Abstract:
BACKGROUND:Sensitization to atopens is an early phenomenon that overlaps with the onset of atopic dermatitis (AD) in infancy. Early epidermal barrier impairment may facilitate the epicutaneous penetration of atopens. OBJECTIVE:To correlate transepidermal water loss (TEWL) and aeroallergen sensitization in infants with AD. METHODS:In this cross-sectional study we enrolled 59 AD children and 30 controls aged 3-12 months. Transepidermal water loss in uninvolved skin, specific immunoglobulin E, atopy patch test (APT) and skin prick tests were performed with respect to seven aeroallergens, i.e., Dermatophagoides pteronyssinus, D. farinae, cat, dog, birch pollen, ambrosia, and cockroach. Environmental conditions were assessed by a questionnaire, and the house dust mite (HDM) concentration was determined in dust samples. RESULTS:Eighty-nine percent of AD infants had a positive APT vs one out of eleven controls. AD infants had a significantly higher mean TEWL than controls (27.4 vs 11.1 g/m(2)/h, P < 0001). Children with two or more positive APT had higher TEWL than the others (31.1 vs 19.0 g/m(2)/h, P < 0.025). No correlation was found between indoor APT results and exposure to HDM, cats, and dogs at home. CONCLUSIONS:This study confirms the high prevalence of delayed sensitization to indoor and outdoor aeroallergens in AD infants, and shows that the higher the TEWL, the higher the prevalence of sensitization to aeroallergens. These data are in favor of a major role of a constitutive epidermal barrier impairment in determining early atopen sensitization in infants with AD.
journal_name
Allergyjournal_title
Allergyauthors
Boralevi F,Hubiche T,Léauté-Labrèze C,Saubusse E,Fayon M,Roul S,Maurice-Tison S,Taïeb Adoi
10.1111/j.1398-9995.2007.01556.xsubject
Has Abstractpub_date
2008-02-01 00:00:00pages
205-10issue
2eissn
0105-4538issn
1398-9995pii
ALL1556journal_volume
63pub_type
杂志文章相关文献
ALLERGY文献大全abstract:BACKGROUND:New routes of administering immunotherapy in respiratory allergy are being studied as an alternative to conventional injective immunotherapy. We carried out a study to evaluate the clinical efficacy and effects of sublingual immunotherapy in patients with Parietaria judaica-induced respiratory allergy. METH...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1398-9995.1999.00203.x
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Serum immunoglobulin E (IgE) level is recognized to be under strong genetic control, but the causal and susceptibility genes remain to be identified. We sought to investigate the association between single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway and total serum IgE l...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2008.01889.x
更新日期:2009-05-01 00:00:00
abstract::Chip pile workers are exposed to high concentrations of airborne mould spores. Few sporadic cases of allergic alveolitis have been reported in Finland. Eight non-smoking workers, six on chip piles and two on bark piles, were examined to study the immunological and clinical response to continuous mould spore exposure. ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1987.tb00380.x
更新日期:1987-10-01 00:00:00
abstract::A family of widely expressed ORM-like (ORMDL) proteins has been recently linked to asthma in genomewide association studies in humans and extensively explored in in vivo studies in mice. ORMDL proteins are key regulators of serine palmitoyltransferase, an enzyme catalyzing the initial step of sphingolipid biosynthesis...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.12877
更新日期:2016-07-01 00:00:00
abstract::The pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused an unprecedented global social and economic impact, and high numbers of deaths. Many risk factors have been identified in the progression of COVID-19 into a severe and critical st...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.14657
更新日期:2020-11-13 00:00:00
abstract:BACKGROUND:Effective methods of reducing dog allergen are required to help alleviate symptoms in asthmatic patients sensitized to dog who refuse to part with their pet. The aim of this study was to investigate the use of the high efficiency particulate air (HEPA) filter air cleaner to reduce airborne Can f 1 in homes w...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.1999.00029.x
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:Endogenous histamine-releasing factors (HRFs) are involved in 30-60% of patients with chronic urticaria (CU). Evidence for their existence comes from in vivo studies of autoreactivity with the autologous serum skin test (ASST), in vitro immunoassays demonstrating autoantibodies against the immunoglobulin E (...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2005.00841.x
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Asthma-like symptoms in young children are orchestrated by the local airway immune response, but current knowledge largely relies on in vitro airway models. Azithromycin has been shown to reduce the duration of episodes with asthma-like symptoms, but efficacy may depend on the individual child's immune respo...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.14651
更新日期:2020-11-04 00:00:00
abstract:BACKGROUND:The effectiveness of acaricides in homes is controversial. OBJECTIVE:To determine whether disodium octaborate tetrahydrate (DOT) combined with vacuuming lowers dust mite numbers and their allergens in carpets and sofas. METHODS:A 6-month study was carried out with 93 homes, which were randomized into three...
