Altered DHEA and DHEAS response to exercise in healthy older adults.

Abstract:

:Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are hormones produced by the adrenal cortex that decline in concentration with age. Decreased DHEA levels are associated with age-related disease and oxidative stress but might be increased in younger adults by exercise. Studies are presented assessing the response of DHEA and DHEAS to varied-intensity exercise in older age. DHEA increased significantly in young adults (14.5 +/- 6.1 ng/ml rising to 21.1 +/- 7.5 ng/ml; p < .01), whereas DHEAS decreased significantly (2.56 +/- 1.11 microg/ml falling to 1.90 +/- 0.8 microg/ml; p < .05), after submaximal exercise. DHEA and DHEAS levels were significantly lower in older adults than in younger adults (p < .01), and there was no observed response of either hormone to exercise in older adults. Lipoprotein protein carbonylation is presented as a measure of oxidative status and significantly decreased in younger adults postexercise. Participants with higher DHEA postexercise had lower LDL protein carbonyl concentrations (Pearson's coefficient -.409, p < .05).

journal_name

J Aging Phys Act

authors

Aldred S,Rohalu M,Edwards K,Burns V

doi

10.1123/japa.17.1.77

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

77-88

issue

1

eissn

1063-8652

issn

1543-267X

journal_volume

17

pub_type

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