Abstract：
:Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat. Its length can be used to estimate the time of clinical diagnosis, which is defined by overt motor symptoms. Non-motor symptoms begin before motor onset, and involve changes in hypothalamus-regulated functions such as sleep, emotion and metabolism. Therefore we hypothesized that hypothalamic changes occur already prior to the clinical diagnosis. We performed voxel-based morphometry and logistic regression analyses of cross-sectional MR images from 220 HD gene carriers and 75 controls in the Predict-HD study. We show that changes in the hypothalamic region are detectable before clinical diagnosis and that its grey matter contents alone are sufficient to distinguish HD gene carriers from control cases. In conclusion, our study shows, for the first time, that alterations in grey matter contents in the hypothalamic region occur at least a decade before clinical diagnosis in HD using MRI.
journal_name
Neurobiol Disjournal_title
Neurobiology of diseaseauthors
Soneson C,Fontes M,Zhou Y,Denisov V,Paulsen JS,Kirik D,Petersén A,Huntington Study Group PREDICT-HD investigators.doi
10.1016/j.nbd.2010.07.013subject
Has Abstractpub_date
2010-12-01 00:00:00pages
531-43issue
3eissn
0969-9961issn
1095-953Xpii
S0969-9961(10)00237-8journal_volume
40pub_type
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