Time course of increased heme oxygenase activity and expression after experimental intracerebral hemorrhage: correlation with oxidative injury.

abstract：:It is well established that inflammatory changes contribute to brain ageing, and an increased concentration of proinflammatory cytokine, interleukin-1beta (IL-1beta), has been reported in the aged brain associated with a deficit in long-term potentiation (LTP) in rat hippocampus. The precise age at which changes are i...

journal_title：Journal of neurochemistry

authors： Griffin R,Nally R,Nolan Y,McCartney Y,Linden J,Lynch MA

更新日期：2006-11-01 00:00:00

abstract：:Abnormal tau accumulations were observed and documented in post-mortem brains of patients affected by Alzheimer's disease (AD) long before the identification of mutations in the Microtubule-associated protein tau (MAPT) gene, encoding the tau protein, in a different neurodegenerative disease called Frontotemporal deme...

journal_title：Journal of neurochemistry

authors： Hannan SB,Dräger NM,Rasse TM,Voigt A,Jahn TR

更新日期：2016-04-01 00:00:00

abstract：:The polypeptide composition and glycosylation of soluble isoforms of neural cell adhesion molecule (NCAM) in developing rat brain, CSF, and plasma were characterized. Soluble NCAM in rat brain consisted of several glycosylated isoforms. The degree of glycosylation was developmentally regulated. After desialylation, fo...

journal_title：Journal of neurochemistry

authors： Krog L,Olsen M,Dalseg AM,Roth J,Bock E

更新日期：1992-09-01 00:00:00

abstract：:The aim of the present study was to gain a deeper insight into the cell signaling pathways involved in the neuroprotection/neurorescue activity of the major green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG). EGCG (1 micro m) caused an immediate (30 min) down-regulation (approximately 40%) of Bad protein level...

journal_title：Journal of neurochemistry

authors： Kalfon L,Youdim MB,Mandel SA

更新日期：2007-02-01 00:00:00

abstract：:Cavernous angiomas are vascular malformations that cause neurodegeneration and symptoms including epileptiform seizures, headache, and motor deficits. Following neurosurgical removal of the angiomas, patients mostly recover well and become seizure-free. This study reports on the levels of certain amino acids in angiom...

journal_title：Journal of neurochemistry

authors： von Essen C,Rydenhag B,Nyström B,Mozzi R,van Gelder N,Hamberger A

更新日期：1996-07-01 00:00:00

abstract：:Maternal separation (MS) is known to affect hippocampal function such as learning and memory, yet the molecular mechanism remains unknown. We hypothesized that these impairments are attributed to abnormities of neural circuit formation by MS, and focused on brain-derived neurotrophic factor (BDNF) as key factor becaus...

journal_title：Journal of neurochemistry

authors： Ohta KI,Suzuki S,Warita K,Kaji T,Kusaka T,Miki T

更新日期：2017-04-01 00:00:00

abstract：:The binding characteristics of [3H] alpha-dihydropicrotoxinin to the picrotoxinin binding site were investigated in membrane preparations of adult rat forebrain and living cultures of rat cerebral cortex. The binding of [3H]alpha-dihydropicrotoxinin to rat forebrain was decreased by lysing, treating with Triton X-100,...

journal_title：Journal of neurochemistry

authors： White WF,Snodgrass SR,Dichter MA

更新日期：1985-03-01 00:00:00

abstract：:Synaptotagmin-7 (Syt-7) is one of two major calcium sensors for exocytosis in adrenal chromaffin cells, the other being synaptotagmin-1 (Syt-1). Despite a broad appreciation for the importance of Syt-7, questions remain as to its localization, function in mediating discharge of dense core granule cargos, and role in t...

journal_title：Journal of neurochemistry

authors： Bendahmane M,Morales A,Kreutzberger AJB,Schenk NA,Mohan R,Bakshi S,Philippe JM,Zhang S,Kiessling V,Tamm LK,Giovannucci DR,Jenkins PM,Anantharam A

更新日期：2020-09-01 00:00:00

abstract：:Mutations in the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome-17 (FTDP-17). Functionally, about half of the known mutations increase the alternative mRNA splicing of exon 10 of the tau gene, resulting in the overproduction of tau isoforms with four microtubule-binding repeats. The other...

journal_title：Journal of neurochemistry

authors： Yoshida H,Crowther RA,Goedert M

更新日期：2002-02-01 00:00:00

abstract：:Spinal cord injury (SCI) elicits a neuroinflammatory reaction dominated by microglia and monocyte-derived macrophages (MDM). Because MDM do not infiltrate the spinal cord until days after injury, it may be possible to control whether they differentiate into neuroprotective or neurotoxic effector cells. However, doing ...

