当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS期刊下所有文献 > Inhibition of NF-KB does not induce c-Jun N-terminal kinase-mediated apoptosis in reperfusion injury.

Inhibition of NF-KB does not induce c-Jun N-terminal kinase-mediated apoptosis in reperfusion injury.

Abstract：

BACKGROUND:The role of C-Jun N-terminal Kinase (c-Jun Kinase) in apoptosis is unclear. It is likely that c-Jun Kinase activation is cell type and stimulus dependent. c-Jun Kinase promotes tumor necrosis factor (TNF)-alpha mediated apoptosis in nuclear factor (NF)-KB deficient cells. Minimal NF-KB expression may be enough to abrogate c-Jun Kinase-mediated apoptosis during reperfusion injury. STUDY DESIGN:Forty Sprague-Dawley rats underwent hemorrhagic ischemia and reperfusion. Twenty experimental animals were treated with the NF-KB inhibitor herbimycin A, and 20 control animals underwent only hemorrhage and reperfusion. Serum TNF-alpha and c-Jun Kinase levels were measured. Adrenal, kidney, liver, ileum, colon, and skeletal muscle tissues were evaluated for apoptosis by hematoxylin and eosin staining. RESULTS:TNF-alpha levels were 400 pg/mL (control) and 385 pg/mL (experimental) during ischemia (p=0.46), increased in controls to 450 pg/mL, and decreased in the experimental arm to 175 pg/mL (p=0.028). c-Jun Kinase levels were 1,525 pg/mL (control) and 1,475 pg/mL (experimental) during ischemia (p=0.35) and increased to 5,250 pg/mL (control) and 5,000 pg/mL (experimental) after reperfusion (p=0.26). In control animals, necrosis was seen in kidney, adrenal, and liver specimens. Compared with controls, experimental animals had average tissue hemorrhage scores of less than 1 (p < 0.001), with no necrosis seen in any experimental arm (p<0.001). CONCLUSIONS:During inhibition of NF-KB, c-Jun Kinase levels remained unchanged. But no increase in cell death or necrosis was seen in tissue samples. Antiapoptotic effects were unchanged with the down-regulation of NF-KB. Minimal expression of NF-KB may be enough to protect against apoptosis in reperfusion injury.

journal_name

J Am Coll Surg

journal_title

Journal of the American College of Surgeons

authors

Rushing GD,Britt LD

doi

10.1016/j.jamcollsurg.2007.01.029

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

964-7; discussion 967-8

issue

5

eissn

1072-7515

issn

1879-1190

pii

S1072-7515(07)00084-1

journal_volume

204

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS文献大全
  • Association Between Burn Injury and Mental Illness among Burn Survivors: A Population-Based, Self-Matched, Longitudinal Cohort Study.

    abstract：BACKGROUND:Mental health disorders are prevalent before and after burn injury. However, the impact of burn injury on risk of subsequent mental health disorders is unknown. STUDY DESIGN:We conducted a population-based, self-matched longitudinal cohort study using administrative data in Ontario, Canada between 2003 and ...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2017.06.004

    authors： Mason SA,Nathens AB,Byrne JP,Ellis J,Fowler RA,Gonzalez A,Karanicolas PJ,Moineddin R,Jeschke MG

    更新日期：2017-10-01 00:00:00

  • Primary fascial closure with mesh reinforcement is superior to bridged mesh repair for abdominal wall reconstruction.

    abstract：BACKGROUND:Many surgeons believe that primary fascial closure with mesh reinforcement should be the goal of abdominal wall reconstruction (AWR), yet others have reported acceptable outcomes when mesh is used to bridge the fascial edges. It has not been clearly shown how the outcomes for these techniques differ. We hypo...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2013.08.015

    authors： Booth JH,Garvey PB,Baumann DP,Selber JC,Nguyen AT,Clemens MW,Liu J,Butler CE

    更新日期：2013-12-01 00:00:00

  • Does vaginal cuff closure decrease the infectious morbidity associated with abdominal hysterectomy?

