CLA differently regulates adipogenesis in stromal vascular cells from porcine subcutaneous adipose and skeletal muscle.

abstract：:In skin fibroblasts grown from four children with a homozygous form of type II hyperlipoproteinemia, the feedback control of sterol synthesis and the inhibitory effect on hydroxymethylglutaryl (HMG) CoA reductase activity by serum or low density lipoprotein were present, though diminished compared with the effects in ...

journal_title：Journal of lipid research

authors： Avigan J,Bhathena SJ,Schreiner ME

更新日期：1975-03-01 00:00:00

abstract：:Zonation affects liver parenchymal cell function and metabolism as well as nonparenchymal cell activation, but whether VLDL production is zonated has yet to be elucidated. Infection induces enhanced VLDL secretion by the liver. Ex vivo studies were undertaken to examine the liver heterogeneity for VLDL formation and s...

journal_title：Journal of lipid research

authors： Aspichueta P,Pérez S,Ochoa B,Fresnedo O

更新日期：2005-05-01 00:00:00

abstract：:Phosphatidylcholine preparations containing saturated and unsaturated molecular species were subjected to KMnO(4)-NaIO(4) oxidation in aqueous acetic acid, which left only disaturated species intact. After the oxidation, the remaining intact phosphatidylcholine was separated by thin-layer chromatography. The procedure...

journal_title：Journal of lipid research

authors： Shimojo T,Abe M,Ota M

更新日期：1974-09-01 00:00:00

abstract：:A new sample preparation method coupled to GC-MS analysis was developed and validated for quantification of sulfate esters of pregnenolone (PREG-S) and dehydroepiandrosterone (DHEA-S) in rat brain. Using a solid-phase extraction recycling protocol, the results show that little or no PREG-S and DHEA-S (<1 pmol/g) is pr...

journal_title：Journal of lipid research

authors： Liere P,Pianos A,Eychenne B,Cambourg A,Liu S,Griffiths W,Schumacher M,Sjövall J,Baulieu EE

更新日期：2004-12-01 00:00:00

abstract：:Livers from fed or 24-hr fasted male rats were perfused in a recycling system. VLDL labeled with [1-14C]oleate (95% in triglyceride), produced in separate perfusions of livers from fed rats, was added to the medium as a pulse. Uptake of VLDL 14C-labeled triglyceride by livers from fasted rats was less than that from f...

journal_title：Journal of lipid research

authors： Wilcox HG,Heimberg M

更新日期：1987-04-01 00:00:00

abstract：:To determine the acute effects of insulin on lipoprotein metabolism, we have followed the plasma lipoprotein lipid and apolipoprotein levels during insulin therapy for the first 24 hr in 13 patients with diabetic ketoacidosis. Corrections were made for plasma volume changes during treatment. Before insulin treatment, ...

journal_title：Journal of lipid research

authors： Weidman SW,Ragland JB,Fisher JN Jr,Kitabchi AE,Sabesin SM

更新日期：1982-01-01 00:00:00

abstract：:Maintaining cellular lipid homeostasis is crucial to oxidative tissues, and it becomes compromised in obesity. Lipid droplets (LD) play a central role in lipid homeostasis by mediating fatty acid (FA) storage in the form of triglyceride, thereby lowering intracellular levels of lipids that mediate cellular lipotoxicit...

journal_title：Journal of lipid research

authors： Wang H,Sreenivasan U,Hu H,Saladino A,Polster BM,Lund LM,Gong DW,Stanley WC,Sztalryd C

更新日期：2011-12-01 00:00:00

abstract：:Scavenger receptor class B type I (SR-BI) has been identified as a functional HDL binding protein that can mediate the selective uptake of cholesteryl ester (CE) from HDL. To quantify the in vivo role of SR-BI in the process of selective uptake, HDL was labeled with cholesteryl ether ([(3)H] CEt-HDL) and (125)I-tyrami...

journal_title：Journal of lipid research

authors： Out R,Hoekstra M,Spijkers JA,Kruijt JK,van Eck M,Bos IS,Twisk J,Van Berkel TJ

更新日期：2004-11-01 00:00:00

abstract：:In an attempt to understand the applicability of various animal models to dyslipidemia in humans and to identify improved preclinical models for target discovery and validation for dyslipidemia, we measured comprehensive plasma lipid profiles in 24 models. These included five mouse strains, six other nonprimate specie...

journal_title：Journal of lipid research

authors： Yin W,Carballo-Jane E,McLaren DG,Mendoza VH,Gagen K,Geoghagen NS,McNamara LA,Gorski JN,Eiermann GJ,Petrov A,Wolff M,Tong X,Wilsie LC,Akiyama TE,Chen J,Thankappan A,Xue J,Ping X,Andrews G,Wickham LA,Gai CL,Trinh

更新日期：2012-01-01 00:00:00

abstract：:In vitro, -polylysine (EPL) strongly inhibited the hydrolysis of trioleoylglycerol emulsified with phosphatidylcholine (PC) and taurocholate by either pancreatic lipase or carboxylester lipase. The EPL concentration required for 50% inhibition of pancreatic lipase, 0.12 microM, was eight times lower than the concentra...

