Abstract：
OBJECTIVE:The goal of this study was to evaluate the efficacy of 100% oxygen and inhaled nitric oxide (iNO) in decreasing pulmonary vascular resistance (PVR) and transpulmonary gradient (TPG) in dilated cardiomyopathy patients being evaluated for orthotopic heart transplantation (OHT); who, despite maximal intravenous (IV) dilator therapy, had persistent moderate-to-severe pulmonary hypertension. DESIGN:A prospective nonrandomized clinical study. SETTING:University hospital, major transplant center. PARTICIPANTS:Twenty-one adult patients undergoing OHT evaluation. INTERVENTIONS:One hundred percent oxygen and iNO at 20 and 40 ppm were sequentially administered to the patients once they were optimized with IV vasodilators and inotropes. MEASUREMENTS AND MAIN RESULTS:Although no significant change was noted with oxygen, iNO 20 ppm reduced the mean pulmonary artery pressure (44.1 +/- 1.7 to 38.6 +/- 1.8 mmHg, p < 0.05), PVR index (823 +/- 47 to 621 +/- 55 dyne/s/m(2)/cm(5), p < 0.05), TPG (22.4 +/- 1.4 to 17.0 +/- 1.5 mmHg, p < 0.05), and right ventricular stroke work index (14.7 +/- 1.2 to 11.1 +/- 1.2 g . m/m(2)/beat, p < 0.05). In 13 of 21 patients, PVR decreased by greater than 25% after iNO therapy. Nine of these patients had PVR and TPG decrease to levels considered acceptable for OHT listing. CONCLUSIONS:iNO can further improve right ventricular hemodynamics even after presumed optimization with IV vasodilators and serves as a test of PVR reversibility during the preoperative assessment of OHT candidates.
journal_name
J Cardiothorac Vasc Anesthjournal_title
Journal of cardiothoracic and vascular anesthesiaauthors
Mahajan A,Shabanie A,Varshney SM,Marijic J,Sopher MJdoi
10.1053/j.jvca.2006.01.028subject
Has Abstractpub_date
2007-02-01 00:00:00pages
51-6issue
1eissn
1053-0770issn
1532-8422pii
S1053-0770(06)00059-0journal_volume
21pub_type
临床试验,杂志文章abstract：OBJECTIVE:To determine whether patients receiving pegorgotein preoperatively would be less likely than patients receiving placebo to demonstrate postoperative cerebral or myocardial dysfunction and thus would be less likely to (1) demonstrate a decline in neuropsychologic testing after cardiopulmonary bypass, (2) recei...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s1053-0770(99)90121-0
更新日期：1999-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the incidence of postoperative atrial fibrillation (POAF), the predisposing factors, the results of treatment before discharge, and the impact on duration and costs of hospitalization. DESIGN:A prospective observational study. METHODS:Patients who underwent cardiac surgery from January 1, 2007 t...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1053/j.jvca.2010.03.009
更新日期：2010-12-01 00:00:00
abstract：OBJECTIVES:To determine whether smoking cessation can reduce the incidence of postoperative hypoxemia (POH) after on-pump coronary artery bypass grafting (CABG) surgery. DESIGN:Prospective, single-center, observational study. SETTING:Single-center university teaching hospital. PARTICIPANTS:The study comprised 300 pa...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1053/j.jvca.2016.05.011
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVE:This study was designed to determine whether ropivacaine plus fentanyl was as effective as bupivacaine plus fentanyl in a continuous thoracic paravertebral block after posterolateral thoracotomy. DESIGN:Patients were randomly assigned in a blinded fashion to receive 1 of 2 solutions for paravertebral analges...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1053/j.jvca.2006.02.032
更新日期：2006-10-01 00:00:00
abstract：:The recurrent or new trends of early extubation after cardiac surgery are here to stay in the 1990s. The preoperative status does not necessarily predict the postoperative course and prolonged mechanical ventilation following cardiac surgery should not be uncritically considered as routine. All patients should be asse...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章,评审
doi：10.1016/s1053-0770(05)80105-3
更新日期：1995-08-01 00:00:00
abstract：OBJECTIVES:To identify the prevalence of and risk factors for inadvertent hypothermia after procedures performed with procedural sedation and analgesia in a cardiac catheterization laboratory. DESIGN:A single-center, prospective observational study. SETTING:A tertiary-care private hospital in Australia. PARTICIPANTS...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1053/j.jvca.2015.06.002
更新日期：2015-10-01 00:00:00
abstract：:Elective cardioversion is a short procedure performed under general anesthesia for the treatment of cardiac dysrhythmias. Selection of the anesthetic agent is important, because a short duration of action and hemodynamic stability are required. Forty-four patients scheduled for elective cardioversion in the coronary c...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/1053-0770(91)90007-g
更新日期：1991-12-01 00:00:00
