当前位置： SCI文献检索 > EUROPEAN JOURNAL OF RADIOLOGY期刊下所有文献 > In vivo quantification of intracerebral GABA by single-voxel (1)H-MRS-How reproducible are the results?

In vivo quantification of intracerebral GABA by single-voxel (1)H-MRS-How reproducible are the results?

Abstract：

:Gamma aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the human brain. It plays a decisive role in a variety of nervous system disorders, such as anxiety disorders, epilepsy, schizophrenia, insomnia, and many others. The reproducibility of GABA quantification results obtained with a single-voxel spectroscopy J-difference editing sequence with Point Resolved Spectroscopy localization (MEGA-PRESS) was determined on a 3.0 Tesla MR scanner in healthy adults. Eleven volunteers were measured in long- and short-term intervals. Intra- and inter-subject reproducibility were evaluated. Internal referencing of GABA+ to total creatine (tCr) and water (H(2)O), as well as two different post-processing methods for the evaluation (signal integration and time-domain fitting) were compared. In all subjects lower coefficient of variation and therefore higher reproducibility can be observed for fitting compared to integration. The GABA+/tCr ratio performs better than the GABA+/H(2)O ratio or GABA+ without internal referencing for both fitting and integration (GABA+/tCr: 13.3% and 17.0%; GABA+/H(2)O: 15.0% and 17.8%; GABA+: 19.2% and 21.7%). Four-day measurements on three subjects showed higher intra- than inter-subject reproducibility (GABA+/tCr approximately 10-12%). With a coefficient of variation of about 13% for inter-subject and 10-12% for intra-subject variability of GABA+/tCr, this technique seems to be a precise tool that can detect GABA confidently. The results of this study show the reproducibility limitations of GABA quantification in vivo, which are necessary for further clinical studies.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Bogner W,Gruber S,Doelken M,Stadlbauer A,Ganslandt O,Boettcher U,Trattnig S,Doerfler A,Stefan H,Hammen T

doi

10.1016/j.ejrad.2009.01.014

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

526-31

issue

3

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(09)00009-6

journal_volume

73

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF RADIOLOGY文献大全
  • Quantitative computed tomography measurements to evaluate airway disease in chronic obstructive pulmonary disease: Relationship to physiological measurements, clinical index and visual assessment of airway disease.

    abstract：PURPOSE:To correlate currently available quantitative CT measurements for airway disease with physiological indices and the body-mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS:This study was approved by o...

    journal_title：European journal of radiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejrad.2016.09.010

    authors： Nambu A,Zach J,Schroeder J,Jin G,Kim SS,Kim YI,Schnell C,Bowler R,Lynch DA

    更新日期：2016-11-01 00:00:00

  • CT-based quantification of bone stock in large head metal-on-metal unilateral total hip replacements.

    abstract：PURPOSE:To explore ipsilateral and contralateral acetabular roof bone stock density in unilateral large head MoM THA whether there is a significant lower acetabular bone stock in the hip with a metal-on-metal (MoM) total hip replacement compared to the contralateral side. Second part of this study is to examine if ther...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2016.01.019

    authors： Boomsma MF,Slouwerhof I,van Lingen C,Pakvis DF,van Dalen JA,Edens MA,Ettema HB,Verheyen CC,Maas M

    更新日期：2016-04-01 00:00:00

  • Generalized subtraction methods in digital mammography.

    abstract：:Digital mammography can greatly facilitate new applications, with the potential of further improving early diagnosis of breast cancer. Indeed, early manifestations of breast cancer are often very subtle and are displayed on the variable pattern of normal anatomy that may either obscure or simulate disease. This is par...

    journal_title：European journal of radiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejrad.2008.07.032

    authors： Taibi A

    更新日期：2009-12-01 00:00:00

  • Volumetric response classification in metastatic solid tumors on MSCT: initial results in a whole-body setting.

