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Laboratory confirmed polymethyl-methacrylate (Palacos)-hypersensitivity after cranioplasty.

Abstract：

:Polymethyl-methacrylate (PMMA) as part of bone cement is a widely used material in the context of orthopaedic implants and also in cranioplasty. Although PMMA is characterised by excellent biocompatibility with low intrinsic toxicity and inflammatory activation, a minor portion of patients develop allergic reactions. We present the case of a 39-year-old woman with an increasing headache and a corresponding erythema over the parieto-occipital cranioplasty, which was performed 42 days prior using a PMMA compound. A patch test specific for bone cement components confirmed the diagnosis of a PMMA delayed-type hypersensitivity reaction. The prevalence of allergic reactions to bone cement components are known to vary from between 0.6% and 1.6%, however no adequate, pre-interventional diagnostic tool is currently available. Therefore, physicians are required to consider this differential diagnosis even after an extremely delayed onset of symptoms. This case describes the first ever-reported case in the literature of hypersensitivity to bone cement cranioplasty.

journal_name

Clin Neurol Neurosurg

journal_title

Clinical neurology and neurosurgery

authors

Gautschi OP,Schlett CL,Fournier JY,Cadosch D

doi

10.1016/j.clineuro.2010.07.013

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

915-6

issue

10

eissn

0303-8467

issn

1872-6968

pii

S0303-8467(10)00227-1

journal_volume

112

pub_type

杂志文章

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