A transcript profiling approach reveals the zinc finger transcription factor ZNF191 is a pleiotropic factor.

Abstract:

BACKGROUND:The human zinc finger protein 191 (ZNF191) is a member of the SCAN domain family of Krüppel-like zinc finger transcription factors. ZNF191 shows 94% identity to its mouse homologue zinc finger protein 191(Zfp191), which is the most highly conserved among the human-mouse SCAN family member orthologues pairs. Zfp191 is widely expressed during early embryogenesis and in adult organs. Moreover, Zfp191-/- embryos have been shown to be severely retarded in development and die approximately at embryonic day E7.5. ZNF191 can specifically interact with the widespread TCAT motif which constitutes the HUMTH01 microsatellite in the tyrosine hydroxylase (TH) gene. Allelic variations of HUMTH01 have been stated to have a quantitative silencing effect on TH gene expression and to correlate with quantitative and qualitative changes in the binding by ZNF191. In addition, ZNF191 displays a suppressive effect on the transcription; however, little downstream targets have identified. RESULTS:We searched for ZNF191 target genes by using a transient overexpression and knockdown strategy in the human embryo kidney (HEK293) cells. Microarray analyses identified 6094 genes modulated by overexpression of ZNF191 and 3332 genes regulated by knockdown of ZNF191, using a threshold of 1.2-fold. Several interested candidate genes, validated by real time RT-PCR, were correlated well with the array data. Interestingly, 1456 genes were identified in both transient overexpression and transient knockdown strategies. The GenMAPP and MappFinder software packages were further used for pathway analysis of these significantly altered genes. Several gene pathways were found to be involved in processes of the regulation of kinase activity, transcription, angiogenesis, brain development and response to DNA damage. CONCLUSION:Our analysis reveals for the first time that ZNF191 is a pleiotropic factor that has a role in hematopoiesis, brain development and cancers.

journal_name

BMC Genomics

journal_title

BMC genomics

authors

Li J,Chen X,Gong X,Liu Y,Feng H,Qiu L,Hu Z,Zhang J

doi

10.1186/1471-2164-10-241

subject

Has Abstract

pub_date

2009-05-22 00:00:00

pages

241

issn

1471-2164

pii

1471-2164-10-241

journal_volume

10

pub_type

杂志文章
  • Genome-based analysis for the identification of genes involved in o-xylene degradation in Rhodococcus opacus R7.

    abstract:BACKGROUND:Bacteria belonging to the Rhodococcus genus play an important role in the degradation of many contaminants, including methylbenzenes. These bacteria, widely distributed in the environment, are known to be a powerhouse of numerous degradation functions, due to their ability to metabolize a wide range of organ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-018-4965-6

    authors: Di Canito A,Zampolli J,Orro A,D'Ursi P,Milanesi L,Sello G,Steinbüchel A,Di Gennaro P

    更新日期:2018-08-06 00:00:00

  • Analysis of plant-derived miRNAs in animal small RNA datasets.

    abstract:BACKGROUND:Plants contain significant quantities of small RNAs (sRNAs) derived from various sRNA biogenesis pathways. Many of these sRNAs play regulatory roles in plants. Previous analysis revealed that numerous sRNAs in corn, rice and soybean seeds have high sequence similarity to animal genes. However, exogenous RNA ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-13-381

    authors: Zhang Y,Wiggins BE,Lawrence C,Petrick J,Ivashuta S,Heck G

    更新日期:2012-08-08 00:00:00

  • Is chemically dispersed oil more toxic to Atlantic cod (Gadus morhua) larvae than mechanically dispersed oil? A transcriptional evaluation.

    abstract:BACKGROUND:The use of dispersants can be an effective way to deal with acute oil spills to limit environmental damage, however very little is known about whether chemically dispersed oil have the same toxic effect on marine organisms as mechanically dispersed oil. We exposed Atlantic cod larvae to chemically and mechan...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-13-702

    authors: Olsvik PA,Lie KK,Nordtug T,Hansen BH

    更新日期:2012-12-14 00:00:00

  • Biclustering of transcriptome sequencing data reveals human tissue-specific circular RNAs.

