Abstract:
BACKGROUND:Little has been reported about the biologic effect of shock waves on human normal or pathologic tendon tissue. We hypothesized that inflammatory cytokine and MMP production would be down-regulated by shock wave stimulation. MATERIALS AND METHODS:Diseased Achilles tendon tissue and healthy flexor hallucis longus tissue were used. Shock wave treatment was applied to cultured cells at 0.17 mJ/mm(2)energy 250, 500, 1000, and 2000 times. RESULTS:A dose-dependent decrease in cell viability was noted in cells receiving 1000 and 2000 shocks (86.0 +/- 5.6%, p = 0.01 and 72.4 +/- 8.9%, p = 0.001) as compared with the normal control. Cell count in the 500-shock group increased by 23.4% as compared with the control (p = 0.05). The concentration of MMP 1, 2, and 13 was higher in diseased tenocytes as compared with normal cells (p = 0.04, all comparisons). IL-6 levels were higher in the diseased tenocytes as compared with normal tenocytes (44.10 +/- 16.72 versus 0.21 +/- 0.55 ng/ml, (p < 0.05). IL-1 levels in normal cells increased (2.24 +/- 5.02 ng/ml to 9.31 +/- 6.85 ng/ml) after shock wave treatment (p = 0.04). In diseased tenocytes, levels of MMP-1 (1.12 +/- 0.23 to 0.75 +/- 0.24 ng/ml; p = 0.04) and MMP-13 (1.43 +/- 0.11 to 0.80 +/- 0.15 ng/ml; p = 0.04) were significantly decreased after shock wave treatment. The IL-6 level in diseased tenocytes was decreased (44.10 +/- 16.72 to 14.66 +/- 9.49 ng/ml) after shock wave treatment (p = 0.04). CONCLUSION:Higher levels of MMPs and ILs were found in human tendinopathy-affected tenocytes as compared with normal cells. ESWT decreased the expression of several MMPs and ILs. CLINICAL RELEVANCE:This mechanism may play an important role in shock wave treatment of tendinopathy clinically.
journal_name
Foot Ankle Intjournal_title
Foot & ankle internationalauthors
Han SH,Lee JW,Guyton GP,Parks BG,Courneya JP,Schon LCdoi
10.3113/FAI-2009-0093subject
Has Abstractpub_date
2009-02-01 00:00:00pages
93-8issue
2eissn
1071-1007issn
1944-7876pii
50021383journal_volume
30pub_type
杂志文章abstract:BACKGROUND:We aimed to define reference lines on standard lateral ankle radiographs that could be used intraoperatively to minimize iatrogenic nerve injury risk in medial displacement calcaneal osteotomy. METHODS:Forty cadaveric specimens were used. In 20 specimens, the sural, medial plantar (MP), and lateral plantar ...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100715595696
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Hallux valgus is a multiplanar deformity of the first ray. Traditional correction methods prioritize the transverse plane, a potential factor resulting in high recurrence rates. Triplanar first tarsometatarsal (TMT) arthrodesis uses a multiplanar approach to correct hallux valgus in all 3 anatomical planes a...
journal_title:Foot & ankle international
pub_type: 杂志文章,多中心研究
doi:10.1177/1071100719847700
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Retrospective assessment of preoperative status is common in nonprospective study designs. The aim of this study was to test the hypothesis that prospective and retrospective evaluations of the preoperative patient condition in hallux surgery gives equal results and therefore can be used interchangeably. ME...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070502601211
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Squamous cell carcinoma arising from chronic osteomyelitis is uncommon, and although most occur in the lower extremities, occurrence in the foot and ankle is rare. METHODS:Between February, 1991, and May, 2003, we treated 14 patients (13 men and one woman) with squamous cell carcinomas arising in chronic os...
journal_title:Foot & ankle international
pub_type: 杂志文章,评审
doi:10.1177/107110070402501109
更新日期:2004-11-01 00:00:00
abstract::The use of locking plate technology in foot and ankle surgery has increased over the last decade. Reported applications include fracture repair, deformity correction, and arthrodesis. There is limited evidence, however, to guide clinicians with regard to the appropriate and optimal use of this technology. This work ai...
