Abstract:
:Prostate cancer (CaP) is a major health problem in males in Western countries. Current therapeutic approaches are limited and many patients die of secondary disease (metastases). There is no cure for metastatic castration-resistant prostate cancer (CRPC). Targeting tumor-associated antigens is fast emerging as an area of promise to treat late stage and recurrent CaP. Extracellular matrix metalloproteinase inducer, EMMPRIN (CD147) is a multifunctional glycoprotein that can modify the tumor microenvironment by activating proteinases, inducing angiogenic factors in tumor and stromal cells, and regulating growth and survival of anchorage-independent tumor cells (micrometastases) and multidrug resistance (MDR). CD44 is a multifunctional protein involved in cell adhesion, migration and drug resistance, and is a primary receptor for hyaluronan (HA), a major component of the extracellular matrix (ECM) with a critical role in cell signaling and cell-ECM interactions in cancer. Our recent studies indicate both CD147 and CD44 are involved in cancer drug resistance and play very important roles in CaP metastasis. Thus, CD147 and CD44 may be ideal therapeutic targets to control metastatic and CRPC disease. This review will discuss their putative roles in CaP metastasis and MDR, and give an overview of literature regarding their expression on human CaP tissues. Additional focus will be on the potential of therapeutic strategies targeting CD147 and CD44 to prevent CaP metastasis and overcome drug resistance.
journal_name
Curr Cancer Drug Targetsjournal_title
Current cancer drug targetsauthors
Hao JL,Cozzi PJ,Khatri A,Power CA,Li Ydoi
10.2174/156800910791190193subject
Has Abstractpub_date
2010-05-01 00:00:00pages
287-306issue
3eissn
1568-0096issn
1873-5576pii
EPub-Abstract-CCDT-34journal_volume
10pub_type
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journal_title:Current cancer drug targets
pub_type: 杂志文章
doi:10.2174/1568009620666201230090531
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
doi:10.2174/1568009616666151112122231
更新日期:2016-01-01 00:00:00
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journal_title:Current cancer drug targets
pub_type: 杂志文章
doi:10.2174/1568009614666140821122718
更新日期:2014-01-01 00:00:00
abstract::The total expression profiles of two medulloblastoma cell lines resistant to the preactivated form of cyclophosphamide (4-hydroperoxycyclophosphamide, 4-HC) were examined using the Affymetrix GeneChip U133A array. Our primary objective was to look for possible genes, other than the well-studied aldehyde dehydrogenases...
journal_title:Current cancer drug targets
pub_type: 杂志文章
doi:10.2174/156800908784293631
更新日期:2008-05-01 00:00:00
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
doi:10.2174/156800906777723930
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
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journal_title:Current cancer drug targets
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
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journal_title:Current cancer drug targets
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更新日期:2018-01-01 00:00:00
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
abstract::Nuclear Hormone Receptors (NR) represent one of the most promising protein families in terms of therapeutic applications. These transcription factors are naturally switched on and off by small molecule hormones presenting physico-chemical properties very similar to therapeutic chemical entities. NRs represent therefor...
journal_title:Current cancer drug targets
pub_type: 杂志文章,评审
doi:10.2174/1568009023333845
更新日期:2002-09-01 00:00:00
abstract::The anticancer properties of histone deacetylase inhibitors have been known for some time. However, it is only recently that the functional identities of the intracellular targets mediating the anticancer properties have started to be revealed. These targets appear to play significant roles in cell cycle control, apop...
journal_title:Current cancer drug targets
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更新日期:2002-12-01 00:00:00