Regional distribution of tetrahydroisoquinoline derivatives in rodent, human, and Parkinson's disease brain.

abstract：:Epilepsy is a serious neurological condition exhibiting complex pathology and deserving of more serious attention. More than 30% of people with epilepsy are not responsive to more than 20 anti-epileptic drugs currently available, reflecting an unmet clinical need for novel therapeutic strategies. Not much is known abo...

journal_title：Journal of neurochemistry

authors： Paudel YN,Semple BD,Jones NC,Othman I,Shaikh MF

更新日期：2019-12-01 00:00:00

abstract：:The present experiments show that N-[3H]-methylcarbamylcholine ([3H]MCC) binds specifically and with high affinity to rat hippocampus, frontal cortex, and striatum. The highest maximal density of binding sites was apparent in frontal cortex and the lowest in hippocampus. [3H]MCC binding was potently inhibited by nicot...

journal_title：Journal of neurochemistry

authors： Araujo DM,Lapchak PA,Collier B,Quirion R

更新日期：1988-07-01 00:00:00

abstract：:The pH dependency of the binding of ligands to adenosine A2a receptors in rat striatal membranes was examined. For those agonists sensitive to adenosine deaminase a solubilised membrane preparation was used. A two- to fourfold increase in affinity was observed for CGS-21680, 5'-N-ethylcarboxamidoadenosine, adenosine, ...

journal_title：Journal of neurochemistry

authors： Askalan R,Richardson PJ

更新日期：1994-10-01 00:00:00

abstract：:By using a 125I-calmodulin overlay assay, three major high-affinity calmodulin-binding proteins, showing apparent molecular masses of 135, 60, and 50 kDa, have been detected in purified nuclear fractions isolated from rat neurons. It has been shown that after extraction of the nuclei with nucleases and high salt, all ...

journal_title：Journal of neurochemistry

authors： Pujol MJ,Bosser R,Vendrell M,Serratosa J,Bachs O

更新日期：1993-04-01 00:00:00

abstract：:Previous studies have indicated that the brains of DBA/2J (D2) mice have a more heavily myelinated CNS than those of C57BL/6J (B6) at postnatal days 17-21. However, the amount of myelin in the brains of F1 (B6 X D2) hybrids is even higher than in their parental strains. To investigate further factors involved in regul...

journal_title：Journal of neurochemistry

authors： Sato C,Yu RK

更新日期：1987-10-01 00:00:00

abstract：:The time course of the reduction in brain protein synthesis following transient bilateral ischemia in the gerbil was characterized and compared with changes in a number of metabolites related to brain energy metabolism. The recovery of brain protein synthesis was similar following ischemic periods of 5, 10, or 20 min;...

journal_title：Journal of neurochemistry

authors： Nowak TS Jr,Fried RL,Lust WD,Passonneau JV

更新日期：1985-02-01 00:00:00

abstract：:Amyloid-β peptide (Aβ) concentration in CSF is potentially a diagnostic and therapeutic target for Alzheimer's disease (AD). The purpose of this study was to clarify the elimination mechanism of human Aβ(1-40) [hAβ (1-40)] from CSF. After intracerebroventricular (ICV) administration, [(125) I]hAβ(1-40) was eliminated ...

journal_title：Journal of neurochemistry

authors： Fujiyoshi M,Tachikawa M,Ohtsuki S,Ito S,Uchida Y,Akanuma S,Kamiie J,Hashimoto T,Hosoya K,Iwatsubo T,Terasaki T

更新日期：2011-08-01 00:00:00

abstract：:Rarefaction of the dendritic tree leading to neuronal dysfunction is a hallmark of many neurodegenerative diseases and we have shown previously that heat shock protein B5 (HspB5)/αB-crystallin is able to increase dendritic complexity in vitro. The aim of this study was to investigate if this effect is also present in ...

journal_title：Journal of neurochemistry

authors： Bartelt-Kirbach B,Wiegreffe C,Birk S,Baur T,Moron M,Britsch S,Golenhofen N

更新日期：2020-11-21 00:00:00

abstract：:Overexpression of gp120, the major coat protein of the HIV-1 virus, in central glial cells, or treatment of neurons with gp120 in culture, produces apoptotic neuronal death. Here we demonstrate that CEP-1347 (KT7515), an inhibitor of mixed lineage kinase 3 (MLK3), an upstream activator of JNK, inhibits gp120IIIB-induc...

journal_title：Journal of neurochemistry

authors： Bodner A,Maroney AC,Finn JP,Ghadge G,Roos R,Miller RJ

更新日期：2002-09-01 00:00:00

abstract：:Intracerebroventricular injection of lipopolysaccharide (LPS) induces a marked increase in circulating interleukin (IL)-6 levels and in IL-6 mRNA expression in brain and peripheral organs. Recently, it was reported that intraperitoneal administration of alpha-adrenoceptor antagonists inhibits centrally injected LPS-in...

