Abstract：
:Ethanol-induced damage in the developing hippocampus may result in cognitive deficits such as those observed in fetal alcohol spectrum disorder (FASD). Cognitive deficits in FASD are partially mediated by alterations in glutamatergic synaptic transmission. Recently, we reported that synaptic transmission mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is impaired following fetal ethanol exposure. This finding led us to develop a rational approach for the treatment of alcohol-related cognitive deficits using aniracetam, an allosteric AMPAR modulator. In the present study, 28 to 34-day-old rats exposed to ethanol in utero were treated with aniracetam, and subsequently exhibited persistent improvement in mEPSC amplitude, frequency, and decay time. Furthermore, these animals expressed positive changes in synaptic single channel properties, suggesting that aniracetam ameliorates prenatal ethanol-induced deficits through modifications at the single channel level. Specifically, single channel open probability, conductance, mean open and closed times, and the number and burst duration were positively affected. Our findings emphasize the utility of compounds which slow the rate of deactivation and desensitization of AMPARs such as aniracetam.
journal_name
Neurobiol Disjournal_title
Neurobiology of diseaseauthors
Wijayawardhane N,Shonesy BC,Vaithianathan T,Pandiella N,Vaglenova J,Breese CR,Dityatev A,Suppiramaniam Vdoi
10.1016/j.nbd.2007.08.001subject
Has Abstractpub_date
2008-01-01 00:00:00pages
81-91issue
1eissn
0969-9961issn
1095-953Xpii
S0969-9961(07)00187-8journal_volume
29pub_type
杂志文章abstract：:We have explored the molecular mechanism underlying amyloid beta-peptide (Abeta)-mediated cytotoxicity in vitro. Exposure of murine cerebral endothelial cells (CECs) or C6 glioma cells to Abeta25-35 resulted in dose-dependent cell death. Ceramide is a pro-apoptotic lipid mediator. Forced elevation of cellular ceramide...
journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neurobiology of disease
pub_type： 杂志文章
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journal_title：Neurobiology of disease
pub_type： 杂志文章,评审
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journal_title：Neurobiology of disease
pub_type： 杂志文章
doi：10.1016/j.nbd.2010.09.016
更新日期：2011-02-01 00:00:00
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journal_title：Neurobiology of disease
pub_type： 杂志文章
doi：10.1016/j.nbd.2007.10.005
更新日期：2008-03-01 00:00:00
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journal_title：Neurobiology of disease
pub_type： 杂志文章
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journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
pub_type： 杂志文章
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journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
pub_type： 杂志文章,评审
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journal_title：Neurobiology of disease
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pub_type： 杂志文章,多中心研究
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journal_title：Neurobiology of disease
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更新日期：2015-01-01 00:00:00
abstract：:Epileptic activity may be more prevalent in early stage Alzheimer's disease (AD) than previously believed. Several studies report spontaneous seizures and interictal discharges in mouse models of AD undergoing age-related Aβ accumulation. The mechanism by which Aβ-induced neuronal excitability can trigger epileptiform...
journal_title：Neurobiology of disease
pub_type： 杂志文章
doi：10.1016/j.nbd.2015.10.019
更新日期：2016-01-01 00:00:00