    abstract：PURPOSE:To examine technical parameters of measurement accuracy and differences in tumor response classification using RECIST 1.1 and volumetric assessment in three common metastasis types (lung nodules, liver lesions, lymph node metastasis) simultaneously. MATERIALS AND METHODS:56 consecutive patients (32 female) age...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2013.05.030

    authors： Wulff AM,Fabel M,Freitag-Wolf S,Tepper M,Knabe HM,Schäfer JP,Jansen O,Bolte H

    更新日期：2013-10-01 00:00:00

  • Is CT-based cinematic rendering superior to volume rendering technique in the preoperative evaluation of multifragmentary intraarticular lower extremity fractures?

    abstract：PURPOSE:Cinematic rendering (CR), a recently launched, FDA-approved rendering technique converts CT image datasets into nearly photorealistic 3D reconstructions by using a unique lighting model. The purpose of this study was to compare CR to volume rendering technique (VRT) images in the preoperative visualization of m...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2020.108911

    authors： Wollschlaeger LM,Boos J,Jungbluth P,Grassmann JP,Schleich C,Latz D,Kroepil P,Antoch G,Windolf J,Schaarschmidt BM

    更新日期：2020-05-01 00:00:00

  • Optimizing digital radiography of children.

    abstract：:Pediatric projection imaging differs from imaging of the adult patient. Children are smaller, more radiosensitive, and less compliant than their adult counterparts. Their characteristics affect the way projection imaging is practiced and how dose is optimized. Computed radiography (CR) and digital radiography (DR) hav...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2009.03.003

    authors： Willis CE

    更新日期：2009-11-01 00:00:00

  • Gastric gastrointestinal stromal tumours (2-5 cm): Correlation of CT features with malignancy and differential diagnosis.

    abstract：PURPOSE:The purpose of this study was to investigate the computed tomography (CT) features of 2-5 cm gastric gastrointestinal stromal tumors (GISTs), schwannomas and leimyomas which have close relationship with malignancy evaluation and differential diagnosis. METHOD:Seventy-six patients with pathologically confirmed ...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2019.108783

    authors： Chen Z,Yang J,Sun J,Wang P

    更新日期：2020-02-01 00:00:00

  • Mesenchymal hamartoma of the liver in infant: its roentgen diagnosis.

    abstract：:A case of mesenchymal hamartoma of the liver in an 18-month-old boy is reported. CT and US revealed a large, cystic tumour surrounded by a thick wall. In the lower portion of the tumour, a small solid component was recognized on CT. Angiography revealed marked arterial displacement, fine tumour vessels and a large rad...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：

    authors： Egawa T,Kuroda C,Yoshioka H,Hori S,Tokunaga K,Fukui Y,Ikeda Y,Okada A,Sakurai M

    更新日期：1983-11-01 00:00:00

  • Factors affecting the rate of false positive marks in CAD in full-field digital mammography.

    abstract：OBJECTIVE:To assess the effect of breast density, fibroglandular tissue volume, and breast volume on the rate of false-positive marks of a computer-assisted detection software in digital mammography. MATERIALS AND METHODS:222 patients with normal digital mammograms and a minimum follow-up of 22 months were retrospecti...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2012.02.017

    authors： Engelken F,Bremme R,Bick U,Hammann-Kloss S,Fallenberg EM

    更新日期：2012-08-01 00:00:00

  • The future of radiology augmented with Artificial Intelligence: A strategy for success.

    abstract：:The rapid development of Artificial Intelligence/deep learning technology and its implementation into routine clinical imaging will cause a major transformation to the practice of radiology. Strategic positioning will ensure the successful transition of radiologists into their new roles as augmented clinicians. This p...

    journal_title：European journal of radiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejrad.2018.03.019

    authors： Liew C

    更新日期：2018-05-01 00:00:00

  • Amide proton transfer (APT) imaging of parotid tumors: Differentiation of malignant and benign tumors.