journal_title:Foot & ankle international
pub_type: 杂志文章,评审
doi:10.1177/1071100714523274
更新日期:2014-05-01 00:00:00
abstract::We conducted magnetic resonance imaging of the posterior tibial (PT) and flexor digitorum longus (FDL) muscle bellies in 12 patients undergoing surgical treatment for unilateral posterior tibial tendon (PTT) dysfunction. All patients had atrophy of the PT muscle compared to the normal leg (mean 10.7%, p = 0.008). In t...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070302400409
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Highly comminuted pilon fractures, especially with a compromised soft tissue envelope, present a challenging treatment scenario. This study presents our results for patients managed with ankle fusion rather than ORIF. MATERIALS AND METHODS:Fourteen patients with ankle joint incongruence after non-reconstruc...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.3113/FAI.2008.0914
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abstract:BACKGROUND:A proximal spherical metatarsal osteotomy was devised to correct not only varus deviation of the first metatarsal, but also dorsiflexion. We expected to increase the medial longitudinal arch by adding plantar flexion at the osteotomy site. To investigate the limitations of this procedure for feet with severe...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.3113/FAI.2008.1025
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Tibiotalocalcaneal (TTC) arthrodesis is a proven solution for severe hindfoot arthropathy that reestablishes stability for plantigrade gait and alleviates pain, while correcting deformity. Intramedullary nailing is an effective option for fixation. The aim of this study was to determine clinical outcome, ana...
journal_title:Foot & ankle international
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abstract:BACKGROUND:The purpose of this study was to review consecutive fifth metatarsal fractures in the author's (KFK) practice from August, 1999, to November, 2003. METHODS:During this period 64 patients (66 fractures; 35 tuberosity fractures, 10 Jones fractures, three stress fractures, two segmental shaft fractures and 16 ...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070502600907
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abstract::An approach to the treatment of dorsal foot pain of neuroma origin is described based upon principals demonstrated to be effective in the treatment of upper extremity dorsoradial neuromas: translocation of the appropriate nerves into a muscle environment away from the joint. In the lower extremity, this requires ident...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110079801900506
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:The incidence and potential life-threatening complications of thromboembolic disease after major orthopaedic surgery has been extensively studied. However, there are two studies pertaining to the incidence of thromboembolic disease after foot and ankle surgery, the findings of which suggest that the incidenc...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070602700907
更新日期:2006-09-01 00:00:00
abstract::Three-phase bone scintigraphy diagnosis of Lisfranc injury in a patient after foot trauma is discussed. Early diagnosis of Lisfranc joint injury is frequently missed and radionuclide bone scintigraphy may show a specific pattern where the x-rays are inconclusive. ...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110079501601107
更新日期:1995-11-01 00:00:00
abstract::We hypothesized that the posterior-to-anterior (PA) calcaneal interlocking screw of the Biomet Ankle Arthrodesis Nail would increase rotational stability secondary to increased bone purchase compared with the standard lateral-to-medial (transverse) screw. Each of 10 fresh human cadaver lower limbs (five matched pairs)...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070102200908
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Bone marrow edema syndrome (BMOS) is a phenomenon primarily affecting the lower extremity. It is characterized by a sudden onset of pain and an ill-defined osseous hyperintense signal in magnetic resonance imaging. The main cause of BMOS is still largely unknown. Its pathophysiology is presumably multifactor...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100717697427
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Dorsal pain from osteoarthritic midfoot joints is thought to be relayed by branches of the medial and lateral plantar, sural, saphenous, and deep peroneal nerves (DPN). However, there is no consensus on the actual number or pathways of the nervous branches for midfoot joint capsular innervation. This study e...
