Comparison of recombinant and plasma-derived antithrombin biodistribution in a rabbit model.

abstract：:In two randomized double-blind studies perioperative bleeding complications and thromboembolic events were assessed in 189 patients (pts) undergoing elective visceral surgery after subcutaneous administration of a low molecular weight (LMW) heparin fragment (KABI fragment 2165) or unfractionated (UF) heparin. The firs...

journal_title：Thrombosis and haemostasis

authors： Koller M,Schoch U,Buchmann P,Largiadèr F,von Felten A,Frick PG

更新日期：1986-12-15 00:00:00

abstract：:Thrombotic complications are frequently associated with atherosclerosis. Lysophosphatidylcholine (LPC), a component accumulated in oxidatively modified LDL (ox-LDL), is known to play a crucial role in the initiation and progression of atherosclerotic vascular lesions. Since a vascular anticoagulant, tissue factor path...

journal_title：Thrombosis and haemostasis

authors： Sato N,Kokame K,Miyata T,Kato H

更新日期：1998-01-01 00:00:00

abstract：:Low molecular weight heparin (LMWH) is used increasingly for prophylaxis and treatment of venous thromboembolism during pregnancy. However, the prophylactic dose for patients at moderate risk varies between centers, and the recommended LMWH dose for the non pregnant patient is frequently used in pregnant women. The ai...

journal_title：Thrombosis and haemostasis

authors： Norris LA,Bonnar J,Smith MP,Steer PJ,Savidge G

更新日期：2004-10-01 00:00:00

abstract：:Leukocytes recruitment to thrombi supports an intimate cellular interaction leading to the enhancement of pro-coagulant functions and pro-inflammatory responses at site of vascular injury. Recent observations of neutrophil extracellular traps (NETs) formation and its mutual reactions with platelet thrombi adds more cl...

journal_title：Thrombosis and haemostasis

authors： Ghasemzadeh M,Hosseini E

更新日期：2015-06-01 00:00:00

abstract：:Binding of the coagulation protease factor VIIa to its receptor Tissue Factor (TF) induces intracellular signals in several cell types including HaCaT keratinocytes. TF belongs to the cytokine receptor family, but is most likely not alone in transferring the complete TF/FVIIa signal over the plasma membrane. The prote...

journal_title：Thrombosis and haemostasis

authors： Wiiger MT,Prydz H

更新日期：2004-07-01 00:00:00

abstract：:Anticoagulant control facilities are being overwhelmed by requests for monitoring and large numbers of patients are not therefore receiving treatment. Procedures designed for point-of-care testing have therefore been developed, the most popular being the CoaguChek. The need for external quality assessment (EQA) of mon...

journal_title：Thrombosis and haemostasis

authors： Jespersen J,Poller L,van den Besselaar AM,van der Meer FJ,Palareti G,Tripodi A,Shiach C,Keown M,Ibrahim S

更新日期：2010-05-01 00:00:00

abstract：:Carboxypeptidase U (CPU, EC 3.4.17.20) is a recently described basic carboxypeptidase which circulates in plasma as the zymogen procarboxypeptidase U (proCPU). In the current study, we report on the presence of the proCPU/CPU system in different mammalian species--pig, guinea pig, dog, mouse, rabbit, rat and human. Th...

journal_title：Thrombosis and haemostasis

authors： Schatteman KA,Goossens FJ,Scharpé SS,Hendriks DF

更新日期：1999-12-01 00:00:00

abstract：:Light to moderate drinking is associated with lower risk of coronary heart (CHD) than non-drinkers. We have examined the relationships between total alcohol intake and type of alcoholic beverage and several potential biological mechanisms. We carried out the study in 3158 men aged 60-79 years drawn from general practi...

journal_title：Thrombosis and haemostasis

authors： Wannamethee SG,Lowe GD,Shaper G,Whincup PH,Rumley A,Walker M,Lennon L

更新日期：2003-12-01 00:00:00

abstract：:Less than 60 cases of acquired factor (F)XIII deficiencies have been reported, most having distinct clinical features. To illustrate the therapeutic challenges of acquired FXIII inhibitors, we report a case of a 65-year-old patient with no previous bleeding history who suddenly developed massive haemorrhages associate...

journal_title：Thrombosis and haemostasis

authors： Boehlen F,Casini A,Chizzolini C,Mansouri B,Kohler HP,Schroeder V,Reber G,de Moerloose P

更新日期：2013-03-01 00:00:00

abstract：:Hirudin is a potent thrombin inhibitor derived from the leech Hirudo medicinalis salivary gland which has considerable potential for therapeutic use in thrombotic disease. The major risk attendant its use is hemorrhage. This study investigates the hypothesis that the prohemostatic effects of DDAVP infusion can curtail...

journal_title：Thrombosis and haemostasis

authors： Bove CM,Casey B,Marder VJ

更新日期：1996-03-01 00:00:00

abstract：:Management strategies for patients with atrial fibrillation (AF) in association with valvular heart disease (VHD) have been less informed by randomized trials, which have largely focused on ‘non-valvular AF’ patients. Thromboembolic risk also varies according to valve lesion and may also be associated with CHA2DS2-VAS...