abstract：OBJECTIVE:Currently, there are no large-scale studies that compare differences in case duration of aortic valve replacements (AVRs). The primary objective of this study was to determine associations of hospital facility type, geographic location, case volume per year, and time of day with duration of valve replacement ...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1053/j.jvca.2017.06.039
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVE:To determine which strategies are currently used for (anti)coagulation management and blood conservation during cardiac surgery in Canada. DESIGN:Institutional survey. SETTING:University hospital. PARTICIPANTS:All sites performing cardiac surgery in Canada. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESUL...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1053/j.jvca.2008.02.005
更新日期：2008-10-01 00:00:00
abstract：:The ASA Closed Claims Project has generated a standardized collection of case summaries of adverse anesthetic outcomes, with the objectives of identifying major areas of anesthesiologist liability and the contribution of substandard care to anesthetic injury. Seventy-six (3%) of the files in the project's current data...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1016/1053-0770(94)90608-4
更新日期：1994-02-01 00:00:00
abstract：OBJECTIVES:This study was conducted to compare continuous cardiac output (CCO) with bolus thermodilution cardiac output (BTD) at steady state, and to compare the response time of STAT CCO with that of trend CCO, mean arterial pressure, and mixed venous oxygen saturation [SvO2] during an acute hemodynamic change. DESIG...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1016/s1053-0770(97)90050-1
更新日期：1997-06-01 00:00:00
abstract：OBJECTIVE:Although failure to achieve an adequate activated coagulation time (ACT) after full heparinization before cardiopulmonary bypass often is attributed to antithrombin (AT) deficiency, it remains unclear if this is a causative mechanism of decreased heparin responsiveness. Therefore, the authors determined the r...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1053/j.jvca.2012.03.011
更新日期：2012-08-01 00:00:00
abstract：:Fiberoptic pulmonary artery flotation catheters have gained clinical acceptance for continuous monitoring of mixed venous oxygen saturation (SvO2), especially in the management of hemodynamically unstable patients. Therefore, the performance of the oximetry system used is extremely important. The accuracy and stabilit...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1016/1053-0770(92)90139-x
更新日期：1992-06-01 00:00:00
abstract：OBJECTIVE:Prophylactic administration of tranexamic acid (TA), an antifibrinolytic agent, decreases bleeding after cardiac surgery with systemic hypothermia (25 degrees C to 29 degrees C). Warmer systemic temperatures during cardiopulmonary bypass (CPB) may reduce bleeding and thus alter the requirement for TA. The eff...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s1053-0770(98)90235-x
更新日期：1998-12-01 00:00:00
abstract：OBJECTIVES:The authors hypothesized that bioimpedance cardiography measured by the Endotracheal Cardiac Output Monitor (ECOM; ConMed, Utica, NY) is a convenient and reliable method for both cardiac index (CI) assessment and prediction in fluid responsiveness. DESIGN:A prospective observational study. SETTING:A teachi...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1053/j.jvca.2011.06.023
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To test the reproducibility of Sonoclot coagulation analysis (SCA; Sienco Inc, Morrison, CO). The authors wished to determine if the mix/release of the preloaded celite activator in standard Sono-cuvettes could be responsible for the high variation coefficients for SCA parameters with citrated whole blood and...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1016/s1053-0770(99)90209-4
更新日期：1999-08-01 00:00:00
abstract：OBJECTIVE:To assess the impact of regional supplemented general anesthesia (RSGEN) on regional myocardial function during abdominal aortic surgery (AAS). DESIGN:Prospective randomized study. SETTING:Single academic medical center. PARTICIPANTS:Seventy-three patients scheduled for infrarenal aortic aneursymectomy. I...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s1053-0770(97)90201-9
更新日期：1997-04-01 00:00:00
abstract：:SEPSIS REMAINS one of the most common causes of childhood morbidity, mortality, and higher healthcare costs, with over 75,000 hospital admissions in the United States and an estimated 4 million cases worldwide per year. While standardized criteria to define sepsis are in flux, the general concept of sepsis is a severe...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章,评审
doi：10.1053/j.jvca.2019.10.029
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVES:This study's purpose was to review non-cardiac surgery (NCS) in patients with hypertrophic obstructive cardiomyopathy (HOCM) to examine perioperative management and quantify postoperative mortality and worsening heart failure. DESIGN:Retrospective review. SETTING:A single tertiary care center. PARTICIPANT...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1053/j.jvca.2015.08.017
