Abstract:
BACKGROUND:Major changes in gene expression occur in the fetal brain to modulate the function of this organ postnatally. Thus, factors can alter the genomics of the fetal brain, predisposing to neurological disorders later in life. We hypothesized that the physiological dynamics of the immune system transcriptome of the fetal brain during the last stage of gestation will reveal patterns of immune function and development in the developing brain. In this study we applied weighted gene co-expression analysis of microarrays performed on ovine fetal brain samples, to model the changes in gene expression throughout the second half of gestation. RESULTS:Clusters of co-expressed genes that strongly increase in expression toward the first day of extra-uterine life are related to the hematopoietic lineage, while activation of immune pathways is induced after birth. Moreover, the pattern of gene expression suggests induction of tolerance mechanisms, probably necessary to protect highly produced proteins--such as myelin basic protein--from an autoimmune attack. CONCLUSIONS:This study provides insight into the dramatic changes in gene expression that take place in the brain during the fetal life, especially during the last stage of gestation, and suggests that the immune system may have an important role in maturation of the fetal brain, which if disrupted or altered, could have negative consequences in postnatal life.
journal_name
BMC Genomicsjournal_title
BMC genomicsauthors
Rabaglino MB,Keller-Wood M,Wood CEdoi
10.1186/1471-2164-15-1001subject
Has Abstractpub_date
2014-11-19 00:00:00pages
1001issn
1471-2164pii
1471-2164-15-1001journal_volume
15pub_type
杂志文章相关文献
BMC GENOMICS文献大全abstract:BACKGROUND:Haplotypes combine the effects of several single nucleotide polymorphisms (SNPs) with high linkage disequilibrium, which benefit the genome-wide association analysis (GWAS). In the haplotype association analysis, both haplotype alleles and blocks are tested. Haplotype alleles can be inferred with the same st...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6552-x
更新日期:2020-02-11 00:00:00
abstract:BACKGROUND:Betula platyphylla is a common tree species in northern China that has high economic and medicinal value. Our laboratory has been devoted to genome research on B. platyphylla for approximately 10 years. As primary organelle genomes, the complete genome sequences of chloroplasts are important to study the div...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5346-x
更新日期:2018-12-20 00:00:00
abstract:BACKGROUND:Association mapping approaches are dependent upon discovery and validation of single nucleotide polymorphisms (SNPs). To further association studies in Anopheles gambiae we conducted a major resequencing programme, primarily targeting regions within or close to candidate genes for insecticide resistance. RE...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-320
更新日期:2009-07-16 00:00:00
abstract:BACKGROUND:The epithelium is the first line of defense against pathogens. Notably the epithelial cells lining the respiratory track are crucial in sensing airborne microbes and mounting an effective immune response via the expression of target genes such as cytokines and chemokines. Gene expression regulation following...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5295-4
更新日期:2018-12-27 00:00:00
abstract:BACKGROUND:The tetraploid durum wheat (Triticum turgidum L. ssp. durum Desf. Husnot) is an important crop which provides the raw material for pasta production and a valuable source of genetic diversity for breeding hexaploid wheat (Triticum aestivum L.). Future breeding efforts to enhance yield potential and climate re...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-5645-x
更新日期:2019-04-10 00:00:00
abstract:BACKGROUND:Fish scales are an important reservoir of calcium and phosphorus and together with the skin function as an integrated barrier against environmental changes and external aggressors. Histological studies have revealed that the skin and scales regenerate rapidly in fish when they are lost or damaged. In the pre...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-490
更新日期:2011-10-07 00:00:00
abstract:BACKGROUND:Brain and immune system are linked in a bi-directional manner. To date, it remained largely unknown why immune components become suppressed, enhanced, or remain unaffected in relation to psychosocial stress. Therefore, we mixed unfamiliar pigs with different levels of aggressiveness. We separated castrated m...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-15-967
更新日期:2014-11-08 00:00:00
