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Isolation and characterization of a previously unrecognized myosin heavy chain gene present in the Syrian hamster.

Abstract：

:A full length (25,000 base-pair) myosin heavy chain gene completely contained within a single cosmid clone was isolated from a Syrian hamster cosmid genomic library. Sequence comparison of the 3' untranslated region indicated the presence of a 75% homology with the rat embryonic myosin heavy chain gene. Extensive 5' flanking region regulatory element conservation was also found when the sequence was compared to the rat myosin heavy chain gene. S1 nuclease digestion analysis, however, indicated that the Syrian hamster myosin heavy chain gene exhibited expression in adult Syrian hamster ventricular tissue, as well as the adult vastus medialis, a fast twitch skeletal muscle. Expression also appears to be enhanced in myopathic relative to control hearts. This myosin heavy chain gene is neither the alpha nor beta cardiac myosin heavy chain gene, but is a unique, previously unrecognized, myosin heavy chain gene present in both myocardial and skeletal muscle tissues.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

McCully JD,Wang RX,Kellam B,Sole MJ,Liew CC

doi

10.1016/0022-2836(91)90251-z

subject

Has Abstract

pub_date

1991-04-20 00:00:00

pages

657-65

issue

4

eissn

0022-2836

issn

1089-8638

pii

0022-2836(91)90251-Z

journal_volume

218

pub_type

杂志文章,评审

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