Abstract：
:We have developed a method to promote longitudinal bone growth at the level of a specific growth-plate (GP) in young rabbits. Insulin-like growth factor-I (IGF-I) was continuously infused by means of an osmotic pump into the bone marrow cavity of the proximal epiphysis of the tibia. Radiological measurement showed a 2-mm overgrowth of the tibia after 4 weeks of treatment, while histological analysis demonstrated a 15% increase in the thickness of the selected GP. The local infusion of IGF-I increased the numbers of both proliferative and hypertrophic chondrocytes and promoted hyperplasia of bony trabeculae within the epiphysis. The distribution of material infused locally into the epiphysis was simulated by the infusion of Indian ink using the same methodology (osmotic pump) as that for IGF-I. Most of the dye remained within the bone marrow cavity of the epiphysis, but a portion infiltrated into the GP, reaching the deep layer of the physeal chondrocytes and primary spongiosa of the metaphysis. These results suggest that the method reported here is a valid one for delivering cytokines or growth factors to the selected GP and for controlling the growth and differentiation of physeal chondrocytes.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Abbaspour A,Takata S,Matsui Y,Katoh S,Takahashi M,Yasui Ndoi
10.1007/s00264-007-0336-7subject
Has Abstractpub_date
2008-06-01 00:00:00pages
395-402issue
3eissn
0341-2695issn
1432-5195journal_volume
32pub_type
杂志文章abstract：PURPOSE:Acetabular component position is important for stability and wear. Fluoroscopy can improve the accuracy of acetabular component placement in the posterior approach and the direct anterior approach (DAA). The purpose of this study was to determine if the direct anterior approach in the supine position facilitate...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-015-2803-x
更新日期：2016-01-01 00:00:00
abstract：PURPOSE:We reviewed our experience with the management of B2 and B3 femoral periprosthetic fractures using a distally fixed modular femoral stem in 55 patients. METHODS:All periprosthetic fractures were managed immediately after injury without using allograft; 53 hips were available for a mean follow up of 67 months. ...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-011-1371-y
更新日期：2012-05-01 00:00:00
abstract：PURPOSE:Patients often attribute increasing pain in an arthritic joint to changing weather patterns. Studies examining the impact of weather on pain severity have yielded equivocal and sometimes contradictory results. The relationship between subchondral pseudocysts and the role they play in this phenomenon has not bee...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-011-1304-9
更新日期：2012-03-01 00:00:00
abstract：:To measure the strength of the juxta-articular trabecular bone in knee replacement, an osteopenetrometer was developed. The principle of its function is tha a needle penetrates the bony tissue and during this penetration the pressure on and the displacement of the needle is registered. The instrument was tested on cad...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00271079
更新日期：1981-01-01 00:00:00
abstract：PURPOSE:Kienböck's disease is an unusual pathology with unknown aetiology within the pediatric population. Several treatment options have been described in the literature; however, there are neither large series nor homogeneous studies that have clarified which treatment is best. The aim of this study was to describe f...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-012-1597-3
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:The purpose of this study is to compare the efficacy of percutaneous Achilles tenotomy (AT) to combined open Achilles tenotomy and posterior capsulotomy (PC+AT) in the correction of residual equinus deformity in congenital talipes equinovarus after Ponseti serial casting in both idiopathic and non-idiopathic cl...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-014-2631-4
更新日期：2015-04-01 00:00:00
abstract：:Ten patients with clinical and radiological evidence of herniated discs at lower lumbar levels were treated with partial discectomy by a lateral percutaneous approach. Eight patients had complete relief from radicular pain and were discharged within four days. They returned to normal daily activity within one month. ...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00271309
