Placental umbilical cord whole blood transfusion: a safe and genuine blood substitute for patients of the under-resourced world at emergency.

Abstract:

BACKGROUND:Afterbirth or placenta is normally discarded. But placental cord blood, because of its rich mix of fetal and adult hemoglobin, plasma, and high platelet count has the potential to be a safe alternative to adult blood. STUDY DESIGN:We transfused 413 U (range 50 mL to 146 mL; mean 86 mL+/-7.6 mL SD; median 80 mL; mean packed cell volume 48+/-4.1% SD; mean hemoglobin concentration 16.2 g/dL+/-1.8 g/dL SD) of placental umbilical cord whole blood, after lower uterine cesarean section from consenting mothers, to 129 informed consenting patients, after screening by the institutional ethics committee, from April 1, 1999, until the present. RESULTS:The list of consenting patients included 54 men and 75 women. Patient age varied from 2 years to 86 years. Seventy-three patients (56.58%) suffered from advanced cancer and 56 (43.42%) patients had other diseases like ankylosing spondylitis, lupus erythematosus, rheumatoid arthritis, aplastic anemia, and thalassemia major. We have not encountered a single case of immunologic or nonimmunologic reaction so far. CONCLUSIONS:We suggest that medical institutions could use this gift of nature, which is free from infection, hypoantigenic with altered metabolic profile, filled with growth factor and cytokine-filled plasma, with the potential of higher oxygen-carrying capacity than adult blood, as an emergency source of blood for the management of disaster or crises anywhere in the world. It also may be safely used for the treatment of malignant and nonmalignant disorders.

journal_name

J Am Coll Surg

authors

Bhattacharya N

doi

10.1016/j.jamcollsurg.2004.12.007

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

557-63

issue

4

eissn

1072-7515

issn

1879-1190

pii

S1072-7515(04)01539-X

journal_volume

200

pub_type

杂志文章
  • A simple one-handed method to secure drains and tubes.

    abstract::A technically elegant, fast and reliable method to secure drains and tubes is presented herein. The method can be used with any type of drains and with any suture material. ...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:

    authors: Sachse RE

    更新日期:1994-06-01 00:00:00

  • Are surgical trials with negative results being interpreted correctly?

    abstract:BACKGROUND:Many published accounts of clinical trials report no differences between the treatment arms, while being underpowered to find differences. This study determined how the authors of these reports interpreted their findings. STUDY DESIGN:We examined 54 reports of surgical trials chosen randomly from a database...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2012.09.015

    authors: Brody BA,Ashton CM,Liu D,Xiong Y,Yao X,Wray NP

    更新日期:2013-01-01 00:00:00

  • Accessory duct sphincteroplasty is preferred for long-term prevention of recurrent acute pancreatitis in patients with pancreas divisum.

    abstract:BACKGROUND:The putative relationship between pancreas divisum and clinical pancreatitis continues to be controversial. Indications for surgical or endoscopic manipulations of the accessory duct ampulla are unclear, and the relative merits of surgical sphincteroplasty, endoscopic sphincterotomy, and accessory duct stent...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:

    authors: Bradley EL 3rd,Stephan RN

    更新日期:1996-07-01 00:00:00

  • Determining benchmarks for evaluation and management coding in an academic division of general surgery.

    abstract:BACKGROUND:Academic divisions of general surgery are facing ever-increasing financial pressures. Cost-cutting is a common approach to maintaining profitability, but strategies to increase revenue should not be ignored. One specific avenue for enhanced revenue generation in general surgery is that of coding for evaluati...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2004.03.002

    authors: Kuo PC,Douglas AR,Oleski D,Jacobs DO,Schroeder RA

    更新日期:2004-07-01 00:00:00

  • Surgical management of late sequelae in survivors of an episode of acute necrotizing pancreatitis.

    abstract:BACKGROUND:After surviving an episode of acute necrotizing pancreatitis (ANP), a variety of late sequelae develop and require nonoperative or operative interventions. Persistent pancreatic fistula, fluid collections, recurrent pancreatitis, sepsis, pain, and intolerance of po intake are seen. STUDY DESIGN:We have main...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2011.12.043

    authors: Beck WC,Bhutani MS,Raju GS,Nealon WH

    更新日期:2012-04-01 00:00:00

  • Comprehensive Analysis of the Effect of Ketorolac Administration after Pancreaticoduodenectomy.

    abstract:BACKGROUND:Outcome improvement is a major goal of pancreatic surgery. Such efforts include decreasing perioperative narcotic use to optimize care and reduce potential contributions to the opioid crisis. Ketorolac, a frequent component of opioid-minimizing recovery pathways, has not been universally adopted over concern...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2020.02.024

    authors: Kunstman JW,Brandt WS,Azar SA,Jean RA,Salem RR

    更新日期:2020-06-01 00:00:00

  • What are the real rates of postoperative complications: elucidating inconsistencies between administrative and clinical data sources.