    abstract：PURPOSE:To assess the usefulness of amide proton transfer (APT) imaging in differentiating parotid tumors. MATERIAL AND METHODS:We retrospectively analyzed 43 histopathologically proven parotid solid tumors with diameters ≥2 cm. Twenty-one tumors were benign and 12 tumors were malignant. Two-dimensional APT imaging wa...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2020.109047

    authors： Kamitani T,Sagiyama K,Togao O,Yamasaki Y,Hida T,Matsuura Y,Murayama Y,Yasumatsu R,Yamamoto H,Yabuuchi H

    更新日期：2020-08-01 00:00:00

  • Could computed tomography be used as a surrogate of endoscopic ultrasonography in the screening and surveillance of small gastric Gastrointestinal stromal tumors?

    abstract：PURPOSE:To investigate whether computed tomography (CT) could be used for screening and surveillance of small gastric gastrointestinal stromal tumors (gGISTs). METHOD:A total of 162 pathologically confirmed small gGISTs (≤2 cm) between September 2007 and November 2019 were retrospectively enrolled. Thirty-six lesions ...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2020.109463

    authors： Jia X,Liu Y,Zhao J,Ji W,Tang L,Gao Z,Zhang L,Zhang Y,Li J,Hong N,Wang Y,Sun Y

    更新日期：2021-02-01 00:00:00

  • Imaging of IgG4-related disease in the extracranial head and neck.

    abstract：PURPOSE:Immunoglobulin G4-related disease (IgG4-RD) is a newly defined fibro-inflammatory multisystemic condition defined by a triad of diagnostic criteria based on clinical presentation, biochemical and histopathological findings. Whereas some subsites of this disease have been well described in the literature so far ...

    journal_title：European journal of radiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejrad.2021.109560

    authors： Dragan AD,Weller A,Lingam RK

    更新日期：2021-01-27 00:00:00

  • Virtual non-enhanced dual-energy CT reconstruction may replace true non-enhanced CT scans in the setting of suspected active hemorrhage.

    abstract：OBJECTIVE:To assess virtual non-enhanced dual energy computed tomography (DECT) reconstruction as a potential alternative to true non-enhanced thoracic and abdominal CT scans in patients with suspected active hemorrhage. METHODS AND MATERIALS:Ninety-seven consecutive patients with suspected active bleeding, who underw...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2018.10.026

    authors： Walter SS,Schneeweiß S,Maurer M,Kraus MS,Wichmann JL,Bongers MN,Lescan M,Bamberg F,Othman AE

    更新日期：2018-12-01 00:00:00

  • Renal cell carcinoma: Associations between tumor imaging features and epidemiological risk factors.

    abstract：PURPOSE:To investigate associations between imaging features of tumors and age, gender and body mass index (BMI) in patients with renal cell carcinoma. METHOD:This IRB-approved, HIPAA-compliant study included 1348 patients with histopathologically confirmed renal cell carcinoma of the clear cell subtype (ccRCC, n = 90...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2020.109096

    authors： Hötker AM,Karlo CA,Di Paolo PL,Zheng J,Moskowitz CS,Russo P,Hricak H,Akin O

    更新日期：2020-08-01 00:00:00

  • Radiology of aortic dissection: pitfalls in diagnosis.

    abstract：:The diagnosis of aortic dissection can be made with certainty when computed tomography or aortography reveals two lumina and a intimal flap between them. If the false lumen is thrombosed, the differential diagnosis between dissection and aneurysm with intraluminal thrombus is difficult. High resolution computed tomogr...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：

    authors： Hekali P,Velt P,Gutierrez O,Töttemann S,Måre K

    更新日期：1986-11-01 00:00:00

  • Impact of butylscopolamine on image quality of magnetic resonance cholangiopancreatography.

    abstract：PURPOSE:To assess the effect of parenteral butylscopolamine on magnetic resonance cholangiopancreatography (MRCP) image quality. MATERIALS AND METHODS:The 3D free-breathing respiratory-compensated MRCP images (mean acquisition time 7min) of 94 consecutive non-paired patients (47 with and 47 without 20mg intramuscular ...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2012.11.023

    authors： Venkatanarasimha N,Jenkins SJ,Yang N,Colak E,Kirpalani A

    更新日期：2013-04-01 00:00:00

  • Mesenteric findings of CT enterography are well correlated with the endoscopic severity of Crohn's disease.

