当前位置： SCI文献检索 > Minerva Anestesiologica期刊下所有文献 > Insulin differentially influences brain glucose and lactate in traumatic brain injured patients.

Insulin differentially influences brain glucose and lactate in traumatic brain injured patients.

Abstract：

BACKGROUND:Hypo- and hyperglycemia must be avoided to prevent additional brain damage following traumatic brain injury (TBI). However, the optimal blood glucose range requiring insulin remains unknown. Cerebral microdialysis is helpful in unmasking signs of metabolic impairment, thereby identifying deleterious blood glucose levels. METHODS:A retrospective analysis of prospectively collected cerebral microdialysis samples obtained from 20 non-diabetic patients with severe TBI treated at the trauma surgical intensive care unit at the University Hospital Zürich, Switzerland. RESULTS:The impact of different arterial blood glucose values and concomitant insulin administration on cerebral interstitial glucose and lactate levels was investigated. In addition, energetic impairment was determined by calculating lactate-to-glucose ratios. Insulin administration was associated with significantly reduced cerebral glucose concentrations and significantly increased lactate-to-glucose ratios with arterial blood glucose levels <5 mM. At arterial blood glucose levels >7 mM, insulin administration was associated with significantly increased interstitial glucose values, significantly decreased lactate concentrations, and markedly diminished lactate-to-glucose ratios. CONCLUSION:Insulin exerts differential effects that depend strongly on the underlying arterial blood glucose concentrations. To avoid energetic impairment, insulin should not be administered at arterial blood glucose levels <5 mM. However, at arterial blood glucose levels >7-8 mM, insulin administration appears to be encouraged to increase extracellular glucose concentrations and decrease energetic impairment reflected by reduced interstitial brain lactate and decreased lactate-to-glucose ratios. Nevertheless, frequent analysis is required to minimize the risk of inducing impaired brain metabolism.

journal_name

Minerva Anestesiol

journal_title

Minerva anestesiologica

authors

Béchir M,Meierhans R,Brandi G,Sommerfeld J,Fasshauer M,Cottini SR,Stocker R,Stover JF

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

896-904

issue

11

eissn

0375-9393

issn

1827-1596

pii

R02105854

journal_volume

76

pub_type

杂志文章

相关文献

Minerva Anestesiologica文献大全
  • [Vecuronium in pediatric anesthesia. Repeated bolus vs continuous infusion].

    abstract：:Vecuronium bromide was employed in 26 pediatric patients; 18 received vecuronium infusion and 11 intermittent bolus administration. The aim of the study was to evaluate the pharmacodynamics of the drug, the lack of cumulative properties, the best infusion rate, the possible advantage of the infusion technique. Neuromu...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：

    authors： Barbone G,Longo G,Bruno F

    更新日期：1992-03-01 00:00:00

  • Molecular weight and molar substitution are more important in HES-induced renal impairment than concentration after hemorrhagic and septic shock.

    abstract：BACKGROUND:Clinical studies have raised concerns about the safety of 6% hydroxyethylstarch (HES) 130/0.42, but the pathomechanisms of this renal impairment remain unknown. To evaluate the effects of different HES concentrations, molar substitutions and molecular weights in HES-induced renal impairment, we used a porcin...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：

    authors： Simon TP,Thiele C,Schuerholz T,Fries M,Stadermann F,Haase G,Amann KU,Marx G

    更新日期：2015-06-01 00:00:00

  • [Anesthesia in Apert syndrome].

    abstract：:The anaesthetic technique chosen for a laparohysterectomy in a woman affected by Apert's acrocephalosyndactilia is described. Difficulties in performing tracheal intubation were overcome by mean of loco-regional anesthesia (LRA). In order to minimize the anaesthetic risk, a standardised preoperative evaluation and ass...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：

    authors： Ciceri G,Arosio G,Brunatti M,Fontana G,Riedo R,Vesconi S

    更新日期：1997-05-01 00:00:00

  • LMA® Protector™ versus traditional LMA to perform endobronchial ultrasound-guided transbronchial needle aspiration: a retrospective analysis.

    abstract：BACKGROUND:The aim of this study was to evaluate the use of laryngeal mask airway (LMA)® Protector™ by comparison with traditional LMA for performing endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). METHODS:This was a retrospective observational single-center study including 143 patients w...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：10.23736/S0375-9393.19.13328-7

    authors： Zamparelli E,Fiorelli A,La Cerra G,Guarino C,Santoriello E,Buono S,Corcione A,Rispoli M

    更新日期：2019-07-01 00:00:00

  • Abdominal organ transplantation.