    abstract:BACKGROUND:Comparison of quality outcomes generated from administrative and clinical datasets have shown inconsistencies. Understanding this is important because data designed to drive performance improvement are used for public reporting of performance. We examined administrative and clinical data and 2 clinical data ...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2011.12.037

    authors: Koch CG,Li L,Hixson E,Tang A,Phillips S,Henderson JM

    更新日期:2012-05-01 00:00:00

  • Prospective randomized single-blinded in vitro and ex vivo evaluation of new and reprocessed laparoscopic trocars.

    abstract:BACKGROUND:Reprocessing of single-use medical instruments has been proposed as a mechanism for managing the rising costs of health care. We compared the performance of new and reprocessed laparoscopic trocars. STUDY DESIGN:New and reprocessed laparoscopic trocars were evaluated. Testing consisted of visual and microsc...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jamcollsurg.2010.08.003

    authors: Mues AC,Haramis G,Casazza C,Okhunov Z,Badani KK,Landman J

    更新日期:2010-12-01 00:00:00

  • Sterility of the surgical site marking between the ink and the epidermis.

    abstract:BACKGROUND:To prevent wrong-site surgery, multiple organizations have endorsed the practice of signing the operative site with an indelible marker. Potential contamination of the surgical field and the inability to prepare the area under the ink film raises concerns. The purpose of this study was to determine if the us...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2007.02.029

    authors: Cullan DB 2nd,Wongworawat MD

    更新日期:2007-08-01 00:00:00

  • Nonelective excisional colorectal surgery in English National Health Service Trusts: a study of outcomes from Hospital Episode Statistics Data between 1996 and 2007.

    abstract:BACKGROUND:Nonelective colorectal surgery is associated with substantial patient morbidity and mortality. This study sought to describe the practice of emergency colorectal surgery in the United Kingdom during an 11-year period using the Hospital Episode Statistics (HES) database. STUDY DESIGN:All nonelective admissio...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2009.11.017

    authors: Faiz O,Warusavitarne J,Bottle A,Tekkis PP,Clark SK,Darzi AW,Aylin P

    更新日期:2010-04-01 00:00:00

  • Preoperative esophageal cancer staging: magnetic resonance imaging of lymph node with ferumoxtran-10, an ultrasmall superparamagnetic iron oxide.

    abstract:BACKGROUND:Accurate detection of metastasis to lymph nodes is an essential component of the approach to treatment. The purpose of this study was to evaluate the utility of magnetic resonance imaging with ferumoxtran-10 in diagnosing lymph node metastasis in esophageal cancer. STUDY DESIGN:Sixteen patients with esophag...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2005.12.004

    authors: Nishimura H,Tanigawa N,Hiramatsu M,Tatsumi Y,Matsuki M,Narabayashi I

    更新日期:2006-04-01 00:00:00

  • Laparoscopic adjustable gastric banding: 1,014 consecutive cases.

    abstract:BACKGROUND:The purpose of this study was to examine 1,014 consecutive laparoscopic adjustable gastric banding (LAGB) procedures with up to 48 months of followup, including evolution and changes in surgical technique, learning curve issues, weight loss outcomes, and complications. STUDY DESIGN:Between October 2000 and ...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2005.05.001

    authors: Ponce J,Paynter S,Fromm R

    更新日期:2005-10-01 00:00:00

  • Thyroid and parathyroid operations in veterans affairs and selected university medical centers: results of the patient safety in surgery study.

    abstract:BACKGROUND:There is increasing interest in surgical outcomes. The Patient Safety in Surgery (PSS) Study database was examined about thyroid and parathyroid procedures to determine risk factors for adverse outcomes and outcomes rates. Relative outcomes performance for the Veterans Affairs (VA) and private-sector populat...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2007.02.073

    authors: Hall BL,Hirbe M,Yan Y,Khuri SF,Henderson WG,Hamilton BH

    更新日期:2007-06-01 00:00:00

  • Beneficial effects of growth hormone and insulin-like growth factor I on intestinal bacterial translocation, endotoxemia, and apoptosis in experimentally jaundiced rats.

    abstract:BACKGROUND:This study was undertaken to investigate the effect of growth hormone (GH) and insulin-like growth factor I (IGF-I), two well-known growth factors, on bacterial translocation, endotoxemia, enterocyte apoptosis, and intestinal and liver histology in a model of experimental obstructive jaundice in rats. STUDY...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/s1072-7515(99)00285-9

    authors: Scopa CD,Koureleas S,Tsamandas AC,Spiliopoulou I,Alexandrides T,Filos KS,Vagianos CE