更新日期：2016-06-01 00:00:00
abstract：:This study compared the use of high-frequency jet ventilation (HFJV) and tidal ventilation (TV) in a group of dogs with induced global myocardial ischemia before and after cardiopulmonary bypass. Transesophageal echocardiography was used to determine whether HFJV with its lower airway pressures could improve cardiac p...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1016/1053-0770(91)90153-k
更新日期：1991-08-01 00:00:00
abstract：BACKGROUND:It has been demonstrated that new regional wall motion abnormalities (RWMAs) are infrequently associated with electrocardiographic (ECG) ischemic changes during coronary artery bypass graft (CABG) surgery. The evaluation of apical or basal areas by biplane transesophageal echocardiography (TEE) may clarify t...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1016/S1053-0770(96)80196-0
更新日期：1996-10-01 00:00:00
abstract：:Left atrial or pulmonary capillary wedge pressure V waves are used immediately after mitral valve replacement to evaluate valve competence. However, their correlation with hemodynamically significant regurgitation has not been established. Transesophageal echocardiography (TEE) was used to prospectively examine whethe...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1016/1053-0770(91)90035-r
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVE:Patients undergoing aortic surgery with deep hypothermic circulatory arrest (DHCA) usually are associated with a high rate of allogeneic blood transfusion, and their red blood cell (RBC) transfusion threshold is unclear and controversial. The purpose of this study was to explore whether a restrictive transfus...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1053/j.jvca.2016.03.128
更新日期：2016-10-01 00:00:00
abstract：OBJECTIVES:The postoperative course following on-pump coronary artery bypass grafting (CABG) in patients with severe left ventricular (LV) systolic dysfunction is often unpredictable. Therefore, the aim of this study was to identify predictors of poor postoperative outcome in this subset of patients. DESIGN:Prospectiv...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1053/j.jvca.2016.04.025
更新日期：2017-02-01 00:00:00
abstract：OBJECTIVE:To compare paravertebral block under thoracoscopy with wound infiltration at an early stage after video-assisted thoracic lobectomy surgery. DESIGN:A prospective, randomized, triple-blinded, placebo-controlled trial. SETTING:A single-center university hospital. PARTICIPANTS:Patients scheduled for video-ass...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1053/j.jvca.2015.06.013
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:To determine whether preoperative regional cerebral oxygen saturation (rSO2) and the decrease in rSO2 during carotid clamping were predictive of the risk for neurologic complications in carotid endarterectomy and to determine the cutoff values of the studied parameters. DESIGN:Cohort, prospective, nonrandomi...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 临床试验,杂志文章
doi：10.1053/j.jvca.2016.10.017
更新日期：2017-06-01 00:00:00
abstract：:Pulmonary thromboendarterectomy (PTE) remains the only curative surgery for patients with chronic thromboembolic pulmonary hypertension (CTEPH). Postoperative intensive care unit care challenges providers with unique disease physiology, operative sequelae, and the potential for detrimental complications. Central conce...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章,评审
doi：10.1053/j.jvca.2019.03.005
更新日期：2019-11-01 00:00:00
abstract：:The efficacy of interpleural administration of sufentanil, 50 micrograms, was compared with that of 150 mg of bupivacaine, 0.5%, with epinephrine, 5 micrograms/mL, or saline, in 30 patients (N = 10 in each group) undergoing lateral thoracotomy. Sufentanil, bupivacaine, or saline was administered interpleurally after i...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章
doi：10.1016/1053-0770(93)90307-7
更新日期：1993-10-01 00:00:00
abstract：OBJECTIVES:Perioperative treatment with angiotensin-converting enzyme (ACE) inhibitors in cardiac surgery with cardiopulmonary bypass is still controversial. Using ACE inhibitors during cardiac surgery might be associated with an increased risk of critical hypotensive episodes. On the other hand, ACE inhibitors could h...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1053/j.jvca.2003.10.011
更新日期：2004-02-01 00:00:00
abstract：:Cardiopulmonary bypass (CPB) has been one of the most important additions to the field of heart surgery in the past century. However, significant morbidity associated with CPB has led to the increasing implementation of off-pump coronary artery bypass (OPCAB). The use of OPCAB has broadened surgical revascularization ...
journal_title：Journal of cardiothoracic and vascular anesthesia
pub_type： 杂志文章,评审
doi：10.1053/j.jvca.2019.05.005
更新日期：2020-01-01 00:00:00
