CYP2B6 G516T genotyping in a UK cohort of HIV-positive patients: polymorphism frequency and influence on efavirenz discontinuation.

abstract：OBJECTIVES:In most lung screening programmes, only subjects ≥ 55 years old and smoking ≥ 30 pack-years are eligible to undergo chest low-dose computed tomography. Whether the same criteria should apply to people living with HIV (PLHIV) is uncertain, given the increased lung cancer risks associated with immunodeficiency...

journal_title：HIV medicine

authors： Makinson A,Tron L,Grabar S,Milleron B,Reynes J,Le Moing V,Morquin D,Lert F,Costagliola D,Guiguet M

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:As more HIV-positive individuals receive antiretroviral therapy (ART), payers are seeking options for covering these increased and sustained drug costs. Strategic use of available generic antiretroviral (ARV) formulations may be feasible. De-simplifying a single-tablet co-formulation (STF) into two or more t...

journal_title：HIV medicine

authors： Krentz HB,Campbell S,Lahl M,Gill MJ

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:The World Health Organization (WHO) recommends screening HIV-infected people for cryptococcal antigens to identify cryptococcosis, a major cause of AIDS-related deaths. As the burden of cryptococcosis is unknown in South Africa's KwaZulu-Natal province, we assessed the cryptococcal antigenuria prevalence amo...

journal_title：HIV medicine

authors： Drain PK,Kleene JM,Coleman SM,Losina E,Katz JN,Giddy J,Ross D,Freedberg KA,Bassett IV

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:The Joint United Nations Programme on HIV/AIDS (UNAIDS)/World Health Organization (WHO) 90-90-90 goals propose that 90% of all people living with HIV should know their HIV status, 90% of those diagnosed should receive antiretroviral therapy (ART), and 90% of those should have durable viral suppression. We ha...

journal_title：HIV medicine

authors： Gisslén M,Svedhem V,Lindborg L,Flamholc L,Norrgren H,Wendahl S,Axelsson M,Sönnerborg A

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The addition of a low dose of ritonavir to protease inhibitors (PIs) has become a widespread strategy to improve PI pharmacokinetics. As resistance is a major barrier to long-term suppression, in salvage therapy genotype and/or phenotype scoring is currently used to predict the response. We evaluated the rel...

journal_title：HIV medicine

authors： Mallolas J,Blanco J,Labarga P,Vergara A,Ocampo A,Sarasa M,Arnedo M,López-Púa Y,García J,Juega J,Guelar A,Terrón A,Dalmau D,García I,Zárraga M,Martínez E,Carné X,Pumarola T,Escayola R,Gatell J

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVES:Our objective was to identify patient factors associated with being untreated for hepatitis C virus (HCV) infection in HIV-coinfected patients. METHODS:A prospective longitudinal study was carried out. HIV-infected patients with active chronic HCV infection included in the HERACLES cohort (NCT02511496) cons...

journal_title：HIV medicine

authors： Rivero-Juarez A,Tellez F,Castaño-Carracedo M,Merino D,Espinosa N,Santos J,Macias J,Paniagua-García M,Zapata-Lopez A,Collado A,Gómez-Vidal MA,Perez-Stachowski J,Muñoz-Medina L,Fernandez-Fuertes E,Rivero A,Grupo de estudio de

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:Although current guidelines recommend resistance testing prior to antiretroviral therapy (ART) reinitiation after treatment interruptions, virological failure of first-line ritonavir-boosted, protease-inhibitor (PI/r)-containing ART is associated with low emergent PI resistance. In patients experiencing unsc...

journal_title：HIV medicine

authors： Tinago W,O'Halloran JA,O'Halloran RM,Macken A,Lambert JS,Sheehan GJ,Mallon PW

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVES:Renal disease is a common and serious complication in HIV-infected patients. METHODS:A retrospective cohort analysis for the period 1989-2010 was carried out to determine the prevalence, incidence and risk factors for end-stage renal disease (ESRD). ESRD was defined as initiation of renal replacement therap...

journal_title：HIV medicine

authors： Bickel M,Marben W,Betz C,Khaykin P,Stephan C,Gute P,Haberl A,Knecht G,Wolf T,Brodt HR,Geiger H,Herrmann E,Jung O

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:We assessed whether changes at week 12 in markers of bone turnover, inflammation, and immune activation were associated with clinically important (≥ 5%) bone mineral density (BMD) loss from baseline to week 48 at the proximal femur (hip) and lumbar spine in the SECOND-LINE study. METHODS:We measured concent...

journal_title：HIV medicine

authors： Mwasakifwa GE,Amin J,White CP,Center JR,Kelleher A,Boyd MA

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to evaluate prospectively the usefulness of fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in investigation of fever of unknown origin (FUO) in HIV-positive patients and to determine whether HIV viraemia impacts on FDG-PET/CT performance. METHODS:Th...

journal_title：HIV medicine

authors： Martin C,Castaigne C,Tondeur M,Flamen P,De Wit S

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The world-wide AIDS epidemic is reflected in Western Europe in an increasing number of HIV-infected persons who originate from Africa. We describe the characteristics and response to antiretroviral therapy (ART) of HIV-infected patients born in Africa and living in France. METHODS:Analysis of data from the ...

journal_title：HIV medicine

authors： Breton G,Lewden C,Spire B,Salmon D,Brun-Vézinet F,Duong M,Allavena C,Leport C,Salamon R,APROCO COPILOTE ANRS CO8 Study Group.

