Abstract：
:Ovarian tumors of low malignant potential (LMP) appear to be intermediate between adenomas and ovarian carcinomas. Such tumors are often associated with a significantly better prognosis than for ovarian carcinomas. However, a subset of LMPs can progress and become lethal even in patients with early-stage disease. In order to seek sensitive diagnostic tools to monitor patients after surgical therapy, we performed a genome-wide scan for LOH in 37 early-stage mucinous LMPs using 91 polymorphic microsatellite markers at an average interval of 50 cM across all of the human chromosomes and 25 LOH markers reported to be associated with ovarian carcinoma. Fractional allelic loss (FAL) values were calculated as (loci scored with LOH)/(total informative loci) for each sample. With respect to tumor recurrence, high FAL values were more frequent in recurrent tumors than in non-recurrent tumors. Using the screening markers, FAL values for recurrent tumors were significantly higher than for non-recurrent tumors (19.8% vs 6.3%, respectively, p < 0.0001). Similar results were obtained using the hotspot markers (22.2% vs 7.1%, respectively, p < 0.0001). A significant correlation between FAL values obtained using screening markers and those based on hotspot markers was observed (R = 0.460, p = 0.003). Our findings suggest that a specific type of genetic instability (i.e., chromosomal instability, CIN) may exist in mucinous LMPs, and that this instability may indicate tumors with an aggressive biological nature. Therefore, FAL values may represent a new biomarker for risk prediction in early-stage mucinous LMP tumors.
journal_name
Eur J Gynaecol Oncoljournal_title
European journal of gynaecological oncologyauthors
Nakayama K,Nakayama N,Ishibashi M,Yeasmin S,Fukumoto M,Miyazaki Ksubject
Has Abstractpub_date
2009-01-01 00:00:00pages
16-9issue
1eissn
0392-2936issn
2709-0086journal_volume
30pub_type
杂志文章abstract：:Solitary carcinomatous metastases to the spleen are rare. The reports of such cases in the literature usually concern late stages of the disease, with generalized carcinomatosis and metastatic foci in several other organs. Primary tumors that most often metastasize to the spleen are carcinomata of the breast, lung and...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：PURPOSE OF INVESTIGATION:To determine the expression of matrix metalloproteinase-9 (MMP-9) expression in malignant and borderline ovarian tumors and its correlation to prognosis. METHODS:Forty-five patients with primary epithelial ovarian tumors were enrolled in this retrospective study from 1988 to 2002. Only maligna...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:With the three modalities of cancer treatment, surgery, radio- and chemo-therapy, even when applied in optimal conditions, over 50% of patients remain incurable because of metastatic disease. Hence the importance of preventive methods of approach to cancer. Host human tumors arise in renewing cell populations, while o...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:402 radical hysterectomies (17 ultraradical) were performed with lymphadenectomy. Positive metastatic nodes (N+) rate was 23.6% with an arithmetic mean of 22 excised lymph nodes. Single N+ belonged mostly to the obturatory group, double N+ to obturatory and external iliac groups, while multiple N+ (24 cases) had no pa...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVE:The purpose of this work is to investigate the feasibility of acoustic radiation force impulse (ARFI) technology in the normal mammary parenchyma and in breast lesions. MATERIALS AND METHODS:The virtual touch tissue quantification (VTQ) value was measured on a total of 150 cases in the normal mammary parench...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:The role of a number of parameters was evaluated in 172 patients with advanced ovarian tumors. The clinical stage appears to be one of the most important of these parameters. Thus 3 years survival of patients in stage II was 40% whereas of those in stage IV only 5%. Granulosa cell tumors and mucinous cystadenocarcinom...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Forty-seven women affected by Stage Ic-IV epithelial carcinoma of the ovary were treated with the combination of cisplatin, adriamycin (40-50 mg/m2 day 1), and cyclophosphamide (800 mg/m2 day 1) (CAP). Two different schedules of cisplatin were used: 20 mg/m2 day 1-->5 (CAP 5), or 80 mg/m2 on day 1 (CAP 1). In the grou...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:To assess the diagnostic performance of forkhead box protein 3 (FoxP3) mRNA in ovarian tumors. MATERIALS AND METHODS:Using quantitative real time reverse transcription PCR (q-RT-PCR), FoxP3 mRNA level was measured in fresh frozen ovarian tumors and its diagnostic performance was compared to those of preoperati...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：:2195 patients affected by endometrial carcinoma were treated at the Tbilisi and the St. Petersburg Oncological Institutes from 1968 to 1987. The incidence of different stages was respectively: I 78.8%; II 11.6%; III 9.0%; IV 0.4%. Adenocarcinoma was the histotype more frequently observed and the grade of differentiati...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,多中心研究
doi：
更新日期：1993-01-01 00:00:00
abstract：OBJECTIVE:To investigate prognostic factors in patients with recurrent cervical cancer after treatment of early-stage disease in order to identify high-risk patients who might benefit from alternative treatment strategies. STUDY DESIGN:The authors retrospectively analyzed clinical and pathology data from 130 recurrent...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：:A case of müllerian adenosarcoma with sarcomatous overgrowth in a postmenopausal 66-year-old female patient after adjuvant tamoxifen treatment for breast carcinoma is described. The patient was asymptomatic and the neoplasm was detected by pelvic sonography. The diagnosis was based on the histological findings after c...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Small cell cancers of the cervix are very rare and aggressive tumours. It is difficult to manage these tumours. They are often diagnosed in an advanced stage and their prognosis is generally poor. There are no clinical trials, due to their rarity, that would suggest optimal treatment. The present report describes a pa...