journal_title：Journal of lipid research

authors： Tsujita T,Takaichi H,Takaku T,Aoyama S,Hiraki J

更新日期：2006-08-01 00:00:00

abstract：:Interactions of apolipoprotein A-I (apoA-I) with cell membranes appear to be important in the initial steps of reverse cholesterol transport. The objective of this work was to examine the effect of three distinct conformations of apoA-I (lipid-free and in 78 A or 96 A reconstituted high density lipoproteins, rHDL) on ...

journal_title：Journal of lipid research

authors： Tricerri MA,Sanchez SA,Arnulphi C,Durbin DM,Gratton E,Jonas A

更新日期：2002-02-01 00:00:00

abstract：:We report on the effect of human apolipoprotein (apo) A-II transgene expression on atherosclerosis susceptibility in two transgenic lines (25.3 and 11.1) whose plasma human apoA-II concentrations (approximately 23 and 96 mg/dl, respectively) span the normal range in humans. After 9 months of an atherogenic diet, 25.3 ...

journal_title：Journal of lipid research

authors： Escolà-Gil JC,Marzal-Casacuberta A,Julve-Gil J,Ishida BY,Ordóñez-Llanos J,Chan L,González-Sastre F,Blanco-Vaca F

更新日期：1998-02-01 00:00:00

abstract：:Recent studies suggest that 7-dehydrocholesterol (7-DHC)-derived oxysterols play important roles in the pathophysiology of Smith-Lemli-Opitz syndrome (SLOS), a metabolic disorder that is caused by defective 3β-hydroxysterol-Δ(7)-reductase (DHCR7). Although 14 oxysterols have been identified as the primary products of ...

journal_title：Journal of lipid research

authors： Xu L,Korade Z,Rosado DA Jr,Mirnics K,Porter NA

更新日期：2013-04-01 00:00:00

abstract：:Four groups of 20 weanling swine each were fed either (a) basal diet, (b) basal plus hydrogenated fat (13% trans), (c) basal plus hydrogenated fat (13% trans) and 0.4% cholesterol, or (d) basal plus beef tallow (all cis). After six months of feeding, the animals were killed and the blood and aortas were removed. Very ...

journal_title：Journal of lipid research

authors： Jackson RL,Morrisett JD,Pownall HJ,Gotto AM Jr,Kamio A,Imai H,Tracy R,Kummerow FA

更新日期：1977-03-01 00:00:00

abstract：:N-3 trans geometrical isomers of 20:5 n-3 and 22:6 n-3 were isolated from rats fed heated linseed oil. The ability of these acids to inhibit 20:4 n-6 metabolism by human platelets was examined. The concentrations required to inhibit 50% of platelet aggregation (IC50) induced by 2.5 microM 20:4 n-6 were higher for the ...

journal_title：Journal of lipid research

authors： O'Keefe SF,Lagarde M,Grandgirard A,Sebedio JL

更新日期：1990-07-01 00:00:00

abstract：:Lipid lamellae present in the outermost layer of the skin, the stratum corneum, form the main barrier for the diffusion of molecules through the skin. The presence of a unique 13 nm lamellar phase and its high crystallinity are characteristic for the stratum corneum lipid phase behavior. In the present study, small-an...

journal_title：Journal of lipid research

authors： de Jager MW,Gooris GS,Ponec M,Bouwstra JA

更新日期：2005-12-01 00:00:00

abstract：:Cardiac triacylglycerol (TG) catabolism critically depends on the TG hydrolytic activity of adipose triglyceride lipase (ATGL). Perilipin 5 (Plin5) is expressed in cardiac muscle (CM) and has been shown to interact with ATGL and its coactivator comparative gene identification-58 (CGI-58). Furthermore, ectopic Plin5 ex...

journal_title：Journal of lipid research

authors： Pollak NM,Schweiger M,Jaeger D,Kolb D,Kumari M,Schreiber R,Kolleritsch S,Markolin P,Grabner GF,Heier C,Zierler KA,Rülicke T,Zimmermann R,Lass A,Zechner R,Haemmerle G

更新日期：2013-04-01 00:00:00

abstract：:Biliary secretion of bile acid glucuronides was studied in control rats and in rats with a congenital defect in hepatobiliary transport of organic anions (GY rats). In control animals, hepatobiliary transport of [3H]lithocholic acid 3-O-glucuronide and [3H]cholic acid 3-O-glucuronide was efficient (greater than 95% in...

journal_title：Journal of lipid research

authors： Kuipers F,Radominska A,Zimniak P,Little JM,Havinga R,Vonk RJ,Lester R

更新日期：1989-12-01 00:00:00

abstract：:Previous studies have demonstrated that perturbations in barrier function stimulate epidermal lipid synthesis and that this increase can be prevented by occlusive membranes. These observations suggest that epidermal lipid synthesis might be related to barrier function and raised the question whether transcutaneous wat...