    abstract:BACKGROUND:Emerging evidence has been experimentally confirmed the tissue-specific expression of circRNAs (circRNAs). Global identification of human tissue-specific circRNAs is crucial for the functionality study, which facilitates the discovery of circRNAs for potential diagnostic biomarkers. RESULTS:In this study, c...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-017-4335-9

    authors: Liu YC,Chiu YJ,Li JR,Sun CH,Liu CC,Huang HD

    更新日期:2018-01-19 00:00:00

  • High-throughput sequencing of Astrammina rara: sampling the giant genome of a giant foraminiferan protist.

    abstract:BACKGROUND:Foraminiferan protists, which are significant players in most marine ecosystems, are also genetic innovators, harboring unique modifications to proteins that make up the basic eukaryotic cell machinery. Despite their ecological and evolutionary importance, foraminiferan genomes are poorly understood due to t...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-12-169

    authors: Habura A,Hou Y,Reilly AA,Bowser SS

    更新日期:2011-03-31 00:00:00

  • Structure and properties of transcriptional networks driving selenite stress response in yeasts.

    abstract:BACKGROUND:Stress responses provide valuable models for deciphering the transcriptional networks controlling the adaptation of the cell to its environment. We analyzed the transcriptome response of yeast to toxic concentrations of selenite. We used gene network mapping tools to identify functional pathways and transcri...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-9-333

    authors: Salin H,Fardeau V,Piccini E,Lelandais G,Tanty V,Lemoine S,Jacq C,Devaux F

    更新日期:2008-07-15 00:00:00

  • Transcriptome profiling of liver of non-genetic low birth weight and long term health consequences.

    abstract:BACKGROUND:It is believed that the main factors of low prenatal growth in mammals are genetic and environmental. We used isogenic mice maintained in standard conditions to analyze how natural non-genetic microsomia (low birth weight) is produced in inbred mice and its long term effect on health. To better understand th...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-15-327

    authors: Miranda A,López-Cardona AP,Laguna-Barraza R,Calle A,López-Vidriero I,Pintado B,Gutiérrez-Adán A

    更新日期:2014-05-01 00:00:00

  • Whole genome comparative analysis of transposable elements provides new insight into mechanisms of their inactivation in fungal genomes.

    abstract:BACKGROUND:Transposable Elements (TEs) are key components that shape the organization and evolution of genomes. Fungi have developed defense mechanisms against TE invasion such as RIP (Repeat-Induced Point mutation), MIP (Methylation Induced Premeiotically) and Quelling (RNA interference). RIP inactivates repeated sequ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-015-1347-1

    authors: Amselem J,Lebrun MH,Quesneville H

    更新日期:2015-02-28 00:00:00

  • Multi-omics analysis reveals regulators of the response to nitrogen limitation in Yarrowia lipolytica.

    abstract:BACKGROUND:Yarrowia lipolytica is an oleaginous ascomycete yeast that stores lipids in response to limitation of nitrogen. While the enzymatic pathways responsible for neutral lipid accumulation in Y. lipolytica are well characterized, regulation of these pathways has received little attention. We therefore sought to c...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-016-2471-2

    authors: Pomraning KR,Kim YM,Nicora CD,Chu RK,Bredeweg EL,Purvine SO,Hu D,Metz TO,Baker SE

    更新日期:2016-02-25 00:00:00

  • Histone H3 lysine 4 methyltransferase is required for facultative heterochromatin at specific loci.