journal_title：Thrombosis and haemostasis

authors： Lip GYH,Collet JP,de Caterina R,Fauchier L,Lane DA,Larsen TB,Marin F,Morais J,Narasimhan C,Olshansky B,Pierard L,Potpara T,Sarrafzadegan N,Sliwa K,Varela G,Vilahur G,Weiss T,Boriani G,Rocca B

更新日期：2017-12-01 00:00:00

abstract：:Heparin-induced thrombocytopenia (HIT), a relatively common complication of heparin therapy, results of platelet activation, via the receptor for the Fc domain of IgG (FcgammaRIIa), by heparin-dependent-antibodies, commonly directed against the heparin-platelet factor 4 (H-PF4) antigenic complex. Our strategy was to u...

journal_title：Thrombosis and haemostasis

authors： Khairy M,Lasne D,Brohard-Bohn B,Aiach M,Rendu F,Bachelot-Loza C

更新日期：2001-06-01 00:00:00

abstract：:ADP plays a crucial role in haemostasis and thrombosis and its receptors are potential targets for antithrombotic drugs. Two G-protein coupled P2 receptors contribute to platelet aggregation: the P2Y1 receptor initiates aggregation through mobilisation of calcium stores, while the more recently identified P2Y12 recept...

journal_title：Thrombosis and haemostasis

authors： Gachet C

更新日期：2001-07-01 00:00:00

abstract：:Heparin cofactor II (HC II) is a heparin-dependent inhibitor of thrombin, distinct from antithrombin III (AT III). This study was designed to evaluate its metabolism in healthy subjects. Purified HC II was labelled with 125I by the lactoperoxidase-glucose oxidase technique. The biological activity of the HC II was unc...

journal_title：Thrombosis and haemostasis

authors： Sié P,Dupouy D,Pichon J,Boneu B

更新日期：1985-10-30 00:00:00

abstract：:Warfarin induction is accomplished by titrating dosage to coagulation test results. Algorithms can guide this process but not identify the starting dose. We hypothesized that an initial warfarin dose approximating the maintenance value would safely enhance rapidity of induction. In a randomized trial we compared a fix...

journal_title：Thrombosis and haemostasis

authors： Shine D,Patel J,Kumar J,Malik A,Jaeger J,Maida M,Ord L,Burrows G

更新日期：2003-02-01 00:00:00

abstract：:Fibrinogen degradation products were investigated for leukocyte chemotactic activity and for enhancement of vascular permeability. Both activities increased progressively with plasmin digestion of fibrinogen. Active fragments were partially purified from 24 hr-plasmin digests. Molecular weights of the permeability inc...

journal_title：Thrombosis and haemostasis

authors： Sueishi K,Nanno S,Tanaka K

更新日期：1981-02-23 00:00:00

abstract：INTRODUCTION: Bleeds such as intra-ventricular (IVH) and pulmonary haemorrhage (PH) are life-threatening events in extremely low birth weight (ELBW) infants. Serial coagulation monitoring by measuring the international normalized ratio (INR) with small volume samples might facilitate early diagnosis and possibly preven...

journal_title：Thrombosis and haemostasis

authors： Thanhaeuser M,Binder C,Derhaschnig U,Jilma B,Kornsteiner-Krenn M,Huber-Dangl M,Repa A,Kreissl A,Berger A,Haiden N

更新日期：2018-07-01 00:00:00

abstract：:Prolonged immobilization and advanced age are considered to be important risk factors for venous thromboembolism (VTE). Nevertheless, the need for VTE prophylaxis in long-term bedridden patients is not known. To assess whether very prolonged immobilization (i.e. over three months) carries an increased risk for clinica...

journal_title：Thrombosis and haemostasis

authors： Gatt ME,Paltiel O,Bursztyn M

更新日期：2004-03-01 00:00:00

abstract：:Examination of the entire von Willebrand factor (VWF) gene for mutations, particularly in types 1 and 3 von Willebrand disease (VWD) is becoming more widely practised. The sequence of the entire VWF gene will soon be compiled as a single sequence. For these reasons, a clearly defined nomenclature to use for numbering ...

journal_title：Thrombosis and haemostasis

authors： Goodeve AC,Eikenboom JC,Ginsburg D,Hilbert L,Mazurier C,Peake IR,Sadler JE,Rodeghiero F,ISTH SSC Subcommittee on von Willebrand factor.