    更新日期:2000-04-01 00:00:00

  • In-hospital mortality after pancreatic resection for chronic pancreatitis: population-based estimates from the nationwide inpatient sample.

    abstract:BACKGROUND:Pancreatic resection can be performed to ameliorate the sequelae of chronic pancreatitis in selected patients. The perceived risk of pancreatectomy may limit its use. Using a national database, this study compared mortality after pancreatic resections for chronic pancreatitis with those performed for neoplas...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2009.05.030

    authors: Hill JS,McPhee JT,Whalen GF,Sullivan ME,Warshaw AL,Tseng JF

    更新日期:2009-10-01 00:00:00

  • Focal hepatic ablation using interstitial photon radiation energy.

    abstract:BACKGROUND:Intratumoral ablative therapy is being used increasingly for the treatment of primary and secondary hepatic malignancies. The interstitial point-source photon radiosurgery system (PRS) is a novel ablative technique that uses radiation therapy similar in dosimetry to interstitial brachytherapy. STUDY DESIGN:...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/s1072-7515(00)00295-7

    authors: Koniaris LG,Chan DY,Magee C,Solomon SB,Anderson JH,Smith DO,De Weese T,Kavoussi LR,Choti MA

    更新日期:2000-08-01 00:00:00

  • Impact of fatigue on neurophysiologic measures of surgical residents.

    abstract:BACKGROUND:To gain additional insight into the impact of fatigue on surgery resident proficiency, we set out to quantify its impact on behavioral and neurophysiologic measures. STUDY DESIGN:Simulations were first created using a visio-haptic joystick attached to a surgical instrument (tool) that allows realistic inter...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2011.03.028

    authors: Kahol K,Smith M,Brandenberger J,Ashby A,Ferrara JJ

    更新日期:2011-07-01 00:00:00

  • GATA-3 expression as a predictor of hormone response in breast cancer.

    abstract:BACKGROUND:Expression of estrogen receptor-alpha (ERalpha) as determined by immunohistochemistry of tumor tissue is currently the most clinically useful test to predict hormone responsiveness of breast cancer. Thirty percent of ERalpha-positive breast cancers do not respond to hormonal therapy. GATA-3 is a transcriptio...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2004.12.025

    authors: Parikh P,Palazzo JP,Rose LJ,Daskalakis C,Weigel RJ

    更新日期:2005-05-01 00:00:00

  • Primary hyperparathyroidism in patients who have received radiation therapy and in patients who have not received radiation therapy.

    abstract:BACKGROUND:Primary hyperparathyroidism (HPT) occurs more frequently in persons who have been exposed to low-dose therapeutic radiation. Little information is available concerning whether or not the clinical, metabolic, and pathologic manifestations, as well as outcome, differ in these patients when compared with patien...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:

    authors: Tezelman S,Rodriguez JM,Shen W,Siperstein AE,Duh QY,Clark OH

    更新日期:1995-01-01 00:00:00

  • Esophageal perforation management using a multidisciplinary minimally invasive treatment algorithm.

    abstract:BACKGROUND:The surgical management of esophageal perforation (EP) often results in mortality and significant morbidity. Recent less invasive approaches to EP management include endoscopic luminal stenting and minimally invasive surgical therapies. We wished to establish therapeutic efficacy of minimally invasive therap...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2013.12.033

    authors: Ben-David K,Behrns K,Hochwald S,Rossidis G,Caban A,Crippen C,Caranasos T,Hughes S,Draganov P,Forsmark C,Chauhan S,Wagh MS,Sarosi G

    更新日期:2014-04-01 00:00:00

  • Pancreas transplantation in C-peptide positive patients: does "type" of diabetes really matter?

    abstract:BACKGROUND:In the past, type 2 (C-peptide positive) diabetes mellitus (DM) was a contraindication for simultaneous pancreas-kidney transplantation (SPKT). STUDY DESIGN:We retrospectively analyzed outcomes in SPKT recipients according to pretransplantation C-peptide levels ≥ 2.0 ng/mL or < 2.0 ng/mL. RESULTS:From Nove...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2014.12.020

    authors: Stratta RJ,Rogers J,Farney AC,Orlando G,El-Hennawy H,Gautreaux MD,Reeves-Daniel A,Palanisamy A,Iskandar SS,Bodner JK

    更新日期:2015-04-01 00:00:00

  • A novel technique for natural orifice endoscopic full-thickness colon wall resection: an experimental pilot study.