    abstract:BACKGROUND:Histone H3 lysine 4 tri-methylation (H3K4me3) and histone H3 lysine 9 tri-methylation (H3K9me3) are widely perceived to be opposing and often mutually exclusive chromatin modifications. However, both are needed for certain light-activated genes in Neurospora crassa (Neurospora), including frequency (frq) and...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-019-5729-7

    authors: Zhu Q,Ramakrishnan M,Park J,Belden WJ

    更新日期:2019-05-08 00:00:00

  • Whole genome sequence analysis of the TALLYHO/Jng mouse.

    abstract:BACKGROUND:The TALLYHO/Jng (TH) mouse is a polygenic model for obesity and type 2 diabetes first described in the literature in 2001. The origin of the TH strain is an outbred colony of the Theiler Original strain and mice derived from this source were selectively bred for male hyperglycemia establishing an inbred stra...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-016-3245-6

    authors: Denvir J,Boskovic G,Fan J,Primerano DA,Parkman JK,Kim JH

    更新日期:2016-11-11 00:00:00

  • Novel Moraxella catarrhalis prophages display hyperconserved non-structural genes despite their genomic diversity.

    abstract:BACKGROUND:Moraxella catarrhalis is an important pathogen that often causes otitis media in children, a disease that is not currently vaccine preventable. Asymptomatic colonisation of the human upper respiratory tract is common and lack of clearance by the immune system is likely due to the emergence of seroresistant g...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-015-2104-1

    authors: Ariff A,Wise MJ,Kahler CM,Tay CY,Peters F,Perkins TT,Chang BJ

    更新日期:2015-10-24 00:00:00

  • Small RNAs from the wheat stripe rust fungus (Puccinia striiformis f.sp. tritici).

    abstract:BACKGROUND:Wheat stripe rust, caused by Puccinia striiformis f. sp. tritici, is a costly global disease that burdens farmers with yield loss and high fungicide expenses. This sophisticated biotrophic parasite infiltrates wheat leaves and develops infection structures inside host cells, appropriating nutrients while sup...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-015-1895-4

    authors: Mueth NA,Ramachandran SR,Hulbert SH

    更新日期:2015-09-21 00:00:00

  • Impact of analytic provenance in genome analysis.

    abstract:BACKGROUND:Many computational methods are available for assembly and annotation of newly sequenced microbial genomes. However, when new genomes are reported in the literature, there is frequently very little critical analysis of choices made during the sequence assembly and gene annotation stages. These choices have a ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-15-S8-S1

    authors: Morrison SS,Pyzh R,Jeon MS,Amaro C,Roig FJ,Baker-Austin C,Oliver JD,Gibas CJ

    更新日期:2014-01-01 00:00:00

  • Diversity, expression and mRNA targeting abilities of Argonaute-targeting miRNAs among selected vascular plants.

    abstract:BACKGROUND:Micro (mi)RNAs are important regulators of plant development. Across plant lineages, Dicer-like 1 (DCL1) proteins process long ds-like structures to produce micro (mi) RNA duplexes in a stepwise manner. These miRNAs are incorporated into Argonaute (AGO) proteins and influence expression of RNAs that have seq...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-15-1049

    authors: Jagtap S,Shivaprasad PV

    更新日期:2014-12-02 00:00:00

  • The alcohol dehydrogenase gene family in sugarcane and its involvement in cold stress regulation.

    abstract:BACKGROUND:Alcohol dehydrogenases (ADHs) in plants are encoded by a multigene family. ADHs participate in growth, development, and adaptation in many plant species, but the evolution and function of the ADH gene family in sugarcane is still unclear. RESULTS:In the present study, 151 ADH genes from 17 species including...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-020-06929-9

    authors: Su W,Ren Y,Wang D,Su Y,Feng J,Zhang C,Tang H,Xu L,Muhammad K,Que Y

    更新日期:2020-07-29 00:00:00

  • Tracking the best reference genes for RT-qPCR data normalization in filamentous fungi.