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to seek correlates of immune protection in HIV infection. We sought to elucidate the association between the presence of human leucocyte antigen (HLA) alleles, as well as killer immunoglobulin receptor (KIR) genotypes, and the susceptibility to HIV infection in a Spanish cohor...

journal_title：HIV medicine

authors： Rallón N,Restrepo C,Vicario JL,Del Romero J,Rodríguez C,García-Samaniego J,García M,Cabello A,Górgolas M,Benito JM

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to describe growth and body composition changes in HIV-positive children after they had initiated or changed antiretroviral therapy (ART) and to correlate these with viral, immune and treatment parameters. METHODS:Ninety-seven prepubertal HIV-positive children were observed over 48 ...

journal_title：HIV medicine

authors： Chantry CJ,Cervia JS,Hughes MD,Alvero C,Hodge J,Borum P,Moye J Jr,PACTG 1010 Team.

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to examine the prevalence of HIV infection in patients presenting in primary care with glandular fever (GF)-like illness. METHODS:Samples from primary care submitted for a GF screen between April 2009 and June 2010 were identified. Samples without an HIV request were anonymized and ...

journal_title：HIV medicine

authors： Hsu DT,Ruf M,O'Shea S,Costelloe S,Peck J,Tong CY

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Three-drug nonoccupational post-exposure prophylaxis (NPEP) typically includes co-formulated emtricitabine-tenofovir (FTC-TDF) and a protease inhibitor. However, protease inhibitors can cause significant toxicities, can interact with prescribed and illicit drugs, and work late in the viral cycle. Agents that...

journal_title：HIV medicine

authors： McAllister J,Read P,McNulty A,Tong WW,Ingersoll A,Carr A

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Universal test and treat (UTT) is recommended for people living with HIV (PLHIV) to reduce morbidity/mortality and minimize transmission. However, concerns exist that this strategy may lead to more crowded hospitals, longer wait times and poorer service, adversely impacting health outcomes for clients with s...

journal_title：HIV medicine

authors： Boeke CE,Khan S,Walsh F,Hettema A,Lejeune C,Spiegelman D,Okello V,Harwell J,Mazibuko S,Bärnighausen T

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Metabolic diseases are frequently observed in HIV-infected persons and, as the risk of contracting these diseases is age-related, their prevalence will increase in the future as a consequence of the benefits of antiretroviral therapy (ART). SUMMARY OF GUIDELINES:All HIV-infected persons should be screened a...

journal_title：HIV medicine

authors： Lundgren JD,Battegay M,Behrens G,De Wit S,Guaraldi G,Katlama C,Martinez E,Nair D,Powderly WG,Reiss P,Sutinen J,Vigano A,EACS Executive Committee.

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVES:To evaluate plasma levels of dehydroepiandrosterone sulphate (DHEAS) in a cohort of HIV-infected patients and to analyse factors associated with DHEAS levels. METHODS:We conducted a cross-sectional survey in the Nîmes University Hospital cohort of HIV-infected patients in south-eastern France. All HIV-infec...

journal_title：HIV medicine

authors： Mauboussin JM,Mahamat A,Peyrière H,Rouanet I,Fabbro-Peray P,Daures JP,Vincent D

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:A significant percentage of patients infected with HIV-1 experience only suboptimal CD4 cell recovery while treated with combination therapy (cART). It is still unclear whether viral properties such as cell tropism play a major role in this incomplete immune response. This study therefore intended to follow ...

journal_title：HIV medicine

authors： Bader J,Schöni-Affolter F,Böni J,Gorgievski-Hrisoho M,Martinetti G,Battegay M,Klimkait T,Swiss HIV Cohort Study.

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:Human leukocyte antigen (HLA)-B(*)5701 is strongly associated with developing a hypersensitivity reaction to abacavir (ABC) in White and Hispanic subjects. Across the UK, limited data exist on HLA-B(*)5701 prevalence in HIV-1-infected subjects. We determined HLA-B(*)5701 prevalence in the general HIV-1-infec...

journal_title：HIV medicine

authors： Orkin C,Sadiq ST,Rice L,Jackson F,UK EPI team.

