Arterial colony stimulating factor-1 influences atherosclerotic lesions by regulating monocyte migration and apoptosis.

abstract：:Significant amounts of ursodeoxycholic acid (UDCA) used for the treatment of patients with primary biliary cirrhosis (PBC) become epimerized at C-3 to isoUDCA. We investigated the metabolism of isoUDCA and a possible pharmacologic effect in five patients (51.4 +/- 5.8 years old; 3 females, 2 males) with PBC and persis...

journal_title：Journal of lipid research

authors： Marschall HU,Broomé U,Einarsson C,Alvelius G,Thomas HG,Matern S

更新日期：2001-05-01 00:00:00

abstract：:Enzymes associated with glycerolipid biosynthesis were examined in microsomal fractions of liver and adipose tissue obtained from swine of various ages. Generally, liver glycerophosphate acyltransferase, phosphatidate phosphohydrolase, diglyceride acyltransferase, and choline phosphotransferase activities were substan...

journal_title：Journal of lipid research

authors： Steffen DG,Phinney G,Brown LJ,Mersmann HJ

更新日期：1979-02-01 00:00:00

abstract：:Mammalian spermatogenesis is a complex developmental program in which a diploid progenitor germ cell transforms into highly specialized spermatozoa. One intriguing aspect of sperm production is the dynamic change in membrane lipid composition that occurs throughout spermatogenesis. Cholesterol content, as well as its ...

journal_title：Journal of lipid research

authors： Keber R,Rozman D,Horvat S

更新日期：2013-01-01 00:00:00

abstract：:In this study, we examined effects of retinol deficiency and three retinoids, all-trans-retinoic acid, 13-cis-retinoic acid, and etretin, the aromatic derivative of retinoic acid on nuclear retinoic acid receptor isoforms alpha, beta, and gamma mRNA in rat adipose tissue. Retinol deficiency caused an almost 50% decrea...

journal_title：Journal of lipid research

authors： Riaz-ul-Haq,Chytil F

更新日期：1992-03-01 00:00:00

abstract：:A-C1 protein is the product of a tumor suppressor gene negatively regulating the oncogene Ras and belongs to the HRASLS (HRAS-like suppressor) subfamily. We recently found that four members of this subfamily expressed in human tissues function as phospholipid-metabolizing enzymes. Here we examined a possible enzyme ac...

journal_title：Journal of lipid research

authors： Shinohara N,Uyama T,Jin XH,Tsuboi K,Tonai T,Houchi H,Ueda N

更新日期：2011-11-01 00:00:00

abstract：:Rat brain increases in weight after birth in three stages: (I) rapidly for the first 2 weeks, (II) at a lower rate from 2 to 5 weeks, and (III) at a still lower rate from 5 weeks to 5 months. During the succeeding period, designated IV, it maintains constant weight up to 1 year of age. Brain ganglioside content increa...

journal_title：Journal of lipid research

authors： Rosenberg A,Stern N

更新日期：1966-01-01 00:00:00

abstract：:In the present study, the effects of taxifolin, a plant flavonoid, on lipid, apolipoprotein B (apoB), and apolipoprotein A-I (apoA-I) synthesis and secretion were determined in HepG2 cells. Pretreatment of cells with (+/-)-taxifolin led to an inhibition of cholesterol synthesis in a dose- and time-dependent manner, wi...

journal_title：Journal of lipid research

authors： Theriault A,Wang Q,Van Iderstine SC,Chen B,Franke AA,Adeli K

更新日期：2000-12-01 00:00:00

abstract：:Thyroid hormone lowers serum cholesterol and alters sterol metabolic processes. This laboratory has previously reported increased biliary lipid secretion as an early effect of triiodothyronine (T3) in the rat. To evaluate whether the bile lipid action of T3 is a primary or secondary effect, the isolated-perfused rat l...

journal_title：Journal of lipid research

authors： Gebhard RL,Stone BG,Andreini JP,Duane WC,Evans CD,Prigge W

更新日期：1992-10-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is associated with a severe pro-inflammatory response; although decreased plasma cholesterol concentration has been linked to systemic inflammation, any association of phospholipid metabolic pathways with ARDS has not been characterized. Plasma phosphatidylcholine (PC), the m...

journal_title：Journal of lipid research

authors： Dushianthan A,Cusack R,Grocott MPW,Postle AD

更新日期：2018-06-01 00:00:00

abstract：:Potentially atherogenic triglyceride-rich lipoprotein (TRL) remnants can be isolated and quantitated as remnant-like particles (RLP), using an immunoaffinity gel containing specific anti-human apolipoprotein A-I (apoA-I) and apoB-100 monoclonal antibodies. The aim of the present study was to determine the relationship...

