Abstract:
:Salicylate, a common drug frequently used long term in the clinic, is well known for causing reversible hearing loss and tinnitus. Our previous study, however, demonstrated that chronic administration of salicylate progressively raised the amplitude of distortion product of otoacoustic emissions (DPOAEs), which are mainly caused by (outer hair cell) OHC electromotility. How salicylate affects OHC electromotility to cause this paradoxical increase remains unclear. One possibility is that it could affect prestin, which is a motor protein that contributes to the mechano-electrical properties of OHCs. In this experiment, we assessed the effect of acute and chronic salicylate treatment on prestin expression. Interestingly, after long-term salicylate injection (200 mg/kg, twice daily for 14 days), prestin gene and protein levels were up-regulated about twofold. These levels returned to baseline 14 days after treatment stopped. Acute injection of salicylate (single injection, 400 mg/kg) did not affect prestin levels. These data reveal that chronic salicylate administration markedly, but reversibly, increased prestin levels which may contribute to the enhanced DPOAE amplitudes we observed previously with similar salicylate treatment, which may be responsible for salicylate-induced tinnitus generation.
journal_name
Int J Audioljournal_title
International journal of audiologyauthors
Yang K,Huang ZW,Liu ZQ,Xiao BK,Peng JHdoi
10.1080/14992020802327998subject
Has Abstractpub_date
2009-01-01 00:00:00pages
18-23issue
1eissn
1499-2027issn
1708-8186pii
908209336journal_volume
48pub_type
杂志文章abstract:OBJECTIVE:This study explored the psychosocial experiences of adults with hearing loss using the self-regulatory model as a theoretical framework. The primary components of the model, namely cognitive representations, emotional representations, and coping responses, were examined. DESIGN:Individual semi-structured int...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2015.1117663
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:The main purpose of this research was to obtain normative data for auditory processing tests for Norwegian speaking children. DESIGN:Participants were administered routine audiological tests and an auditory processing test-battery consisting of Filtered Words, Competing Words, Dichotic Digits, Gaps In Noise,...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992027.2017.1366670
更新日期:2018-01-01 00:00:00
abstract::Hearing-aid use in the elderly population is problematic since not all people who would benefit from hearing aids actually obtain one. In this study, the relationship between pre-fitting expectations and willingness to use hearing aids is addressed. One hundred adult hearing aid candidates (mean age 68.6 years) were r...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020701843111
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:To establish the effect of self-rated and measured functional hearing on depression, taking age and gender into account. Additionally, the study investigates if hearing-aid usage mitigates the effect, and if other physical health problems and social engagement confound it. DESIGN:Cross-sectional data from th...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2015.1046503
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To introduce the Italian adaptation of the STARR test based on a roving-level adaptive method to mimic challenging real-life listening conditions for use in people with auditory prostheses. DESIGN:Normative data were collected and interlist-variability, as well as learning effects, were investigated using a...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2015.1124296
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the feasibility of conducting a randomized controlled trial (RCT) on the effect of motivational interviewing (MI) on hearing-aid use. DESIGN:This was a pilot single-blind, randomized parallel-group study conducted in the UK. STUDY SAMPLE:Thirty-seven adult patients who...
journal_title:International journal of audiology
pub_type: 杂志文章,随机对照试验
doi:10.3109/14992027.2015.1074733
更新日期:2016-01-01 00:00:00
abstract::The aim of the present study was to investigate the consequences of chronic otitis media on inner ear function. Retrospective analysis of conventional pure-tone audiometry tests was carried out on 344 patients who were scheduled for surgical treatment of unilateral chronic otitis media without other risk factors for s...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020500243737
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:To describe getting used to hearing aids from the perspective of adult hearing-aid users. DESIGN:Three focus group discussions were carried out. A topic guide and discussion exercises were used to elicit views on getting used to hearing aids. Discussion was audio recorded, transcribed verbatim, and subjected...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2014.938782
更新日期:2014-12-01 00:00:00
abstract::The purpose of this research was to investigate the congruent/incongruent perceptions of hearing-loss related quality of life between members of couples and to determine how incongruence was affected by individual psychosocial characteristics, specifically measures of mood (negative affect and positive affect), stress...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992020903311396
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to explore the use of virtual visits to monitor hearing aid use with data logging measurements and provide parent support for hearing aid management. DESIGN:A 6-month longitudinal case study design was used. STUDY SAMPLE:Four families and two providers participated. RESULTS:Av...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992027.2016.1226521
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:Word recognition is a basic component in a comprehensive hearing evaluation, but data are lacking for listeners speaking two languages. This study obtained such data for Russian natives in the US and analysed the data using the perceptual assimilation model (PAM) and speech learning model (SLM). DESIGN:Liste...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2012.680075
更新日期:2012-08-01 00:00:00
abstract::This study aimed to determine if adolescents/young adults gained additional perceptual benefit from sequential bilateral cochlear implants within 12 months, and to document adaptation to the second implant. Assessments comprised a pediatric version of The Speech, Spatial and Qualities of Hearing Scale (SSQ), anecdotal...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992020903470767
更新日期:2010-05-01 00:00:00
abstract::Tinnitus is a condition that is difficult to treat, and treatment outcomes are difficult to measure The majority of people who experience tinnitus are not troubled by it; however, the troubled minority are referred by an otorhinolaryngologist for specialist clinic help. The aim of this study was to investigate how the...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020400050052
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:Evaluation of the Sennheiser HD 202 II supra-aural headphones as an alternative headphone to enable more affordable hearing screening. DESIGN:Study 1 measured the equivalent threshold sound pressure levels (ETSPL) of the Sennheiser HD 202 II. Study 2 evaluated the attenuation of the headphones. Study 3 deter...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992027.2016.1214756
更新日期:2016-11-01 00:00:00
abstract::Objective: To assess the recognition of lexical tones in Mandarin-speaking bimodal cochlear implant (CI) subjects.Design: Lexical tone recognition in quiet and noise (SNR= +5 dB) was measured with electric stimulation (CI alone) or bimodal stimulation (CI + hearing aid (HA)). The recognition and confusion rates of the...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992027.2020.1719437
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:Evaluation of the effectiveness of imaging and genetic testing, and establishment of a cost-effective diagnostic protocol for the etiologic diagnosis of sensorineural hearing loss (SNHL) in Brazil. DESIGN:Prospective cohort study. STUDY SAMPLE:Analysis of 100 unrelated Brazilian patients with severe to prof...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2013.817689
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVE:Auditory processing disorder patients may have deficits in auditory temporal resolution. This study explored: (1) the ear specific norms for young adults using the adaptive tests of temporal resolution (ATTR); (2) the reliability of ATTR using two different modes of stimuli presentation; and (3) the concurren...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2014.952457
更新日期:2015-01-01 00:00:00
abstract::Children (n = 141) referred to 5 clinical sites for auditory processing disorder assessment were tested with two dichotic listening tests, one with word pairs and the other with pairs of digits, as part of a comprehensive diagnostic battery. Scores from the Randomized Dichotic Digits Test and the Dichotic Words Test w...