journal_title:Allergy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1398-9995.2003.00100.x
更新日期:2003-04-01 00:00:00
abstract::Antigenic extracts prepared from pollen samples collected at weekly intervals during the same season did not exhibit significant variation in protein concentration. Stored pollen samples from different years, however, showed highly significant variations in protein concentration. The protein content of samples from di...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1991.tb00587.x
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:Farm environment in childhood may protect against sensitization, allergic rhinitis, and asthma. METHODS:Subjects were obtained from 10 667 Finnish first-year university students who responded to a questionnaire survey on IgE-mediated diseases. Two random samples were selected from 1631 respondents in Turku:...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2002.23341.x
更新日期:2002-12-01 00:00:00
abstract::Although genetic factors play a role in the etiology of atopic disease, the rapid increases in the prevalence of these diseases over the last few decades suggest that environmental, rather than genetic factors are the driving force behind the increasing prevalence. In modern societies, there is increased time spent in...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.14624
更新日期:2020-10-09 00:00:00
abstract:BACKGROUND:The diagnosis of allergic reactions to drugs is difficult. Most skin tests are not standardized, and in vitro tests are needed to avoid provocation tests. Cross-linking of IgE on basophils is known to cause the release of both cysteinyl leukotriene (Cys-LT) and histamine. We aimed to evaluate the diagnostic ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2001.00103.x
更新日期:2001-07-01 00:00:00
abstract::The usefulness of the leukocyte migration inhibition factor (LIF) test to detect cow milk (CM) hypersensitivity was studied in 40 children with suspected allergy to CM. Hypersensitivity was carefully investigated by oral milk challenges, which gave a final confirmation of cow milk hypersensitivity in 12 subjects, and ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1987.tb00392.x
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:The reasons for the rise in asthma and allergies remain unclear. To identify risk or protective factors, it is essential to carry out longitudinal epidemiological studies, preferably birth cohort studies. In Europe, several birth cohort studies on asthma and atopic diseases have been initiated over the last ...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2006.00989.x
更新日期:2006-02-01 00:00:00
abstract::The association between food allergy and celiac disease (CD) is still to be clarified. We screened for CD 319 patients with severe food allergy (IgE > 85 kU/l against food proteins and a history of severe allergic reactions) who underwent specific food oral immunotherapy (OIT), together with 128 children with mild all...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12692
更新日期:2015-10-01 00:00:00
abstract::Birch and other related trees of the families Betulaceae and Fagaceae (alder, hazel, oak, hornbeam, chestnut, and beech) constitute the birch homologous group. This grouping is primarily based on the extensive IgE cross-reactivity of allergen homologs to the major birch allergen Bet v 1. Birch pollen is the most domin...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/all.13758
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Immune-modulation such as tolerance induction appears to be an upcoming concept to prevent development of atopic diseases. Pregnancy might present a critical period for preventing allergic sensitization of the progeny. We investigated the effect of maternal allergen exposures during pregnancy on allergen-ind...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2011.02775.x
更新日期:2012-03-01 00:00:00
abstract::We developed an antigen- and isotype-specific ELISA for the rapid detection of native serum immune complexes (IC). It is a sandwich assay, in which a solid phase antigen-specific capture antibody selectively binds the antigen-specific IC via the antigen. The isotype of the bound IC is then identified using an enzyme-l...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1988.tb01626.x
