Design of a family study among high-risk Caribbean Hispanics: the Northern Manhattan Family Study.

Abstract:

:Stroke continues to kill disproportionately more Blacks and Hispanics than Whites in the United States. Racial/ethnic variations in the incidence of stroke and prevalence of stroke risk factors are probably explained by both genetic and environmental influences. Family studies can help identify genetic predisposition to stroke and potential stroke precursors. Few studies have evaluated the heritability of these stroke risk factors among non-White populations, and none have focused on Caribbean Hispanic populations. The aim of the Northern Manhattan Family Study (NOMAFS) is to investigate the gene-environment interaction of stroke risk factors among Caribbean Hispanics. The unique recruitment and methodologic approaches used in this study are relevant to the design and conduct of genetic aggregation studies to investigate complex genetic disorders in non-White populations. The aim of this paper is to describe the NOMAFS and report enrollment and characteristics of the participants. The NOMAFS will provide a data resource for the exploration of the genetic determinants of highly heritable stroke precursor phenotypes that are less complex than the stroke phenotype. Understanding the gene environment interaction is the critical next step toward the development of new and unique approaches to disease prevention and interventions.

journal_name

Ethn Dis

journal_title

Ethnicity & disease

authors

Sacco RL,Sabala EA,Rundek T,Juo SH,Huang JS,DiTullio M,Homma S,Almonte K,Lithgow CG,Boden-Albala B

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

351-7

issue

2

eissn

1049-510X

issn

1945-0826

journal_volume

17

pub_type

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