journal_title:International journal of audiology
pub_type: 杂志文章,多中心研究
doi:10.3109/14992027.2015.1128003
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Providing appropriate feedback to caregivers is an important part of the paediatric audiological assessment. This preliminary study explored caregiver recall and understanding of audiological diagnostic information subsequent to an initial paediatric diagnostic assessment. DESIGN:A qualitative study was cond...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2012.721014
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:This paper reports a consanguineous deaf family with three different mutations in the GJB2 gene. DESIGN:Four members of an Iranian deaf family were recruited in this study. The GJB2 coding region and exon-intron boundaries were investigated using direct sequencing. STUDY SAMPLE:The proposita was a 12-year-o...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2013.850748
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:This study aimed to explore the perspectives of caregivers regarding the information and support they received following diagnosis of their child's hearing loss. DESIGN:A mixed methods explanatory sequential design was conducted. STUDY SAMPLE:A total of 445 caregivers of children completed a written survey,...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992027.2017.1301683
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:The high energy demand of the auditory and visual pathways render these sensory systems prone to diseases that impair mitochondrial function. Primary open-angle glaucoma, a neurodegenerative disease of the optic nerve, has recently been associated with a spectrum of mitochondrial abnormalities. This study sou...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2011.609185
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:This study surveyed youth recreational firearm users (YRFUs) regarding shooting habits, reported use of hearing protection devices (HPDs), self-assessed auditory status, and attitudes about firearm noise and hearing loss. DESIGN:A descriptive study using a 28-item survey administered by personal interview. ...
journal_title:International journal of audiology
pub_type: 杂志文章,多中心研究
doi:10.3109/14992027.2013.857437
更新日期:2014-03-01 00:00:00
abstract::This investigation examined how age and test condition affect one's ability to comprehend discourse passages, and determined whether age and test condition affect discourse comprehension and closed-set sentence recognition in a similar way. Young and older adults were tested with closed-set sentences from the newly-cr...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020802301662
更新日期:2008-11-01 00:00:00
abstract::Objective: To clarify the distinction between Auditory Processing Disorder (APD) and Attention Deficit Disorder (ADD) using the CHC Model.Design: A cross-sectional study compared responses of caregivers about their children's behaviour to identify characteristics of APD (CHC Model) and ADD (DSM-5).Study Sample: Caregi...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992027.2019.1682199
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:Recent retrospective studies report differences in auditory neurophysiology between concussed athletes and uninjured controls using the frequency-following response (FFR). Adopting a prospective design in college football players, we compared FFRs before and after a concussion and evaluated test-retest relia...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992027.2020.1860261
更新日期:2021-01-13 00:00:00
abstract::The aim of this study was to compare auditory functions and to analyse the prevalence of hearing impairment and the relationship of self-reported hearing disability with audiometric test results among 75-year-old people in three Nordic localities. The representative samples came from Glostrup, Denmark (n = 571), Göteb...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020500189112
更新日期:2005-09-01 00:00:00
abstract::The purpose of this study was to understand the parental perspective on paediatric cochlear implantation over time. Face-to-face semi-structured interviews were conducted with 216 families of children who were implanted at the Nottingham Paediatric Cochlear Implant Programme between 1989 and 2002, and who were attendi...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992020500146500
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:An experiment was conducted to investigate the possibility that speech perception could be improved for some cochlear implant (CI) users by adjustment of the frequency allocation to the electrodes, following assessment of pitch perception along the electrode array. STUDY SAMPLE:Thirteen adult CI users with M...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.1080/14992027.2018.1516048
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To examine the effectiveness of targeted surveillance for the identification of moderate-profound PCHI in babies who pass the newborn hearing screen in England and have risk factors. DESIGN:Retrospective analysis. STUDY SAMPLE:2,307,880 children born 01/04/06-30/09/09 in England. RESULTS:Overall the preval...
journal_title:International journal of audiology
pub_type: 杂志文章
doi:10.3109/14992027.2013.769067
更新日期:2013-06-01 00:00:00