journal_title：Journal of neurochemistry

authors： Song DK,Im YB,Jung JS,Suh HW,Huh SO,Park SW,Wie MB,Kim YH

更新日期：1999-04-01 00:00:00

abstract：:Analysis of the initial rates of 45Ca2+ uptake by rat brain mitochondria in Ca2+-1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid buffers indicated that nontelencephalic mitochondria exhibited both a much less pronounced stimulatory effect of spermine and significantly more hyperbolic kinetics of Ca2+ uptake t...

journal_title：Journal of neurochemistry

authors： Jensen JR,Lynch G,Baudry M

更新日期：1989-10-01 00:00:00

abstract：:Intracranial microdialysis was used to investigate the origin of extracellular gamma-aminobutyric acid (GABA) in the ventral pallidum. Changes in basal GABA levels in response to membrane depolarizers, ion-channel blockers, and receptor agonists were determined. Antagonism of Ca2+ fluxes with high Mg2+ in a Ca(2+)-fre...

journal_title：Journal of neurochemistry

authors： Bourdelais AJ,Kalivas PW

更新日期：1992-06-01 00:00:00

abstract：:The olfactory bulb (OB) contains the highest concentration of the insulin receptor (IR) kinase in the central nervous system; however, its functional role and modulation in this region remains poorly understood. IR kinase contains a number of proline-rich motifs, making it an excellent candidate for modulation by SH(3...

journal_title：Journal of neurochemistry

authors： Marks DR,Fadool DA

更新日期：2007-11-01 00:00:00

abstract：:Transcriptional dysregulation is a hallmark of Huntington's disease (HD) and one cause of this dysregulation is enhanced activity of the REST-mSIN3a-mSIN3b-CoREST-HDAC repressor complex, which silences transcription through REST binding to the RE1/NRSE silencer. Normally, huntingtin (HTT) prevents this binding, allowi...

journal_title：Journal of neurochemistry

authors： Conforti P,Zuccato C,Gaudenzi G,Ieraci A,Camnasio S,Buckley NJ,Mutti C,Cotelli F,Contini A,Cattaneo E

更新日期：2013-10-01 00:00:00

abstract：:Rosiglitazone is a member of the thiazolidinedione family of synthetic peroxisome proliferator-activated receptor (PPAR) agonists. It is a selective ligand of the PPARgamma subtype and functions by regulating the transcription of insulin-responsive genes. A screen of FDA-approved compounds identified rosiglitazone as ...

journal_title：Journal of neurochemistry

authors： Doonan F,Wallace DM,O'Driscoll C,Cotter TG

更新日期：2009-04-01 00:00:00

abstract：:Chick imprinting behavior is a good model for the study of learning and memory. Imprinting object is recognized and processed in the visual wulst, and the memory is stored in the intermediate medial mesopallium in the dorsal pallium of the telencephalon. We identified chicken cholecystokinin (CCK)-expressing cells loc...

journal_title：Journal of neurochemistry

authors： Maekawa F,Nakamori T,Uchimura M,Fujiwara K,Yada T,Tsukahara S,Kanamatsu T,Tanaka K,Ohki-Hamazaki H

更新日期：2007-09-01 00:00:00

abstract：:Carboxymethylation and phosphorylation of protein phosphatase 2A (PP2A) catalytic C subunit are evolutionary conserved mechanisms that critically control PP2A holoenzyme assembly and substrate specificity. Down-regulation of PP2A methylation and PP2A enzymes containing the B alpha regulatory subunit occur in Alzheimer...

journal_title：Journal of neurochemistry

authors： Nunbhakdi-Craig V,Schuechner S,Sontag JM,Montgomery L,Pallas DC,Juno C,Mudrak I,Ogris E,Sontag E

更新日期：2007-05-01 00:00:00

abstract：:The present study aimed to examine the proteins involved in the methamphetamine (MA)-induced nigrostriatal dopaminergic toxicity. Infusion of anisomycin into striatum and substantia nigra both abolished the MA-induced striatal dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) depletions, indicating a critical role ...

journal_title：Journal of neurochemistry

authors： Liao PC,Kuo YM,Hsu HC,Cherng CG,Yu L

更新日期：2005-10-01 00:00:00

abstract：:Androgens affect cognitive processes in both humans and animals. The effects of androgens may be limited to certain cognitive domains, specifically spatial memory, but this hypothesis remains elusive. Here, we tested castrated and sham-operated mice in various behavioral tasks to ask whether androgens affect multiple ...

journal_title：Journal of neurochemistry

authors： Benice TS,Raber J

更新日期：2009-08-01 00:00:00

abstract：:PCR was used to isolate identical partial cDNA clones encoding a serotonin 5-HT3 receptor subunit from rat nodose and superior cervical ganglia. The amino acid sequence predicted from these clones, extending from the putative transmembrane domain I to the stop codon, demonstrated a 93% homology with the 5-HT3 receptor...