journal_title：Journal of neurochemistry

authors： Longbrake EE,Lai W,Ankeny DP,Popovich PG

更新日期：2007-08-01 00:00:00

abstract：:Damage or stress in many organelles may trigger apoptosis by several not yet fully elucidated mechanisms. A cell death pathway is induced by endoplasmic reticulum (ER) stress elicited by the unfolded protein response and/or by aberrant Ca(2+) signalling. Reticulon-1C (RTN-1C) belongs to the reticulon family, neuroendo...

journal_title：Journal of neurochemistry

authors： Di Sano F,Fazi B,Tufi R,Nardacci R,Piacentini M

更新日期：2007-07-01 00:00:00

abstract：:Dopamine and norepinephrine are involved in regulation of melatonin synthesis in the pineal gland. In bovine pineal gland, D1- and D2-dopaminergic and alpha 1-adrenergic receptors have been characterized pharmacologically in several laboratories, while beta 1-adrenergic receptors have been studied using physiological ...

journal_title：Journal of neurochemistry

authors： Simonneaux V,Happe HK,Ebadi M,Murrin LC

更新日期：1991-11-01 00:00:00

abstract：:The technique of intracerebral dialysis in combination with a sensitive and specific radioenzymatic method was used for recovery and quantification of endogenous extracellular acetylcholine from the striata of freely moving rats. A thin dialysis tube was inserted transversally through the caudate nuclei, and the tube ...

journal_title：Journal of neurochemistry

authors： Consolo S,Wu CF,Fiorentini F,Ladinsky H,Vezzani A

更新日期：1987-05-01 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA) receptors mediate increases in intracellular calcium that can be modulated by protein kinase C (PKC). As PKC modulation of NMDA receptors in neurons is complex, we studied the effects of PKC activation on recombinant NMDA receptor-mediated calcium rises in a nonneuronal mammalian cell line,...

journal_title：Journal of neurochemistry

authors： Grant ER,Bacskai BJ,Anegawa NJ,Pleasure DE,Lynch DR

更新日期：1998-10-01 00:00:00

abstract：:The alpha-synuclein (Snca) gene is expressed at higher levels in alcohol-naïve, inbred alcohol-preferring (iP) rats than in alcohol-non preferring (iNP) rats. Snca modulates dopamine transmission and the dopamineregic system, which play a role in mediating the rewarding properties of alcohol consumption. Thus, underst...

journal_title：Journal of neurochemistry

authors： Liang T,Carr LG

更新日期：2006-10-01 00:00:00

abstract：:Reactive oxygen species (ROS) and oxidative stress have long been linked to cell death of neurons in many neurodegenerative conditions. However, the exact molecular mechanisms triggered by oxidative stress in neurodegeneration are at present unclear. In the current work we have used the human neuroblastoma SH-SY5Y cel...

journal_title：Journal of neurochemistry

authors： Sanvicens N,Gómez-Vicente V,Messeguer A,Cotter TG

更新日期：2006-08-01 00:00:00

abstract：:The characteristics of glycosylation of a brain-specific glycoprotein, 1D4 antigen, and the epitope recognized by its monoclonal antibody were studied. Removal of high-mannose and hybrid types of N-linked oligosaccharides by treatment with endoglycosidase H converted the molecular mass of the 1D4 antigen from 89 kDa t...

journal_title：Journal of neurochemistry

authors： Sano S,Ito S,Nakamura M,Nakagawa H

更新日期：1990-10-01 00:00:00

abstract：:In adult New Zealand white rabbits, the effects of food deprivation and of massive elevations of plasma uridine or thymidine concentrations on CSF and plasma nucleoside and oxypurine concentrations were studied. Nucleoside and oxypurine levels were determined by high performance liquid chromatography using unequivocal...

journal_title：Journal of neurochemistry

authors： Eells JT,Spector R,Huntoon S

更新日期：1984-06-01 00:00:00

abstract：:Cyclin-dependent kinase 5 (Cdk5) is emerging as a neuronal protein kinase involved in multiple aspects of neurotransmission in both post- and presynaptic compartments. Within the reward/motor circuitry of the basal ganglia, Cdk5 regulates dopamine neurotransmission via phosphorylation of the postsynaptic signal transd...

journal_title：Journal of neurochemistry

authors： Kansy JW,Daubner SC,Nishi A,Sotogaku N,Lloyd MD,Nguyen C,Lu L,Haycock JW,Hope BT,Fitzpatrick PF,Bibb JA

更新日期：2004-10-01 00:00:00

abstract：:Poly A(+) messenger RNA (mRNA) was isolated from the brains of 3-week-old mice and translated in a cell-free system derived from wheat germ. Maximal stimulation of the system by brain mRNA was observed at a relatively low K+ concentration (45 mM) and low mRNA concentration (1-10 microgram/ml). The translational system...

