Abstract:
OBJECTIVE:The aim of this study was to examine the association between the CYP2D6 and CYP2C19 genotype-predicted combined phenotypes and short-term measures of psychotropic efficacy and toxicity. METHODS:A rater-blinded, retrospective genotype association design examined a cohort of hospitalized pediatric psychiatric patients genotyped for CYP2D6 and CYP2C19 as part of clinical care. These combined genotypes were used to predict a combined phenotype. The primary efficacy outcome measure was the behavior intervention score (BIS), a function of the number of recorded timeouts/seclusions, therapeutic holds, and physical restraints. Drug tolerability was defined as the total number of recorded adverse drug reactions. RESULTS:Primary analysis was performed on 279 pediatric patients taking CYP2D6- or CYP2C19- dependent psychotropics. Combined phenotype was associated with BIS (p = 0.01) and number of adverse drug reactions (p = 0.03). Combined poor metabolizers treated with psychotropics had the lowest BIS (highest efficacy) and the highest number of adverse drug reactions. Combined ultrarapid metabolizers had the highest BIS (lowest efficacy) and the lowest number of adverse drug reactions. CONCLUSION:Common variants in CYP2D6 and CYP2C19 are associated with the short-term efficacy and tolerability of psychotropic medications in hospitalized pediatric patients.
journal_name
J Child Adolesc Psychopharmacoljournal_title
Journal of child and adolescent psychopharmacologyauthors
Prows CA,Nick TG,Saldaña SN,Pathak S,Liu C,Zhang K,Daniels ZS,Vinks AA,Glauser TAdoi
10.1089/cap.2008.0103subject
Has Abstractpub_date
2009-08-01 00:00:00pages
385-94issue
4eissn
1044-5463issn
1557-8992journal_volume
19pub_type
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更新日期:2007-02-01 00:00:00
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doi:10.1089/cap.2005.15.693
更新日期:2005-08-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
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doi:10.1089/cap.2005.15.901
更新日期:2005-12-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2004-04-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2009-10-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2003-01-01 00:00:00
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更新日期:1999-01-01 00:00:00
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journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章
doi:10.1089/104454603321666234
更新日期:2003-04-01 00:00:00
abstract::Bipolar disorder (BP) in youth is an impairing psychiatric disorder associated with high rates of relapse and recurrence. High rates of psychiatric and medical co-morbidities account for additional illness burden in pediatric BP. The elevated risk of overweight and obesity in this population is of particular concern. ...
journal_title:Journal of child and adolescent psychopharmacology
pub_type: 杂志文章
doi:10.1089/cap.2010.0104
更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-10-01 00:00:00