    abstract：BACKGROUND:Infectious morbidity after total abdominal hysterectomy includes fever (31%) and antibiotic administration (45%). Whether vaginal cuff closure reduces postoperative infectious morbidity remains unresolved. STUDY DESIGN:We reviewed the records of 172 consecutive abdominal hysterectomies for nonmalignant dise...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：

    authors： Korn AP,Grullon K,Hessol N,Lin P,Siopak J

    更新日期：1997-10-01 00:00:00

  • Atypical variants of classic achalasia are common and currently under-recognized: a study of prevalence and clinical features.

    abstract：BACKGROUND:Advances in esophageal manometry have facilitated identification of variants of achalasia, suggesting they are more common than previously thought. This study assesses the frequency and clinical characteristics of patients with motility abnormalities similar to, but not meeting criteria for, classic achalasi...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2011.02.008

    authors： Galey KM,Wilshire CL,Niebisch S,Jones CE,Raymond DP,Litle VR,Watson TJ,Peters JH

    更新日期：2011-07-01 00:00:00

  • Portal vein resection in borderline resectable pancreatic cancer: a United Kingdom multicenter study.

    abstract：BACKGROUND:Until recently, in the United Kingdom, borderline resectable pancreatic cancer with invasion into the portomesenteric veins often resulted in surgical bypass because of the presumed high risk for complications and the uncertainty of a survival benefit associated with a vascular resection. Portomesenteric vei...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jamcollsurg.2013.11.017

    authors： Ravikumar R,Sabin C,Abu Hilal M,Bramhall S,White S,Wigmore S,Imber CJ,Fusai G,UK Vascular Resection in Pancreatic Cancer Study Group.

    更新日期：2014-03-01 00:00:00

  • Placental umbilical cord whole blood transfusion: a safe and genuine blood substitute for patients of the under-resourced world at emergency.

    abstract：BACKGROUND:Afterbirth or placenta is normally discarded. But placental cord blood, because of its rich mix of fetal and adult hemoglobin, plasma, and high platelet count has the potential to be a safe alternative to adult blood. STUDY DESIGN:We transfused 413 U (range 50 mL to 146 mL; mean 86 mL+/-7.6 mL SD; median 80...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2004.12.007

    authors： Bhattacharya N

    更新日期：2005-04-01 00:00:00

  • Clinical Risk Score to Predict Pancreatic Fistula after Pancreatoduodenectomy: Independent External Validation for Open and Laparoscopic Approaches.

    abstract：BACKGROUND:A clinical risk score for pancreatic fistula (CRS-PF) was recently reported to predict postoperative pancreatic fistula (POPF) after pancreatoduodenectomy (PD). An independent external validation has not been performed. Our hypothesis was that CRS-PF predicts POPF after both laparoscopic and open PD. STUDY ...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2015.05.011

    authors： Shubert CR,Wagie AE,Farnell MB,Nagorney DM,Que FG,Reid Lombardo KM,Truty MJ,Smoot RL,Kendrick ML

    更新日期：2015-09-01 00:00:00

  • Diagnosis and treatment of Mirizzi syndrome: 23-year Mayo Clinic experience.

    abstract：BACKGROUND:Mirizzi syndrome (MS) is characterized by extrinsic compression of the common hepatic duct by stones impacted in the cystic duct or gallbladder neck. Open cholecystectomy (OC) has been the standard treatment; however, laparoscopy has challenged this approach. STUDY DESIGN:The objective of this study was to ...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2011.03.008

    authors： Erben Y,Benavente-Chenhalls LA,Donohue JM,Que FG,Kendrick ML,Reid-Lombardo KM,Farnell MB,Nagorney DM

    更新日期：2011-07-01 00:00:00

  • Report of a Simplified Frailty Score Predictive of Short-Term Postoperative Morbidity and Mortality.

    abstract：BACKGROUND:Frailty is an objective method of quantifying a patient's fitness for surgery. Its clinical use is limited by the time needed to complete, as well as a lack of evidence-based interventions to improve outcomes in identified frail patients. The purpose of this study was to critically analyze the components of ...

