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Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination.

Abstract：

:Osteopontin (OPN) is a key immunoregulator in the autoimmune-mediated demyelinating disease multiple sclerosis. OPN may also play a role in the remyelination since it is 1) a ligand for alpha V integrins, several of which regulate the properties of the oligodendrocyte precursor cells (OPCs) primarily responsible for remyelination, and 2) enhances myelin membrane formation in OPC lines. Here we show that OPN is expressed at high levels during remyelination of toxin-induced demyelination. The increased expression is due to mRNA expression in macrophages and follows differences in macrophage responses to demyelination in young and old adult animals. To identify the role of OPN in remyelination focal demyelination was induced in wild-type and OPN(-/-) mice. There was no difference in the rate of remyelination between the two groups indicating that OPN is not a critical component of remyelination.

journal_name

Neurobiol Dis

journal_title

Neurobiology of disease

authors

Zhao C,Fancy SP,ffrench-Constant C,Franklin RJ

doi

10.1016/j.nbd.2008.04.007

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

209-17

issue

2

eissn

0969-9961

issn

1095-953X

pii

S0969-9961(08)00076-4

journal_volume

31

pub_type

杂志文章

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