    abstract：:The improvement in the success of solid organ transplantation over the past decades is remarkable and well documented. It is now a well-accepted treatment modality for patients with end-stage organ disease. Within the field of transplantation, abdominal organ transplantation is significantly more common than thoracic ...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章,评审

    doi：

    authors： Niemann CU,Eilers H

    更新日期：2010-04-01 00:00:00

  • Effective doses of cisatracurium. Potentiation by sevoflurane and increasing requirements with age.

    abstract：BACKGROUND:The aim of the study was to investigate whether or not sevoflurane at different concentrations influenced the ED(effective dose) 50, 90 and 95 of cisatracurium and whether there is any relationship with age. METHODS:Individual dose response curves for cisatracurium were constructed in 80 consecutive patient...

    journal_title：Minerva anestesiologica

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Melloni C,Antolini F

    更新日期：2000-03-01 00:00:00

  • [Theoretical bases of a cardio-synchronised jet injection system into the vena cava].

    abstract：:Aim of this paper is to present a procedure aimed at raising the flow rate in the vena cava. To this purpose some fluid is injected at high speed in the vessel, accelerating the flow and dragging the stagnating flow upstream the catheter. In order to raise the efficiency of the system and to avoid damage to heart valv...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：

    authors： Banetta L,Santini E,Banetta S

    更新日期：2002-03-01 00:00:00

  • Epidural analgesia in children: planning, organization and development of a new program.

    abstract：BACKGROUND:The goal of the present work is to describe the development and results of the pediatric epidural analgesia program at the ''Hospital Nacional de Pediatria Prof. Dr. J. P. Garrahan'' in Argentina. METHODS:Patients with thoracotomy, abdominal surgery, osteotomy, amputations or severe trauma were included in ...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：

    authors： Ingelmo PM,Gelsumino C,Acosta AP,Lopez V,Gimenez C,Halac A,Lira P,Schon A,Spagnolo B,Pignataro A,Nunez G,Gamboa M,Buquicchio I,Astuto M,Fumagalli R

    更新日期：2007-11-01 00:00:00

  • Regional anaesthesia in vascular surgery: a multidisciplinary approach to accelerate recovery and postoperative discharge.

    abstract：:A multimodal, rehabilitative, fast discharge approach to abdominal aortic surgery is analyzed. The approach was developed in two phases during the years 1997-2000: in the first phase (1997) patients had thoracic epidural anesthesia plus TIVA and analgesia. They had improvement of the classical surrogate outcomes and a...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：

    authors： Albani A,Renghi A,Gramaglia L,Pascu M,Brustia P,Montone N

    更新日期：2001-09-01 00:00:00

  • Efficacy of propofol compared to midazolam as an intravenous premedication agent.

    abstract：BACKGROUND:It is common practice to administer a premedication to patients about to undergo anesthesia. This study compared the effects of a small intravenous bolus of propofol versus midazolam administered as a premedication. METHODS:In this prospective, randomized, double-blind, placebo-controlled study, 60 healthy ...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章,随机对照试验

    doi：

    authors： Quario Rondo L,Thompson C

    更新日期：2008-05-01 00:00:00

  • Preconditioning effects of the anesthetic administered to the donor on grafted kidney function in living donor kidney transplantation recipients.

    abstract：BACKGROUND:In living donor kidney transplantation (LDKT), we evaluated if there was any difference in grafted kidney function according to the type of anesthetic used in the donor because some laboratory studies have demonstrated that volatile anesthetics at clinically relevant concentrations protect the kidneys agains...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章,随机对照试验

    doi：

    authors： Lee JH,Joo DJ,Kim JM,Park JH,Kim YS,Koo BN

    更新日期：2013-05-01 00:00:00

  • [Continuous intravenous infusion with patient-controlled anesthesia for postoperative analgesia in cesarean section: morphine versus buprenorphine].

    abstract：:A double blind comparison between morphine and buprenorphine was performed in 20 patients using a new demand and continuous infusion analgesic system to provide analgesia after cesarean section. The patients were randomized in two equal groups to receive either morphine 1 mg/h or buprenorphine 0.03 mg/h. The PCA syste...

    journal_title：Minerva anestesiologica

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Capogna G,Celleno D,Sebastiani M,Costantino P,Reggio S

    更新日期：1989-01-01 00:00:00

  • Lactic acidosis.

    abstract：:The detection of tissue hypoxia and its correction is one of the aim of the hemodynamic monitoring. Classical hemodynamic variable often fail to achieve this goal. Lactate measurements may be a good indicator of tissue hypoxia. Selected review of the articles on lactate in critically ill patients. Tissue hypoxia is as...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章,评审

    doi：

    authors： De Backer D

    更新日期：2003-04-01 00:00:00

  • Comparison of intrathecal hyperbaric and isobaric levobupivacaine in urological surgery.