    abstract：BACKGROUND:Maintenance of mucosal healing is a primary goal when treating Crohn's disease (CD). Endoscopy is the most precise method for the assessment of mucosal healing, but is considered overly invasive for patients with CD. In contrast, CT enterography (CTE) is less invasive, but little is known about the correlati...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2016.10.022

    authors： Sakurai T,Katsuno T,Saito K,Yoshihama S,Nakagawa T,Koseki H,Taida T,Ishigami H,Okimoto KI,Maruoka D,Matsumura T,Arai M,Yokosuka O

    更新日期：2017-04-01 00:00:00

  • Demonstrating the effect of theophylline treatment on diaphragmatic movement in chronic obstructive pulmonary disease patients by MR-fluoroscopy.

    abstract：INTRODUCTION:The purpose of this study was to determine the increase in diaphragmatic excursion of patients with chronic obstructive pulmonary disease (COPD) treated with theophylline by MR-fluoroscopy which is an innovative method to demonstrate effectiveness of this treatment. MATERIALS AND METHODS:Investigations we...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/S0720-048X(03)00210-9

    authors： Etlik O,Sakarya ME,Uzun K,Harman M,Temizoz O,Durmus A

    更新日期：2004-08-01 00:00:00

  • Multimodal imaging in cerebral gliomas and its neuropathological correlation.

    abstract：INTRODUCTION:Concerning the preoperative clinical diagnostic work-up of glioma patients, tumor heterogeneity challenges the oncological therapy. The current study assesses the performance of a multimodal imaging approach to differentiate between areas in malignant gliomas and to investigate the extent to which such a c...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2014.02.006

    authors： Gempt J,Soehngen E,Förster S,Ryang YM,Schlegel J,Zimmer C,Meyer B,Ringel F,Grams AE,Förschler A

    更新日期：2014-05-01 00:00:00

  • Sonographic determination of normal spleen size in an adult African population.

    abstract：OBJECTIVE:The purpose of this study was to determine the normal range of spleen size in an adult African population, and compare the findings to published data to determine any correlation with ethnicity. MATERIALS AND METHODS:Three hundred and seventy-four African adults without conditions that can affect the spleen ...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2009.09.025

    authors： Mustapha Z,Tahir A,Tukur M,Bukar M,Lee WK

    更新日期：2010-07-01 00:00:00

  • Ultrafine needle CO2 splenoportography: a comparative investigation with transarterial portography and MR portography.

    abstract：PURPOSE:To evaluate the safety and quality of CO2 splenoportography (CO2-SP) by comparison to 3-dimensional dynamic contrast-enhanced magnetic resonance portography (3D-DCE-MRP) and transarterial portography (TAP). MATERIALS AND METHODS:CO2-SP, 3D-DCE-MRP and TAP were performed within 3 days in 35 patients. CO2-SP was...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2006.03.006

    authors： Teng GJ,Deng G,Liu ZS,Fang W,Zhu GY,Li GZ,Guo JH,He SC,Dong YH

    更新日期：2006-09-01 00:00:00

  • Validation and absolute quantification of MR perfusion compared with CT perfusion in patients with unilateral cerebral arterial stenosis.

    abstract：OBJECTIVE:The aim of the study was to assess absolute quantification of dynamic susceptibility contrast-enhanced magnetic resonance perfusion (MRP) comparing with computed tomography perfusion (CTP) in patients with unilateral stenosis. MATERIALS AND METHODS:We retrospectively post-processed MRP in 20 patients with un...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2012.07.018

    authors： Chiu FY,Kao YH,Teng MM,Chung HW,Chang FC,Cho IC,Chen WC

    更新日期：2012-12-01 00:00:00

  • Retrieval of intravascular foreign bodies with goose neck snare.