journal_title：Journal of lipid research

authors： Marcoux C,Hopkins PN,Wang T,Leary ET,Nakajima K,Davignon J,Cohn JS

更新日期：2000-09-01 00:00:00

abstract：:Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) and facilitates the efflux of unesterified cholesterol. SR-BI expression in macrophages presumably plays a role in atherosclerosis. The role of SR-BI for selective CE uptake and cholesterol efflux in macrophages was...

journal_title：Journal of lipid research

authors： Brundert M,Heeren J,Bahar-Bayansar M,Ewert A,Moore KJ,Rinninger F

更新日期：2006-11-01 00:00:00

abstract：:The secondary bile acid lithocholic acid (LCA) and its derivatives act as selective modulators of the vitamin D receptor (VDR), although their structures fundamentally differ from that of the natural hormone 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3)]. Here, we have determined the crystal structures of the ligand-binding...

journal_title：Journal of lipid research

authors： Masuno H,Ikura T,Morizono D,Orita I,Yamada S,Shimizu M,Ito N

更新日期：2013-08-01 00:00:00

abstract：:HDLs have been proposed to have antiatherogenic properties because of their role in reverse cholesterol transport as lipid acceptors. To elucidate the phospholipid profile of these particles, we used electrospray ionization mass spectrometry to examine the phosphatidylcholine (PC) and sphingomyelin (SM) composition of...

journal_title：Journal of lipid research

authors： Lee CY,Lesimple A,Larsen A,Mamer O,Genest J

更新日期：2005-06-01 00:00:00

abstract：:PAF-dependent transacetylase (TA) modifies the functions of platelet-activating factor (PAF), a potent inflammatory lipid, either by transferring the acetyl group from PAF to lysophospholipids (TAL activity), or to sphingosine (TAS activity) or by hydrolyzing PAF (acetylhydrolase activity). In stimulated endothelial c...

journal_title：Journal of lipid research

authors： Balestrieri ML,Castaldo D,Balestrieri C,Quagliuolo L,Giovane A,Servillo L

更新日期：2003-02-01 00:00:00

abstract：:Mutations in the genes coding for patatin-like phospholipase domain-containing 1 (PNPLA1) and α/β-hydrolase domain-containing 5 (ABHD5), also known as comparative gene identification 58, are causative for ichthyosis, a severe skin barrier disorder. Individuals with mutations in either of these genes show a defect in e...

journal_title：Journal of lipid research

authors： Kien B,Grond S,Haemmerle G,Lass A,Eichmann TO,Radner FPW

更新日期：2018-12-01 00:00:00

abstract：:We have previously demonstrated the potential usefulness of capillary columns coated with a high temperature polarizable phenylmethylsilicone liquid phase in plasma lipid profiling (Kuksis, A., J.J. Myher, and P. Sandra. 1990. J. Chromatogr. 500: 427-441). The present study reports improved operating conditions along ...

journal_title：Journal of lipid research

authors： Kuksis A,Myher JJ,Geher K

更新日期：1993-06-01 00:00:00

abstract：:The proton NMR spectra of the N-methyl choline region of normal and lecithin:cholesterol acyltransferase (LCAT)-deficient lipoproteins and of egg yolk phosphatidylcholine-cholesterol 55:45 (mol %) vesicle mixtures have been examined in the presence and absence of manganous sulfate as a line-broadening reagent. Mangano...

journal_title：Journal of lipid research

authors： Parmar YI,Sparks DL,Frohlich J,Cullis PR,Pritchard PH

更新日期：1989-05-01 00:00:00

abstract：:In promoting oxidation of 0.02 m potassium linoleate in a buffered (pH 7.0) aqueous dispersion at 37 degrees C, ascorbic acid at low concentrations (1.8 x 10(-6) and 1.8 x 10(-5) m) in combination with copper (1.3 x 10(-7) to 1.3 x 10(-3) m) had greater catalytic activity than the additive activity of the two catalyst...

journal_title：Journal of lipid research

authors： Haase G,Dunkley WL

更新日期：1969-09-01 00:00:00

abstract：:Very few studies have investigated the interrelations between proprotein convertase subtilisin/kexin type 9 (PCSK9) metabolism, cholesterol synthesis, and cholesterol absorption. We aimed to address this issue in a large clinical trial of 245 patients with hypercholesterolemia. Serum lipids, PCSK9, lathosterol (choles...

journal_title：Journal of lipid research

authors： Silbernagel G,Steiner LK,Hollstein T,Fauler G,Scharnagl H,Stojakovic T,Schumann F,Bölükbasi B,März W,Steinhagen-Thiessen E,Laufs U,Kassner U

更新日期：2019-01-01 00:00:00

abstract：:We investigated the formation and pharmacology of prostaglandin E(3) (PGE(3)) derived from fish oil eicosapentaenoic acid (EPA) in human lung cancer A549 cells. Exposure of A549 cells to EPA resulted in the rapid formation and export of PGE(3.) The extracellular ratio of PGE(3) to PGE(2) increased from 0.08 in control...

