Abstract:
:Conotoxins are small disulfide-rich peptides from the venom of cone snails. Along with other conopeptides, they target a wide range of membrane receptors, ion channels, and transporters, and because of their high potency and selectivity for defined subtypes of these receptors, they have attracted a great deal of attention recently as leads in drug development. However, like most peptides, conopeptides potentially suffer from the disadvantages of poor absorption, poor stability, or short biological half-lives. Recently, various chemical approaches, including residue substitutions, backbone cyclization, and disulfide-bridge modification, have been reported to increase the stability of conopeptides. These manufactured interventions add to the array of post-translational modifications that occur naturally in conopeptides. They enhance the versatility of these peptides as tools in neuroscience and as drug leads.
journal_name
ACS Chem Bioljournal_title
ACS chemical biologyauthors
Craik DJ,Adams DJdoi
10.1021/cb700091jsubject
Has Abstractpub_date
2007-07-20 00:00:00pages
457-68issue
7eissn
1554-8929issn
1554-8937journal_volume
2pub_type
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