    journal_title：Journal of the American College of Surgeons

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.jamcollsurg.2015.01.053

    authors： Revenig LM,Canter DJ,Kim S,Liu Y,Sweeney JF,Sarmiento JM,Kooby DA,Maithel SK,Hill LL,Master VA,Ogan K

    更新日期：2015-05-01 00:00:00

  • A technique of direct percutaneous jejunostomy tube placement.

    abstract：:A technique for replacement of a feeding jejunostomy tube using endoscopic direct visualization is described herein. It can be used in patients who have had a previously placed open jejunostomy tube removed after recovery from resection of the gastrointestinal tract. This is accomplished quite easily using local anest...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：

    authors： Pritchard TJ,Bloom AD

    更新日期：1994-02-01 00:00:00

  • Cost-effectiveness of preoperative sestamibi scan for primary hyperparathyroidism is dependent solely upon the surgeon's choice of operative procedure.

    abstract：BACKGROUND:In 1991, a National Institutes of Health Consensus Panel stated that preoperative localization for primary hyperparathyroidism is not cost effective. Since then, the sestamibi scan has been applied to parathyroid disease with excellent results, even allowing unilateral exploration under local anesthesia. ST...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章,meta分析

    doi：10.1016/s1072-7515(98)00016-7

    authors： Denham DW,Norman J

    更新日期：1998-03-01 00:00:00

  • Outcomes of synthetic mesh in contaminated ventral hernia repairs.

    abstract：BACKGROUND:Given the questionable long-term durability of biologic meshes, additional prosthetic options for ventral hernia repairs (VHR) in contaminated fields are necessary. Recent evidence suggests improved bacterial resistance of reduced-weight, large-pore synthetics, giving a potential mesh alternative for repair ...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jamcollsurg.2013.07.382

    authors： Carbonell AM,Criss CN,Cobb WS,Novitsky YW,Rosen MJ

    更新日期：2013-12-01 00:00:00

  • Postoperative Myocardial Infarction in Administrative Data vs Clinical Registry: A Multi-Institutional Study.

    abstract：BACKGROUND:Previous studies have documented significant differences between administrative data and registry data in the determination of postoperative MI. The goal of this study was to characterize discordance between administrative and registry data in the determination of postoperative myocardial infarction (MI). S...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jamcollsurg.2017.09.016

    authors： Etzioni DA,Lessow C,Bordeianou LG,Kunitake H,Deery SE,Carchman E,Papageorge CM,Fuhrman G,Seiler RL,Ogilvie J,Habermann EB,Chang YH,Money SR

    更新日期：2018-01-01 00:00:00

  • Sterility of the surgical site marking between the ink and the epidermis.

    abstract：BACKGROUND:To prevent wrong-site surgery, multiple organizations have endorsed the practice of signing the operative site with an indelible marker. Potential contamination of the surgical field and the inability to prepare the area under the ink film raises concerns. The purpose of this study was to determine if the us...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2007.02.029

    authors： Cullan DB 2nd,Wongworawat MD

    更新日期：2007-08-01 00:00:00

  • A survey of hospital management practices for vulvar melanoma.

    abstract：BACKGROUND:Vulvar melanoma is a very rare form of cancer. The purpose of this study was to describe practice patterns for the management of vulvar melanoma. STUDY DESIGN:The National Cancer Data Base was reviewed from 1985 through 1994 for patient reports submitted with a diagnosis of vulvar melanoma. RESULTS:Five hu...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/s1072-7515(99)00033-2

    authors： Creasman WT,Phillips JL,Menck HR

    更新日期：1999-06-01 00:00:00

  • Digital fecal occult blood testing in the ambulatory urology clinic.

    abstract：BACKGROUND:This study was designed to evaluate the use and yield of fecal occult blood testing (FOBT) in an ambulatory urology clinic. STUDY DESIGN:Patients seen in the ambulatory urology clinic were prospectively evaluated with FOBT. The test was performed only on patients when a rectal examination was indicated as p...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2007.06.295

    authors： Goetzl MA,Outman JE,Griebling TL,Holzbeierlein JM,Weigel JW,Thrasher JB

    更新日期：2008-01-01 00:00:00

  • Dipyridamole protects the liver against warm ischemia and reperfusion injury.