journal_title：Journal of lipid research

authors： Grubauer G,Elias PM,Feingold KR

更新日期：1989-03-01 00:00:00

abstract：:Studies were carried out to determine whether apolipoprotein (apo) A-II, like apoA-I, can recruit phospholipid and cholesterol from cell membranes, thereby forming nascent apoA-II-specific HDL. ApoA-II and apoA-I were purified from plasma and each was incubated with CHO cells at a concentration of 10 micrograms/ml. Li...

journal_title：Journal of lipid research

authors： Forte TM,Bielicki JK,Goth-Goldstein R,Selmek J,McCall MR

更新日期：1995-01-01 00:00:00

abstract：:A subgroup of peroxisomal disorders, peroxisome biogenesis defects (PBD), can be differentiated by elevated levels of C(27) bile acids in plasma and bile. Patients with peroxisomal disorders, who lack the ability to chain-shorten the C(27) bile acid intermediates into C(24) bile acids, show elevated levels of C(27) bi...

journal_title：Journal of lipid research

authors： Johnson DW,ten Brink HJ,Schuit RC,Jakobs C

更新日期：2001-01-01 00:00:00

abstract：:The in vivo formation of the sulfate ester of glycolithocholate is a critical step in the elimination of this hepatotoxic bile salt. Rhesus monkeys fed chenodeoxycholate or ursodeoxycholate, the precursors of lithocholate, develop frank cirrhosis in association with accumulation of nonsulfated glycolithocholate in bil...

journal_title：Journal of lipid research

authors： Barnes S,Waldrop R,Crenshaw J,King RJ,Taylor KB

更新日期：1986-11-01 00:00:00

abstract：:Lipid metabolism plays an important role in the regulation of cellular homeostasis. However, because it is difficult to measure the actual rates of synthesis and degradation of individual lipid species, lipid compositions are often used as a surrogate to evaluate lipid metabolism even though they provide only static s...

journal_title：Journal of lipid research

authors： Schlame M,Xu Y,Erdjument-Bromage H,Neubert TA,Ren M

更新日期：2020-01-01 00:00:00

abstract：:The pathogenesis of aortic valve stenosis (AS) is characterized by the accumulation of LDL-derived cholesterol in the diseased valves. Since LDL particles also contain plant sterols, we investigated whether plant sterols accumulate in aortic valve lesions. Serum samples were collected from 82 patients with severe AS a...

journal_title：Journal of lipid research

authors： Helske S,Miettinen T,Gylling H,Mäyränpää M,Lommi J,Turto H,Werkkala K,Kupari M,Kovanen PT

更新日期：2008-07-01 00:00:00

abstract：:The tear film covers the anterior eye and the precise balance of its various constituting components is critical for maintaining ocular health. The composition of the tear film amphiphilic lipid sublayer, in particular, has largely remained a matter of contention due to the limiting concentrations of these lipid amphi...

journal_title：Journal of lipid research

authors： Lam SM,Tong L,Duan X,Petznick A,Wenk MR,Shui G

更新日期：2014-02-01 00:00:00

abstract：:ABCA1 exports cholesterol and phospholipids from cells by a multistep pathway that involves forming cell surface lipid domains, solubilizing these lipids by apolipoproteins, binding of apolipoproteins to ABCA1, and activating signaling processes. Here we used a mutational analysis approach to evaluate the relationship...

journal_title：Journal of lipid research

authors： Vaughan AM,Tang C,Oram JF

更新日期：2009-02-01 00:00:00

abstract：:A higher incidence of coronary artery disease is associated with a lower level of HDL-cholesterol. We searched for genetic loci influencing HDL-cholesterol in F2 mice from a cross between MRL/MpJ and SM/J mice. Quantitative trait loci (QTL) mapping revealed one significant HDL QTL (Apoa2 locus), four suggestive QTL on...

journal_title：Journal of lipid research

authors： Leduc MS,Blair RH,Verdugo RA,Tsaih SW,Walsh K,Churchill GA,Paigen B

更新日期：2012-06-01 00:00:00

abstract：:The surface area, A, of contracting fatty acid monolayers was measured as a function of time, t, at constant surface pressure. In the initial temporal phase, ln A was linear with radical t. In a subsequent steady-state phase, ln A was linear with t. The initial desorption coefficient for sodium palmitate, K(i), and th...

journal_title：Journal of lipid research

authors： Patil GS,Matthews RH,Cornwell DG

更新日期：1973-01-01 00:00:00

abstract：:We have defined the lipid composition of copper-oxidized LDL (Cu-oxLDL) and a macrophage-foam cell model generated by the uptake of this modified lipoprotein. An HPLC method previously developed by our group for the measurement of lipid oxidation products of LDL was extended to permit the analysis of an array of 7-ket...

journal_title：Journal of lipid research

authors： Brown AJ,Dean RT,Jessup W

更新日期：1996-02-01 00:00:00

abstract：:The role of lipid transfer proteins during plasma membrane biogenesis was explored. Developing amphibia embryos were used because during their growth an active plasma membrane biosynthesis occurs together with negligible mitochondrial and endoplasmic reticulum proliferation. Sonicated vesicles, containing 14C-labeled ...

journal_title：Journal of lipid research

authors： Rusiñol A,Salomón RA,Bloj B

更新日期：1987-01-01 00:00:00