Abstract:
:The basal ganglia-thalamo-cortical circuits are viewed as segregated parallel feed back loops crucially involved in motor control, cognition, and emotional processing. Their role in planning novel, as compared to overlearned movement patterns is as yet not well defined. We tested for the involvement of the associative striatum (caudate/anterior putamen) in the generation of novel movement patterns, which is a critical cognitive requirement for non-routine motor behavior. Using event related functional MRI in 14 right-handed male subjects, we analyzed brain activity in the planning phase of four digit finger sequences. Subjects either executed a single overlearned four digit sequence (RECALL), or self-determined four digit sequences of varying order (GENERATE). In both conditions, RECALL and GENERATE, planning was associated with activation in mesial/lateral premotor cortices, motor cingulate cortex, superior parietal cortex, basal ganglia, insula, thalamus, and midbrain nuclei. When contrasting the planning phase of GENERATE with the planning phase of RECALL, there was significantly higher activation within this distributed network. At the level of the basal ganglia, the planning phase of GENERATE was associated with differentially higher activation located specifically within the associative striatum bilaterally. On the other hand, the execution phase during both conditions was associated with a shift of activity towards the posterior part of the putamen. Our data show the specific involvement of the associative striatum during the planning of non-routine movement patterns and illustrate the propagation of activity from rostral to dorsal basal ganglia sites during different stages of motor processing.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Jankowski J,Scheef L,Hüppe C,Boecker Hdoi
10.1016/j.neuroimage.2008.10.059subject
Has Abstractpub_date
2009-02-15 00:00:00pages
1369-79issue
4eissn
1053-8119issn
1095-9572pii
S1053-8119(08)01159-2journal_volume
44pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract::This paper presents the conjecture that functional integration may be mediated by the mutual induction and maintenance of stereotyped spatiotemporal patterns of activity (i.e., transients) in different neuronal populations. In contradistinction to temporal and rate coding models of neuronal interactions, transient cod...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1006/nimg.1997.0260
更新日期:1997-04-01 00:00:00
abstract::The present study examined the interaction of the central executive in working memory with visual attention. Native Chinese participants were given two versions of a number subtraction task, one of low demand and one of high demand, and were asked to ignore a simultaneously presented peripheral distractor. The distrac...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.neuroimage.2004.06.025
更新日期:2004-10-01 00:00:00
abstract::Locus Coeruleus (LC) is a neuromelanin-rich brainstem structure that is the source of noradrenaline in the cortex and is thought to modulate attention and memory. LC imaging in vivo is commonly performed with a 2D T1-weighted Turbo Spin Echo (TSE) MRI sequence, an approach that suffers from several drawbacks at 3T, in...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.07.045
更新日期:2018-03-01 00:00:00
abstract::Repetition has been shown to activate the so-called 'dorsal stream', a network of temporo-parieto-frontal areas subserving the mapping of acoustic speech input onto articulatory-motor representations. Among these areas, a region in the posterior Sylvian fissure at the temporo-parietal boundary (also called 'area Spt')...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.07.025
更新日期:2012-01-02 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) techniques, such as echo-planar imaging, can permit rapid, sensitive, whole-brain measurements of local blood flow-induced MR signal changes seen during cognitive paradigms. Changes in blood oxygenation due to mismatch of flow and oxygen metabolism cause dynamic variations ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.1997.0289
更新日期:1997-10-01 00:00:00
abstract::Neural networks that span the medial temporal lobe (MTL), prefrontal cortex, and posterior cortical regions are essential to episodic memory function in humans. Encoding and retrieval are supported by the engagement of both distinct neural pathways across the cortex and common structures within the medial temporal lob...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.03.042
更新日期:2017-07-15 00:00:00
abstract::MRI based on T1 relaxation contrast is increasingly being used to study brain morphology and myelination. Although it provides for excellent distinction between the major tissue types of gray matter, white matter, and CSF, reproducible quantification of T1 relaxation rates is difficult due to the complexity of the con...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.12.032