    abstract:BACKGROUND:Natural orifice endoscopic full-thickness colon resection attempts to overcome the need for invasive surgery in selected colorectal indications. Because basic technical requirements have not been met so far, the aim of this study was to develop a novel technique for endolumenal colon-wedge resection addressi...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2011.05.015

    authors: Rieder E,Martinec DV,Dunst CM,Swanström LL

    更新日期:2011-09-01 00:00:00

  • Thyrothymic thyroid rests: incidence and relationship to the thyroid gland.

    abstract:BACKGROUND:Rests of thyroid tissue within the thyrothymic area are relatively common and might be of clinical importance. The purpose of this study is to define the incidence and anatomy of thyroid tissue located in the line of the thyrothymic ligament, referred to here as "rests." STUDY DESIGN:Prospective descriptive...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/s1072-7515(02)01319-4

    authors: Sackett WR,Reeve TS,Barraclough B,Delbridge L

    更新日期:2002-11-01 00:00:00

  • Surgeon as Double Agent: Perception of Conflicting Expectations of Patient Care and Stewardship of Resources.

    abstract:BACKGROUND:Physicians must satisfy 2 competing expectations: advocate for patients and serve as stewards of resources. No guidelines exist for surgeons on resolving this conflict. We surveyed surgeons' perceptions about these dual obligations. STUDY DESIGN:We conducted our study at 2 large university hospitals in 3 di...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2020.04.037

    authors: Kopar PK,Lui FY

    更新日期:2020-08-01 00:00:00

  • Postoperative liver failure after major hepatic resection for hepatocellular carcinoma in the modern era with special reference to remnant liver volume.

    abstract:BACKGROUND:Postoperative liver failure is a life-threatening complication after hepatic resection. Because of recent advances in liver surgery technique and a more stringent patient selection, mortality after hepatic resection has steadily decreased, but its incidence still ranges from 10% to 20%. The factors linked to...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/s1072-7515(98)00301-9

    authors: Shirabe K,Shimada M,Gion T,Hasegawa H,Takenaka K,Utsunomiya T,Sugimachi K

    更新日期:1999-03-01 00:00:00

  • Laparoscopic repair of lumbar hernias.

    abstract:BACKGROUND:Lumbar hernias are rare defects in the posterolateral abdominal wall that may be congenital or acquired. Repairing these defects is difficult by virtue of their location and the inherent weakness of the surrounding tissues. We report a series of seven patients who had their lumbar hernias repaired laparoscop...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/s1072-7515(98)00124-0

    authors: Arca MJ,Heniford BT,Pokorny R,Wilson MA,Mayes J,Gagner M

    更新日期:1998-08-01 00:00:00

  • Oral calcium supplements to enhance early hospital discharge after bilateral surgical treatment of the thyroid gland or exploration of the parathyroid glands.

    abstract::One hundred and seventy consecutive patients undergoing parathyroid gland exploration and bilateral thyroidectomy received, postoperatively, routine oral calcium supplementation, close monitoring of total serum calcium, and addition of vitamin D for specific criteria, all to accomplish a postoperative course free of s...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:

    authors: Moore FD Jr

    更新日期:1994-01-01 00:00:00

  • A predictive model for identifying surgical patients at risk of methicillin-resistant Staphylococcus aureus carriage on admission.

    abstract:BACKGROUND:Legislative mandates and current guidelines for control of nosocomial transmission of methicillin-resistant Staphylococcus aureus (MRSA) recommend screening of patients at risk of MRSA carriage on hospital admission. Indiscriminate application of these guidelines can result in a large number of unnecessary s...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2008.05.023

    authors: Harbarth S,Sax H,Uckay I,Fankhauser C,Agostinho A,Christenson JT,Renzi G,Schrenzel J,Pittet D

    更新日期:2008-11-01 00:00:00

  • Certification by the American Board of Surgery among US medical school graduates.

    abstract:BACKGROUND:We sought to identify variables associated with American Board of Medical Specialties (ABMS)-member board certification and lack thereof among US medical graduates who planned at medical school graduation to become certified in surgery and entered graduate medical education in general surgery. STUDY DESIGN:...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2012.01.049

    authors: Andriole DA,Jeffe DB

    更新日期:2012-05-01 00:00:00

  • Is a minor clinical anastomotic leak clinically significant after resection of colorectal cancer?

    abstract:BACKGROUND:There are few reports comparing the variety and frequency of postoperative complications between patients with a major clinical leak requiring emergency abdominal reoperation and those with a minor leak diagnosed from clinical signs and managed expectantly without reoperation. This study examined the associa...

    journal_title:Journal of the American College of Surgeons

    pub_type: 杂志文章

    doi:10.1016/j.jamcollsurg.2007.05.031

    authors: Tytherleigh MG,Bokey L,Chapuis PH,Dent OF

    更新日期:2007-11-01 00:00:00