journal_title:Foot & ankle international
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更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:There is limited consensus on the optimal operative technique for correcting heel varus in patients with Charcot-Marie-Tooth (CMT) disease. This comparative study evaluated the ability of 4 lateralizing calcaneal osteotomies, with and without Dwyer wedge resection and coronal rotation of the posterior tubero...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100718781572
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abstract:BACKGROUND:The superficial peroneal nerve (SPN) and its branches are at risk during surgical exposures. Our study aimed to demonstrate the distribution of the SPN on the dorsum of the foot to aid in surgical procedures close to this nerve. METHODS:The SPN was dissected in 30 cadaver lower limbs (13 male and two female...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070602700609
更新日期:2006-06-01 00:00:00
abstract::Sixty-three patients (118 toes) were evaluated at an average 61 month follow-up following PIP resection arthroplasty for a fixed hammertoe deformity. The deformity involved the second toe in 35%, the third toe in 21%, the fourth toe in 24%, and the fifth toe in 20%. The involved toe averaged 2 mm. greater length than ...
journal_title:Foot & ankle international
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
abstract::The effect of a simulated leg length discrepancy on foot loading patterns and gait cycle times in normal individuals was investigated. Thirty feet of 15 normal volunteers were evaluated. Leg length discrepancy was simulated using flexible polyurethane soles. As leg length discrepancy increased, the total loading incre...
journal_title:Foot & ankle international
pub_type: 杂志文章
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abstract::This article describes a patient with a 10-year history of persistent ankle pain. Differential diagnosis included osteoid osteoma and anterior ankle impingement. This patient subsequently underwent arthroscopic excision of a lesion on the talar neck following a complete radiographic work-up, which was nondiagnostic. T...
journal_title:Foot & ankle international
pub_type: 杂志文章,评审
doi:10.1177/107110079501600409
更新日期:1995-04-01 00:00:00
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journal_title:Foot & ankle international
pub_type: 临床试验,杂志文章
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更新日期:2004-06-01 00:00:00
abstract::Arthritis of the fourth and fifth tarsometatarsal joints, recalcitrant to nonoperative treatment, presents a difficult clinical situation. As part of the lateral rays, these joints have considerable motion, making fusion a very disabling operation. Between 1990 and 1998, 12 patients, who had failed nonoperative treatm...
journal_title:Foot & ankle international
pub_type: 杂志文章
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更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:Recently, peripheral nerve blocks have increasingly been used in orthopedic surgery. The foot block is an alternative for anesthesia in cases of forefoot and midfoot operations. We propose a modification of the block technique due to potential difficulties concerning the tibial nerve. MATERIALS AND METHODS:...
journal_title:Foot & ankle international
pub_type: 临床试验,杂志文章
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更新日期:2010-07-01 00:00:00
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journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070202300909
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:The mini-invasive Mitchell-Kramer procedure is a new method of operative correction of mild to moderate hallux valgus deformity. The aim of this study was to describe the technique and evaluate the results of the procedure. METHODS:We evaluated 54 patients who underwent mini-invasive distal metatarsal osteo...
journal_title:Foot & ankle international
pub_type: 杂志文章
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abstract:BACKGROUND:Both the percutaneous technique with arthroscopic assistance, also known as arthroscopic Broström (AB), and the arthroscopic all-inside ligament repair (AI) are widely used to treat chronic lateral ankle instability. The aim of this study was to compare the clinical outcomes of these 2 arthroscopic stabilizi...
journal_title:Foot & ankle international
pub_type: 杂志文章
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abstract:BACKGROUND:Recently, it has been shown that avascular necrosis of the talus can occur in only a portion of the talar body. There is little information regarding the geographic location of the avascular segment and the clinical significance of an incomplete avascular process. METHODS:Seven patients with partial avascul...
journal_title:Foot & ankle international
pub_type: 杂志文章
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abstract:BACKGROUND:Treatment options for plantar fasciitis have resulted in varied patient outcomes. The aim of this study was to compare a novel treatment, cryopreserved human amniotic membrane (c-hAM), to a traditional treatment, corticosteroid. Our hypothesis was that c-hAM would be safe and comparable to corticosteroids fo...
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:It is still unknown how ankle range of motion changes following total ankle arthroplasty. This study was undertaken to more accurately address patient expectations, guide postoperative rehabilitation, and improve our understanding of how ankle range of motion changes with time. METHODS:119 total ankle repla...
journal_title:Foot & ankle international
pub_type: 杂志文章
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