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:High sensation-seekers (HSS) pursue novelty even at the cost of self-harm. When challenged, HSS are less anxious, show blunted physiological (cortisol, startle) and neurobiological (prefrontal-limbic) responses, and devalue aversive outcomes. Here, we investigate how these features interact under conditions ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.08.038
更新日期:2014-12-01 00:00:00
abstract::We present an MEG/EEG framework to reveal statistically significant brain areas engaged in the same cognitive process across trials without resort to averaging procedures. The variability of neuronal responses is assumed to take place only in the reconstructed time series of cortical sources and not in their positions...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/s1053-8119(03)00221-0
更新日期:2003-09-01 00:00:00
abstract::Comparing the neural outcomes of two randomized experimental groups is a primary aim of many functional neuroimaging studies. However, between-group effects can be obscured by heterogeneity in neural responses. Optimal Combined Moderator (OCM) approaches have previously been used to clarify heterogeneity in clinical o...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2018.07.051
更新日期:2018-11-01 00:00:00
abstract::White matter hyperintensities (WMHs) are commonly seen on brain magnetic resonance imaging (MRI) scans of elderly individuals, but their functional significance remains controversial. We used perfusion-weighted MRI to determine the impact of WMHs on cortical regional cerebral blood volume (rCBV). We studied 24 elderly...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2003.11.015
更新日期:2004-04-01 00:00:00
abstract::We describe a new measure of Granger causality, componential Granger causality, and show how it can be applied to the identification of the directionality of influences between brain areas with functional neuroimaging data. Componential Granger causality measures the effect of y on x, but allows interaction effects be...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.08.047
更新日期:2012-01-16 00:00:00
abstract::We studied the functional neuroanatomy of attention to speed of motion using functional magnetic resonance imaging in eight healthy subjects, who performed a speed discrimination (SID) task using a random textured pattern moving at a reference speed of 6 deg/s. During the control condition (DIM), with retinal stimulat...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2000.0587
更新日期:2000-06-01 00:00:00
abstract::This paper describes the application of large deformation diffeomorphic metric mapping to cortical surfaces based on the shape and geometric properties of subregions of the superior temporal gyrus in the human brain. The anatomical surfaces of the cortex are represented as triangulated meshes. The diffeomorphic matchi...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.08.053
更新日期:2007-02-01 00:00:00
abstract::Understanding the neurocognitive basis of risk-taking behavior is an important issue, especially in economic decision-making. Classical behavioral studies have shown that risk-attitude changes across different contexts, but little is so far known about the brain correlates of processing of outcomes across such context...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.08.068
更新日期:2010-01-15 00:00:00
abstract::Along with meaning and form, words can be described on the basis of their grammatical properties. Grammatical gender is often used to investigate the latter as it is a grammatical property that is independent of meaning. The left inferior frontal gyrus (IFG) has been implicated in the encoding of grammatical gender, b...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.04.097
更新日期:2009-08-15 00:00:00
abstract::Alzheimer's disease (AD) is characterized by specific and progressive reductions in fluorodeoxyglucose positron emission tomography (FDG PET) measurements of the cerebral metabolic rate for glucose (CMRgl), some of which may precede the onset of symptoms. In this report, we describe twelve-month CMRgl declines in 69 p...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.02.064
更新日期:2010-06-01 00:00:00
abstract::Intraoperative Thermal Imaging (ITI) is a novel neuroimaging technique that can potentially locate the margins of primary and metastatic brain tumors. As a result, the additional real-time anatomical and pathophysiological information may significantly contribute to an improved extent of tumor resection. Our objective...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2009.03.043
更新日期:2009-08-01 00:00:00