    abstract：BACKGROUND:Adenosine, a metabolite of adenosine triphosphate degradation during ischemia, is reported to attenuate ischemia and reperfusion injury in several tissues. Dipyridamole is a nucleoside transport inhibitor that augments endogenous adenosine. In this study, we tested whether dipyridamole would attenuate hepati...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2003.12.002

    authors： Taniguchi M,Magata S,Suzuki T,Shimamura T,Jin MB,Iida J,Furukawa H,Todo S

    更新日期：2004-05-01 00:00:00

  • Predictors of Survival in Patients with Resectable Gastric Cancer Treated with Preoperative Chemoradiation Therapy and Gastrectomy.

    abstract：BACKGROUND:The purpose of this study was to determine the overall survival (OS) of patients with resectable gastric cancer treated with preoperative chemoradiation therapy and gastrectomy. STUDY DESIGN:The medical records of patients with gastric adenocarcinoma presenting to our institution (January 1995 to August 201...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2015.04.004

    authors： Badgwell B,Blum M,Estrella J,Chiang YJ,Das P,Matamoros A,Fournier K,Mansfield P,Ajani J

    更新日期：2015-07-01 00:00:00

  • Impact of deceased organ donor demographics and critical care end points on liver transplantation and graft survival rates.

    abstract：BACKGROUND:The criteria for organ acceptance remain inconsistent, which limits the ability to standardize critical care practices. We sought to examine predictors of liver graft use and survival to better guide the selection and management of potential organ donors. STUDY DESIGN:A prospective observational study of al...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jamcollsurg.2014.09.020

    authors： Bloom MB,Raza S,Bhakta A,Ewing T,Patel M,Ley EJ,Margulies DR,Salim A,Malinoski D

    更新日期：2015-01-01 00:00:00

  • Quality check of a quality measure: surgical wound classification discrepancies impact risk-stratified surgical site infection rates in pediatric appendicitis.

    abstract：BACKGROUND:The impact of quality measures in health care and reimbursement is growing. Ensuring the accuracy of quality measures, including any risk-stratification variables, is necessary. Surgical site infection rates, risk stratified by surgical wound classification (SWC) among other variables, are increasingly consi...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2013.07.398

    authors： Levy SM,Holzmann-Pazgal G,Lally KP,Davis K,Kao LS,Tsao K

    更新日期：2013-12-01 00:00:00

  • Improved extubation rates and earlier liberation from mechanical ventilation with implementation of a daily spontaneous-breathing trial protocol.

    abstract：BACKGROUND:Daily spontaneous-breathing trials (SBTs) are promulgated as the best method for assessing readiness for discontinuation of mechanical ventilation. SBT protocols have also been shown to improve outcomes as opposed to wild-type implementation of daily SBT recommendations. Here we determine whether implementat...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2007.08.022

    authors： Robertson TE,Sona C,Schallom L,Buckles M,Cracchiolo L,Schuerer D,Coopersmith CM,Song F,Buchman TG

    更新日期：2008-03-01 00:00:00

  • Nationwide Outcomes Measurement in Colorectal Cancer Surgery: Improving Quality and Reducing Costs.

    abstract：BACKGROUND:Recent literature suggests that focus in health care should shift from reducing costs to improving quality; where quality of health care improves, cost reduction will follow. Our primary aim was to investigate whether improving the quality of surgical colorectal cancer care, by using a national quality impro...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2015.09.020

    authors： Govaert JA,van Dijk WA,Fiocco M,Scheffer AC,Gietelink L,Wouters MW,Tollenaar RA

    更新日期：2016-01-01 00:00:00

  • Elective abdominal aortic aneurysm repair: relationship of hospital teaching status to repair type, resource use, and outcomes.

    abstract：BACKGROUND:There has been a dramatic increase in the use of endovascular technology for treatment of abdominal aortic aneurysms (AAA), but practice patterns have not been well-evaluated. Hospital resource use and outcomes after elective endovascular abdominal aortic repair (EVAR) and open surgical repair were assessed ...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2009.05.024

    authors： Vogel TR,Dombrovskiy VY,Graham AM

    更新日期：2009-09-01 00:00:00

  • Peripheral ports are a new option for central venous access.