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：AIM:The aim of this study was to determine the diagnostic value of thrombocytosis and high CA 125 levels in women with benign and malign adnexal masses. Thrombocytosis (platelet counts > 400 x 10(9)/l) has been identified as a poor prognostic factor in many cancers including certain gynecologic malignant tumors such as...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Cervical cancer is the most common cancer among women in South India. More than 70% of the cases present in stage IIB and IIIB and of these more than 50% fail conventional treatment. The purpose of the present study was to determine the prognostic significance of Bcl-2 and p53 expression in squamous cell carcinomas of...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:From 1965 to 1984, 105 cases of ovarian dermoid cysts have been diagnosed and treated at the First Clinic of Obstetrics and Gynecology, Catania University, Catania, Italy. The patients were aged between 9 and 70 years, with a higher frequency of dermoid cysts between 26 and 30 years (21.91%, 23 cases). In 0.95% (1 cas...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Mullerian adenosarcoma--a variant of mullerian mixed mesodermal tumor of the uterus--is typically composed of benign but sometimes mildly atypical glandular epithelial elements admixed with malignant sarcomatous stroma. This rare tumor, which accounts for only about 8% of all uterine sarcomas, usually originates in th...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：:Nowadays new sophisticated techniques of molecular biology based on the principles of hybridization between nucleic acids, allow a correct diagnosis of genital HPV infection. In the present paper, beside traditional diagnostic methods, we used In Situ Hybridization (ISH) and Polymerase Chain Reaction (PCR) to detect t...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Patients with advanced ovarian cancer have a chance of less than 50% after radical debulking surgery. In spite of the currently more effective combination chemotherapy agents that have become available as adjuvant therapy in the last decade, the prognosis of patients with residual tumor mass larger than 1 cm in diamet...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
abstract：PURPOSE:To compare physician and nurse practitioner accuracy in recognizing cervical dysplasia during colposcopy. MATERIALS AND METHODS:A retrospective review was performed of cervical excisional biopsies from 2007 to 2009 performed by gynecologists and nurse practitioners in the same patient population. Cervical cone...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:This paper reviews the anatomical spread and failure patterns of surgical Stage I endometrial cancer. The controversial aspects of the optimal adjuvant treatment are presented. An attempt is made to identify the most effective management approach based on the pertinent literature data. ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：:A case of cervical cancer in a 32-year-old woman with a genotype 6 HPV genital infection that developed from a cervical low-grade SIL after a LLETZ procedure two years before is presented. This case obliges us to reconsider both the benign nature of low-grade lesions and the potentially good prognosis of low-risk HPV ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:The Authors, on the basis of the literature and their own experience, propose a diagnostic schedule for detection of breast disease based on integrated thermography, diaphanoscopy, echography and mammography. ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Ninety-two cases of primary carcinoma of the vagina treated at the Massachusetts General Hospital were reviewed from 1961 to 1981. Forty patients were found to have recurrence. Their original clinical stage, location of lesion, histologic subtype, tumor differentiation, and treatment modality were examined to predict ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Tamoxifen, a nonsteroidal antiestrogen, is used for pre- and postmenopausal patients with breast cancer. Data on a possible association of endometrial pathologies with Tamoxifen treatment have been accumulating. The current literature and our experience are presented. ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:A combined modality therapy (irradiation plus low-dose Adriamycin and Cyclophosphamide) was delivered to 41 patient affected by extensive bone diffusion from breast carcinoma. A 36% (15/41) objective response rate was obtained, no change was also detectable in 36%, while progressive disease in 28% (11/41). A subjectiv...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:A case of microcarcinoma of the vulva (depth of invasion less than 5 mm) with an unexpected natural history is reported. The 338 cases, up today, reported in literature are reviewed and therapeutical protocols discussed. ...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to collect data about the incidence of high-risk HPV (16, 18, 33) types in in situ cervical cancers, and to evaluate the reliability of the morphological signs of HPV infection by comparing the presence of these signs to the PCR-proven HPV virus infection. METHODS:Fifty patients...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Xanthogranulomas from the retroperitoneal space are rare. To our knowledge only a few cases have been reported in the literature in the retroperitoneal space. In this report, the authors present the case of a 24-year-old woman with a recurrence of this rare tumor. Two years after resection, the mass showed rapid local...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:In this study we have evaluated 301 internal mammary lymphoscintigraphies. The results were compared with the histology of internal mammary lymphoscintigraphies, lymphatic chain and axillary lymph nodes, with the anatomo-pathological stage of the disease, with primary tumor site, and also with patients survival. The i...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Sarcoma of the breast constitutes less than 1% of all malignant breast tumors and liposarcoma of the breast has an incidence of 0.3% of all the mammary sarcomas. A 90-year-old woman presented with a mass in the upper outer quadrant of the right breast measuring 25 x 15 x 7 cm. Mammography was performed and the mass wa...
journal_title：European journal of gynaecological oncology
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