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND:Measurement of exposure to the dust mite allergen Der p 1 is important in asthma research and is potentially useful in managing asthma. As no single measure can capture all characteristics of an exposure, it is important to recognize differences in the available methods of measuring exposure to Der p 1. MET...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2003.00228.x
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Eosinophilic airway inflammation is the hallmark of asthma, but it has also been reported in other conditions such as allergic rhinitis. We have tested whether the analysis of cells and chemicals in sputum can distinguish between patients with mild allergic asthma, those with allergic rhinitis, and healthy c...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1034/j.1398-9995.2000.00312.x
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:The pathogenesis of the ocular surface disease in atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) has not been fully understood. We tried to clarify the differences in the ocular surface status in patients with AKC, VKC, and healthy control subjects. METHODS:Twenty-four eyes of 12 AK...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2007.01414.x
更新日期:2007-08-01 00:00:00
abstract::A total of 139 workers (71% of the available work force) in four grain elevator stores in Aalborg, Denmark, participated in a cross-sectional study on the prevalence of storage mite allergy among grain elevator workers. All underwent interview, prick test with a standard panel of allergens and the storage mites Acarus...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1987.tb00357.x
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:Chronic respiratory diseases (CRD) are greatly underestimated. The aim of this study was to assess the burden associated with reported CRD and chronic obstructive pulmonary disease, as defined on the basis of various standardized criteria, by estimating their point prevalence in a sample of individuals atten...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2009.01956.x
更新日期:2009-07-01 00:00:00
abstract::Histamine is the primary mediator involved the pathophysiology of allergic rhinitis and chronic urticaria, and this explains the prominent role that histamine H(1)-receptor antagonists have in the treatment of these disorders. However, histamine is clearly not the only mediator involved in the inflammatory cascade. Th...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1111/j.1398-9995.2008.01640.x
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Occupational allergy forms an attractive model to study the development of allergic responses, as in some occupations it has a high incidence and develops quickly. In a cohort of starting laboratory animal workers, we previously found 20% sensitization to animal allergens within 2 years. METHODS:We compared...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2009.02323.x
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Omalizumab, a recombinant monoclonal anti-immunoglobulin E (IgE) antibody, shows proven efficacy in the treatment of allergic diseases. A little is known about the immunological pathways affected by the decrease of circulating free IgE during omalizumab treatment. AIM OF THE STUDY:To investigate the immunol...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.2006.01180.x
更新日期:2006-09-01 00:00:00
abstract::Allergic rhinitis is an inflammatory disorder of the nasal mucosa typified by the symptoms of nasal itch, sneeze, anterior nasal secretions, and nasal blockage. These symptoms arise from the interaction between mediators and neural, vascular, and glandular structures within the nose. Nasal itch, sneezes, and rhinorrho...
journal_title:Allergy
pub_type: 杂志文章,评审
doi:10.1034/j.1398-9995.2000.00802.x
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:WHO guidelines advocate breastfeeding for 6 months, and EAACI guideline recommends exclusive breastfeeding for 4-6 months. However, evidence for breastfeeding to prevent asthma and allergic disease is conflicting. We examined whether following recommended breastfeeding guidelines alters the long-term risks o...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/all.12833
更新日期:2016-05-01 00:00:00
abstract::We describe a case of contact allergic sensitization to budesonide in a nasal spray used in the treatment of allergic rhinitis. No cross-sensitivity to other topical corticosteroids was found. ...
journal_title:Allergy
pub_type: 杂志文章
doi:10.1111/j.1398-9995.1992.tb02392.x
更新日期:1992-12-01 00:00:00