Abstract：
:Neuronal activity-induced changes in vascular tone and oxygen consumption result in a dynamic evolution of blood flow, volume, and oxygenation. Functional neuroimaging techniques, such as functional magnetic resonance imaging, optical imaging, and PET, provide indirect measures of the neural-induced vascular dynamics driving the blood parameters. Models connecting changes in vascular tone and oxygen consumption to observed changes in the blood parameters are needed to guide more quantitative physiological interpretation of these functional neuroimaging modalities. Effective lumped-parameter vascular balloon and Windkessel models have been developed for this purpose, but the lumping of the complex vascular network into a series of arterioles, capillaries, and venules allows only qualitative interpretation. We have therefore developed a parallel vascular anatomical network (VAN) model based on microscopically measurable properties to improve quantitative interpretation of the vascular response. The model, derived from measured physical properties, predicts baseline blood pressure and oxygen saturation distributions and dynamic responses consistent with literature. Furthermore, the VAN model allows investigation of spatial features of the dynamic vascular and oxygen response to neuronal activity. We find that a passive surround negative vascular response ("negative BOLD") is predicted, but that it underestimates recently observed surround negativity suggesting that additional active surround vasoconstriction is required to explain the experimental data.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Boas DA,Jones SR,Devor A,Huppert TJ,Dale AMdoi
10.1016/j.neuroimage.2007.12.061subject
Has Abstractpub_date
2008-04-15 00:00:00pages
1116-29issue
3eissn
1053-8119issn
1095-9572pii
S1053-8119(08)00008-6journal_volume
40pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract：:We used magnetic resonance imaging (MRI) and cortical pattern matching to map differences in cortical gray matter deficits between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), and explored the possible influence of gender on these patterns. Twenty-nine patients with AD (age 77.9 +/- 5.5), 16 patients ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2004.04.026
更新日期：2004-09-01 00:00:00
abstract：:Group independent component analysis (ICA) has been widely applied to studies of multi-subject fMRI data for computing subject specific independent components with correspondence across subjects. However, the independence of subject specific independent components (ICs) derived from group ICA has not been explicitly o...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2012.11.008
更新日期：2013-04-01 00:00:00
abstract：:Human communication and survival depend on effective social information processing. Abundant behavioral evidence has shown that humans efficiently judge preferences for other individuals, a critical task in social interaction, yet the neural mechanism of this basic social evaluation, remains less than clear. Using a s...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.02.044
更新日期：2010-06-01 00:00:00
abstract：:In the early days of BOLD fMRI, the acquisition of T(2)(*) weighted data was greatly facilitated by rapid scan techniques such as EPI. The latter, however, was only available on a few MRI systems that were equipped with specialized hardware that allowed rapid switching of the imaging gradients. For this reason, soon a...
journal_title：NeuroImage
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.neuroimage.2012.01.017
更新日期：2012-08-15 00:00:00
abstract：:The Center for Magnetic Resonance (CMRR) at the University of Minnesota was one of the laboratories where the work that simultaneously and independently introduced functional magnetic resonance imaging (fMRI) of human brain activity was carried out. However, unlike other laboratories pursuing fMRI at the time, our wor...
journal_title：NeuroImage
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.neuroimage.2012.01.134
更新日期：2012-08-15 00:00:00
abstract：:Early-life development is characterized by dramatic changes, impacting lifespan function more than changes in any other period. Developmental origins of neurocognitive late-life functions are acknowledged, but detailed longitudinal magnetic resonance imaging studies of brain maturation and direct comparisons with agin...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2012.11.039
更新日期：2013-03-01 00:00:00
abstract：:According to recent research on language comprehension, the semantic features of a text are not the only determinants of whether incoming information is understood as consistent. Listeners' pre-existing affective states play a crucial role as well. The current fMRI experiment examines the effects of happy and sad mood...