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVES:An article by the Swiss AIDS Commission states that patients with stably suppressed viraemia [i.e. several successive HIV-1 RNA plasma concentrations (viral loads, VL) below the limits of detection during 6 months or more of highly active antiretroviral therapy (HAART)] are unlikely to be infectious. Questio...

journal_title：HIV medicine

authors： Combescure C,Vallier N,Ledergerber B,Cavassini M,Furrer H,Rauch A,Battegay M,Bernasconi E,Vernazza P,Hirschel B,Swiss HIV Cohort Study.

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:A prospective study was carried out to assess HIV-1 and HIV-2 mother-to-child transmission (MTCT) rates in Portugal between 1999 and 2005 by analysing the proportion of diagnosed infected children born to HIV-positive mothers. MATERIALS AND METHODS:Serial blood samples were collected from 1315 children at ri...

journal_title：HIV medicine

authors： Pádua E,Almeida C,Nunes B,Cortes Martins H,Castela J,Neves C,Paixão MT

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to identify and describe the characteristics of persons born in the UK who acquire HIV infection abroad. METHODS:Analyses using case reports and follow-up data from the national HIV database held at the Health Protection Agency were performed. RESULTS:Fifteen per cent (2066 of 13 8...

journal_title：HIV medicine

authors： Rice B,Gilbart VL,Lawrence J,Smith R,Kall M,Delpech V

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:Financial stress has been identified as a barrier to antiretroviral adherence, but only in resource- limited settings. Almost half of HIV-infected Australian adults earn no regular income and, despite highly subsidised antiretroviral therapy and universal health care, 3% of HIV-infected Australians cease ant...

journal_title：HIV medicine

authors： McAllister J,Beardsworth G,Lavie E,MacRae K,Carr A

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVES:The aims of the present study were to estimate the prevalence of renal impairment (RI) among HIV-infected adult patients and to investigate the associated factors. METHODS:A cross-sectional survey was conducted in a French hospital-based cohort. Clearance of creatinine (CC) was calculated using the Cockcrof...

journal_title：HIV medicine

authors： Déti EK,Thiébaut R,Bonnet F,Lawson-Ayayi S,Dupon M,Neau D,Pellegrin JL,Malvy D,Tchamgoué S,Dabis F,Morlat P,Groupe d'Epidémiologie Clinique du SIDA en Aquitaine.

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVES:Few studies have explored the optimal dosing for efavirenz in individuals from China. We investigated plasma efavirenz concentrations and their association with efficacy and tolerance of efavirenz 600 mg daily in Chinese HIV-infected adults. METHODS:An analysis was performed using plasma samples from 455 pa...

journal_title：HIV medicine

authors： Guo F,Cheng X,Hsieh E,Du X,Fu Q,Peng W,Li Y,Song X,Routy JP,Li T

更新日期：2018-05-15 00:00:00

abstract：OBJECTIVES:Direct-acting antiviral agents (DAAs) have become the standard of care for the treatment of chronic hepatitis C virus (HCV) infection. We aimed to assess treatment uptake and efficacy in routine clinical settings among HIV/HCV coinfected patients after the introduction of the first generation DAAs. METHODS:...

journal_title：HIV medicine

authors： Schaerer V,Haubitz S,Kovari H,Ledergerber B,Ambrosioni J,Cavassini M,Stoeckle M,Schmid P,Decosterd L,Aouri M,Böni J,Günthard HF,Furrer H,Metzner KJ,Fehr J,Rauch A,Swiss HIV Cohort Study.

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to assess the currently available evidence concerning the management of dyslipidaemias in HIV-infected individuals treated with antiretroviral therapy. METHODS:Randomized trials, published within the 5 years preceding 5 October 2005, were identified in PubMed Medline, Embase, and Th...

journal_title：HIV medicine

authors： McGoldrick C,Leen CL

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVES:The perceived threat of HIV transmission through spitting and biting is evidenced by the increasing use of "spit hoods" by Police Forces in the UK. In addition, a draft parliamentary bill has called for increased penalties for assaults on emergency workers, citing the risk of communicable disease transmissio...

journal_title：HIV medicine

authors： Cresswell FV,Ellis J,Hartley J,Sabin CA,Orkin C,Churchill DR

更新日期：2018-04-23 00:00:00

abstract：OBJECTIVES:Anaemia represents a common toxicity with amphotericin B-based induction therapy in HIV-infected persons with cryptococcal meningitis. We sought to examine the impact of amphotericin-related anaemia on survival. METHODS:We used data from Ugandan and South African trial participants to characterize the varia...

journal_title：HIV medicine

authors： Tugume L,Morawski BM,Abassi M,Bahr NC,Kiggundu R,Nabeta HW,Hullsiek KH,Taseera K,Musubire AK,Schutz C,Muzoora C,Williams DA,Rolfes MA,Meintjes G,Rhein J,Meya DB,Boulware DR

更新日期：2017-01-01 00:00:00