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Juvenile nasopharyngeal angiofibroma: no evidence for inheritance or association with familial adenomatous polyposis.

Abstract：

:Juvenile nasopharyngeal angiofibromas (JNAs) are rare tumors with prominent vascularity and locally destructive growth. The pathogenesis of JNA is largely unknown. A causal association between JNA and familial adenomatous polyposis has been suggested. Twenty-one patients diagnosed with juvenile angiofibroma filled out a detailed patient questionnaire. No patients reported any relatives with nasopharyngeal angiofibroma or familial adenomatous polyposis. No significant regional clustering suggestive for founder effect could be identified. We believe that if there were a strong genetic predisposition or association with familial adenomatous polyposis, it should have been seen in this patient sample.

journal_name

Fam Cancer

journal_title

Familial cancer

authors

Klockars T,Renkonen S,Leivo I,Hagström J,Mäkitie AA

doi

10.1007/s10689-010-9331-z

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

401-3

issue

3

eissn

1389-9600

issn

1573-7292

journal_volume

9

pub_type

杂志文章

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