    abstract:BACKGROUND:A critical step in the RT-qPCR workflow for studying gene expression is data normalization, one of the strategies being the use of reference genes. This study aimed to identify and validate a selection of reference genes for relative quantification in Talaromyces versatilis, a relevant industrial filamentous...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-015-1224-y

    authors: Llanos A,François JM,Parrou JL

    更新日期:2015-02-14 00:00:00

  • A multi-treatment experimental system to examine photosynthetic differentiation in the maize leaf.

    abstract:BACKGROUND:The establishment of C4 photosynthesis in maize is associated with differential accumulation of gene transcripts and proteins between bundle sheath and mesophyll photosynthetic cell types. We have physically separated photosynthetic cell types in the leaf blade to characterize differences in gene expression ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-8-12

    authors: Sawers RJ,Liu P,Anufrikova K,Hwang JT,Brutnell TP

    更新日期:2007-01-09 00:00:00

  • Identification of hydroxy fatty acid and triacylglycerol metabolism-related genes in lesquerella through seed transcriptome analysis.

    abstract:BACKGROUND:Castor oil is the only commercial source of hydroxy fatty acid that has industrial value. The production of castor oil is hampered by the presence of the toxin ricin in its seed. Lesquerella seed also accumulates hydroxy fatty acid and is free of ricin, and thus it is being developed as a new crop for hydrox...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-015-1413-8

    authors: Kim HU,Chen GQ

    更新日期:2015-03-24 00:00:00

  • Effects of the total replacement of fish-based diet with plant-based diet on the hepatic transcriptome of two European sea bass (Dicentrarchus labrax) half-sibfamilies showing different growth rates with the plant-based diet.

    abstract:BACKGROUND:Efforts towards utilisation of diets without fish meal (FM) or fish oil (FO) in finfish aquaculture have been being made for more than two decades. Metabolic responses to substitution of fishery products have been shown to impact growth performance and immune system of fish as well as their subsequent nutrit...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-12-522

    authors: Geay F,Ferraresso S,Zambonino-Infante JL,Bargelloni L,Quentel C,Vandeputte M,Kaushik S,Cahu CL,Mazurais D

    更新日期:2011-10-23 00:00:00

  • Bidirectional promoters exhibit characteristic chromatin modification signature associated with transcription elongation in both sense and antisense directions.

    abstract:BACKGROUND:In contrast to unidirectional promoters wherein antisense transcription results in short transcripts which are rapidly degraded, bidirectional promoters produce mature transcripts in both sense and antisense orientation. To understand the molecular mechanism of how productive bidirectional transcription is r...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-018-4697-7

    authors: Jangid RK,Kelkar A,Muley VY,Galande S

    更新日期:2018-05-02 00:00:00

  • Characterization of genome-wide segmental duplications reveals a common genomic feature of association with immunity among domestic animals.

    abstract:BACKGROUND:Segmental duplications (SDs) commonly exist in plant and animal genomes, playing crucial roles in genomic rearrangement, gene innovation and the formation of copy number variants. However, they have received little attention in most livestock species. RESULTS:Aiming at characterizing SDs across the genomes ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-017-3690-x

    authors: Feng X,Jiang J,Padhi A,Ning C,Fu J,Wang A,Mrode R,Liu JF

    更新日期:2017-04-12 00:00:00

  • DAWN: a resource for yielding insights into the diversity among wheat genomes.

    abstract:BACKGROUND:Democratising the growing body of whole genome sequencing data available for Triticum aestivum (bread wheat) has been impeded by the lack of a genome reference and the large computational requirements for analysing these data sets. RESULTS:DAWN (Diversity Among Wheat geNomes) integrates data from the T. aes...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-018-5228-2

    authors: Watson-Haigh NS,Suchecki R,Kalashyan E,Garcia M,Baumann U

    更新日期:2018-12-17 00:00:00

  • The genome of Ensifer alkalisoli YIC4027 provides insights for host specificity and environmental adaptations.

