Intra-Arterial Platelet Infusion for Intractable Hemorrhage and Refractory Thrombocytopenia in Children With Gastrointestinal Graft-Versus-Host Disease.

Abstract:

:Acute gastrointestinal graft-versus-host disease (GVHD) refractory to first-line treatment with systemic corticosteroids results in increased morbidity and potential mortality. We retrospectively assessed the feasibility and efficacy of catheter-directed intra-arterial platelet infusion (IAPI) in two pediatric patients with steroid and transfusion refractory gastrointestinal GVHD causing intractable lower gastrointestinal hemorrhage and refractory thrombocytopenia, that were referred for salvage therapy. Immediate angiographic response was noted with a resolution of hemorrhage and decreased blood requirements. We reviewed the literature regarding this treatment modality and compared it to the available minimally invasive transcatheter techniques to control gastrointestinal hemorrhage.

journal_name

Pediatr Blood Cancer

journal_title

Pediatric blood & cancer

authors

Kably IM,Ziga ED,Andreansky M

doi

10.1002/pbc.25633

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

2226-8

issue

12

eissn

1545-5009

issn

1545-5017

journal_volume

62

pub_type

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