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Restriction fragment length polymorphisms among Japanese detected with a dihydropteridine reductase cDNA gene probe.

Abstract：

:Using a human dihydropteridine reductase (DHPR) cDNA, the frequency of restriction fragment length polymorphisms (RFLPs) with restriction endonucleases AvaII, MspI, NcoI and HinfI was estimated in unrelated, unaffected Japanese. The allele frequencies are different from those found in Caucasians, especially with MspI and HinfI. However, approximately 60% of Japanese are heterozygous for at least one of the RFLPs and analysis of one family with DHPR deficiency was shown to be informative. RFLP linkage analysis will be useful in the Japanese population as previously reported for Caucasians.

journal_name

J Inherit Metab Dis

journal_title

Journal of inherited metabolic disease

authors

Hayasaka K,Narisawa K,Ohura T,Ogawa E,Dahl HH

doi

10.1007/BF01800212

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

873-8

issue

6

eissn

0141-8955

issn

1573-2665

journal_volume

13

pub_type

杂志文章

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