    abstract：AIM:The aim of our study was to compare the efficacy of hyperbaric and isobaric solutions of intrathecal levobupivacaine for transurethral endoscopic surgery. METHODS:Urological patients who were scheduled for elective surgery under spinal anesthesia were enrolled. The heavy group received 13.5 mg of hyperbaric levobu...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章,随机对照试验

    doi：

    authors： Sen H,Purtuloglu T,Sizlan A,Yanarates O,Ates F,Gundu I,Ozkan S,Dagli G

    更新日期：2010-01-01 00:00:00

  • [Comparison of 2 low molecular weight heparins in patients undergoing major abdominal surgery].

    abstract：INTRODUCTION AND AIMS:Thromboembolic disease can, in a large number of cases, be prevented in patients undergoing major surgery by using low molecular weight heparin (LMWH). These molecules extracted from standard heparin using a variety of cleavage methods possess different physical and chemical characteristics. The a...

    journal_title：Minerva anestesiologica

    pub_type： 临床试验,杂志文章

    doi：

    authors： Mabilia MA,Minicucci S,Pettiti G,Tamponi G,Bogli F

    更新日期：1996-12-01 00:00:00

  • [Idiopathic long QT-syndrome. Changes in the duration of the QTC during anesthesia with propofol].

    abstract：:A prolonged electrocardiographic QTc interval may be unsafe during general anesthesia; thus successful anesthetic management in patients affected by congenital long QT syndrome include avoidance of any event that increases sympathetic activity and drugs that prolong QT interval. Propofol seems to have less effect on t...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：

    authors： Azzolini M,Ragagni M,Pfaender M,Dallape L,Gasperotti G

    更新日期：1993-07-01 00:00:00

  • Non-invasive ventilation outside the Intensive Care Unit for acute respiratory failure.

    abstract：:Non invasive ventilation (NIV) has been shown to be an effective therapy in selected patients with acute respiratory failure. Due to its benefit and relative ease of use, NIV is frequently used. In addition, the shortage and high cost of intensive care beds have prompted the use of NIV outside the intensive care unit....

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章,评审

    doi：

    authors： Chiumello D,Conti G,Foti G,Giacomini Matteo M,Braschi A,Iapichino G

    更新日期：2009-07-01 00:00:00

  • [Case of high spinal anesthesia as a complication of an interscalenic brachial plexus block].

    abstract：:A case of high spinal anesthesia complicating an interscalene brachial plexus block is described. After an apparently straightforward location of the plexus with good paresthesias, the injection of 10 ml of local anesthetic caused a high spinal block whose main feature was apnea. The patient retained his consciousness...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：

    authors： Gregoretti S

    更新日期：1980-03-01 00:00:00

  • Remifentanil for intraoperative analgesia during the endoscopic surgical treatment of pituitary lesions.

    abstract：AIM:The authors have evaluated remifentanil for intraoperative analgesia in endonasal endoscopic surgery for pituitary lesions. METHODS: EXPERIMENTAL DESIGN:a perspective, randomized and comparative study between remifentanil and fentanyl for intraoperative analgesia was performed in an operating room of the neurosur...

    journal_title：Minerva anestesiologica

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Gargiulo G,Cafiero T,Frangiosa A,Burrelli R,Cortesano P,Cappabianca P,Cavallo LM,Esposito F

    更新日期：2003-03-01 00:00:00

  • Early dysglycemia and mortality in traumatic brain injury and subarachnoid hemorrhage.

    abstract：BACKGROUND:Traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) are the most common causes of severe acute brain injury in younger Intensive Care Unit (ICU) patients. Dysglycemia (abnormal peak glycemia, glycemic variability, mean glycemia, nadir glycemia) is common in these patients but its comparative outco...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：10.23736/S0375-9393.19.13307-X

    authors： Pappacena S,Bailey M,Cabrini L,Landoni G,Udy A,Pilcher DV,Young P,Bellomo R

    更新日期：2019-08-01 00:00:00

  • Blunted inflammatory response to lipopolysaccharide endotracheal instillation due to thermal preconditioning.

    abstract：AIM:Heat shock proteins (HSPs), induced by thermal stress, make the cells more resistant to following stress. We aimed to verify if rats heating reduces the production of TNF-alpha in a model of acute respiratory distress syndrome (ARDS). METHODS:We divided 34 Wistar rats in Group A and Group B. The rats of Group A re...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：

    authors： Di Filippo A,Rinaldi S,Pascente C,Messeri D,De Gaudio AR

    更新日期：2005-10-01 00:00:00

  • [Acute cocaine poisoning in a body packer. Clinical case].

    abstract：:This report takes into consideration the complications due to "body packers" cocaine absorption. In particular we report a clinical case in which severe dysrhythmias occurred. We think an early insertion of a pacemaker able to rid ectopic focus by overdriving is essential by comparison with an effective anti-dysrhythm...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：

    authors： Marcovigi P,Leoni S,Calbi G,Valtancoli E,Granata A,Gudenzi P,Casadei C,Ravaglia G