journal_title：NeuroImage
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neuroimage.2014.09.008
更新日期：2014-12-01 00:00:00
abstract：:The human brain can be described as a network of specialized and spatially distributed regions. The activity of individual regions can be estimated using electroencephalography and the structure of the network can be measured using diffusion magnetic resonance imaging. However, the communication between the different ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.116017
更新日期：2019-11-01 00:00:00
abstract：:Perfusion weighted MRI has proven very useful for deriving hemodynamic parameters such as CBF, CBV and MTT. These quantities are important diagnostically, e.g. in acute stroke, where they are used to delineate ischemic regions. Yet the standard method for estimating CBF based on singular value decomposition (SVD) has ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2006.06.015
更新日期：2006-11-01 00:00:00
abstract：:The Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC - www.nitrc.org) suite of services include a resources registry, image repository and a cloud computational environment to meet the needs of the neuroimaging researcher. NITRC provides image-sharing functionality through both the NITRC Resource Regi...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.05.074
更新日期：2016-01-01 00:00:00
abstract：:Although the majority of fMRI studies exploit magnitude changes only, there is an increasing interest regarding the potential additive information conveyed by the phase signal. This integrated part of the complex number furnished by the MR scanners can also be used for exploring direct detection of neuronal activity a...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.10.095
更新日期：2012-02-15 00:00:00
abstract：:Brain presynaptic dopaminergic function can be assessed using 18F-DOPA positron emission tomography (PET). Regional 18F-DOPA utilization may be used to index dopaminergic abnormalities over time or dopaminergic response to treatment in clinical populations. Such studies require prior knowledge of the stability of the ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.12.058
更新日期：2010-04-01 00:00:00
abstract：:Statistical parametric mapping (SPM) is currently the most widely used method for analysis of functional activation images. This paper reports a quantitative evaluation of the sensitivity and accuracy of SPM, using a realistic simulator of PET image formation, which accounted for the main physical processes involved i...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1006/nimg.2000.0655
更新日期：2001-01-01 00:00:00
abstract：:A fundamental component of brain development is the formation of large-scale networks across the cortex. One such network, the default network, undergoes a protracted development, displaying weak connectivity in childhood that strengthens in adolescence and becomes most robust in adulthood. Little is known about the g...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.10.030
更新日期：2012-02-01 00:00:00
abstract：:Beta amyloid is a protein fragment snipped from the amyloid precursor protein (APP). Aggregation of these peptides into amyloid plaques is one of the hallmarks of Alzheimer's disease. MR imaging of beta amyloid plaques has been attempted using various techniques, notably with T2* contrast. The non-invasive detectabili...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.02.019
更新日期：2019-05-01 00:00:00
abstract：:The thickness of the cerebral cortex can provide valuable information about normal and abnormal neuroanatomy. High resolution MRI together with powerful image processing techniques has made it possible to perform these measurements automatically over the whole brain. Here we present a method for automatically generati...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.01.027
更新日期：2008-05-01 00:00:00
abstract：:To elucidate the function of the lateral prefrontal cortex (LPFC) in taste encoding, it is worth applying to taste, the psychological paradigms of intentional memorization that have been used with other extensively studied senses, and thus updating current models for LPFC functions to include a taste modality. Using m...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2005.12.021
更新日期：2006-06-01 00:00:00
abstract：:Previous studies demonstrated that visual perception of handwritten letters activates the left primary motor cortex more strongly than printed letters. Here, we used EEG to record cortical responses evoked by single letters to directly test if their visual processing is actually influenced by their motor content. We m...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2012.07.020
更新日期：2012-11-15 00:00:00
abstract：:This study investigates neural correlates of music-evoked fear and joy with fMRI. Studies on neural correlates of music-evoked fear are scant, and there are only a few studies on neural correlates of joy in general. Eighteen individuals listened to excerpts of fear-evoking, joy-evoking, as well as neutral music and ra...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2013.05.008