abstract:BACKGROUND:The Ion Torrent PGM is a popular benchtop sequencer that shows promise in replacing conventional Sanger sequencing as the gold standard for mutation detection. Despite the PGM's reported high accuracy in calling single nucleotide variations, it tends to generate many false positive calls in detecting inserti...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-15-516
更新日期:2014-06-24 00:00:00
abstract:BACKGROUND:Phenomics provides new technologies and platforms as a systematic phenome-genome approach. However, few studies have reported on the systematic mining of shared genetics among clinical biochemical indices based on phenomics methods, especially in China. This study aimed to apply phenomics to systematically e...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6363-0
更新日期:2019-12-16 00:00:00
abstract:BACKGROUND:As consumers continue to request food products that have health advantages, it will be important for the livestock industry to supply a product that meet these demands. One such nutrient is fatty acids, which have been implicated as playing a role in cardiovascular disease. Therefore, the objective of this s...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-14-730
更新日期:2013-10-25 00:00:00
abstract:BACKGROUND:Phenylalanine ammonia lyase (PAL) is a key enzyme of the phenylpropanoid pathway that catalyzes the deamination of phenylalanine to trans-cinnamic acid, a precursor for the lignin and flavonoid biosynthetic pathways. To date, PAL genes have been less extensively studied in gymnosperms than in angiosperms. Ou...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-13-S3-S1
更新日期:2012-06-11 00:00:00
abstract:BACKGROUND:Intragenic tandem repeats occur throughout all domains of life and impart functional and structural variability to diverse translation products. Repeat proteins confer distinctive surface phenotypes to many unicellular organisms, including those with minimal genomes such as the wall-less bacterial monoderms,...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-430
更新日期:2010-07-13 00:00:00
abstract:BACKGROUND:It has been shown that nearly a quarter of the initial predicted gene models in the Plasmodium falciparum genome contain errors. Although there have been efforts to obtain complete cDNA sequences to correct the errors, the coverage of cDNA sequences on the predicted genes is still incomplete, and many gene m...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-587
更新日期:2011-11-30 00:00:00
abstract:BACKGROUND:Teleost intestine is crucial for seawater acclimation by sensing osmolality of imbibed seawater and regulating drinking and water/ion absorption. Regulatory genes for transforming intestinal function have not been identified. A transcriptomic approach was used to search for such genes in the intestine of eur...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-15-1134
更新日期:2014-12-18 00:00:00
abstract:BACKGROUND:Arsenic (As) exposure is a significant worldwide environmental health concern. Low dose, chronic arsenic exposure has been associated with a higher than normal risk of skin, lung, and bladder cancer, as well as cardiovascular disease and diabetes. While arsenic-induced biological changes play a role in disea...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1295-9
更新日期:2015-03-19 00:00:00
abstract:BACKGROUND:Elucidating gut microbiota among gallstone patients as well as the complex bacterial colonization of cholesterol gallstones may help in both the prediction and subsequent lowered risk of cholelithiasis. To this end, we studied the composition of bacterial communities of gut, bile, and gallstones from 29 gall...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-14-669
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:The freshwater snail Lymnaea stagnalis (L. stagnalis) has served as a successful model for studies in the field of Neuroscience. However, a serious drawback in the molecular analysis of the nervous system of L. stagnalis has been the lack of large-scale genomic or neuronal transcriptome information, thereby ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-451
更新日期:2009-09-23 00:00:00
abstract:BACKGROUND:The transcriptome and its regulation bridge the genome and the phenome. Recent RNA-seq studies unveiled complex transcriptomes with previously unknown transcripts and functions. To investigate the characteristics of neural transcriptomes and possible functions of previously unknown transcripts, we analyzed a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-494
更新日期:2011-10-10 00:00:00
abstract:BACKGROUND:Ammopiptanthus mongolicus (Maxim. ex Kom.) Cheng f., an evergreen broadleaf legume shrub, is distributed in Mid-Asia where the temperature can be as low as -30°C during the winter. Although A. mongolicus is an ideal model to study the plant response to cold stress, insufficient genomic resources for this spe...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-14-488