journal_title：Journal of lipid research

authors： Yang P,Chan D,Felix E,Cartwright C,Menter DG,Madden T,Klein RD,Fischer SM,Newman RA

更新日期：2004-06-01 00:00:00

abstract：:Paraoxonase-1 (PON1) is known to be associated with high density lipoproteins. We optimized buffer conditions to obtain quantitative recovery of PON1 (arylesterase) activity and analyzed the distribution of PON1 in mice using a combination of size-exclusion chromatography and ultracentrifugation. Size-exclusion chroma...

journal_title：Journal of lipid research

authors： Connelly PW,Maguire GF,Draganov DI

更新日期：2004-03-01 00:00:00

abstract：:Acyl-CoA thioesterase (Acot)2 localizes to the mitochondrial matrix and hydrolyses long-chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxi-dative tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role is unknown. Using a model of adenoviral Acot2 overexpr...

journal_title：Journal of lipid research

authors： Moffat C,Bhatia L,Nguyen T,Lynch P,Wang M,Wang D,Ilkayeva OR,Han X,Hirschey MD,Claypool SM,Seifert EL

更新日期：2014-12-01 00:00:00

abstract：:The genus Acinetobacter is composed of ubiquitous, generally nonpathogen environmental bacteria. Interest concerning these microorganisms has increased during the last 30 years, because some strains, belonging to the so-called A. baumannii-A. calcoaceticus complex, have been implicated in some severe pathological stat...

journal_title：Journal of lipid research

authors： Leone S,Sturiale L,Pessione E,Mazzoli R,Giunta C,Lanzetta R,Garozzo D,Molinaro A,Parrilli M

更新日期：2007-05-01 00:00:00

abstract：:Sphingoglycolipids (SGLs) are cell membrane constituents. As the ceramide structure influences the biological properties of the SGL, we characterized by electrospray ionization tandem mass spectrometry the molecular species of ceramides present in SGL of mouse brain. We report here for the first time the presence in m...

journal_title：Journal of lipid research

authors： Colsch B,Afonso C,Popa I,Portoukalian J,Fournier F,Tabet JC,Baumann N

更新日期：2004-02-01 00:00:00

abstract：:In Tangier disease, absence of ATP binding cassette transporter A1 (ABCA1) results in reduced plasma HDL and elevated triglyceride (TG) levels. We hypothesized that hepatocyte ABCA1 regulates VLDL TG secretion through nascent HDL production. Silencing of ABCA1 expression in oleate-stimulated rat hepatoma cells resulte...

journal_title：Journal of lipid research

authors： Chung S,Gebre AK,Seo J,Shelness GS,Parks JS

更新日期：2010-04-01 00:00:00

abstract：:Vitamin E is a naturally occurring fat-soluble antioxidant which has been proposed as a treatment for both primary and secondary protection against cardiovascular (CV) events. Promising data from observational epidemiological studies associating higher vitamin E dietary intake with lower risk of CV events have not bee...

journal_title：Journal of lipid research

authors： Vardi M,Levy NS,Levy AP

更新日期：2013-09-01 00:00:00

abstract：:Acyl-CoA:monoglyceride acyltransferase in microsomal preparations from the small intestine of the rat has been measured by means of continuous recording spectrophotometry. The reaction of 5,5'-dithiobis(2-nitrobenzoic acid) with CoA has been employed for this assay and optimal conditions for the reaction have been def...

journal_title：Journal of lipid research

authors： Rodgers JB Jr

更新日期：1969-07-01 00:00:00

abstract：:The mitochondrial lipids from avocado fruit, cauliflower buds, and potato tubers, and the lipids of chloroplasts isolated from avocado fruit and from cauliflower leaves were identified and the concentrations were determined. The lipid composition was compared with that of beef heart mitochondria. Phospholipids constit...

journal_title：Journal of lipid research

authors： Schwertner HA,Biale JB

更新日期：1973-03-01 00:00:00

abstract：:To identify novel fatty acid diol synthases, putative candidate sequences from Penicillium species were analyzed, and hydroxy fatty acid production by crude Penicillium enzyme extracts was assessed. Penicillium chrysogenum was found to produce an unknown dihydroxy fatty acid, a candidate gene implicated in this produc...

journal_title：Journal of lipid research

authors： Shin KC,Seo MJ,Oh DK

更新日期：2016-02-01 00:00:00

abstract：:The hepatic synthesis of sterol was measured in the male Mongolian gerbil (Meriones unguiculatus) in vivo following the administration of [3H]water by monitoring the incorporation of radioactivity into digitonin-precipitable sterol. A diurnal rhythm in cholesterol synthesis was exhibited under conditions of ad libitum...

journal_title：Journal of lipid research

authors： Mercer NJ,Holub BJ

更新日期：1981-07-01 00:00:00