Intermittent oral trimethoprim/sulfamethoxazole on two non-consecutive days per week is effective as Pneumocystis jiroveci pneumonia prophylaxis in pediatric patients receiving chemotherapy or hematopoietic stem cell transplantation.

Abstract:

:Pneumocystis jiroveci pneumonia (PCP) is a serious complication in patients receiving chemotherapy or hematopoietic stem cell transplantation. Current recommendations for trimethoprim-sulfamethoxazole (TMP-SMZ) dosing as PCP prophylaxis in immunocompromised patients are based on either daily dosing or dosing three consecutive days per week. We report our experience of prophylaxis with TMP-SMZ twice daily on two non-consecutive days per week in 145 immunocompromised children with hematologic disorders, cancer, or metabolic disorders following chemotherapy or hematopoietic stem cell transplantation. There were no breakthrough cases of PCP. We therefore conclude our prophylaxis regimen is effective against PCP in immunocompromised children.

journal_name

Pediatr Blood Cancer

journal_title

Pediatric blood & cancer

authors

Ohata Y,Ohta H,Hashii Y,Tokimasa S,Ozono K,Hara J

doi

10.1002/pbc.21774

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

142-4

issue

1

eissn

1545-5009

issn

1545-5017

journal_volume

52

pub_type

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