更新日期：1987-01-01 00:00:00
abstract：:We measured cytokine secretion patterns in peripheral blood and granulation tissue by flow cytometry in 16 human immunodeficiency virus (HIV) positive and 26 HIV negative patients with spinal tuberculosis. Anti-retroviral therapy was not prescribed. There were no significant differences in the postoperative morbidity ...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s002640000125
更新日期：2000-01-01 00:00:00
abstract：PURPOSE:The aim of the present study was to compare the clinical outcomes of mobile-bearing unicompartmental knee arthroplasty (MB-UKA) and open-wedge high tibial osteotomy (OWHTO) for advanced isolated medial osteoarthritis (OA). METHODS:Patients with advanced medial compartment OA (Ahlbäck grade ≥ II) who underwent ...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-018-3880-4
更新日期：2018-10-01 00:00:00
abstract：:Septic and aseptic loosening with or without extensive bone loss after total knee replacement are the most common indications for knee fusion. Both external fixation and intramedullary nailing can be used for the treatment, though the latter appears to be the method of choice for most patients. Nine patients were trea...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-006-0129-4
更新日期：2006-12-01 00:00:00
abstract：PURPOSE:We investigated the incidence, natural history, and functional consequences of a newly developed flexion contracture after total knee arthroplasty (TKA). METHODS:Forty patients with full knee extension preoperatively who developed a postoperative flexion contracture were match-paired 1:2 with 80 patients who h...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-013-1993-3
更新日期：2013-10-01 00:00:00
abstract：:In 1975 we carried out a survey in Hong Kong to locate Chinese children with congenital dislocation of the hip. Analysis of the available records between 1960 and 1975 gave an observed incidence which was at least 10 times less than found in Caucasians. The age and sex distribution, radiographic findings and the left-...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00266064
更新日期：1981-01-01 00:00:00
abstract：:We reviewed a series of consecutive total hip replacements with cemented femoral components. Modern cementing techniques were followed in all cases, but two different medullary plugs were used-one was polyethylene and the other bioabsorbable gelatin. Cement mantle quality and plug migration were assessed by three diff...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-003-0506-1
更新日期：2004-02-01 00:00:00
abstract：PURPOSE:This study aims to evaluate (1) the probability to achieve normal pelvic radiographs in children with developmental dysplasia of the hip (DDH) treated by closed reduction and (2) the amount of time needed to achieve normal pelvic radiographs and to assess what factors influence both probability and time to achi...
journal_title：International orthopaedics
pub_type： 杂志文章,多中心研究
doi：10.1007/s00264-020-04479-z
更新日期：2020-03-01 00:00:00
abstract：:A randomized, double blind study of low level laser treatment of chondromalacia of the patella in 40 patients has been undertaken. Chondromalacia was established by arthroscopy and was related to subjective symptoms. Eight treatments were given during five weeks by a physiotherapist with the use of a GAAS pulsed laser...
journal_title：International orthopaedics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00186879
更新日期：1991-01-01 00:00:00
abstract：:A tentative classification of Perthes' disease according to the extent of epiphyseal and metaphyseal involvement in lateral radiographs of the hip was applied to 61 hips in 55 patients. Forty-four hips were treated by containment (Tachjian's trilateral socket hip abduction orthosis) and 17 hips were treated surgically...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00266603
更新日期：1980-01-01 00:00:00
abstract：:One hundred fractures of the tibial shaft were treated by early weight-bearing in a below knee patellar tendon bearing plaster cast. The rate of union, and the range of knee and ankle motion were assessed. Ninety-five per cent had good or excellent results. This method of treatment is particularly valuable in the thir...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00268506
更新日期：1989-01-01 00:00:00
abstract：:A patient is reported who had multiple cartilaginous exostoses with malignant transformation of a pelvic osteochondroma. ...