    abstract：PURPOSE:to evaluate the efficacy and advantages of the snare systems in the retrieval of foreign bodies from vascular system. MATERIALS AND METHODS:the snare technique has been used for intravascular foreign body retrieval. We performed percutaneous extraction of intravascular foreign bodies using combination multipur...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/S0720-048X(03)00078-0

    authors： Koseoglu K,Parildar M,Oran I,Memis A

    更新日期：2004-03-01 00:00:00

  • Observer agreement in the reporting of knee and lumbar spine magnetic resonance (MR) imaging examinations: selectively trained MR radiographers and consultant radiologists compared with an index radiologist.

    abstract：PURPOSE:To assess agreement between trained radiographers and consultant radiologists compared with an index radiologist when reporting on magnetic resonance imaging (MRI) examinations of the knee and lumbar spine and to examine the subsequent effect of discordant reports on patient management and outcome. METHODS:At ...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2013.05.024

    authors： Brealey S,Piper K,King D,Bland M,Caddick J,Campbell P,Gibbon A,Highland A,Jenkins N,Petty D,Warren D

    更新日期：2013-10-01 00:00:00

  • The regional myocardial microvascular dysfunction differences in hypertrophic cardiomyopathy patients with or without left ventricular outflow tract obstruction: assessment with first-pass perfusion imaging using 3.0-T cardiac magnetic resonance.

    abstract：PURPOSE:To assess regional myocardial microvascular dysfunction differences in hypertrophic cardiomyopathy (HCM) patients with or without left ventricular outflow tract obstruction using 3.0-T cardiac magnetic resonance (CMR) first-pass perfusion imaging. MATERIALS AND METHODS:Forty-two HCM patients, including 25 HCM ...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2014.01.008

    authors： Xu HY,Yang ZG,Sun JY,Wen LY,Zhang G,Zhang S,Guo YK

    更新日期：2014-04-01 00:00:00

  • Image guided injection therapies in athletes-Do they work and what should we be using?

    abstract：:In the modern management of the injured elite athlete, the goals of guided injection therapies have extended beyond simple reduction of pain to enhancement of tissue healing and accelerated return to competition, faster than natural healing can allow. This article will review the injection therapies which are frequent...

    journal_title：European journal of radiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ejrad.2018.12.001

    authors： Lee JC,Ahmed N,Allen GM

    更新日期：2019-01-01 00:00:00

  • Reduced perfusion in white matter lesions in multiple sclerosis.

    abstract：OBJECTIVE:To investigate dynamic susceptibility contrast (DSC) perfusion weighted imaging (PWI) in white matter lesions (WML) in patients with multiple sclerosis (MS), using automatically generated binary masks of brain tissue. BACKGROUND:WML in MS have in some studies demonstrated perfusion abnormalities compared to ...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2015.09.007

    authors： Sowa P,Bjørnerud A,Nygaard GO,Damangir S,Spulber G,Celius EG,Due-Tønnessen P,Harbo HF,Beyer MK

    更新日期：2015-12-01 00:00:00

  • Ultrasonography versus excretory urography: value in urological disease.

    abstract：:Considerable savings in cost and some reduction in gonad dose and contrast medium allergy can be expected if excretory urography can be replaced by real-time ultrasonography as the first examination in upper urinary tract disease. For one year, all patients referred for excretory urography (UG) are first examined with...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：

    authors： Aslaksen A,Göthlin JH

    更新日期：1988-08-01 00:00:00

  • Effects of respiratory manoeuvres on hepatic vein Doppler waveform and flow velocities in a healthy population.

    abstract：OBJECTIVE:This study was performed to determine the variations in Doppler waveforms and flow velocity during respiratory manoeuvres in healthy individuals with no liver disease. MATERIALS AND METHODS:In total, 100 individuals (75 women and 25 men) without known cardiac or liver disease were examined prospectively with...

    journal_title：European journal of radiology

    pub_type： 杂志文章

    doi：10.1016/j.ejrad.2010.01.011

    authors： Altinkaya N,Koc Z,Ulusan S,Demir S,Gurel K

    更新日期：2011-07-01 00:00:00