Abstract:
:The aim of the present study is to better understand oxygen-sensitive adaptative pathways underlying the hypoxic preconditioning-induced protection of the brain against ischemia. Using oligonucleotide microarrays, we examined the brain genomic response of adult mice following hypoxia preconditioning (8% O2 for 1 or 6 h of hypoxia with reoxygenation 12, 18, 24 h or 72 h) and ischemia (6 h), preceeded (tolerant state) or not, by preconditioning. Real-time PCR was used to validate the results. Most gene expression increases occurred during hypoxia, including those of HIF-1-dependent genes (RTP801, AM, VEGF, p21, GLUT-1), early response genes (IER3) and transcriptional factors (ATF3, C/EBPdelta). A second wave of changes occurred 24 h after reoxygenation (S100A5, TH, Calretinin, PBX3). A third one occurred during ischemia itself, revealing that hypoxic preconditioning modifies the brain genomic response to ischemia. In addition, we show that some identical genes are overexpressed by hypoxia in both neonatal and adult brains (VEGF, EPO, GLUT-1, AM, MTs, C/EBPdelta).
journal_name
Neurobiol Disjournal_title
Neurobiology of diseaseauthors
Tang Y,Pacary E,Fréret T,Divoux D,Petit E,Schumann-Bard P,Bernaudin Mdoi
10.1016/j.nbd.2005.06.002keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
18-28issue
1eissn
0969-9961issn
1095-953Xpii
S0969-9961(05)00168-3journal_volume
21pub_type
杂志文章abstract:BACKGROUND:Epidemiological studies suggest that the risk of neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia is increased by prenatal exposure to viral or bacterial infection during pregnancy. It is still unclear how activation of the maternal immune response interacts with underlyi...
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pub_type: 杂志文章,评审
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journal_title:Neurobiology of disease
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journal_title:Neurobiology of disease
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doi:10.1016/s0969-9961(03)00040-8
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journal_title:Neurobiology of disease
pub_type: 杂志文章
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journal_title:Neurobiology of disease
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Neurobiology of disease
pub_type: 杂志文章
doi:10.1016/j.nbd.2007.03.014
更新日期:2007-08-01 00:00:00
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journal_title:Neurobiology of disease
pub_type: 杂志文章,评审
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journal_title:Neurobiology of disease
pub_type: 杂志文章
doi:10.1006/nbdi.2000.0292
更新日期:2000-08-01 00:00:00
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journal_title:Neurobiology of disease
pub_type: 杂志文章
doi:10.1016/j.nbd.2006.08.002
更新日期:2006-11-01 00:00:00
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journal_title:Neurobiology of disease
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:Neurobiology of disease
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journal_title:Neurobiology of disease
pub_type: 杂志文章
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更新日期:2007-06-01 00:00:00
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journal_title:Neurobiology of disease
pub_type: 杂志文章
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journal_title:Neurobiology of disease
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abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron death. A 20% of familial ALS cases are associated with mutations in the gene coding for superoxide dismutase 1 (SOD1). The accumulation of abnormal aggregates of different proteins is a common feature in motor neurons of p...
journal_title:Neurobiology of disease
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journal_title:Neurobiology of disease
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abstract::We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (L-DOPA)-induced dyskinesia and Parkinson disease (PD). 6-Hydroxydopamine (6-OHDA)-lesioned rats were treated with L-DOPA or physiological saline for 22 days and repeatedly tested for antiakinetic response t...
journal_title:Neurobiology of disease
pub_type: 杂志文章
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