journal_title：International orthopaedics
pub_type： 杂志文章,评审
doi：10.1007/s002640050136
更新日期：1997-01-01 00:00:00
abstract：:There is no evidence surrounding the benefits, effects or clinical outcomes treating asymptomatic urinary tract colonisation. A series of 558 patients undergoing elective admission for orthopaedic surgery were recruited prior to surgery and were screened for urinary tract infection (UTI). Patients had their urine dips...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-008-0573-4
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:Stage II posterior tibial tendon dysfunction (PTTD) can be treated by flexor digitorum longus (FDL) tendon transfer and medial displacement calcaneal osteotomy (MDCO). Numerous authors have studied the clinical and radiographic results of this procedure. However, little is known about the kinematic changes. The...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-013-2071-6
更新日期：2013-09-01 00:00:00
abstract：:We have treated 350 displaced Colles fractures by percutaneous fixation with K wires arranged in a 'basket' formation, as described by Kapandji. This technique enables satisfactory stabilisation of the fragments and early mobilisation and rehabilitation, usually without the use of a plaster cast or brace. We describe ...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00266982
更新日期：1988-01-01 00:00:00
abstract：PURPOSE:The failure of total hip systems caused by wear-particle-induced loosening has focused interest on factors potentially affecting wear rate. Remnants of the blasting material were reported on grit-blasted surfaces for cementless fixation. These particles are believed to cause third-body wear and implant loosenin...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-013-2135-7
更新日期：2014-04-01 00:00:00
abstract：:The aim of this study was to determine the diagnostic value of systemic biochemical markers of bone turnover in aseptic loosening in hip arthroplasty, namely the urine levels of three bone resorption peptides - crosslinked n-telopeptides (NTX), c-telopeptides (CTX I) and deoxypyridinoline (DPD). We compared 52 patient...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-007-0477-8
更新日期：2009-02-01 00:00:00
abstract：:In a randomised clinical trial in 50 patients with symptomatic osteoarthritis of the medial compartment of the knee, the clinical results of high tibial osteotomy (HTO) according to the open wedge osteotomy (OWO) and closed wedge osteotomy (CWO) were compared. In both groups locked plate fixation was used. Clinical an...
journal_title：International orthopaedics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00264-009-0861-7
更新日期：2010-02-01 00:00:00
abstract：:During a 4-year period, 32 patients with type C unstable sacral fractures were treated in our university hospital. All patients had neurological deficits as a result of their sacral fracture. The average age was 31.2 (range 22-54) years and the average Hannover Polytrauma Score (PTS) was 24 (range 19-40) points. Twelv...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-007-0468-9
更新日期：2009-02-01 00:00:00
abstract：PURPOSE:The myofibroblast, a contractile fibroblastic cell expressing α-smooth muscle actin (α-SMA), has been reported to play a role in ligament healing. The aim of this study was to evaluate the feasibility of transplanting culture-derived myofibroblasts in injured rabbit medial collateral ligaments (MCL) and in inta...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-012-1519-4
更新日期：2012-08-01 00:00:00
abstract：:We report three cases of para-articular chondroma and osteochondroma in the region of infrapatellar fat pad. All three lesions were resected and examined histologically. Two of them were primarily cartilaginous with a lobular pattern internally, and one uniformly osseous with peripheral cartilage. We conclude that the...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s002640050322
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Controversies regarding the treatment of advanced tuberculosis of the knee still exist. We retrospectively investigated protocols of total knee arthroplasty (TKA) and their efficacy in patients with advanced tuberculosis. METHODS:Nine TKAs associated with advanced tuberculosis were performed at our institut...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-015-3050-x
更新日期：2016-07-01 00:00:00
abstract：:This experimental study was undertaken in mice to investigate the procedures for storage of allogenic cancellous bone. Cancellous grafts were were stored at -80 degrees C, -196 degrees C or freeze dried. Grafts were implanted into a defect in the recipient's femur and after one week the cellular kinetic activity was a...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00178753
更新日期：1990-01-01 00:00:00
abstract：PURPOSE:To evaluate the influence of stem offset and neck shaft angles on the range of motion before component impingement (ROMCI) and bony impingement (ROMBI), and the types of impingement in total hip arthroplasty (THA). METHODS:Using the computed tomography data of 101 patients who underwent THA, three-dimensional ...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-015-2826-3
更新日期：2016-02-01 00:00:00