    abstract：BACKGROUND:Peripheral ports represent a new option for central venous access that have a low complication rate while providing long duration. This study provides five years of evaluation of this device. STUDY DESIGN:All patients had follow-up evaluation concurrently, with detailed information collected for the first 7...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：

    authors： Schuman E,Ragsdale J

    更新日期：1995-04-01 00:00:00

  • Vaginoplasty using deepithelialized vulvar transposition flaps: the Grünberger method.

    abstract：BACKGROUND:One of the most important criteria indicative of the longterm success of vaginal enlargement is the absence of postoperative contracture. Numerous procedures have been developed for reconstruction of an inadequate vagina. Some are technically complex techniques (myo- and fasciocutaneous flaps) with few posto...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/s1072-7515(02)01541-7

    authors： Wierrani F,Grünberger W

    更新日期：2003-01-01 00:00:00

  • Modification of the "push" technique for percutaneous endoscopic gastrostomy in infants and children.

    abstract：BACKGROUND:Percutaneous endoscopic gastrostomy (PEG) by the "push" technique avoids peri-catheter infection, repeated insertion of the endoscope, potential esophageal injury from the catheter, and the possible need for another endoscopy for catheter removal associated with the "pull" technique. In small infants, howeve...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：

    authors： Robertson FM,Crombleholme TM,Latchaw LA,Jacir NN

    更新日期：1996-03-01 00:00:00

  • Outcomes with split liver transplantation are equivalent to those with whole organ transplantation.

    abstract：BACKGROUND:Split liver transplantation is an excellent option for expansion of the donor organ pool. However, reports of increased morbidity in split liver recipients may limit use of this technique. STUDY DESIGN:This was a single center retrospective analysis investigating split liver transplantation. Between August ...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2013.03.003

    authors： Doyle MB,Maynard E,Lin Y,Vachharajani N,Shenoy S,Anderson C,Earl M,Lowell JA,Chapman WC

    更新日期：2013-07-01 00:00:00

  • Laparoscopic repair of lumbar hernias.

    abstract：BACKGROUND:Lumbar hernias are rare defects in the posterolateral abdominal wall that may be congenital or acquired. Repairing these defects is difficult by virtue of their location and the inherent weakness of the surrounding tissues. We report a series of seven patients who had their lumbar hernias repaired laparoscop...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/s1072-7515(98)00124-0

    authors： Arca MJ,Heniford BT,Pokorny R,Wilson MA,Mayes J,Gagner M

    更新日期：1998-08-01 00:00:00

  • Preoperative esophageal cancer staging: magnetic resonance imaging of lymph node with ferumoxtran-10, an ultrasmall superparamagnetic iron oxide.

    abstract：BACKGROUND:Accurate detection of metastasis to lymph nodes is an essential component of the approach to treatment. The purpose of this study was to evaluate the utility of magnetic resonance imaging with ferumoxtran-10 in diagnosing lymph node metastasis in esophageal cancer. STUDY DESIGN:Sixteen patients with esophag...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/j.jamcollsurg.2005.12.004

    authors： Nishimura H,Tanigawa N,Hiramatsu M,Tatsumi Y,Matsuki M,Narabayashi I

    更新日期：2006-04-01 00:00:00

  • Fifteen-year experience in axillofemoral bypass with externally supported knitted Dacron prosthesis in a Japanese hospital.

    abstract：BACKGROUND:Recently, several reports in the United States have demonstrated remarkable improvement in the patency of axillofemoral (AXF) bypass with an externally supported prosthesis. The purpose of this study was to review the prognoses regarding graft patency, limb salvage, and survival of patients who underwent AXF...

    journal_title：Journal of the American College of Surgeons

    pub_type： 杂志文章

    doi：10.1016/s1072-7515(98)00084-2

    authors： Mii S,Mori A,Sakata H,Kawazoe N

    更新日期：1998-05-01 00:00:00