journal_title：Journal of neurochemistry

authors： Miquel MC,Emerit MB,Gingrich JA,Nosjean A,Hamon M,el Mestikawy S

更新日期：1995-08-01 00:00:00

abstract：:We report here that anti-L1 antiserum, raised against material from embryonic brain, and anti-NILE antiserum, raised against purified NILE (nerve growth factor-inducible large external) glycoprotein of PC12 cells, immunoprecipitate from PC12 cells material of the same apparent molecular weight (230 kilodaltons) by sod...

journal_title：Journal of neurochemistry

authors： Sajovic P,Kouvelas E,Trenkner E

更新日期：1986-08-01 00:00:00

abstract：:Diminished energy metabolism and reduced activity of brain alpha-ketoglutarate dehydrogenase complex (KGDHC) occur in a number of neurodegenerative diseases. The relation between diminished KGDHC activity and altered energy metabolism is unknown. The present study tested whether a reduction in the KGDHC activity would...

journal_title：Journal of neurochemistry

authors： Shi Q,Risa Ø,Sonnewald U,Gibson GE

更新日期：2009-05-01 00:00:00

abstract：:Astrocytes have important roles in control of extracellular environment, de novo synthesis of neurotransmitters, and regulation of neurotransmission and blood flow. All of these functions require energy, suggesting that astrocytic metabolism should rise and fall with changes in neuronal activity and that brain imaging...

journal_title：Journal of neurochemistry

authors： Dienel GA,Schmidt KC,Cruz NF

更新日期：2007-11-01 00:00:00

abstract：:Benzodiazepine receptor binding was measured in cerebellar cortex of 15 patients with dominantly inherited olivopontocerebellar atrophy (OPCA). The majority of these patients had a moderate to marked Purkinje cell loss, as judged by the lowered levels of dentate nucleus gamma-aminobutyric acid (GABA), a marker of Purk...

journal_title：Journal of neurochemistry

authors： Kish SJ,Perry TL,Hornykiewicz O

更新日期：1984-02-01 00:00:00

abstract：:Our previous work demonstrated that immunoproteasome is up-regulated in the retina and brain in response to injury that does not involve an inflammatory response (J. Neurochem. 2008; 106:158). These results suggest additional non-immune functions for the immunoproteasome in the cellular stress response pathway. The pr...

journal_title：Journal of neurochemistry

authors： Hussong SA,Kapphahn RJ,Phillips SL,Maldonado M,Ferrington DA

更新日期：2010-06-01 00:00:00

abstract：:delta 1-Pyrroline, 5-methyl-delta 1-pyrroline, and 5,5-dimethyl-delta 1-pyrroline have been identified as substances metabolized to gamma-aminobutyric acid (GABA), 4-aminopentanoic acid (methylGABA), and 4-amino-4-methylpentanoic acid (dimethylGABA), respectively. An enzyme system residing in the soluble fraction of r...

journal_title：Journal of neurochemistry

authors： Callery PS,Geelhaar LA,Nayar MS,Stogniew M,Rao KG

更新日期：1982-04-01 00:00:00

abstract：:In vivo microdialysis in C57BL/6J (B6) mouse was used to test the hypothesis that activating adenosine A(2A) receptors in the pontine reticular formation (PRF) increases acetylcholine (ACh) release and rapid eye movement (REM) sleep. Eight concentrations of the adenosine A(2A) receptor agonist 2-p-(2-carboxyethyl)phen...

journal_title：Journal of neurochemistry

authors： Coleman CG,Baghdoyan HA,Lydic R

更新日期：2006-03-01 00:00:00

abstract：:The protein anosmin-1, coded by the KAL1 gene responsible for the X-linked form of Kallmann syndrome (KS), exerts its biological effects mainly through the interaction with and signal modulation of fibroblast growth factor receptor 1 (FGFR1). We have previously shown the interaction of the third fibronectin-like type ...

journal_title：Journal of neurochemistry

authors： Esteban PF,Murcia-Belmonte V,García-González D,de Castro F

更新日期：2013-03-01 00:00:00

abstract：:Slices of rabbit caudate and hypothalamus take up and accumulate [3H]imipramine. In superfused slices of both structures electrical stimulation or exposure to tyramine failed to release recently taken up [3H]imipramine. Depolarization by exposure to 30--60 mM-potassium caused only a small release of [3H]imipramine tha...

journal_title：Journal of neurochemistry

authors： Langer SZ,Galzin AM,Kamal LA

更新日期：1982-02-01 00:00:00

abstract：:The decrease of pyruvate and ketoglutarate dehydrogenase complex activities is the main cause of energy and acetyl-CoA deficits in thiamine deficiency-evoked cholinergic encephalopathies. However, disturbances in pathways of acetyl-CoA metabolism leading to appearance of cholinergic deficits remain unknown. Therefore,...

journal_title：Journal of neurochemistry

authors： Jankowska-Kulawy A,Bielarczyk H,Pawełczyk T,Wróblewska M,Szutowicz A

更新日期：2010-10-01 00:00:00