更新日期：2001-05-01 00:00:00

abstract：:The in vitro vitamin K-dependent carboxylation of peptide- or protein-bound glutamate residues is generally studied in detergent-solubilized microsomes from rat or cow liver. Under the conditions usually employed, the efficiency of the carboxylation reaction is low (less than 1% of the carboxylatable residues is conve...

journal_title：Thrombosis and haemostasis

authors： Soute BA,Ulrich MM,Vermeer C

更新日期：1987-02-03 00:00:00

abstract：:Seasonal variation in venous thromboembolism (VTE) risk in individuals with familial predisposition to VTE has not been explored. This nationwide study aimed to determine whether there are age- and sex-specific seasonal differences in risk of hospitalisation of VTE among individuals with and without a family history o...

journal_title：Thrombosis and haemostasis

authors： Zöller B,Li X,Ohlsson H,Sundquist J,Sundquist K

更新日期：2013-12-01 00:00:00

abstract：:Tissue factor (TF) is the primary initiator of the coagulation cascade and is thought to play a key role in the generation of arterial thrombosis. Recent studies have suggested that TF mediates inflammatory processes in the arterial wall and may be an important regulator of intimal hyperplasia. We have employed geneti...

journal_title：Thrombosis and haemostasis

authors： Pyo RT,Sato Y,Mackman N,Taubman MB

更新日期：2004-09-01 00:00:00

abstract：:The pathogenesis of abdominal aortic aneurysm (AAA) involves a central component of chronic inflammation which is predominantly mediated by myeloid cells. We hypothesized that the local inflammatory activity may be reflected in systemic alterations of neutrophil and monocyte populations as well as in soluble factors o...

journal_title：Thrombosis and haemostasis

authors： Zagrapan B,Eilenberg W,Prausmueller S,Nawrozi P,Muench K,Hetzer S,Elleder V,Rajic R,Juster F,Martelanz L,Hayden H,Klopf J,Inan C,Teubenbacher P,Weigl MP,Kirchweger P,Beitzke D,Jilma B,Wojta J,Bailey MA,Scott DJA,

更新日期：2019-05-01 00:00:00

abstract：:Growing evidence indicates that rheumatoid arthritis (RA) is associated with an increased risk for thromboembolic cardiovascular events. We investigated thrombin generation profiles in RA patients and their dependence on plasma factor/inhibitor composition. Plasma factor (F) compositions (II, V, VII, VIII, IX, X), ant...

journal_title：Thrombosis and haemostasis

authors： Undas A,Gissel M,Kwasny-Krochin B,Gluszko P,Mann KG,Brummel-Ziedins KE

更新日期：2010-08-01 00:00:00

abstract：:Adjunctive use of phosphodiesterase (PDE) inhibitor can enhance antiplatelet and vasoprotective properties in patients with cardiovascular disease. The aim of this study was to evaluate the impact of PDE5 inhibitor dipyridamole on platelet function in stented patients with high platelet reactivity (HPR) during dual an...

journal_title：Thrombosis and haemostasis

authors： Park Y,Jeong YH,Tantry US,Ahn JH,Kim KH,Koh JS,Park JR,Hwang SJ,Kwak CH,Hwang JY,Gurbel PA

更新日期：2014-12-01 00:00:00

abstract：:Human platelets have unique and reproducible mRNA profiles, with evidence for distinct profiles in haematopoietic stem cell disorders associated with thrombocytosis. Platelet transcript profiling is traditionally studied by microarray analysis, quantitative reverse transcription-PCR or serial analysis of gene expressi...

journal_title：Thrombosis and haemostasis

authors： Gnatenko DV,Zhu W,Bahou WF

更新日期：2008-11-01 00:00:00

abstract：:The prevalence of coagulation disorders in patients with upper extremity deep-vein thrombosis (UE-DVT) is unknown due to only a few observational studies of limited size reporting varying results. Therefore, we aimed to evaluate the prevalence of thrombophilia in patients with UE-DVT compared to patients with lower ex...

journal_title：Thrombosis and haemostasis

authors： Linnemann B,Meister F,Schwonberg J,Schindewolf M,Zgouras D,Lindhoff-Last E,MAISTHRO registry.

更新日期：2008-09-01 00:00:00

abstract：:The walls of rabbit mesenteric arterioles and venules (diameter 20 to 40 microns) were punctured with glass micropipets (tip diameter 6 to 8 microns). Thromboembolic reactions resulting from this standardized, small mechanical vessel wall injury could be quantified in vivo with the use of intravital video-microscopy. ...

journal_title：Thrombosis and haemostasis

authors： oude Egbrink MG,Tangelder GJ,Slaaf DW,Reneman RS

更新日期：1988-02-25 00:00:00

abstract：:We have tried to offer a unifying hypothesis tying vessel wall narrowing in atherosclerotic plaques to plaque rupture and healing (Fig. 7). This hypothesis is supported by evidence that smooth muscle cells are capable of interacting with a fibrin clot, specifically contracting a fibrin clot, and that inhibition of coa...

journal_title：Thrombosis and haemostasis

authors： Yee KO,Schwartz SM

更新日期：1999-08-01 00:00:00

abstract：:Factor XI (FXI) plays a dual role in haemostasis and thrombosis. It contributes to thrombin generation and promotes inhibition of fibrinolysis. Severe FXI deficiency was shown to confer protection against arterial and venous thrombosis in animal models without compromising haemostasis. We have previously shown that pa...

journal_title：Thrombosis and haemostasis

authors： Salomon O,Steinberg DM,Zucker M,Varon D,Zivelin A,Seligsohn U

更新日期：2011-02-01 00:00:00