abstract::Modern theories of drug dependence hold the hedonic effects of drug-taking central to understanding the motivation for compulsive drug use. Previous neuroimaging studies have begun to identify brain regions associated with acute drug effects after passive delivery. In this study, a more naturalistic model of cocaine s...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1016/j.neuroimage.2005.03.030
更新日期:2005-07-15 00:00:00
abstract::Functional MRI (fMRI) has previously been shown to be able to measure hundreds of milliseconds differences in timings of activities in different brain regions, even though the underlying blood oxygenation level-dependent (BOLD) response is delayed and dispersed on the order of seconds. This capability may contribute t...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.10.052
更新日期:2013-02-01 00:00:00
abstract:INTRODUCTION:Advances in image segmentation of magnetic resonance images (MRI) have demonstrated that multi-atlas approaches improve segmentation over regular atlas-based approaches. These approaches often rely on a large number of manually segmented atlases (e.g. 30-80) that take significant time and expertise to prod...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.04.054
更新日期:2014-11-01 00:00:00
abstract::The magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI) correlates of early brain development were examined in cohort of 18 very preterm neonates (27-31 gestational weeks) presenting with normal radiological findings scanned within 2weeks after birth (28-32 gestational weeks). A combination of non-li...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.02.051
更新日期:2015-05-15 00:00:00
abstract::White matter hyperintensities (WMH) are a frequent finding on brain MRI of elderly subjects, and have been associated with various risk factors, as well as with development of cognitive and functional impairment. While an overall association between WMH load and risk factors is well described, possible spatially restr...
journal_title:NeuroImage
pub_type: 杂志文章,多中心研究
doi:10.1016/j.neuroimage.2012.01.106
更新日期:2012-04-15 00:00:00
abstract::Head motion systematically distorts clinical and research MRI data. Motion artifacts have biased findings from many structural and functional brain MRI studies. An effective way to remove motion artifacts is to exclude MRI data frames affected by head motion. However, such post-hoc frame censoring can lead to data los...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.08.025
更新日期:2017-11-01 00:00:00
abstract::Temporal lobe epilepsy with hippocampus sclerosis (HS) is the most frequent focal epilepsy and often refractory to anticonvulsant therapy. Secondary structural damage has been reported in several studies of temporal lobe epilepsy and unilateral hippocampal sclerosis. Applying diffusion tensor imaging (DTI) we investig...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.03.013
更新日期:2009-07-01 00:00:00
abstract::Transcranial magnetic stimulation with a focal coil was used to map the cortical representation of a hand muscle in four healthy subjects. In each subject, the three-dimensional locations of the magnetic stimulation positions and about 400 positions on the surface of the head were digitized. The amplitude-weighted cen...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.1996.0001
更新日期:1996-02-01 00:00:00
abstract::Statistical parametric mapping (SPM) locates significant clusters based on a ratio of signal to noise (a 'contrast' of the parameters divided by its standard error) meaning that very low noise regions, for example outside the brain, can attain artefactually high statistical values. Similarly, the commonly applied prep...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.10.027
更新日期:2012-02-01 00:00:00
abstract::Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a wide phenotypic range, often affecting personality and communication. Previous voxel-based morphometry (VBM) studies of ASD have identified both gray- and white-matter volume changes. However, the cerebral cortex is a 2-D sheet with a highly folded...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.12.047
更新日期:2010-04-01 00:00:00
abstract::Hand loss can now be reversed through surgical transplantation years or decades after amputation. Remarkably, these patients come to use their new hand to skilfully grasp and manipulate objects. The brain mechanisms that make this possible are unknown. Here we test the hypothesis that the anterior intraparietal cortex...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.09.052
更新日期:2019-04-15 00:00:00
abstract::SPADE is a new acquisition scheme for fMRI based on dual echo EPI. As in previous work, additional spin echo EPI images are used to recover signal in regions that are affected by susceptibility related sensitivity loss in gradient echo EPI. However, with SPADE the additional spin echo images are only acquired for the ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2009.10.059
更新日期:2010-02-01 00:00:00