journal_title：Journal of neurochemistry

authors： Matthees J,Campagnoni AT

更新日期：1980-10-01 00:00:00

abstract：:The K+-stimulated efflux of endogenous taurine from primary rat cerebellar astrocyte cultures prepared from 7-9-day-old rats was studied at 16-18 days in vitro using HPLC analysis. Taurine efflux was dose-dependent at K+ concentrations between 10 mM and 80 mM, with an EC50 of approximately 50 mM. Maximum stimulation o...

journal_title：Journal of neurochemistry

authors： Philibert RA,Rogers KL,Allen AJ,Dutton GR

更新日期：1988-07-01 00:00:00

abstract：:Changes in the activity of Na+,K+-ATPase and in the water, Na+, and K+ levels in the parietal cortex, hippocampus, and thalamus were investigated in rats 1, 3, 6, and 24 h following systemic kainic acid injection. An increase in Na+,K+-ATPase activity was observed in all three regions 3 h after the treatment, with a s...

journal_title：Journal of neurochemistry

authors： Sztriha L,Joó F,Dux L,Böti Z

更新日期：1987-07-01 00:00:00

abstract：:The nervous tissue-specific protein B-50 (GAP-43), which has been implicated in the regulation of neurotransmitter release, is a member of a family of atypical calmodulin-binding proteins. To investigate to what extent calmodulin and the interaction between B-50 and calmodulin are involved in the mechanism of Ca(2+)-i...

journal_title：Journal of neurochemistry

authors： Hens JJ,Oestreicher AB,De Wit M,Marquart A,Gispen WH,De Graan PN

更新日期：1996-05-01 00:00:00

abstract：:The prescribed drugs for treatment of cognitive deficits in Alzheimer's disease (AD) patients are regarded as symptomatic drugs. Effective disease modifying therapies are not yet prescribed in AD patients. Three major hallmarks of AD (e.g. cholinergic hypofunction, Aβ and tau neuropathologies) are closely linked raisi...

journal_title：Journal of neurochemistry

authors： Fisher A

更新日期：2012-01-01 00:00:00

abstract：:Fused in sarcoma (FUS) is a ubiquitously expressed RNA/DNA-binding protein that plays different roles in the cell. FUS pathology has been reported in neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in FUS have also been linked to a subset of familial ALS. FUS...

journal_title：Journal of neurochemistry

authors： Arenas A,Kuang L,Zhang J,Kingren MS,Zhu H

更新日期：2020-12-22 00:00:00

abstract：:Our gut harbours trillions of microorganisms essential for the maintenance of homeostasis and host physiology in health and disease. In the last decade, there has been a growing interest in understanding the bidirectional pathway of communication between our microbiota and the central nervous system. With regard to re...

journal_title：Journal of neurochemistry

authors： García-Cabrerizo R,Carbia C,O Riordan KJ,Schellekens H,Cryan JF

更新日期：2020-12-25 00:00:00

abstract：:Rarefaction of the dendritic tree leading to neuronal dysfunction is a hallmark of many neurodegenerative diseases and we have shown previously that heat shock protein B5 (HspB5)/αB-crystallin is able to increase dendritic complexity in vitro. The aim of this study was to investigate if this effect is also present in ...

journal_title：Journal of neurochemistry

authors： Bartelt-Kirbach B,Wiegreffe C,Birk S,Baur T,Moron M,Britsch S,Golenhofen N

更新日期：2020-11-21 00:00:00

abstract：:A contribution of α-Synuclein (α-Syn) to etiology of Parkinson´s disease (PD) and Dementia with Lewy bodies (DLB) is currently undisputed, while the impact of the closely related β-Synuclein (β-Syn) on these disorders remains enigmatic. β-Syn has long been considered to be an attenuator of the neurotoxic effects of α-...

journal_title：Journal of neurochemistry

authors： Raina A,Leite K,Guerin S,Mahajani SU,Chakrabarti KS,Voll D,Becker S,Griesinger C,Bähr M,Kügler S

更新日期：2020-07-30 00:00:00

abstract：:The weaver mutant mouse has a genetically determined defect in the nigrostriatal dopaminergic system. The present study was undertaken to test the hypothesis that in the weaver mutant mouse, striatal nerve terminals undergo compensatory changes in response to this deficiency. To test this hypothesis, we studied the ba...

journal_title：Journal of neurochemistry

authors： Simon JR,Yu H,Richter JA,Vasko MR,Ghetti B

更新日期：1991-11-01 00:00:00

abstract：:Leptinotoxin-h (LPTx), a neurotoxin (otherwise designated beta-leptinotarsin-h) known to stimulate the release of neurotransmitters from synapses, was purified from the hemolymph of the potato beetle, Leptinotarsa haldemani, by a simplification of the procedure originally developed by Crosland et al. [Biochemistry 23,...

journal_title：Journal of neurochemistry

authors： Madeddu L,Pozzan T,Robello M,Rolandi R,Hsiao TH,Meldolesi J

更新日期：1985-12-01 00:00:00