    更新日期：1995-03-01 00:00:00

  • Urinary neutrophil gelatinase-associated lipocalin to hepcidin ratio as a biomarker of acute kidney injury in intensive care unit patients.

    abstract：BACKGROUND:Labile iron is important in the pathogenesis of acute kidney injury (AKI). Neutrophil gelatinase-associated lipocalin (NGAL) and hepcidin control iron metabolism and are upregulated during renal stress. However, higher levels of urinary NGAL are associated with AKI severity whereas higher urinary hepcidin le...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：

    authors： Mårtensson J,Glassford NJ,Jones S,Eastwood GM,Young H,Peck L,Ostland V,Westerman M,Venge P,Bellomo R

    更新日期：2015-11-01 00:00:00

  • [Experience of an intermediate respiratory intensive therapy in the treatment of prolonged weaning from mechanical ventilation].

    abstract：:109 patients who suffered from an episode of acute respiratory failure, necessitated mechanical ventilation (MV) in a general Intensive Care Unit (ICU) and admitted to our Respiratory Intermediate Intensive Unit (RIIU), were retrospectively evaluated for outcome and weaning success. The patients, 69 +/- 9 years old, p...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章,评审

    doi：

    authors： Vitacca M,Clini E,Porta R,Sereni D,Ambrosino N

    更新日期：1996-03-01 00:00:00

  • [Hormone evaluation in brain death].

    abstract：BACKGROUND:In this study, the level and the variation of a number of hormone and metabolic parameters during brain death treatment in potential organ donors have been monitored. METHODS:Thirty-nine consecutive brain-dead patients were enrolled in 3 Intensive Care Units of Regional Hospitals of the North of Italy. All ...

    journal_title：Minerva anestesiologica

    pub_type： 临床试验,杂志文章

    doi：

    authors： Gravame V,Porretti L,Cardillo M,Marchesi G,Rizzi M,Sacchi C,Candiani A,Chiaranda M,Gualandris L,Taioli E,Scalamogna M

    更新日期：1999-10-01 00:00:00

  • [Postoperative cerebral edema. Physiopathology of the edema and medical therapy].

    abstract：:Cerebral edema complicates many neurosurgical conditions, such as head injuries, neoplasms and infections, and is the direct result of operative trauma. The recognition and the treatment of brain edema are of great practical importance, particularly in those conditions leading to brain herniations and/or intracranial ...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章,评审

    doi：

    authors： Tommasino C

    更新日期：1992-04-01 00:00:00

  • Are hot-burning sensations produced by the axonal damage of afferent unmyelinated fibres?

    abstract：AIM:Pain resulting from nerve lesions is classically referred to as a ''burning pain''. Both the axonal damage and sensitization of unmyelinated C-fibres have been considered as the possible generators of this sensation. The aim of this study was to verify the hypothesis that hot-burning sensations are produced by the ...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：

    authors： Buonocore M,Bonezzi C

    更新日期：2006-05-01 00:00:00

  • Ambulatory inguinal herniorrhaphy: paravertebral block versus spinal anesthesia.

    abstract：AIM:Inguinal herniorrhaphy (IH) is a common surgical procedure that can be successfully performed by using general, regional or local anesthesia and is usually performed in an outpatient setting. In this study, recovery profile, incidence of adverse effects, postoperative pain scores and patient satisfaction between pa...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章,随机对照试验

    doi：

    authors： Akcaboy EY,Akcaboy ZN,Gogus N

    更新日期：2009-12-01 00:00:00

  • Self-directed deliberate practice with virtual fiberoptic intubation improves initial skills for anesthesia residents.

    abstract：BACKGROUND:Fiberoptic intubation is a core skill in anesthesiology. However, this complex psychomotor skill is challenging to learn in the clinical setting. The goal of this study was to evaluate the Virtual Fiberoptic Intubation (VFI) software as an adjunct to the traditional fibreoptic intubation teaching. METHODS:A...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章,随机对照试验

    doi：

    authors： Giglioli S,Boet S,De Gaudio AR,Linden M,Schaeffer R,Bould MD,Diemunsch P

    更新日期：2012-04-01 00:00:00

  • [Tranylcypromine and general anesthesia. Description of a clinical case].

    abstract：:The Authors report a collapsial reaction during general anaesthesia for total hip replacement in a patient treated with tranylcipromine, an inhibitor of MAO, as antidepressant agent. She had discontinued drug intake eight days before. Nevertheless a serious collapsial reaction appeared in association with general anae...

    journal_title：Minerva anestesiologica

    pub_type： 杂志文章

    doi：

    authors： Vimercati C,Monsagrati A,Seveso M

    更新日期：1990-06-01 00:00:00