethral Cowper gland duct, and is a rather uncommon finding in pediatric age. It is frequently asymptomatic but sometimes may cause voiding symptoms and urinary tract infection (UTI). This case report describes an unusual manifestation of syringocele presenting w...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2009-02-01 00:00:00
abstract：:Megapolycalicosis is defined as a congenital dilatation of calices without evidence of obstruction. In absence of complications such as infection and stones, megapolycalicosis would not have a particular clinical relevance if not for the possible misinterpretation as hydronephrosis. A case of megapolycalicosis is pres...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：AIM:The aim of this study was to evaluate the reaction to the procedural pain of preterm newborn and to demonstrate the different effectiveness of the two analgesic and not pharmacological techniques of recent clinical acquisition, the use of glucose solution and the sensorial saturation, in order to identify an optima...
journal_title：Minerva pediatrica
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2011-08-01 00:00:00
abstract：:Cerebral palsy (CP) is a description of a spectrum of central nervous system (CNS) impairments that affect mobility, communication, intellectual ability, and neurobehavior as a result of developmental brain dysfunction. CP is the most common contributor to motor disability in children with prevalence of about 2-3/1000...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:To evaluate if vesicoureteral reflux (VUR) contralateral to the multicystic dysplastic kidney can interfere with the compensatory renal hypertrophy. METHODS:Twenty-seven patients (17 males, 10 females) with multicystic dysplastic kidney (MDK) (14 on the right, 13 on the left) have been treated at the Nephro...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:The introduction of the new diagnostic tools for neuroimaging has resulted in the early recognition of congenital brain tumors. In the present report we describe 39 children, in whom the diagnosis of an intracranial tumor has been obtained during the first 12 months of life. These patients represent 14.4% of a pediatr...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：:The usefulness of measuring xylosaemia, carotenaemia and the antigliadin antibodies in the diagnosis and monitoring of coeliac diseases has been examined, 89 children, 57 with aspecific chronic diarrhoea and 32 with coeliachia were examined. The xylose proved less sensitive (80%) and less specific (84.2%) than caroten...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：:Intracranial tuberculoma is a possible complication of meningeal, miliary or pulmonary tuberculosis. In developing countries it represents 30% of space-occupying intracranial lesions, in industrialised countries only 0.1-0.2%. One recently recognised phenomenon is the development ex novo or the enlargement of the tube...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2005-10-01 00:00:00
abstract：:Noonan syndrome was first described over 20 years ago by Noonan and Ehmke. They defined a specific group of nine patients with valvular pulmonary stenosis who, in addition, had short stature, mild mental retardation, hypertelorism and unusual facies. The incidence of Noonan syndrome has been estimated to be between 1 ...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:Since most of the children observed in our Centre present enuresis with voiding disturbance, we carried out a study where these patients were treated with the DDAVP + Oxybutinin association. METHODS:We have treated 89 children with enuresis and voiding disturbances (urge incontinence, voiding urgency, urina...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1999-05-01 00:00:00