    abstract:BACKGROUND:Ensifer alkalisoli YIC4027, a recently characterized nitrogen-fixing bacterium of the genus Ensifer, has been isolated from root nodules of the host plant Sesbania cannabina. This plant is widely used as green manure and for soil remediation. E. alkalisoli YIC4027 can grow in saline-alkaline soils and is a n...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-019-6004-7

    authors: Dang X,Xie Z,Liu W,Sun Y,Liu X,Zhu Y,Staehelin C

    更新日期:2019-08-12 00:00:00

  • Transcriptomics of the late gestation ovine fetal brain: modeling the co-expression of immune marker genes.

    abstract:BACKGROUND:Major changes in gene expression occur in the fetal brain to modulate the function of this organ postnatally. Thus, factors can alter the genomics of the fetal brain, predisposing to neurological disorders later in life. We hypothesized that the physiological dynamics of the immune system transcriptome of th...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-15-1001

    authors: Rabaglino MB,Keller-Wood M,Wood CE

    更新日期:2014-11-19 00:00:00

  • Small RNA and degradome deep sequencing reveal respective roles of cold-related microRNAs across Chinese wild grapevine and cultivated grapevine.

    abstract:BACKGROUND:Chinese wild grapevine (Vitis amurensis) has remarkable cold stress tolerance, exceeding that of the common cultivated grapevine (Vitis vinifera L.). RESULT:Here, we surveyed the expression dynamics of microRNAs (miRNAs) across Chinese wild grapevine (cv. Beibinghong) and cultivated grapevine (cv. Cabernet ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-019-6111-5

    authors: Wang P,Yang Y,Shi H,Wang Y,Ren F

    更新日期:2019-10-15 00:00:00

  • An analysis of the transcriptome of Teladorsagia circumcincta: its biological and biotechnological implications.

    abstract:BACKGROUND:Teladorsagia circumcincta (order Strongylida) is an economically important parasitic nematode of small ruminants (including sheep and goats) in temperate climatic regions of the world. Improved insights into the molecular biology of this parasite could underpin alternative methods required to control this an...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-13-S7-S10

    authors: Menon R,Gasser RB,Mitreva M,Ranganathan S

    更新日期:2012-01-01 00:00:00

  • The wheat pathogen Zymoseptoria tritici senses and responds to different wavelengths of light.

    abstract:BACKGROUND:The ascomycete fungus Zymoseptoria tritici (synonyms: Mycosphaerella graminicola, Septoria tritici) is a major pathogen of wheat that causes the economically important foliar disease Septoria tritici blotch. Despite its importance as a pathogen, little is known about the reaction of this fungus to light. To ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-020-06899-y

    authors: McCorison CB,Goodwin SB

    更新日期:2020-07-25 00:00:00

  • Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate.

    abstract:BACKGROUND:The common marmoset monkey (Callithrix jacchus), a small non-endangered New World primate native to eastern Brazil, is becoming increasingly used as a non-human primate model in biomedical research, drug development and safety assessment. In contrast to the growing interest for the marmoset as an animal mode...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-8-190

    authors: Datson NA,Morsink MC,Atanasova S,Armstrong VW,Zischler H,Schlumbohm C,Dutilh BE,Huynen MA,Waegele B,Ruepp A,de Kloet ER,Fuchs E

    更新日期:2007-06-25 00:00:00

  • Comparative genomic analysis reveals occurrence of genetic recombination in virulent Cryptosporidium hominis subtypes and telomeric gene duplications in Cryptosporidium parvum.

    abstract:BACKGROUND:Cryptosporidium hominis is a dominant species for human cryptosporidiosis. Within the species, IbA10G2 is the most virulent subtype responsible for all C. hominis-associated outbreaks in Europe and Australia, and is a dominant outbreak subtype in the United States. In recent yearsIaA28R4 is becoming a major ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-015-1517-1

    authors: Guo Y,Tang K,Rowe LA,Li N,Roellig DM,Knipe K,Frace M,Yang C,Feng Y,Xiao L

    更新日期:2015-04-18 00:00:00