更新日期：2013-11-01 00:00:00
abstract：INTRODUCTION:To investigate in vivo differences in the distribution of alpha4beta2 subtypes of nAChR using the ligand (123)I-5-Iodo-3-[2(S)-2-azetidinylmethoxy] pyridine (5IA-85380) and single photon emission computed tomography (SPECT) in DLB and similarly aged controls. METHODS:Thirty-one subjects (15 DLB and 16 con...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.01.010
更新日期：2008-04-15 00:00:00
abstract：:To investigate the spatial and temporal changes in electro-cortical brain activity and hand kinematics during the acquisition of an internal model of a novel screen-cursor transformation, we employed single-trial infomax independent component analysis (ICA), spectral estimation, and kinematics methods. Participants pe...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2003.10.037
更新日期：2004-03-01 00:00:00
abstract：:Brain white matter connections have become a focus of major interest with important maturational processes occurring in newborns. To study the complex microstructural developmental changes in-vivo, it is imperative that non-invasive neuroimaging approaches are developed for this age-group. Multi-b-value diffusion weig...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.03.057
更新日期：2014-08-01 00:00:00
abstract：:The human insula has been parcellated on the basis of resting state functional connectivity and diffusion tensor imaging. Little is known about the organization of the insula when involved in active tasks. We explored this issue using a novel meta-analytic clustering approach. We queried the BrainMap database asking f...
journal_title：NeuroImage
pub_type： 杂志文章,meta分析
doi：10.1016/j.neuroimage.2012.04.012
更新日期：2012-08-01 00:00:00
abstract：:The female brain contains a larger proportion of gray matter tissue, while the male brain comprises more white matter. Findings like these have sparked increasing interest in studying dimorphism of the human brain: the general effect of gender on aspects of brain architecture. To date, the vast majority of imaging stu...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2012.12.068
更新日期：2013-04-15 00:00:00
abstract：AIM:Voxel-based morphometry analysis of neurological disorders would benefit if it could use data acquired from different scanners, but scanner based contrast variation could interfere with the detection of disease-specific structural abnormalities. In this study we examine MRI data from three different sites to invest...
journal_title：NeuroImage
pub_type： 杂志文章,多中心研究
doi：10.1016/j.neuroimage.2008.05.007
更新日期：2008-08-15 00:00:00
abstract：:Patients with Bipolar Disorder (BD) perform poorly on tasks of selective attention and inhibitory control. Although similar behavioural deficits have been noted in their relatives, it is yet unclear whether they reflect dysfunction in the same neural circuits. We used functional magnetic resonance imaging and the Stro...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.02.052
更新日期：2011-06-01 00:00:00
abstract：:Inhibitory control of actions is one important aspect in daily life to warrant adequate context related behavior. Alpha activity (oscillatory brain activity around 10Hz) has been suggested to play a major role for the implementation of inhibitory control. In the present study electrophysiological correlates of volunta...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2012.09.048
更新日期：2013-01-15 00:00:00
abstract：:Blinks and saccades, both ubiquitous in natural viewing conditions, cause rapid changes of visual inputs that are hardly consciously perceived. The neural dynamics in early visual areas of the human brain underlying this remarkable visual stability are still incompletely understood. We used electrocorticography (ECoG)...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2021.117788
更新日期：2021-01-24 00:00:00
abstract：:In 2001, we published a paper on the representation of faces and objects in ventral temporal cortex that introduced a new method for fMRI analysis, which subsequently came to be called multivariate pattern analysis (MVPA). MVPA now refers to a diverse set of methods that analyze neural responses as patterns of activit...
journal_title：NeuroImage
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.neuroimage.2012.03.016
更新日期：2012-08-15 00:00:00
abstract：:Successful behavior depends on the ability to detect and respond to relevant cues, especially under challenging conditions. This essential component of attention has been hypothesized to be mediated by multiple neuromodulator systems, but the contributions of individual systems (e.g., cholinergic, dopaminergic) have r...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2017.02.006
更新日期：2017-04-01 00:00:00