更新日期:2013-07-18 00:00:00
abstract:BACKGROUND:The Per-Arnt-Sim (PAS) domain represents a ubiquitous structural fold that is involved in bacterial sensing and adaptation systems, including several virulence related functions. Although PAS domains and the subclass of PhoQ-DcuS-CitA (PDC) domains have a common structure, there is limited amino acid sequenc...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-14-524
更新日期:2013-07-31 00:00:00
abstract:BACKGROUND:Brown planthopper (BPH), Nilaparvata lugens Stål, is one of the most destructive insect pests of rice. The molecular responses of plants to sucking insects resemble responses to pathogen infection. However, the molecular mechanism of BPH-resistance in rice remains unclear. Transcription factors (TF) are up-s...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-13-687
更新日期:2012-12-10 00:00:00
abstract:MOTIVATION:Deciphering gene interaction networks (GINs) from time-course gene expression (TCGx) data is highly valuable to understand gene behaviors (e.g., activation, inhibition, time-lagged causality) at the system level. Existing methods usually use a global or local proximity measure to infer GINs from a single dat...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-16-S12-S4
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Intensive selection has resulted in increased growth rates and muscularity in broiler chickens, in addition to adverse effects, including delayed organ development, sudden death syndrome, and altered metabolic rates. The biological mechanisms underlying selection responses remain largely unknown. Non-artific...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3845-9
更新日期:2017-06-20 00:00:00
abstract:BACKGROUND:Helicobacter pylori is presumed to be co-evolved with its human host and is a highly diverse gastric pathogen at genetic levels. Ancient origins of H. pylori in the New World are still debatable. It is not clear how different waves of human migrations in South America contributed to the evolution of strain d...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-7-191
更新日期:2006-07-27 00:00:00
abstract:BACKGROUND:Descriptive hierarchical Poisson models and population-genetic coalescent mixture models are used to describe the observed variation in single-nucleotide polymorphism (SNP) density from samples of size two across the human genome. RESULTS:Using empirical estimates of recombination rate across the human geno...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-8-146
更新日期:2007-06-06 00:00:00
abstract:BACKGROUND:Endogenous α-synuclein (α-Syn) is involved in many pathophysiological processes in the secondary injury stage after acute spinal cord injury (SCI), and the mechanism governing these functions has not been thoroughly elucidated to date. This research aims to characterize the effect of α-Syn knockdown on trans...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-019-6244-6
更新日期:2019-11-14 00:00:00
abstract:BACKGROUND:The pond snail Lymnaea stagnalis (L. stagnalis) has been widely used as a model organism in neurobiology, ecotoxicology, and parasitology due to the relative simplicity of its central nervous system (CNS). However, its usefulness is restricted by a limited availability of transcriptome data. While sequence i...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07287-2
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Insect mitochondrial genomes (mitogenomes) are the most extensively used genetic marker for evolutionary and population genetics studies of insects. The Pentatomoidea superfamily is economically important and the largest superfamily within Pentatomomorpha with over 7,000 species. To better understand the div...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1679-x
更新日期:2015-06-16 00:00:00
abstract:BACKGROUND:Compromised intestinal barrier (CIB) has been associated with many enteropathies, including colorectal cancer (CRC) and inflammatory bowel disease (IBD). We hypothesized that CIB could lead to increased host-derived contents including epithelial cells into the gut, change its physio-metabolic properties, and...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-6749-z
更新日期:2020-05-11 00:00:00
abstract::In 2009 the International Society for Computational Biology (ISCB) started to roll out regional bioinformatics conferences in Africa, Latin America and Asia. The open and competitive bid for the first meeting in Asia (ISCB-Asia) was awarded to Asia-Pacific Bioinformatics Network (APBioNet) which has been running the I...
journal_title:BMC genomics
pub_type:
doi:10.1186/1471-2164-12-S3-S1
更新日期:2011-11-30 00:00:00